Articles tagged with Clinical Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Researchers validate a new blood test platform that can measure multiple biomarkers of Alzheimer's disease, potentially improving early diagnostics and treatment. The platform captures changes in proteins related to neurodegenerative diseases and may help track disease progression over time.
A recent Canadian study reveals that transgender populations in Canada experience a significantly higher prevalence of serious mental disorders and suicidality compared to cisgender peers. The study, published in JAMA, is based on data from nearly 10,000 Canadians aged 15 or older.
A new supplement celebrating the 100th volume of the Journal of Alzheimer’s Disease presents insights into the state of art in AD research. Recent advancements in geroscience have led to the development of preventive medical strategies targeting aging, holding promise for reducing disease risk.
A new study found that COVID-19 infection increased the risk of heart attack and stroke for up to three years after infection. The risk was higher among people with A, B or AB blood types compared to type O, according to researchers analyzing data in the UK Biobank.
A new study from UCSF has found that ChatGPT overprescribes in emergency care situations, providing unnecessary x-rays and antibiotics. The AI model was less accurate than resident physicians, with a tendency to err on the side of caution. Researchers emphasize the need for better frameworks to evaluate clinical information before AI c...
A study of 668 infants found a small decrease in birth weight for gestational age with every 1°C increase in average daily heat stress during the first trimester. Infants up to two years old exposed to high heat may have lower weights and heights for their age.
A new image processing strategy for cardiac magnetic resonance imaging identifies areas responsible for complex ventricular tachycardias, enabling preoperative planning and reducing procedure times and complications. The systematic approach eliminates operator bias and increases sensitivity for detecting these regions.
Researchers have developed a novel gene therapy approach that targets and breaks down faulty ribonucleic acids in the KCNA2 gene, which is associated with recurring seizures. The therapy has shown promise in reducing excessive neuron activity linked to epilepsy.
Industry-sponsored trials have grown while federally funded enrollment remains flat, jeopardizing research in cancer prevention, screening, and health disparities. Diversified funding and strong advocacy are needed to ensure all patient populations benefit from research advancements.
Researchers argue that stigma can play a huge role in health outcomes, leading to disengagement from care, coerced sterilization, and lack of informed choices. Addressing stigma through evidence-based approaches, such as staff training and relationship building, can improve healthcare services.
A new study found that 5-fluorouracil kills cells by interfering with RNA synthesis, not DNA damage. The findings suggest that combining 5-FU with drugs affecting RNA synthesis could make it more effective in patients with gastrointestinal cancers.
A team of scientists from NTU Singapore and HKU found that electro-acupuncture can reverse the effects of obesity in obese individuals and mice on a high fat diet. The treatment targets osteoprotegerin, a protein linked to fat cell formation and obesity development.
Researchers found that patients had the same success rate when treated for 24 hours compared to 72 hours, with no difference in need for transfusion, ventilation, or vasopressors. This suggests that shorter octreotide therapy may be sufficient and could help reduce hospital stays and costs.
Researchers found that lap support overestimated systolic pressure by nearly 4 mmHg and an unsupported arm hanging at the side overestimated systolic pressure by nearly 7 mmHg. The study emphasizes the importance of adhering to clinical guidelines for accurate blood pressure measurement.
Researchers have used AI to analyze digital images of pathology slides and identified risk factors for aggressive brain tumors that differ between men and women. These findings could lead to more individualized care and improved treatment outcomes for glioblastoma patients.
A study by Ohio State University researchers found that combining pimozide with CB-839 can effectively suppress glioblastoma growth by blocking lipid production and starvation of tumor cells. This innovative combination may also hold promise for treating other cancers relying on glutamine and lipids.
A study by UC San Francisco found that more screen time is associated with severe symptoms of depression, anxiety, inattention, and aggression in 9-10 year olds. The effects were small but consistent, with activities like video chatting and playing video games strongly linked to depressive symptoms.
A non-invasive blood test measuring circulating tumor cells can predict treatment response, disease progression, and overall survival in men with metastatic prostate cancer. Patients with more CTCs had shorter median survival lengths and a greater risk of death.
A recent study found that tau protein buildup disrupts the salience network, a crucial communication network in the brain, leading to behavioral changes. The study used advanced medical imaging to analyze the brains of 128 people with early-stage dementia and showed a strong association between tau disruption and behavioral symptoms.
Recent clinical trials of neoadjuvant therapy before radical prostatectomy, such as the ACDC-RP trial, have struggled to show significant survival benefits. Researchers recommend maximal androgen blockade with an androgen receptor pathway inhibitor as the 'backbone' of neoadjuvant therapy trials.
A new CAR-T cell therapy targeting CD7 on leukaemia cells has shown promising results in treating T-ALL patients who have exhausted all standard treatment options. The therapy achieved complete remission in 16 out of 17 patients, with some remaining in remission for over five years.
Virginia Tech researchers publish real-time data to better understand what happens when people lose their balance. The study uses wrist-worn voice recorders to capture immediate, self-reported data from participants, providing a more reliable understanding of the circumstances surrounding balance loss among older adults.
Researchers have developed a molecule called LaKe that can mimic the metabolic response to regular exercise and fasting by increasing lactate and ketone levels in the blood. This molecule has the potential to alleviate concentration difficulties, treat brain trauma, Parkinson's, and dementia, and improve overall health.
Researchers at Wake Forest University School of Medicine will investigate factors that facilitate or hinder conversations between physicians and patients about medical misinformation. The study aims to develop a toolkit to increase health literacy and counter misinformation among older adults, who are disproportionately affected by hea...
Researchers have developed a peptide inhibitor called RI-AG03 that effectively prevents Tau protein aggregation in lab and fruit fly studies. The breakthrough targets both major aggregation-promoting 'hotspots' of the Tau protein, potentially paving the way for more effective treatments for neurodegenerative diseases.
Researchers have successfully transplanted human embryonic stem cell-derived retinal organoid sheets into monkeys with macular holes, resulting in graft survival and maturation of light-detecting cells. The study suggests that this method could become a practical treatment option for difficult macular hole cases.
Researchers review UBA1 loss of function in VEXAS Syndrome, a hematoinflammatory disorder characterized by severe inflammation, cytopenias, and oncogenicity. They explore therapeutic options, including clone-targeting drugs, to combat this challenging disease.
A study found that doxycycline post-exposure prophylaxis (doxy-PEP) did not significantly alter the overall composition of gut bacteria in individuals who took it for six months. However, the researchers noted signs of resistance building against tetracycline, a class of antibiotics to which doxycycline belongs.
A study of over 1,329 adults and 1,907 caregivers found that two-thirds of adults with food allergies and three-quarters of adult caregivers reported psychological distress related to food allergy. The biggest barrier to access to psychological help was cost, highlighting the need for free or low-cost support.
The new funding supports the first-of-its-kind single-cell mass spectrometer in Maine and one of the first in the country. Researchers can now analyze proteins and metabolites from individual cells, providing unprecedented detail into disease mechanisms.
A new study explores a promising combined therapy for multiple sclerosis, using tolerogenic dendritic cells modified with myelin antigens. Researchers found that these cells from patients have a persistent pro-inflammatory signature, making them less effective compared to those derived from healthy individuals.
A new study aims to increase follow-up care for patients who receive abnormal stool-based fecal immunochemical tests, focusing on improving coordination between primary and specialty clinics. The goal is to improve colorectal cancer screening processes in underserved populations, increasing survival and reducing mortality.
A multicenter study found that specific KRAS mutations in pancreatic cancer can affect patient outcomes, with some variants associated with better overall survival. The research suggests revising clinical guidelines to recommend routine molecular testing in all patients with pancreatic cancer.
Researchers at NYU Langone Health will use visible-light OCT technology to detect biomarkers of neurodegenerative disease, including Alzheimer’s and Parkinson’s diseases. The study aims to identify retinal layers and monitor the effects of therapies.
A study suggests that online insomnia treatment, SHUTi, can provide meaningful relief for caregivers struggling with sleep difficulties. The program showed promising results in improving sleep quality and reducing stress among high-intensity caregivers, those shouldering the greatest responsibilities in caring for their loved ones.
Researchers from Johns Hopkins Medicine discovered how a brain cell surface molecule shapes neuron behavior, finding that it suppresses selectivity in neurons. The study's findings may help scientists better understand causes of autism, schizophrenia, and epilepsy.
The latest APA journal issues explore schizophrenia spectrum disorders, PTSD treatment, and college mental health. Research highlights include new approaches to psychosis treatment and findings on mental health in higher education.
Researchers discovered TERT gene activation as a key factor in determining the clinical course of pulmonary carcinoid tumours, with aggressive growth linked to telomerase activation. The study aims to improve treatment planning and targeted therapeutic strategies for cancer types.
Two UCF cancer researchers, Alicja Copik and Debbie Altomare, have received $100,000 grants from the Florida Breast Cancer Foundation to develop new treatments for breast cancer. They focus on enhancing natural killer cells to fight cancer and harnessing the body's immune system to create new therapies.
Researchers developed a new combined therapy for multiple sclerosis, combining tolerogenic dendritic cells with Dimethyl Fumarate to restore immune balance. The treatment showed promise in preclinical studies, reducing symptoms in mice and potentially offering hope for patients worldwide.
Pragmatic clinical trials compare treatments in everyday clinical settings, but adoption of trial findings has been inconsistent. To address this, the authors propose adaptive trial designs to align trial goals with healthcare system needs. By doing so, they aim to generate evidence that truly improves patient care.
Brendan G. Carr, MD, MS, receives the Colin C. Rorrie Award for Excellence in Health Policy, recognized for his work on building regional systems for emergency care and advocating for increased collaboration between public and private sectors. Ugo Ezenkwele, MD, MPH, receives the Leon L. Haley Jr. Award for Excellence in Diversity, Inc...
SEARCH aims to accelerate healthcare innovation by generating FAIRified synthetic data for use in AI/ML models, enabling large-scale data collaborations while preserving privacy and compliance. The hub will deliver reliable methodologies for synthetic data generation, significantly increasing the availability of interoperable datasets.
Researchers have developed a lab-grown spine model that can test the effects of valproic acid on fetal development. The study found that co-treatment with Rapamycin can prevent the negative effects of valproic acid, enabling women to take life-saving medication while having healthy children.
A new American Thoracic Society report provides practical frameworks to address systemic racism in asthma care. The report highlights the need to engage affected communities and critically evaluate funding mechanisms to promote antiracism practices in research.
The expert panel discussion sheds light on the best practices for injecting hyaluronic acid (HA) fillers in the infraorbital hollows. Top surgeons share their preferred fillers and techniques, providing valuable insights for treating undereye dark circles.
The American College of Chest Physicians has released a new clinical guideline on endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) specimen processing and handling to standardize the process. The guidelines aim to improve diagnostic yield and specimen preservation for downstream ancillary testing.
Researchers at University of Pittsburgh discover that deep brain stimulation instantly improves arm and hand strength and function weakened by traumatic brain injury or stroke. The therapy stimulates the motor thalamus, a key relay hub of movement control, and significantly improves activation of muscles and grip force.
A new hand-held scanner can generate highly detailed 3D images in seconds, paving the way for earlier disease diagnosis. The technology uses laser-generated ultrasound waves to visualize subtle changes in blood vessels, helping inform patient care and diagnose conditions like cancer and cardiovascular disease.
Researchers from Brigham and Women's Hospital found that older adults who sustained a traumatic injury were more likely to be diagnosed with Alzheimer's disease and related dementias if they experienced falls. The study suggests that completing cognitive screenings in older patients after a fall could help detect dementia sooner.
Researchers have uncovered a shared genetic basis for bipolar disorder type I and epilepsy, identifying 1,300 genetic variants influencing both conditions. The study suggests that mood stabilizers may be effective in treating both illnesses, and could lead to personalized medicine approaches.
A survey found that spiritual beliefs and distrust of clinical research contribute to Black patients' hesitation to enroll in cancer trials. Despite trusting their medical teams, some patients express concerns about the purpose of research and its potential impact on their health and community.
Amy Vandiver receives the award to conduct aging-related Omics research at UCLA. Her project focuses on novel metrics of aging in RNA-sequencing data.
A new study found that the IOTA ADNEX ultrasound model can detect up to 96% of ovarian cancers in postmenopausal women, outperforming the current standard test. The research team recommends replacing the risk of malignancy (RMI1) test with the IOTA ADNEX model.
A new study published in the Journal of the American College of Cardiology found that subclinical atherosclerosis is independently associated with the risk of dying from any cause. The study also showed that monitoring the progression of atherosclerosis can improve the prediction and prevention of death from any cause.
A recent study found that limiting food consumption within a 10-hour window per day improved key indicators of heart health in adults with metabolic syndrome. The study demonstrated significant reductions in blood sugar and cholesterol levels, as well as lower levels of hemoglobin A1c, a marker of long-term blood sugar management.
A team of researchers from USC and Caltech developed a new noninvasive tool to measure brain blood pressure, assessing stroke risk through changes in blood flow and volume during a stress test. The affordable, portable device has the potential to transform stroke care by providing more reliable data than existing questionnaires.
A study published in JACC demonstrates that subclinical atherosclerosis burden and progression independently predict death from any cause. Asymptomatic individuals with high carotid plaque burden and coronary artery calcification are at increased risk of mortality.
A new trial suggests that adding immunotherapy to chemoradiation can extend survival in patients with limited-stage small cell lung cancer. However, the findings also indicate that delivering the treatments at different times yields varying results, with concurrent treatment not offering improved survival benefits.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.