Articles tagged with Clinical Research
Researchers at University of Pittsburgh discover that deep brain stimulation instantly improves arm and hand strength and function weakened by traumatic brain injury or stroke. The therapy stimulates the motor thalamus, a key relay hub of movement control, and significantly improves activation of muscles and grip force.
A new hand-held scanner can generate highly detailed 3D images in seconds, paving the way for earlier disease diagnosis. The technology uses laser-generated ultrasound waves to visualize subtle changes in blood vessels, helping inform patient care and diagnose conditions like cancer and cardiovascular disease.
Researchers from Brigham and Women's Hospital found that older adults who sustained a traumatic injury were more likely to be diagnosed with Alzheimer's disease and related dementias if they experienced falls. The study suggests that completing cognitive screenings in older patients after a fall could help detect dementia sooner.
Researchers have uncovered a shared genetic basis for bipolar disorder type I and epilepsy, identifying 1,300 genetic variants influencing both conditions. The study suggests that mood stabilizers may be effective in treating both illnesses, and could lead to personalized medicine approaches.
A survey found that spiritual beliefs and distrust of clinical research contribute to Black patients' hesitation to enroll in cancer trials. Despite trusting their medical teams, some patients express concerns about the purpose of research and its potential impact on their health and community.
Amy Vandiver receives the award to conduct aging-related Omics research at UCLA. Her project focuses on novel metrics of aging in RNA-sequencing data.
A new study found that the IOTA ADNEX ultrasound model can detect up to 96% of ovarian cancers in postmenopausal women, outperforming the current standard test. The research team recommends replacing the risk of malignancy (RMI1) test with the IOTA ADNEX model.
A new study published in the Journal of the American College of Cardiology found that subclinical atherosclerosis is independently associated with the risk of dying from any cause. The study also showed that monitoring the progression of atherosclerosis can improve the prediction and prevention of death from any cause.
A recent study found that limiting food consumption within a 10-hour window per day improved key indicators of heart health in adults with metabolic syndrome. The study demonstrated significant reductions in blood sugar and cholesterol levels, as well as lower levels of hemoglobin A1c, a marker of long-term blood sugar management.
A team of researchers from USC and Caltech developed a new noninvasive tool to measure brain blood pressure, assessing stroke risk through changes in blood flow and volume during a stress test. The affordable, portable device has the potential to transform stroke care by providing more reliable data than existing questionnaires.
A study published in JACC demonstrates that subclinical atherosclerosis burden and progression independently predict death from any cause. Asymptomatic individuals with high carotid plaque burden and coronary artery calcification are at increased risk of mortality.
A new trial suggests that adding immunotherapy to chemoradiation can extend survival in patients with limited-stage small cell lung cancer. However, the findings also indicate that delivering the treatments at different times yields varying results, with concurrent treatment not offering improved survival benefits.
A clinical trial found time-restricted eating improved blood sugar regulation and reduced markers of metabolic dysfunction in adults with metabolic syndrome. Participants who followed a customized eight-to-ten-hour eating window saw significant improvements compared to standard treatments.
A pooled analysis of three large, phase III clinical trials found that more than 40% of brain metastases patients can fully reverse cognitive losses with conformal radiation techniques. Recovery was more likely for those treated with highly targeted radiation compared to standard whole-brain treatment.
A phase II clinical trial found that radiopharmaceuticals, specifically 177Lu-Dotatate, can extend progression-free survival for patients with refractory meningioma by nearly 80% after six months. The therapy offers a safe and effective treatment option for those with aggressive tumor growth.
Researchers identify a homozygous SPAG9 gene mutation associated with intellectual disability, progressive cognitive decline, and heterogeneous brain abnormalities. The study provides a unique model for understanding disruptions in cellular transport mechanisms leading to neurodevelopmental and degenerative brain conditions.
Leading researchers from Penn Medicine will showcase clinical trial results and new data on FLASH radiation therapy. The institution is one of the world’s leading academic medical centers, with a proud history of groundbreaking discoveries and innovations.
Researchers found lamotrigine to reduce stiffness in non-dystrophic myotonias by around the same amount as mexiletine, offering a new treatment option. The trial results have direct implications for patient care and provide more 'real-world' options for patients with this life-changing muscle disorder.
A recent study reveals that pharmaceutical industry sponsors dominate US cancer research, with a substantial increase in industry-sponsored clinical trials over the past decade. Federally funded studies have been underinvested and have missed opportunities for scientific advancements.
The Academy of Breastfeeding Medicine has released comprehensive guidelines for protecting, promoting, and supporting breastfeeding in emergency situations. The recommendations aim to safeguard the health and well-being of infants in disasters and conflicts by ensuring safe nutrition and immune protection.
UCLA investigators presented data on chemoradiotherapy in rectal cancer, MRI-guided radiotherapy for prostate cancer, and symptom self-reporting during treatment. Researchers developed a predictive model to identify patients most likely to respond to chemoradiotherapy in rectal cancer.
Researchers at University of California - San Diego have discovered that Crohn's disease consists of two distinct molecular subtypes, each exhibiting unique patterns of genetic mutation and cellular phenotypes. This finding could lead to more effective management strategies, with therapies tailored to specific subtypes.
Researchers discovered that activating the pentose phosphate pathway makes antitumor CD8 T cells more likely to stay in an immature state, leading to better results in animal models and human organoids. This metabolic reprogramming strategy may enhance checkpoint inhibitor therapy by boosting a long-term supply of active cytotoxic T ce...
A study published in the Journal of American Geriatrics Society uses wrist-worn voice recorders to collect real-time data on balance loss among community-dwelling older adults. The findings suggest that these recorders can capture the circumstances and context of balance losses more accurately than traditional recall methods.
A new study suggests the hormone hepcidin may trigger psoriasis by causing iron overload in the skin. This excess iron amplifies the damaging effects of UV sunlight, leading to hyperproliferative chronic diseases like psoriasis. A potential treatment targeting hepcidin could improve treatment options for millions.
According to the Global Cancer Observatory (GLOBOCAN), lung cancer is the most common type of cancer, with 2.2 million new cases and 1.8 million deaths worldwide in 2020. China had the highest number of new cases, and incidence and mortality rates have been steadily rising from 1990 to 2019.
Researchers have provided compelling evidence that perceived stress can directly trigger the relapse of psoriatic skin lesions. The study used a humanized mouse model to show that sonic stress led to a relapse in all psoriasis lesions within 14 days, accompanied by increased inflammation and immune activation.
A single-dose gene therapy has been shown to significantly reduce bleeding episodes in adults with hemophilia B, with an average reduction of 71% compared to standard treatment. The therapy, which enables the liver to produce clotting factor IX, has been FDA-approved for use in patients with this genetic disorder.
A new study found that a high body roundness index over 6 years was associated with an increased risk of developing cardiovascular disease in adults older than 45. The study, published in the Journal of the American Heart Association, suggested that BRI may be a valuable predictor of cardiovascular disease risk.
A study published in Food Innovation and Advances found that M3G supplementation improved colonic mucosal barrier function, reducing inflammation and increasing physical barrier strength. The compound inhibited the over-activation of the Notch signaling pathway, suggesting its potential therapeutic application for intestinal health.
The University of Pittsburgh has been awarded a 10-year, $100 million contract from the U.S. Department of Defense to continue its Linking Investigations in Trauma and Emergency Services (LITES) Network. The network will fund new research on trauma care and expand ongoing studies.
Researchers at Texas A&M University have developed a method to recharge cellular mitochondria using nanotechnology, potentially extending healthy lifespans and improving outcomes for patients with age-related diseases. The molybdenum disulfide nanoparticles stimulate mitochondrial regeneration, helping cells generate more energy.
The American Heart Association joins a $10 million grant from the Global Cardiovascular Research Funders Forum for international scientific research on cardiovascular health in women. The International Research Challenge aims to address significant gaps in research, diagnosis, and care for women worldwide.
A study conducted by the University of Gothenburg found that meal boxes with healthy recipes and subsidized meals led to a greater reduction in children's BMI compared to lifestyle treatment alone. The intervention also involved family meals, which were perceived as tolerable and reduced conflicts over food shopping.
Researchers are conducting a comprehensive health and nutrition examination study to assess the status of active-duty service members. The study will gather data on dietary intake, nutritional status, cardiovascular health, and other measures to guide evidence-based screening and intervention strategies for improving health in the mili...
A study suggests that semaglutide may have therapeutic value in preventing opioid overdoses by reducing the associated risk. The results require further validation, but the findings indicate a potential benefit for patients with comorbid type 2 diabetes and opioid use disorder.
A new study has found that baseline testosterone, age, and duration of ADT are key predictors of testosterone recovery. The researchers developed a nomogram to estimate recovery times based on patient-specific characteristics, providing valuable insights for improving patient outcomes.
Researchers at St. Jude Children's Research Hospital found that patients with ETV6::RUNX1 and high-hyperdiploid B-ALL can achieve positive outcomes with low-intensity chemotherapy, tailoring treatment based on genetic subtypes and early treatment response. This approach reduces side effects and improves event-free survival rates.
The 2024 guideline provides comprehensive recommendations for assessing cardiovascular disease risk and managing patients taking SGLT2-inhibitors. It also highlights the importance of judicious screening and evidence-based management of cardiovascular conditions before, during, and after noncardiac surgery.
Researchers have discovered that COVID-19 patients experience worse cognitive function 12-18 months after hospitalization, with reduced brain volume and abnormal protein levels. This affects global cognitive deficits equivalent to twenty years of normal aging.
Video games created as mental health interventions can be modest tools in improving the mental well-being of children and teens with anxiety, depression, and ADHD. These digital mental health interventions showed a reduction in symptoms related to ADHD and depression, but not for anxiety.
Researchers have found that ultra-short heart rate variability measures can accurately capture autonomic function in severe TBI survivors using 30-60 second recordings. The study validates the reliability of these ultra-short HRV measures, which may provide an objective marker for post-TBI autonomic health.
A new analytical tool called PATH can quantify tumor cell plasticity, which is a key characteristic of cancer that leads to treatment resistance and metastatic spread. Researchers used PATH to analyze tumor samples from animal models and human patients, revealing new details of how tumors exploit plasticity to spread.
A significant proportion of American adults suffer from absolute and functional iron deficiency, which can lead to adverse health outcomes. The study highlights the importance of screening strategies for iron deficiency, as it is a common issue that may be overlooked or undertreated.
Research conducted at Columbia Mailman School of Public Health found a link between prediabetes among young people and adverse pregnancy outcomes later in life. The study, which included over 14,000 individuals aged 10-24 years, found that preconception prediabetes was associated with an increased risk of gestational diabetes, hyperten...
Researchers have identified eight novel genetic mutations in patients with CSF1R-Related Disorder worldwide, highlighting the prevalence of the disease and paving the way for future individualized treatment. The discovery also suggests that genetic and environmental factors may influence the disease.
A Mount Sinai study links prediabetes among young people with a higher likelihood of gestational diabetes and hypertensive disorders during pregnancy. The findings highlight the need for clear clinical guidance on screening and counseling youth with elevated blood glucose levels.
A study found family physicians in rural hospitals had a 34.3% lower risk of cesarean deliveries compared to hospitals with both family physicians and obstetricians. Nurses reported a stronger culture of support for vaginal births, promoting safer maternal care.
New research identifies critical gaps in mental health care for adults with schizophrenia spectrum disorders. Adults with schizophrenia spectrum disorders experience high rates of comorbid conditions, such as major depressive episode and post-traumatic stress disorder. The study found that only 26% received minimally adequate treatment.
A collaborative program between a university and clinic has increased GP numbers from one to eight in resource-deprived areas of Yokohama. The initiative enhances clinical care, education, and research opportunities while fostering community engagement and diverse perspectives.
Older cancer survivors are at a higher risk of stroke, heart attack, and hospital admission for heart failure. Chemotherapy is also linked to elevated rates of these conditions.
A recent study by the Wellcome Sanger Institute and GeneDx analyzed nearly 30,000 families with developmental disorders, revealing that known genes explain over 80% of cases caused by recessive genetic variants. The team identified several new genes associated with these conditions, providing answers for previously undiagnosed families...
The NIH is establishing a network to integrate genomics into learning health systems, analyzing and improving the use of genomic information in patient care. The goal is to create generalizable knowledge and genomic medicine practices that can be shared with under-resourced settings, improving patient outcomes.
Jenny Hoang, a senior at the University of Texas at Arlington, received the third-place award for her research on diazo compounds. The LSAMP program has inspired her to pursue medical school and encouraged other students to aim for Ph.D.s in physics or particle physics.
Long COVID patients face numerous barriers and frustrations in receiving care, yet express a desire for collaborative treatment planning. The study highlights the need for improved communication and collaboration between patients and healthcare professionals.
The European capacity for antibiotic research and development requires sustained investment to combat growing resistance. Collaboration and risk-sharing can help keep companies in anti-infective drug development, as a temporary funding strategy may lead to lost efforts.
Researchers at MIT found that a two-dose schedule for an HIV vaccine can generate a strong response to the virus, outperforming a traditional seven-dose regimen. The first dose primes the immune system, helping it to produce antibodies more effectively when a larger dose is administered one week later.
A nationwide cohort study revealed a higher risk of placental problems, premature births, and severe bleeding in subsequent deliveries following uterine artery embolization. Babies born to mothers who underwent UAE also had a higher chance of major birth defects, particularly heart problems.
A new study led by Uppsala University researchers found that a single treatment session playing the video game Tetris can reduce PTSD symptoms. After five weeks and six months, participants showed significant improvements in reducing intrusive memories and alleviating other symptoms.
Scientists used artificial intelligence and molecular dynamics simulations to understand how enzymes fold lasso peptides into a unique structure. They identified key residues important for interaction with the substrate, enabling the design of new cyclase variants that can produce potent lasso peptides.