Articles tagged with Clinical Research
New research led by Johns Hopkins Medicine reveals that age-related changes in fibroblast cells enable pancreatic cancer tumor growth. The study found that older patients have poorer prognoses due to altered proteins released by fibroblasts, which promote cancer cell growth and spread.
A new screening tool has been developed to catch endometrial cancer cases earlier, saving lives. The partnership between Pennington Biomedical's Metamor Institute and the LSU School of Medicine has already screened over 2,000 women and found abnormal bleeding in many cases.
A recent study found that parents and clinicians are in favor of a mobile app to help manage child cancer pain at home. The app aims to ease the burden on caregivers and provide personalized pain management support. Recommendations for the app include improved accessibility, language options, and gamification features to involve children.
A study by Dr Sebastian Korb at the University of Essex found that a brief weak grin makes faces appear more joyful, creating the illusion of happiness. The research used electrical stimulation to spark smiles and has potential for future clinical applications.
A new study suggests that individuals with low income are frequently misdiagnosed and lack access to effective treatment for eating disorders. Researchers offer guidelines for therapists to make accommodations for these patients, including providing government or local food resources and engaging with local food banks.
Researchers have defined what a premature aging disease is and developed tools to diagnose progeria patients, allowing them to identify new syndromes. The study also identified correlations between progeroid syndromes and other conditions, providing a significant step forward in understanding premature aging.
Researchers identified NTRK gene fusion in 1.5% of Finnish papillary thyroid cancer patients, with notable co-occurring genetic alterations and favorable treatment outcomes. The study highlights the potential for biobank samples linked to electronic health records to describe patient characteristics and outcomes.
Researchers have confirmed a new method for precise body composition analysis using 3D surface scans and dual-energy X-ray absorptiometry. This approach yields accurate measurements of fat, lean muscle, and bone, surpassing commercial software in clinical settings.
A recent study by Cleveland Clinic researchers discovered a connection between elevated niacin levels and an increased risk of heart disease. The study found that high levels of 4PY, a breakdown product from excess niacin, were strongly linked to the development of heart attacks and strokes.
Researchers optimized polygenic risk scores using ancestrally diverse genomic data to improve accuracy across diverse populations. The recalibrated tests provided a more accurate assessment of disease risk for individuals with varied ancestral backgrounds.
A team of researchers at the Broad Institute has developed 10 polygenic risk scores for use in clinical research, optimizing them for diverse populations. The tests calculate a person's lifetime odds of developing diseases such as heart disease and type 2 diabetes, and can help guide clinical decision-making.
A large retrospective cohort analysis found that neoadjuvant chemotherapy improved overall and progression-free survival for locally advanced penile squamous cell carcinoma patients. The study also showed that platinum-based chemotherapy was well-tolerated, with low treatment-related mortality.
The FDA has approved omalizumab for the reduction of allergic reactions, including anaphylaxis, in adults and children aged 1 year and older with food allergy. The approval is based on data from a Phase 3 clinical trial sponsored by NIAID.
Researchers at University of California - San Francisco have developed a precise map of what is happening in the brain’s auditory cortex when someone hears a melody. The study found that some aspects of music are entwined with how we understand speech, while other important aspects stand alone. The brain uses two sets of neurons to ass...
Research shows that lowering doses and adjusting chemotherapy schedules for older adults with advanced cancer can reduce toxic side effects and preserve daily functions. Over 30% of patients benefited from treatment regimen modifications, with a 15% reduced risk of serious clinician-rated toxic effects.
A four-drug chemotherapy regimen, NALIRIFOX, has been approved by the FDA for frontline treatment of metastatic pancreatic adenocarcinoma. The regimen, combining irinotecan liposome, oxaliplatin, leucovorin, and fluorouracil, resulted in longer overall survival compared to a two-drug protocol.
A new treatment combining a novel drug with traditional chemotherapy has been shown to increase the survival of patients with malignant mesothelioma, a rare and aggressive cancer. The ATOMIC-meso trial found that this treatment quadrupled the survival at 36 months compared to placebo-chemotherapy.
A large national study of over 6,000 patients found that video visits, texting and mailing pills were effective and safe for medication abortion. The research supports the safety and efficacy of telemedicine abortion, which has become increasingly important due to clinic closures and wait times.
Researchers at Harvard University have developed a new antibiotic compound, cresomycin, that effectively targets and kills multiple strains of drug-resistant bacteria. The breakthrough demonstrates improved ability to bind to bacterial ribosomes, overcoming resistance mechanisms.
Researchers at Mayo Clinic shed light on the biology of zombie cells and their link to aging-related health issues. A study found that specific senescent biomarkers can predict mortality beyond chronological age and chronic disease presence.
Researchers found GV1001 decreases BACE and Aβ1-42 levels, reducing neurodegeneration and senescence in 3xTg-AD mice. It also increases survival, telomere length, and telomerase activity, contributing to improved lifespan.
A study published in Oncotarget has identified specific mutational and therapeutic landscapes of pancreatic cancer in the Russian population. By applying machine learning models to full exome individual data, researchers received personalized recommendations for targeted treatment options for each clinical case.
Researchers identify a promising prognostic biomarker for lung cancer using circulating tumor DNA-based minimal residual disease detection. The study found that this method can effectively guide treatment decisions and predict recurrence risk, potentially modifying the lung cancer treatment paradigm.
Researchers developed a test to predict which heart attack patients are likely to experience dysfunction after receiving mechanical pumps. The test measures pulmonary vascular compliance and its adaptability, helping doctors prevent right ventricle failure.
Researchers use bacteriophages to target and kill drug-resistant bacteria, with a patient experiencing complete resolution of infection after combination therapy. However, immune response may lead to recurrence, highlighting need for further clinical trials.
A study by Ohio State University Wexner Medical Center found that crisis response planning can rapidly reduce suicidal thoughts among U.S. military members and veterans receiving massed cognitive processing therapy for PTSD. The intervention was tested in a randomized controlled trial involving 157 participants, with promising results.
A study of 11,000 children found that maternal tobacco use during pregnancy is associated with enduring deficits in childhood neurocognition. Continued research on the link between maternal tobacco use and cognitive performance is needed.
A CHLA research team found that socio-economic factors like family support, employment status, patient age, race, and language spoken can impact clinical outcomes. Children with limited social support systems and working caregivers have worse outcomes.
A study published in the Journal of the American College of Surgeons found that gastric bypass surgery results in high rates of Type-2 diabetes remission five years after the operation, even after patients regain a significant amount of weight. In contrast, patients who underwent sleeve gastrectomy and regained their weight were five t...
A Phase 2b clinical trial published in The Lancet found that abatacept reduces progression to rheumatoid arthritis and can also ease symptoms. After a year-long treatment, patients treated with abatacept showed significant reductions in disease onset and inflammation.
A team of physicists and veterinary scientists at Purdue University has developed a method to detect chemoresistance in cancer patients using biodynamic imaging (BDI). This technique measures the motions inside cancer cells and how they respond to chemotherapy, identifying patients who will not respond to treatment. The study shows pro...
Researchers developed a compact, cost-effective PA sensing instrument for biomedical tissue diagnosis, showcasing its potential to streamline sampling processes and improve diagnostic accuracy for breast disease. The instrument successfully differentiated various tissue types based on quantitative spectral parameters.
The new advisory highlights the dramatic advances in understanding and treatment of cardiovascular diseases over the past century. These advancements have saved millions of lives and reduced heart disease death rates by more than half since 1950.
Researchers found Mad2 gene expression levels correlate with chromosomal abnormalities in esophageal squamous cell carcinoma, highlighting potential as a clinical biomarker. The study also revealed the deregulation of the Rb-E2F1 circuit and its impact on histone modifications.
A new American Heart Association scientific statement emphasizes the need for increased awareness of heart disease as a major health risk for women, particularly those with pregnancy complications. Early detection and treatment of risk factors may help prevent future heart attack, heart failure, and stroke.
The aryl hydrocarbon receptor is highly correlated with various aging hallmarks, including mitochondrial abnormalities and cellular senescence. AhR signaling regulates airway inflammation in asthma, suggesting its crucial role in regulating asthma phenotypes.
The Redox Medicine Society will host its 26th International Conference on Redox Medicine in Paris, featuring keynotes, sessions, and round-table discussions on advancements and applications in clinical settings. The conference aims to facilitate innovation and excellence in the field of redox medicine.
A comprehensive report on pediatric long COVID symptoms has been published, revealing clues to risk factors and common symptoms such as fatigue, headaches, and musculoskeletal pain. The study found that older age, more severe initial infection, and underlying medical conditions are associated with an increased risk of long COVID.
Researchers document various reasons for long-term clinical symptoms in patients infected with SARS-CoV-2. Key findings include immune system alterations, chronic inflammation, endothelial dysfunction, and mitochondrial issues contributing to post-COVID syndrome.
Researchers propose a novel augmentation regimen, IPIAD, combining five generic non-oncology drugs with standard chemotherapy for pancreatic ductal adenocarcinoma. The IPIAD regimen uses repurposed drugs like irbesartan and azithromycin to potentially slow disease growth and improve outcomes.
Researchers identified blood proteomic markers associated with hepatocellular carcinoma (HCC) in patients with cirrhosis. The study found a set of biomarkers, including TGF-β driven mechanistic biomarkers and Myostatin and Pyruvate Kinase M2, which may stratify risk for HCC.
A small, wearable ultrasound sticker can monitor organ stiffness and detect subtle changes that signal disease progression. The device has been shown to identify early signs of acute liver failure in rats and may one day help doctors diagnose internal organ failure more effectively.
Researchers found that injecting a substance to block an artery and combining it with surgery significantly reduced the risk of repeat surgery for patients with subdural hematomas. The study, published at the American Stroke Association's International Stroke Conference, showed a nearly 3-fold reduction in re-operation rates.
Researchers develop a new strategy to make CAR T cell therapy more effective and safer by targeting multiple surface proteins on malignant tumour cells. The approach shows promise in fighting cancer cells while sparing healthy B lymphocytes.
Children's Hospital Colorado is one of nine core sites nationally in the Pediatric Heart Network, a collective working to improve outcomes and quality of life for children with heart disease. The hospital's Heart Institute will conduct multisite research projects over the next seven years.
A new tumor spatial mapping tool will help clinicians assess the aggressiveness of cancer and personalize treatment. The tool maps the functional state of oncoproteins onto tumour images, allowing for more accurate diagnosis and informed treatment decisions.
A Rutgers Health-led study found that South Asian and East Asian older adults are less likely to believe in the benefits of participating in health research studies without direct personal gain. This hesitation may lead to a lack of representation in research, affecting the development of dementia treatments.
A new study by University of Toronto researchers found that quitting smoking significantly reduces the risk of death from vascular disease and cancer. Former smokers can expect to live up to six years longer after quitting, with benefits seen within just three years.
Researchers develop a novel genomic classification system that categorizes patients into 12 distinct groups based on their underlying genomic profiles. The individualized risk model, IRMMa, uses advanced statistical methodologies to generate tailored predictions of patient response to different therapies.
A new study published in The Lancet Oncology demonstrates that the drug enobosarm has anti-tumour effects in oestrogen receptor positive breast cancer patients, providing a novel approach to treatment. The study showed that enobosarm was well tolerated with no significant impact on quality of life.
A study by Massachusetts General Hospital found that 88% of liver transplant center websites and 46% of addiction psychiatry websites use stigmatizing language, potentially discouraging patients from seeking treatment. The researchers call for non-stigmatizing language in patient-facing materials to improve health outcomes.
New findings from a study on ketamine's efficacy in treating severe depression reveal that 52% of participants achieved remission after just three infusions. The study also found that half of those who had thought often of suicide before receiving ketamine experienced a dramatic drop in suicidal impulses.
A clinical trial found that patients who received care recommendations from an AI-based system had fewer recurrent strokes, heart attacks, or vascular death within three months. The study suggests that this technology can improve patient outcomes and aid neurologists in making informed decisions.
A machine-learning tool trained on brain MRI scans of over 2,000 people worldwide can accurately predict psychosis before it occurs. The tool achieved an accuracy rate of 85% in training and 73% in testing, suggesting its potential as a valuable aid for early diagnosis.
Researchers found elevated PROX1 levels in advanced colon adenocarcinoma, correlating with poor prognosis. PROX1 modulates CRC cell behavior, influencing invasiveness and survival outcomes. The combined PROX1/α-SMA gene set emerges as a potential CRC prognostic marker.
A systematic review found that female individuals and caregivers tend to report a greater impact of food allergy on health-related quality of life. Additionally, males may experience more improvements in quality of life following immunotherapy for food allergy.
Johns Hopkins researchers have made progress toward developing a blood test to identify disease-associated changes in the brain linked to postpartum depression and other psychiatric disorders. They identified 26 placental mRNAs present in maternal blood only during pregnancy, which reflected changes occurring inside the tissues.
A recent analysis found a strong link between air pollution and mortality from cardiovascular diseases worldwide. In low-income countries, household air pollution caused significantly more stroke-related deaths than outdoor air pollution.
A research team has discovered a novel mechanism by which stress affects the brain, revealing a potential new pathway for treating depression. Stress increases the production of MMP-8, an enzyme that alters neuron function and leads to behavioral changes.
Researchers found that positioning stroke patients with large vessel ischemic strokes at 0-degrees resulted in significant improvements in neurological function compared to those with 30-degree head positioning. This approach optimized blood flow through the narrowed artery and improved collateral arteries, leading to better outcomes.