Articles tagged with Clinical Research
Researchers at the University of Alabama at Birmingham found that BNP levels are high in end-stage heart failure patients with cardiogenic shock, but no longer a reliable predictor of clinical outcomes after ventricular assist device (VAD) implantation. This study suggests reevaluating routine use of BNP testing for these patients.
The Massive Transfusion in Children-II (MATIC-II) clinical trial will test multiple interventions for life-threatening bleeding in children. The trial aims to determine the most effective and safe bundle of care for pediatric trauma patients, with a focus on precision transfusion medicine.
Preeclampsia, a major cause of maternal mortality, has increased by 37% in Texas since 2017. A new $1.47 million NIH grant will support research initiatives to address preeclampsia rates in six Panhandle counties.
The American Heart Association and the American Academy of Neurology have announced a new scholarship program supporting early career trainees focused on brain health. The Ralph L. Sacco Scholarships will award two $150,000 scholarships annually to pursue research or public health service projects on prevention and maintenance of brain...
A recent study by the University of Toronto has found a significant link between food insecurity and muscle dysmorphia symptoms among adolescent and young adult Canadians. The research revealed that individuals experiencing food insecurity were more likely to suffer from symptoms of muscle dysmorphia, including functional impairment an...
Researchers propose that cerebrospinal fluid leaks could contribute to the link between traumatic brain injury and dementia. The hypothesis suggests that treating these leaks could mitigate dementia symptoms in some patients with a history of TBI. Further research is needed to confirm this potential association.
Researchers uncover clues about how chemicals released by brain cells regulate our attention span, finding that two neurotransmitters work together in a precise sequence to regulate signal transmission. This discovery could lead to new treatments for neurological conditions associated with concentration difficulties.
Researchers from Mass General Brigham find that traumatic brain injury increases risk of cardiovascular and cognitive dysfunction. Non-neurological conditions associated with TBI, such as hypertension and changes in the brain-gut connection, contribute to elevated cardiovascular risk.
Researchers launch EU-funded initiative to uncover EBV's role in MS, aiming to find underlying mechanism and develop antiviral treatments. The project seeks to improve disease course or stop progression, with potential for preventive strategies like vaccination.
Researchers found higher 5-year survival rates among Kaiser Permanente patients compared to National Cancer Institute's Surveillance, Epidemiology, and End Results (SEER) estimates. Improved screening rates, cancer treatment pathways, and coordinated care may have contributed to these higher survival rates.
A new study suggests that theta-burst transcranial magnetic stimulation therapy can lead to improved self-control, reduced cravings, and less smoking in individuals with nicotine dependence. This treatment targets the brain region responsible for inhibitory control, which is often impaired in smokers.
A Phase 1 trial of a preventive HIV vaccine candidate has begun enrollment in the US and South Africa. The vaccine, VIR-1388, aims to instruct immune cells to recognize and respond to HIV.
Researchers at St. Jude Children's Research Hospital refined the definition of hyperdiploidy in childhood B-cell acute lymphoblastic leukemia (B-ALL), using DNA index to predict patient outcomes. The study found that a simpler system captures a significant proportion of patients with excellent prognoses, and that individual chromosome ...
The Mount Sinai Hospital's Cohen Center will expand its research and clinical care to include 'long Lyme Disease/Lyme+', exploring key similarities and differences with long COVID. The center will offer novel therapies, including virtual reality and non-invasive brain stimulation technologies, as well as personalized cognitive rehabili...
Researchers at U of A are developing an AI-powered system to analyze cardiac images, enabling clinicians to diagnose heart disease more accurately. The project aims to reduce healthcare costs and improve patient outcomes, with potential global implications.
Researchers developed a DNA damage-induced senescence model in osteoarthritic chondrocytes, which reliably induces cellular senescence and accumulates senescent cells in OA joint tissues. The study provides a useful model to develop therapeutic approaches targeting senescence in osteoarthritis.
Researchers have identified new genetic markers to detect Lynch syndrome-associated colorectal cancer with 92% accuracy. The discovery could lead to a non-invasive screening option using stool samples, reducing the need for annual colonoscopies and invasive tests.
Researchers have identified a pattern of brain activity, or biomarker, related to clinical signs of recovery from treatment-resistant depression. The study found that 90% of patients showed significant improvement in depression symptoms after six months of DBS therapy.
A new three-year grant will provide specialized dementia services and supports to underserved communities in Broward County. The project aims to improve quality of life for individuals living with or at risk of Alzheimer's disease, as well as their family caregivers.
A new study uses AI to predict mortality rates in patients with hip fractures, identifying key biomarkers for poor outcomes. The model achieved accurate predictions using basic blood and lab test data as well as demographic information.
The journal publishes articles promoting solution-based approaches at individual, hospital, and policy levels to address DEI. The themed edition aims to eliminate healthcare disparities by fostering meaningful change and progress.
A new study from the University of Pennsylvania School of Medicine found a significant link between inflammatory bowel disease (IBD) and atopic dermatitis (AD), with adults having a 34% increased risk and children having a 44% increased risk. The severity of AD was also associated with an increased risk of developing IBD.
The AAO-HNSF 2023 Annual Meeting & OTO Experience will feature groundbreaking clinical research and professional development emerging within otolaryngology. The meeting will showcase the latest scientific oral presentations on various topics, including Otology, Laryngology, Endocrine Surgery, and more.
Pediatric patients experience pain that can be detrimental to their brain structure and lead to emotional and behavioral problems. Validated tools such as the Wong-Baker FACES scale and COMFORT scale help healthcare providers assess pain effectively.
A new study found that only one out of four recommended screening tools for sepsis is reliable, with NEWS-2 accurately predicting 72.2% of all sepsis cases. The study also highlights the need for better awareness and more frequent use of effective screening tools to improve early sepsis recognition and survival rates.
Researchers developed a reliable and reproducible real-time live tissue sensitivity assay (RT-LTSA) using fresh tumor samples to predict patients' clinical response to chemotherapy. The study showed improved disease-free survival and reduced recurrence rates in patients who received RT-LTSA sensitive adjuvant regimens.
The NIH has released a strategic plan for research on herpes simplex virus 1 and 2, outlining four priorities: improving fundamental knowledge, accelerating diagnosis, treating HSV while seeking a curative therapeutic, and preventing infection. The plan aims to reduce the burden of HSV-1 and HSV-2 in the US.
Researchers found that patients prescribed amoxicillin-clavulanate had higher rates of gastrointestinal symptoms and yeast infections than those prescribed amoxicillin. The study showed no difference in treatment failure rates between the two antibiotics, with treatment failure occurring in less than 2% of cases.
The study of 6,499 patients suggests that higher buprenorphine doses can reduce time to discontinuation. This finding challenges current recommended dosages for improving treatment retention.
The September issue of the CHEST journal features research on long COVID, including a review on exercise pathophysiology in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome and Postacute Sequelae of SARS-CoV-2. Original studies also explore asthma treatment with albuterol-budesonide inhalers and sleep therapy using oronasal masks.
Researchers found that AI/ML based programs can successfully detect PCOS with an accuracy of 80-90%, making it a promising tool for early diagnosis and reducing the burden on patients. The study suggests integrating large population-based studies with electronic health datasets to identify sensitive diagnostic biomarkers.
Researchers developed a personalized combination treatment that turned on an immunometabolic switch to effectively control aggressive prostate cancer. The treatment showed complete tumor control and long-lasting survival without side effects in a mouse model of advanced prostate cancer.
Researchers have designed an implantable device that carries hundreds of thousands of insulin-producing islet cells and has its own on-board oxygen factory, generating oxygen by splitting water vapor. The device was tested in diabetic mice and maintained normal blood glucose levels for at least a month.
A new study by UCSF researchers has found that people who use both cannabis and tobacco have significantly higher rates of depression and anxiety than those who use either substance alone or not at all. The study analyzed data from 53,843 Americans and found that among dual users, 26.5% reported anxiety and 28.3% reported depression.
The University of Colorado Anschutz Medical Campus has received a $54 million grant from the National Institutes of Health to advance clinical and translational science. The grant will enable the Colorado Clinical and Translational Sciences Institute (CCTSI) to translate discoveries into better health and patient care across the state.
Research found that depression screening methods, such as the Patient Health Questionnaire-9, correctly identified more patients who attempted suicide than suicide risk screenings. The study suggests that comprehensive screenings tools may be more effective in identifying patients at risk of suicide and depression.
A large international study led by Danish researchers may have brought us closer to a cure for HIV. The study found that patients who received monoclonal antibodies before pausing their regular treatment experienced a period of virus suppression, and some even saw their immune system partially or completely suppress the virus.
A novel study shows that Senolytics can prevent the transfer of senescence, a key mechanism of ageing, and associated physical and cognitive impairments in recipients of older donor organs. This breakthrough could lead to improved outcomes and increase organ availability for transplantation.
Researchers found that early treatment of child obesity is effective in improving weight status and metabolic health. Children whose parents received parental support had the best results, with more showing a clinically relevant improvement.
A new study found that islet transplantation significantly reduces the risk of kidney transplant failure and mortality in patients with type 1 diabetes. The study compared the long-term outcomes of patients who received an islet transplantation with those who underwent kidney transplantation and managed their diabetes with insulin alone.
A Phase 1 trial of FluMos-v2 has begun at the NIH's Clinical Center, evaluating its safety and immune response. The vaccine aims to provide protection against multiple flu strains, with the potential for less frequent dosing than traditional seasonal vaccines.
Researchers developed statistical models using ultrasound measurements and protein levels to predict stillbirth, neonatal death, or extreme preterm delivery. The findings aim to identify suitable candidates for clinical trials testing novel treatments for fetal growth restriction.
A recent study from MIT found that measuring diversity of mutations within a tumor generates more accurate predictions of treatment success than overall mutation count. This discovery could help doctors identify patients who would benefit most from checkpoint blockade inhibitors.
A new study sheds light on the molecular mechanisms behind immunotherapy's lack of response in certain types of cancer. Researchers found that intratumoral heterogeneity damps the immune response, leading to diminished effectiveness.
A recent study published in the Journal of Diabetes Science and Technology found that HbA1c levels are markedly higher in young black youth compared to whites with type 1 diabetes. This disparity can lead to increased risk of hypoglycemia and long-term complications if primarily used for insulin management.
Researchers at EMBL Grenoble have obtained the first structure of p38α being activated by MKK6, opening up new directions for developing drugs to stop cytokine storms. The inflammatory response is triggered by a series of kinases, and inactivating p38α could prevent inflammation from occurring.
Researchers at Weill Cornell Medicine discovered a distinct type of stem cell that secretes protein MFGE8, favoring tumor metastases to the spine. This finding helps explain why solid tumors often spread to the spine and could lead to new orthopedic and cancer treatments.
Researchers developed a technique called CHOOSE that allows them to test the effect of multiple mutations in parallel and at a single-cell level within human brain organoids. The study identified critical transcriptional changes regulated through common networks, or GRNs, and found that some cell types are more susceptible to autism mu...
Researchers identified distinct genomic characteristics that impact prognosis for patients with triple negative apocrine carcinoma. The study confirmed a five-year disease-free survival rate of 92.2% for these patients, significantly higher than those diagnosed with other types of TNBC.
A Pittsburgh-based surveillance system detected a drug-resistant Pseudomonas aeruginosa infection linked to artificial tears months before the national public health alert. The findings demonstrate the effectiveness of whole genome sequencing-based surveillance in detecting outbreaks and preventing nationwide cases.
Researchers discuss new drugs available for HER2-positive breast cancer patients with brain metastasis, showing improved outcomes and quality of life. The development of targeted therapies has led to better survival rates among these patients.
A new study from Boston Medical Center found that injectable extended-release buprenorphine is limited by cost and treatment retention, while oral buprenorphine may be a more cost-effective option. The opioid overdose crisis requires a broad range of effective treatments, including injectable formulations.
A third of UK medical students lack sexual misconduct training, leaving graduates unprepared to handle harassment and abuse in the workplace. The study reveals a significant variation in training methods across medical universities, highlighting the need for standardization.
A comprehensive global analysis found that these stop-smoking aids are nearly twice as effective as single forms of NRT. Dual forms of NRT, such as combining a patch with gum or a lozenge, were found to be nearly as effective as nicotine e-cigarettes and prescription medications.
A new imaging technique, multifocal acoustic radiation force-based reverberant optical coherence elastography (RevOCE), has been developed to measure the elasticity of multiple eye components simultaneously. This approach offers high resolution measurements of the stiffness of eye structures and could revolutionize how we study ocular ...
Researchers have developed an automated breath-by-breath measure to assess the severity of obstructive sleep apnea, predicting cardiovascular disease and mortality. The ventilatory burden tool provides a validated alternative to AHI, offering stable results and risk predictions.
A large-scale international study of childhood cancer survivors found that women who received high-dose doxorubicin chemotherapy without chest radiation have a significantly increased risk of breast cancer before age 40. The researchers are calling for broadening guidelines for breast cancer screening in these patients.
Researchers at the University of Missouri have identified a way to improve immunological memory produced by T cells in response to influenza infection, potentially leading to more effective vaccines and treatments. The study found that manipulating a molecular signaling pathway can strengthen and prolong the immune response.
Researchers found that EHR systems rated as being difficult to operate did not perform well in safety tests. When clinicians experienced difficulties with EHRs, those systems were less likely to flag medication errors.
A phase I clinical trial shows that transplanting P63+ lung progenitor cells can repair damaged lung tissue in patients with chronic obstructive pulmonary disease (COPD), improving breathing and quality of life. The treatment increased lung function, reduced symptoms, and even repaired mild emphysema in some patients.