News on the use of animals, and their alternatives, in biomedical research. Covers animal models, primate studies, tissue chips, research ethics, and disease modeling.
Despite service restrictions, veterinary practices adapted to unprecedented circumstances, offering convenient remote consultations and addressing urgent care needs. Delays and cancellations of procedures affected some dogs, but the majority of respondents found remote consultations to be a reliable option.
Researchers found that dogs process human and canine vocalizations differently in their brains, responding to emotional content and distinct neural pathways. This groundbreaking study provides new insights into the neural functions of canine auditory perception.
Researchers found a correlation between Parkinson's gene alpha-synuclein and vocal production in zebra finches. The study suggests that this link could lead to earlier diagnoses and treatments for Parkinson's patients.
A new canine coronavirus variant has been identified in human patients with pneumonia, showing a shift from infecting both the intestines and respiratory system to only the respiratory system. Researchers used state-of-the-art tools to assess evolution pressures that may have influenced this shift.
Researchers found that fruit bats use echolocation during the day despite having excellent vision, suggesting a combination of both senses for enhanced navigation. This study highlights the importance of integrating different senses, like humans using visual and auditory information when crossing streets.
A recent study led by Georgetown University researchers found that city wildlife may not be a significant threat for future pandemics. Urban-adapted animals host roughly ten times as many diseases, but after adjusting for sampling bias, the risk of human-infective viruses is no greater than in rural areas.
A large-scale international study, led by Tel Aviv University's Dr. Omri Bronstein, found that many species of echinoids, including sea urchins, survived a mass extinction event 50 million years earlier than thought. The findings suggest that estimates of evolutionary timelines may err by tens of millions of years.
A multi-pillar approach to nutrition can help increase lifespan by promoting optimal carbohydrate intake from non-refined sources, low but sufficient protein from plant-based sources, and enough plant-based fats. The 'longevity diet' may also involve intermittent fasting and a 5-day cycle of a fasting or fasting-mimicking diet every 3-...
Fossil finds from the High Alps reveal giant ichthyosaurs that lived around 205 million years ago, measuring up to 20 meters in length. The discovery sheds new light on these prehistoric creatures and their paleobiological implications.
Researchers have identified helpful and unhelpful aspects of the immune response that determine whether TB infections can be kept under control. The findings may help design a more effective vaccine by targeting specific cell subsets and modulating intercellular signaling.
Scientists at the University of Oxford have developed an 'optomemristor' device that facilitates three-factor learning and emulation of biological computations, making it possible to perform complex machine learning tasks. The device uses both light and electrical signals to interact and consume very little energy.
Researchers at Gauhati University studied roadkill on a 64-kilometer stretch of National Highway 715 in India's Kaziranga-Karbi Anglong Landscape. They found dramatic mortality rates among frogs, toads, snakes, and lizards, with over 6000 animals killed annually.
Researchers have identified a new strain of the myxoma virus that has enabled it to leap from European rabbits to Iberian hares, causing lethal disease in both species. The study suggests that this viral adaptation may also improve the virus's ability to replicate in human cancer cells.
Researchers at Kyoto University have produced induced pluripotent stem cells (iPSCs) from the endangered Grévy's zebra, showcasing similarities with human and mouse stem cells. The study's findings provide insight into evolutionary conservation between mammals and may help advance research on endangered species.
Researchers at Tokyo University of Science identify brain regions and signaling pathways involved in fear extinction via delta receptor activation. The study suggests a potential therapeutic agent for post-traumatic stress disorders by suppressing fearful memories.
Research suggests that EMFs can cause Alzheimer's disease by building up calcium levels in brain cells. This increase leads to changes in the brain, which develop conditions for Alzheimer's. The study highlights the importance of reducing EMF exposure to prevent or delay the onset of Alzheimer's.
A study suggests that intense exercise can help rats resist cues for high-fat food pellets, even after a 30-day diet. The researchers found that exercise modulated the rats' willingness to work for these cues, reflecting their craving level.
Johns Hopkins scientists discovered three brain areas – premotor, primary motor, and primary somatosensory – that work together to control sequential movements. These regions are involved in processing sensory cues and adapting to unexpected events, which could lead to new treatments for motor disorders.
Researchers have identified a genetic marker that predicts East Coast fever tolerance in cattle, paving the way for breeding programs and potentially reducing livestock losses by up to 100%. The discovery could also lead to more sustainable and cost-effective farming practices in Africa.
A survey of veterinarians in the US and Canada reveals a significant increase in cannabis poisoning cases among pets since Canada's 2018 legalization, with most cases treated successfully. The study highlights the importance of understanding the effects of cannabis on pets to inform veterinary efforts and policies.
Scientists at Johns Hopkins Medicine have successfully cultivated human muscle stem cells capable of renewing themselves and repairing muscle tissue damage in mice. The self-renewing stem cells were created by reprogramming laboratory-grown human skin cells, which then differentiated into specific cell types using a nutrient-rich broth.
Researchers have developed a new treatment for chronic inflammation by targeting the ASC protein with nanobodies, which can dissolve harmful molecular complexes and counteract inflammation. The treatment has shown promising results in mouse models, alleviating symptoms of rheumatoid arthritis and gout.
Human activity on Hainan Island is causing changes in the body shapes and diets of tropical birds, resulting in biotic homogenisation. Despite efforts to protect biodiversity, the island's unique ecosystem is being affected by large-scale economic and land-use changes.
A five-year, $13 million grant will investigate the molecular and cellular mechanisms of prion transmission in CWD. The researchers aim to understand the inter-species transmission potential of the disease and its ability to spread from animals to humans.
New research from The University of Manchester found that poaching combined with individual rhino's reproductive variance significantly increases the risk to black rhino survival. Reproductive skew, or variation in breeding success between females, can exacerbate extinction risk by up to 70% in small populations.
A team of researchers from INRS has developed a new tool to measure the effects of endocrine disruptors in wastewater. Using human cell lines, they can detect the presence of these contaminants and predict their harmful effects without resorting to animal testing.
Researchers propose that wildlife can return phosphorus to the land by restoring interconnected animal communities, revitalizing ancient pathways of natural fertilization. This approach aims to generate sources of fertilizer for farmers and increase ecosystem resilience in the face of climate change.
Researchers used network science to distinguish between viruses that can infect human cells and those that cannot. They identified a region on the virus spike protein critical for cell infection, which could inform vaccine development.
Researchers aim to replicate buzz pollination using microrobots to understand its importance in agriculture and conservation. The project could lead to stronger motivation for conserving diverse bee species and optimizing fruit and vegetable yields.
Naked mole-rats of higher social rank have a larger spleen, which may enable them to fight infections better and deal with inflammation more easily. The researchers also suspect that the spleen influences an animal's longevity, as successful naked mole-rats live longer.
The American marten study found that monitoring the species has an 'umbrella effect' on 11 other mammals, detecting population declines. However, habitat loss and climate change threaten the marten's survival. The researchers developed a monitoring protocol for the winter season to detect protected species.
A comprehensive study of 8,000 birds in Israel found significant changes in bird morphology over the past 70 years, likely due to global warming. Some species became lighter while others gained size, increasing their surface area-to-volume ratio to facilitate heat loss.
A new study found that vitamin K2 supplementation improved spatial memory, learning ability, and reduced evidence of cognitive impairment, depression, and anxiety in rats. The researchers suggest that vitamin K may help preserve cognitive functions by affecting biological pathways involving inflammation and antioxidant activity.
Scientists have developed a method using DNA from blood meals of blood-sucking leeches to survey vertebrate species in large areas. The study, led by Harvard researchers, identified 86 vertebrate species in the reserve, including near-threatened and threatened species.
Researchers at the University of Otago have developed a new method for obtaining ancient genomic data from small vertebrate remains, causing no visible damage to the underlying bone. The study presents a breakthrough in analyzing materials in museum collections and rare, valuable specimens.
A new study suggests that dramatic swings in food intake can have long-term impacts on cardiovascular health and metabolism. Researchers found that rats who experienced cycles of weight loss and gain had reduced heart and kidney function, as well as increased insulin resistance.
A new study found that infant monkeys conceived while their mothers were exposed to wildfire smoke showed increased inflammation, memory deficits, and a more passive temperament compared to those conceived later. The effects suggest that some component of wildfire smoke can act as a teratogen, affecting fetal development.
A new study supports the idea that humans inherited our love of alcohol from primate ancestors, who consumed fermented fruit with high alcohol content. Monkeys eat and digest alcohol-rich fruits, using it as a source of calories, shedding light on human affinity for booze.
A study published in Scientific Reports found that mammals with larger brains than similar-sized species were more likely to have survived extinction. The researchers investigated brain sizes of 291 living mammal species and 50 extinct species, discovering a significant correlation between brain size and survival.
A new test, RHEOLEX, can quickly detect breeding bull fertility levels using a simple, home pregnancy test-like device. The test mimics the biological process of rheotaxis, in which sperm swim upstream in the reproductive tract, to quantify the sperm's ability.
Researchers found that livestock grazing had no negative impact on snow leopard distribution or density, and the species can coexist due to their separate ecological niches. The study suggests a more nuanced approach to conservation and land use, prioritizing the preservation of rocky mosaics.
Researchers found that an intranasal application of oxytocin could make lion interactions less life-threatening. After the treatments, lions displayed reduced vigilance towards other lions and became more tolerant of their presence.
In a study on cannibalism in poison frog tadpoles, researchers found that relatedness affects aggression levels. Large tadpoles were less aggressive towards their smaller siblings than non-siblings, suggesting they can discriminate between relatives and change behavior accordingly.
Researchers developed an automated auditory training program that enables marmoset monkeys to perform hearing tests in their familiar environment on a voluntary basis. The study demonstrates the animals' ability to abstract from learned sounds and suggests they are ideal model animals for hearing system research.
A study analyzing 10 years of citizen science data on wildlife roadkill in Flanders found that some species are more prone to being killed by vehicles. The research used data from online platforms like Waarnemingen.be, which has collected over 90,000 roadkill records since 2008.
A study using century-old museum collections and modern data shows that about a third of bird species in Chicago are laying eggs nearly a month earlier than they did a hundred years ago. Climate change is believed to be the main culprit behind this shift, with rising temperatures affecting nesting habits.
Researchers used camera traps to monitor interactions between Panama's epiphytic Zamia pseudoparasitica and animals, revealing that a nocturnal tree-dwelling mammal called northern olingos may be responsible for seed dispersal. The study sheds light on the plant's persistence in the forest canopy.
Researchers at Kobe University discover that immobilization induces loss of muscle mass by disrupting calcium levels and triggering the KLF15-IL-6 pathway. This finding may lead to the development of a treatment for muscle loss, known as sarcopenia, which affects aging societies.
A research team found that limiting energy in neurons increases hyperexcitability and severity of seizures in mice. The ketogenic diet restored mitochondrial function and reduced seizure intensity.
A new study from the University of Copenhagen suggests that the poison from the sea snail species Conus rolani can function as a painkiller, blocking out pain in mice for an even longer time than morphine. This discovery offers a potential alternative to addictive painkillers like morphine and opioids.
A survey of Finnish dog-owners found that repetitive behaviors like tail-chasing are more common among first-time owners, those living with larger families, and exercising for less than an hour per day. These behaviors were associated with a range of environmental, lifestyle, and genetic factors.
Researchers found that Spinosaurus and its close relative Baryonyx had dense bones that would have allowed them to submerge underwater to hunt. In contrast, Suchomimus had lighter bones that made swimming difficult, leading the team to conclude that these dinosaurs likely waded instead.
Researchers discovered a new venom compound in deep-water cone snails, similar to the hormone somatostatin, with possible pharmaceutical applications for treating chronic pain and other human maladies. The study highlights the rich biochemical diversity of animal venoms and the need to explore new compounds.
Scientists at University of Illinois and Mie University develop monoclonal antibodies to prevent lung cell death in mouse models of idiopathic pulmonary fibrosis and acute respiratory disease syndrome. Non-invasive diagnostic tools also presented could aid in predicting disease progression and identifying patients at risk.
A new study finds that forest bird nestlings are smaller and less likely to survive extreme heat, while urban birds seem to adapt better. The research highlights the fragility of natural populations and the need for further understanding and protection.
Scientists developed a natural antibacterial texture inspired by insect wings, killing up to 70% of bacteria. The innovation aims to reduce food waste, particularly in meat and dairy exports, and extend the shelf life of packaged food.
A recent study found that genetic changes in dogs' brain tissues are primarily about the number of genes affected rather than their function. The researchers discovered that approximately 3,500 genes were differentially expressed between young and old dogs, with most genes showing reduced activity in older animals.
A recent study found that bison reintroduction to mixed-grass prairies increases bird diversity and cervid occupancy in riparian areas. Vegetation changes associated with bison grazing promote biodiversity, benefiting multiple species.
A new rice rat species, possibly arboreal, was discovered in Ecuador through detailed skull analysis. The species, Mindomys kutuku, has distinct characteristics that distinguish it from its sister species.
A gene called Fer2 has been identified as a key player in protecting dopaminergic neurons from degeneration. In flies and mice, overproduction of Fer2 reduces oxidative stress and prevents neurological defects characteristic of Parkinson's disease.