Articles tagged with Clinical Research
Researchers propose combining osimertinib with gefitinib to increase progression-free survival rates in EGFR-mutant lung cancer patients. A comprehensive PC approach could dramatically boost PFS for 80% of patients, eliminating harm and improving treatment outcomes.
A study by IRB Barcelona and Sant Joan de Déu Hospital reveals three distinct patterns explaining the occurrence of second cancers in children, including a mutational footprint from chemotherapy. The research advances understanding of pediatric cancer and highlights the importance of clinical data sharing.
Researchers developed a web-based decision aid to support pregnant individuals in making informed decisions about tubal sterilization. The study found that those who used the decision aid had significantly higher knowledge of the procedure's permanence and reduced uncertainty, compared to those who did not use it.
A landmark study stratifies people with type 2 diabetes using routine variables to visualize metabolic diversity. The algorithm identifies different subtypes of the disease, which can help in targeted prevention and treatment.
Researchers found that Kallistatin expression increases after weight loss, improving hepatic insulin sensitivity in obese mice. This protein may be an interesting therapeutic target for treating obesity and type 2 diabetes.
Researchers at the University of Texas at Arlington have developed a method to determine the clinical potency of psilocybin and psilocin in Psilocybe cubensis mushrooms. This technique uses liquid chromatography with tandem mass spectrometry, allowing for accurate extraction and measurement of the strength of the mushrooms.
A new multitasking substance has been identified to prevent and treat both flu and COVID-19 infections concurrently. The long-acting recombinant cytokine protein rhIL-7-hyFc demonstrated therapeutic and preventive effects against various respiratory diseases, including COVID-19, influenza virus, and respiratory syncytial virus.
Researchers developed an improved method for G4 landscape determination, revealing that sequence property-specific constraints in the nuclear environment mitigate G4 formation. The technique, AbC G4-ChIP, captures G4s efficiently without bias, showing that depletion of a repeat-binding protein enhances net G4 capture at specific sites.
Researchers found no significant differences in participants with AHIs and controls, except for increased self-reported fatigue, post-traumatic stress, and depression. Forty-one percent of AHI group members met criteria for functional neurological disorders or had significant somatic symptoms.
People with dementia experience declines in social well-being as their disease progresses, while caregivers become isolated due to caregiving responsibilities. Experts recommend screening for loneliness and finding ways to keep individuals socially connected to improve quality of life and reduce health outcomes.
Researchers mapped the evolution of urinary tract cancer cells using single-cell resolution, revealing stable molecular characteristics despite metastasis. The study provides new avenues for personalized treatment strategies and targeted therapies.
A new study has discovered that Streptococcus anginosus bacteria play a significant role in causing stomach cancer. The research showed that S. anginosus infection led to gastric inflammation, cell damage, and the growth of stomach cancer cells, doubling tumour size and weight in some cases.
The RUBY Part 2 trial shows significant improvement in progression-free survival for patients with primary advanced or recurrent endometrial cancer treated with dostarlimab. Dostarlimab plus niraparib plus carboplatin/paclitaxel demonstrates a role for PARP inhibitor maintenance in improving patient outcomes.
Bruno Scheller developed a procedure using drug-coated balloons to treat coronary and peripheral artery disease, improving patients' quality of life. The technique has been widely recognized and effective, with countless patients spared further pain and surgery.
Researchers found that specialized nursing facility clinicians (SNFists) can decrease the likelihood of nursing home residents experiencing stressful hospitalizations. Care from SNFists also improved the quality of life in their last days, with a 6% decreased risk of hospitalizations due to various reasons. The study suggests increasin...
A study by Linköping University found that a daily intake of liquorice containing 100mg glycyrrhizic acid raised blood pressure by an average of 3.1mmHg in young healthy people. This effect was seen in all participants, but the most sensitive individuals showed increased fluid volume and heart workload.
A new study published in the journal Stroke found that African American veterans with PTSD had a significantly higher risk of re-hospitalization after a stroke compared to those without PTSD. This was not observed among white veterans. The study highlights the importance of targeted care for high-risk populations and reducing modifiabl...
Research suggests that long COVID's impact on the health system is due to high volumes of COVID-19 cases rather than symptom severity. Symptoms reported with long COVID include fatigue, brain fog, and shortness of breath, but are indistinguishable from those experienced by individuals with seasonal influenza or other post-viral illnesses.
Rory James Tinker, MD, has been selected as the recipient of the 2024 Richard King Award for his outstanding publication on phenotypic presentation of Mendelian disease. The award recognizes his research's impact on identifying, diagnosing, and treating rare disorders.
A new study found that low-level laser therapy (PBM) provides immediate pain relief for Burning Mouth Syndrome (BMS) patients, with a significant drop in pain scores after each treatment. The study also observed a cumulative effect of PBM on alleviating BMS symptoms, especially up to the third treatment.
Melissa A. Kelly, co-director of Geisinger's MyCode Genomic Screening and Counseling Program, received the award for her work integrating genomic medicine into healthcare through Geisinger's MyCode Community Health Initiative. The initiative has reported over 5,000 medically relevant results to patient-participants, many of whom were u...
Meena Sethuraman, a third-year medical student, received the 2024 ACMG Foundation/Revvity Travel Award for her research on genetic variants in fatty acid oxidation disorders. The award recognizes her platform presentation on characterizing pathogenicity of ACADVL variants in very long-chain acyl-CoA dehydrogenase deficiency.
Reducing surgeon manipulation of predicted operating room time improved overall scheduling accuracy, with a significant decrease in underscheduled operations and manipulations. The study found that educating surgeons about the importance of accurate OR planning increased accuracy rates by 6.2 percentage points.
Researchers at HKU made a significant breakthrough in understanding the role of the secretin hormone in regulating energy metabolism and bone homeostasis. They found that secretin plays a vital role in controlling both appetite and bone density, challenging traditional views of its primary function.
The ACMG Foundation for Genetic and Genomic Medicine has presented seven Next Generation fellowship awards to promising early career professionals in medical genetics and genomics. The recipients include Xueyang Pan, Bianca Seminotti, and Adriel Yejin Kim, who will support their research projects with corporate donations from Pfizer, S...
The college will investigate the harmful effects of alternative tobacco products, exploring their toxicity and addictiveness. The funding supports a trio of studies led by the Center for Research on Tobacco and Health, which aims to inform better regulation and improve public health.
Christiana Wang, a second-year PhD candidate, has been awarded the prestigious award for her platform presentation on antisense oligonucleotide therapy for a dominant negative SPTAN1 pathogenic variant. Her research aims to develop individualized therapy for treating rare genetic disorders.
The T2oFu method offers a new approach to quantitative phase and polarization-sensitive tomography, enabling high-contrast images of muscle fibers with implications for diagnosing skeletal myopathies. The technique has been successfully tested on heart tissue samples with cardiac amyloidosis, providing promising results.
Researchers successfully implemented pooled saliva testing to detect congenital cytomegalovirus (cCMV) infection in newborns, achieving an empirical efficiency of 6 and reducing required tests by 83%. The study highlights the significance of early detection through this method, particularly for asymptomatic cases.
A new study led by Worcester Polytechnic Institute aims to determine whether AI can help doctors predict which patients will benefit from mindfulness-based stress reduction in managing chronic lower back pain. The research uses machine learning and physiological data from fitness sensors to detect patterns that may not be apparent to d...
A new study from Uppsala University found that women with germ cell tumors have a significantly lower five-year survival rate (85.2%) compared to men (98.2%). The researchers suggest that concentrating patients in fewer hospitals and using treatment strategies for testicular cancer could improve survival rates and reduce side effects.
A novel risk score predicts cardiovascular complications after bone marrow transplant with high accuracy, helping guide patient selection and post-transplant management. Patients with preexisting cardiovascular conditions are more likely to experience long-term complications.
Researchers at Children's Hospital Los Angeles found significant variation in opioid treatment for critically ill infants across different institutions and geographic regions. The study reports wide variability in opioid prescribing practices, which can impact hospitalization length of stay, healthcare costs, and long-term outcomes.
A first-of-its-kind study uses gait analysis to detect subtle impairments in older adults with mild cognitive impairment, suggesting curved path walking as a more sensitive detection method. The novel system employs a non-invasive depth camera to record gait and provides detailed information on functional performance.
A Phase III clinical trial showed that cancer patients who received specialized mental health support experienced lasting improvements in quality of life, reduced pain, depression, and fatigue. The intervention also led to lower risk of cardiovascular disease in family caregivers and substantial cost savings for the healthcare system.
Researchers developed a wearable device for non-invasive monitoring of hemodynamic indicators like heart rate, blood pressure, and oxygen saturation. The photoacoustic imaging watch offers valuable insights into disease diagnosis and treatment.
A landmark study published in JAMA Pediatrics found that COVID vaccines are safe to administer during pregnancy, with no abnormal delays in infants when tested at 12 months and 18 months. The study of over 2,200 infants from across the country also found an increased risk of delay among male infants at 12 months but not at 18 months.
Research from UCSF found COVID antigens lingering in blood up to 14 months and tissue samples for over two years after infection. The persistence of these fragments may drive long COVID symptoms and associated risks.
A recent study investigated eating habits and physical activity in colorectal cancer (CRC) patients with overweight/obesity. The results show that these patients have higher prevalence of metastasis, recurrence, and death compared to eutrophic patients.
A new AI technology has been developed to detect severe cases of retinopathy of prematurity (ROP) with 100% accuracy. The system analyzes retinal images and can identify blood vessel anomalies, enabling early treatment and potentially saving sight for thousands of premature infants globally.
A recent study at Salk Institute evaluates the reliability of patient-derived organoids as a clinical model for pancreatic cancer. The findings reveal that organoids' gene expression and drug responses are not affected by commercial extracellular matrix brands, but one product increases growth rate.
A study published in the International Journal of Gynecology & Obstetrics found that Medicaid expansion in Maryland led to improved newborn outcomes, including better Agar scores and reduced need for assisted ventilation. However, there were no significant differences in Cesarean section deliveries.
Research has shown that dulaglutide, a diabetes drug, can reduce depressive-like behaviors in mice. The study identified four major pathways involved and linked markers of depression to lipid metabolism and tryptophan metabolism. This new perspective may facilitate the use of dulaglutide as a potential therapeutic strategy for depression.
Researchers at Johns Hopkins Kimmel Cancer Center and University School of Medicine developed an algorithm, REAL-FAST, to identify high-risk precancerous lesions on the fallopian tubes. The test accurately detected cancer 95.8% of the time and correctly ruled out cancer 97.1% of the time.
A new study combines virtual reality exposure with transcranial direct current stimulation to treat post-traumatic stress disorder in military veterans. The innovative approach shows significant reductions in PTSD symptom severity and accelerates psychological adjustment, offering hope for an effective treatment.
Researchers at MIT discovered that daily exposure to light and sound with a frequency of 40 hertz protects brain cells from chemotherapy-induced damage, preventing memory loss and improving cognitive functions. The treatment also helped prevent DNA damage, inflammation, and promoted the growth of oligodendrocytes, the cells responsible...
Researchers discovered GZ17-6.02's ability to interact with proteasome inhibitors in a greater than additive fashion to kill multiple myeloma cells and alone inhibit inhibitor-resistant cells. The compound combination also activated key pathways and increased autophagosome formation, leading to tumor cell killing.
A comprehensive review published in the Journal of Experimental Orthopaedics presents the outcomes and surgical methods of anterolateral augmentation procedures for skeletally immature patients. The study shows promising results for these procedures, which may reduce re-injury rates after ACL reconstruction in youth.
A UTEP clinical trial will enroll local school district employees in a program challenging them to walk at least 50K steps per week. The study aims to improve health equity and measure the effectiveness of group fitness challenges in Hispanic populations.
A new study by the Microbicide Trials Network found no safety concerns with using the dapivirine vaginal ring during all stages of pregnancy. The research provides sufficient evidence that the ring is safe to use throughout pregnancy to protect against HIV, which poses a higher risk than at any other time.
A new study led by Cleveland Clinic researchers suggests that sildenafil may help protect brain cells from Alzheimer's disease. The study found that sildenafil can lower levels of neurotoxic tau proteins and improve brain function in patients with Alzheimer's.
Researchers have designed a candidate drug to target the K-Ras G12D mutation, responsible for nearly half of all pancreatic cancer cases. The molecule permanently modifies the mutation, stopping tumor growth in cancer cell lines and animal models.
Researchers investigated combining Sacituzumab govitecan with platinum-based chemotherapeutics for triple-negative breast cancer, urinary bladder carcinoma, and small-cell lung carcinoma. The study showed additive to synergistic antitumor effects in vitro and in vivo, with improved outcomes in tumor-bearing animals.
A Rutgers Health study found that military service members view law enforcement officers, military service members, and veterans as the most credible sources to discuss secure firearm storage for suicide prevention. The study suggests that leveraging these sources can help increase secure storage among this population.
A University of Cincinnati study found liraglutide to be efficacious and safe for weight loss in individuals with stable bipolar disorder, without destabilizing the illness. The drug reduced binge eating behavior and significantly lowered hemoglobin A1C levels.
Researchers developed protein-based microcapsules to enhance aptamer sensors, enabling direct detection of target molecules in biological samples. The system demonstrates robust protection against harmful proteins and simultaneous real-time sensing of multiple targets.
A new machine learning approach using Alu elements in blood plasma has improved the detection of cancer early by reaching 98.9% specificity. The test can catch 41% more cancer cases than existing biomarkers and is expected to complement other cancer tests.
A new method allows fibromyalgia to be identified from a blood sample with high accuracy and speed. Researchers analyzed small molecules in the blood using Raman spectroscopy and found specific chemical signatures that distinguish fibromyalgia from other diseases.
A new cellphone app developed by physician-scientists uses artificial intelligence to accurately diagnose ear infections in young children, reducing unnecessary antibiotic use. The AI tool is more accurate than trained clinicians and offers a simple solution for healthcare providers.
Researchers at the University of Alberta have discovered a new class of antiviral drugs that stimulate interferon production to reverse the effect of SARS-CoV-2 on cells. The study shows that these drugs can significantly reduce the amount of virus found in the lungs and prevent severe symptoms.