Articles tagged with Clinical Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
A pooled analysis of three large, phase III clinical trials found that more than 40% of brain metastases patients can fully reverse cognitive losses with conformal radiation techniques. Recovery was more likely for those treated with highly targeted radiation compared to standard whole-brain treatment.
A phase II clinical trial found that radiopharmaceuticals, specifically 177Lu-Dotatate, can extend progression-free survival for patients with refractory meningioma by nearly 80% after six months. The therapy offers a safe and effective treatment option for those with aggressive tumor growth.
Researchers identify a homozygous SPAG9 gene mutation associated with intellectual disability, progressive cognitive decline, and heterogeneous brain abnormalities. The study provides a unique model for understanding disruptions in cellular transport mechanisms leading to neurodevelopmental and degenerative brain conditions.
Leading researchers from Penn Medicine will showcase clinical trial results and new data on FLASH radiation therapy. The institution is one of the world’s leading academic medical centers, with a proud history of groundbreaking discoveries and innovations.
Researchers found lamotrigine to reduce stiffness in non-dystrophic myotonias by around the same amount as mexiletine, offering a new treatment option. The trial results have direct implications for patient care and provide more 'real-world' options for patients with this life-changing muscle disorder.
A recent study reveals that pharmaceutical industry sponsors dominate US cancer research, with a substantial increase in industry-sponsored clinical trials over the past decade. Federally funded studies have been underinvested and have missed opportunities for scientific advancements.
The Academy of Breastfeeding Medicine has released comprehensive guidelines for protecting, promoting, and supporting breastfeeding in emergency situations. The recommendations aim to safeguard the health and well-being of infants in disasters and conflicts by ensuring safe nutrition and immune protection.
UCLA investigators presented data on chemoradiotherapy in rectal cancer, MRI-guided radiotherapy for prostate cancer, and symptom self-reporting during treatment. Researchers developed a predictive model to identify patients most likely to respond to chemoradiotherapy in rectal cancer.
Researchers at University of California - San Diego have discovered that Crohn's disease consists of two distinct molecular subtypes, each exhibiting unique patterns of genetic mutation and cellular phenotypes. This finding could lead to more effective management strategies, with therapies tailored to specific subtypes.
Researchers discovered that activating the pentose phosphate pathway makes antitumor CD8 T cells more likely to stay in an immature state, leading to better results in animal models and human organoids. This metabolic reprogramming strategy may enhance checkpoint inhibitor therapy by boosting a long-term supply of active cytotoxic T ce...
A study published in the Journal of American Geriatrics Society uses wrist-worn voice recorders to collect real-time data on balance loss among community-dwelling older adults. The findings suggest that these recorders can capture the circumstances and context of balance losses more accurately than traditional recall methods.
A new study suggests the hormone hepcidin may trigger psoriasis by causing iron overload in the skin. This excess iron amplifies the damaging effects of UV sunlight, leading to hyperproliferative chronic diseases like psoriasis. A potential treatment targeting hepcidin could improve treatment options for millions.
According to the Global Cancer Observatory (GLOBOCAN), lung cancer is the most common type of cancer, with 2.2 million new cases and 1.8 million deaths worldwide in 2020. China had the highest number of new cases, and incidence and mortality rates have been steadily rising from 1990 to 2019.
Researchers have provided compelling evidence that perceived stress can directly trigger the relapse of psoriatic skin lesions. The study used a humanized mouse model to show that sonic stress led to a relapse in all psoriasis lesions within 14 days, accompanied by increased inflammation and immune activation.
A single-dose gene therapy has been shown to significantly reduce bleeding episodes in adults with hemophilia B, with an average reduction of 71% compared to standard treatment. The therapy, which enables the liver to produce clotting factor IX, has been FDA-approved for use in patients with this genetic disorder.
A new study found that a high body roundness index over 6 years was associated with an increased risk of developing cardiovascular disease in adults older than 45. The study, published in the Journal of the American Heart Association, suggested that BRI may be a valuable predictor of cardiovascular disease risk.
A study published in Food Innovation and Advances found that M3G supplementation improved colonic mucosal barrier function, reducing inflammation and increasing physical barrier strength. The compound inhibited the over-activation of the Notch signaling pathway, suggesting its potential therapeutic application for intestinal health.
The University of Pittsburgh has been awarded a 10-year, $100 million contract from the U.S. Department of Defense to continue its Linking Investigations in Trauma and Emergency Services (LITES) Network. The network will fund new research on trauma care and expand ongoing studies.
Researchers at Texas A&M University have developed a method to recharge cellular mitochondria using nanotechnology, potentially extending healthy lifespans and improving outcomes for patients with age-related diseases. The molybdenum disulfide nanoparticles stimulate mitochondrial regeneration, helping cells generate more energy.
The American Heart Association joins a $10 million grant from the Global Cardiovascular Research Funders Forum for international scientific research on cardiovascular health in women. The International Research Challenge aims to address significant gaps in research, diagnosis, and care for women worldwide.
A study conducted by the University of Gothenburg found that meal boxes with healthy recipes and subsidized meals led to a greater reduction in children's BMI compared to lifestyle treatment alone. The intervention also involved family meals, which were perceived as tolerable and reduced conflicts over food shopping.
Researchers are conducting a comprehensive health and nutrition examination study to assess the status of active-duty service members. The study will gather data on dietary intake, nutritional status, cardiovascular health, and other measures to guide evidence-based screening and intervention strategies for improving health in the mili...
A study suggests that semaglutide may have therapeutic value in preventing opioid overdoses by reducing the associated risk. The results require further validation, but the findings indicate a potential benefit for patients with comorbid type 2 diabetes and opioid use disorder.
A new study has found that baseline testosterone, age, and duration of ADT are key predictors of testosterone recovery. The researchers developed a nomogram to estimate recovery times based on patient-specific characteristics, providing valuable insights for improving patient outcomes.
Researchers at St. Jude Children's Research Hospital found that patients with ETV6::RUNX1 and high-hyperdiploid B-ALL can achieve positive outcomes with low-intensity chemotherapy, tailoring treatment based on genetic subtypes and early treatment response. This approach reduces side effects and improves event-free survival rates.
The 2024 guideline provides comprehensive recommendations for assessing cardiovascular disease risk and managing patients taking SGLT2-inhibitors. It also highlights the importance of judicious screening and evidence-based management of cardiovascular conditions before, during, and after noncardiac surgery.
Researchers have discovered that COVID-19 patients experience worse cognitive function 12-18 months after hospitalization, with reduced brain volume and abnormal protein levels. This affects global cognitive deficits equivalent to twenty years of normal aging.
Video games created as mental health interventions can be modest tools in improving the mental well-being of children and teens with anxiety, depression, and ADHD. These digital mental health interventions showed a reduction in symptoms related to ADHD and depression, but not for anxiety.
Researchers have found that ultra-short heart rate variability measures can accurately capture autonomic function in severe TBI survivors using 30-60 second recordings. The study validates the reliability of these ultra-short HRV measures, which may provide an objective marker for post-TBI autonomic health.
A new analytical tool called PATH can quantify tumor cell plasticity, which is a key characteristic of cancer that leads to treatment resistance and metastatic spread. Researchers used PATH to analyze tumor samples from animal models and human patients, revealing new details of how tumors exploit plasticity to spread.
A significant proportion of American adults suffer from absolute and functional iron deficiency, which can lead to adverse health outcomes. The study highlights the importance of screening strategies for iron deficiency, as it is a common issue that may be overlooked or undertreated.
Research conducted at Columbia Mailman School of Public Health found a link between prediabetes among young people and adverse pregnancy outcomes later in life. The study, which included over 14,000 individuals aged 10-24 years, found that preconception prediabetes was associated with an increased risk of gestational diabetes, hyperten...
Researchers have identified eight novel genetic mutations in patients with CSF1R-Related Disorder worldwide, highlighting the prevalence of the disease and paving the way for future individualized treatment. The discovery also suggests that genetic and environmental factors may influence the disease.
A Mount Sinai study links prediabetes among young people with a higher likelihood of gestational diabetes and hypertensive disorders during pregnancy. The findings highlight the need for clear clinical guidance on screening and counseling youth with elevated blood glucose levels.
A study found family physicians in rural hospitals had a 34.3% lower risk of cesarean deliveries compared to hospitals with both family physicians and obstetricians. Nurses reported a stronger culture of support for vaginal births, promoting safer maternal care.
New research identifies critical gaps in mental health care for adults with schizophrenia spectrum disorders. Adults with schizophrenia spectrum disorders experience high rates of comorbid conditions, such as major depressive episode and post-traumatic stress disorder. The study found that only 26% received minimally adequate treatment.
A collaborative program between a university and clinic has increased GP numbers from one to eight in resource-deprived areas of Yokohama. The initiative enhances clinical care, education, and research opportunities while fostering community engagement and diverse perspectives.
Older cancer survivors are at a higher risk of stroke, heart attack, and hospital admission for heart failure. Chemotherapy is also linked to elevated rates of these conditions.
A recent study by the Wellcome Sanger Institute and GeneDx analyzed nearly 30,000 families with developmental disorders, revealing that known genes explain over 80% of cases caused by recessive genetic variants. The team identified several new genes associated with these conditions, providing answers for previously undiagnosed families...
The NIH is establishing a network to integrate genomics into learning health systems, analyzing and improving the use of genomic information in patient care. The goal is to create generalizable knowledge and genomic medicine practices that can be shared with under-resourced settings, improving patient outcomes.
Jenny Hoang, a senior at the University of Texas at Arlington, received the third-place award for her research on diazo compounds. The LSAMP program has inspired her to pursue medical school and encouraged other students to aim for Ph.D.s in physics or particle physics.
Long COVID patients face numerous barriers and frustrations in receiving care, yet express a desire for collaborative treatment planning. The study highlights the need for improved communication and collaboration between patients and healthcare professionals.
The European capacity for antibiotic research and development requires sustained investment to combat growing resistance. Collaboration and risk-sharing can help keep companies in anti-infective drug development, as a temporary funding strategy may lead to lost efforts.
Researchers at MIT found that a two-dose schedule for an HIV vaccine can generate a strong response to the virus, outperforming a traditional seven-dose regimen. The first dose primes the immune system, helping it to produce antibodies more effectively when a larger dose is administered one week later.
A nationwide cohort study revealed a higher risk of placental problems, premature births, and severe bleeding in subsequent deliveries following uterine artery embolization. Babies born to mothers who underwent UAE also had a higher chance of major birth defects, particularly heart problems.
A new study led by Uppsala University researchers found that a single treatment session playing the video game Tetris can reduce PTSD symptoms. After five weeks and six months, participants showed significant improvements in reducing intrusive memories and alleviating other symptoms.
Scientists used artificial intelligence and molecular dynamics simulations to understand how enzymes fold lasso peptides into a unique structure. They identified key residues important for interaction with the substrate, enabling the design of new cyclase variants that can produce potent lasso peptides.
The Mount Sinai Health System has expanded its psychedelic psychotherapy research center with a new facility in upper Manhattan. The Center will support rigorous clinical trials for well-known compounds like MDMA, psilocybin, and ketamine, which have shown potential in alleviating symptoms of PTSD, depression, anxiety, and other stress...
Researchers at ETH Zurich have found an antidepressant, vortioxetine, effective against glioblastomas, a particularly aggressive brain tumor with no cure. The drug's ability to cross the blood-brain barrier and trigger a signalling cascade makes it promising for treating this deadly tumour.
A study finds that cardiometabolic indicators like metabolic syndrome and diabetes impair coronary microvascular function, increasing cardiovascular risk. The presence of subclinical atherosclerosis also contributes to altered microvessel function.
A new study highlights the challenges faced by women in relationships with partners diagnosed with ADHD, finding a link between their symptoms and higher rates of depression. Engaging in health-promoting activities can reduce depressive symptoms and improve well-being for these women.
Researchers developed a personalized vaccine to treat rare blood cancer, which nearly doubled disease-free progression time. The vaccine appears safe and effective in activating the immune response against tumor cells.
A new study found that vulnerable patients treated at Commission on Cancer-accredited hospitals had a 9% lower mortality rate and were more likely to receive guideline-based care. This is attributed to CoC accreditation requirements for treatment guideline adherence, community engagement, and addressing barriers to care.
A pioneering study identified critical biomarkers that can predict disability worsening in MS. Elevated serum neurofilament light chain and serum glial fibrillary acidic protein levels correlate with progression independent of relapse activity, guiding personalized treatment approaches.
The integration of artificial intelligence in intratumoral immunotherapy can refine diagnoses, guide interventions, predict treatment responses, and adapt therapeutic strategies. This enables the enhancement of patient outcomes, including improved survival rates and quality of life.
Researchers at Tel Aviv University discovered that aneuploid cells, which have an abnormal number of chromosomes, are more susceptible to certain types of anticancer drugs. The studies found that disrupting the MAPK pathway increases the sensitivity of these cancer cells to chemotherapy.
Researchers found that low extracellular sodium concentrations decrease specific mRNA expression and nitric oxide production in microglia, potentially contributing to hyponatremia-induced neuronal dysfunctions. Microglial activation can lead to inflammation and regulate neurotransmission.
A survey of UK general practitioners reveals that 20% of doctors use generative AI tools like ChatGPT in their practice. The study highlights the potential benefits of AI in reducing administrative burdens and supporting clinical decision-making, but also raises concerns about errors, biases, and patient privacy.
A new study found that patients with 4 or 5 identified risk factors, including age 18-24 years and schizophrenia spectrum disorders, had over 100 times the incidence of Neuroleptic Malignant Syndrome. The data provide a basis for early identification and monitoring of children and youth at elevated risk.
The Cancer Cooperative Group System is being re-engineered to bring new money to correlative science research through public-private partnerships, aiming to remove barriers for researchers to access biological samples. This will facilitate the integration of innovative science into cancer clinical trials.