Articles tagged with Clinical Research
Researchers from Columbia University have validated GLS2's ability to promote ferroptosis in murine models. This study suggests that targeting GLS2 may be a potential therapeutic strategy against liver diseases, particularly hepatocellular carcinoma.
In a phase I trial, an oncolytic virus treatment designed by Brigham researchers extended survival among patients with recurrent glioblastoma, especially those with pre-existing viral antibodies. The therapy reshaped the tumor's surrounding environment to stimulate an anti-tumor immune response.
Clinical quality registries collect and store health information to optimize healthcare and management in ICUs, providing valuable data for scientific research and epidemiological maps. The review highlights the role of CQRs in benchmarking strategies between hospitals and improving resource management.
A study of 1,732 adults found that 69% used the snooze function or set multiple alarms. Snoozing resulted in lost sleep but prevented awakening from slow-wave sleep. In a second study, 30 minutes of snoozing improved cognitive performance.
A new yeast-based screening method has been developed to unravel how plants synthesize medicinal compounds, identifying key enzymes in a kratom tree. The method complements traditional approaches by capturing protein-protein interactions between plant enzymes.
Dana-Farber Cancer Institute presents several studies on novel treatments, combination therapies, and personalized medicine for lung, kidney, and neuroendocrine tumors. The studies include pivotal trials on adagrasib with pembrolizumab for non-small cell lung cancer and belzutifan versus everolimus for clear cell renal cell carcinoma.
The American College of Surgeons (ACS) Clinical Congress 2023 offers media credentials to cover groundbreaking research, connect with surgeon experts, and learn about the latest trends in surgery. Key topics include artificial intelligence, COVID-19's impact on cancer care, and pediatric trauma.
A recent study found a compelling link between vitamin B12 deficiency and chronic inflammation, which can lead to various health problems. The research revealed an inverse relationship between vitamin B12 levels and inflammatory markers in humans and mice, suggesting that higher vitamin B12 levels may lower inflammatory markers.
The ATLANTIS trial found that amitriptyline significantly improved IBS symptoms, with participants taking the medication reporting a bigger improvement in symptom scores after six months. The medication was well-tolerated and showed no significant impact on anxiety or depression scores.
A team of researchers has developed a new visualization tool combining high-speed cameras and fluorescent injection to distinguish tumor tissue from normal tissue across cancer types. The technique, known as fluorescence lifetime (FLT) imaging, achieved an accuracy of over 97% in distinguishing tumor tissue from healthy tissue.
A study comparing dreams from Western and non-Western populations found that non-Western groups produced more cathartic and socially-oriented dreams, while Western groups had more threatening but less emotionally resolving dreams. The results suggest a strong link between societal norms and the function of dreams.
The team created a glycoengineering platform that simplifies the production of customized sugar carbohydrates, known as glycans, which play a crucial role in various therapeutic applications. This innovation enables the engineering of new glycans with unprecedented flexibility, addressing limitations in existing approaches.
A study of 222 US hospitals found that 79.4% of patient-facing websites did not mention abortion, with limited information provided when it was mentioned. This lack of disclosure may contribute to stigma surrounding abortion care.
A recent study published in CHEST Science Journal reveals that high-performance ICUs exhibited lower mortality rates during the COVID-19 pandemic, with a range of 3.6% to 63.2%. The research also found that these ICUs had better patient outcomes before and after the pandemic, regardless of disease severity or comorbidities.
Researchers have discovered new insights into microglia-astrocyte communication and its impact on intracerebral hemorrhage, as well as the testicular toxicity of triptolide. Additionally, a study on epicardial cells has identified key gene markers associated with cardiac regenerative therapy strategies.
Researchers discovered BMAL1 is significantly upregulated in senescent cells and modulates the senescence program through AP-1. The study highlights a previously unappreciated role of BMAL1 in regulating cellular senescence and circadian clock components.
Research has discovered a significant connection between birthweight and the onset of nonalcoholic fatty liver disease (MASLD) in young people. Babies born with low birthweight were found to be four times more likely to develop MASLD in childhood, adolescence, or young adulthood.
A large-scale prospective study identified significant variations in the gut microbiome of individuals who developed pre-cancerous colonic lesions. These findings suggest that the microbiome could act as a valuable tool to improve existing tests, advancing early detection methods for colorectal cancer.
A clinical trial has shown that an investigational drug, encaleret, can restore parathyroid function and normalize blood calcium levels in people with autosomal dominant hypocalcemia type 1. The treatment was effective in restoring every participant's blood calcium level to normal within 24 weeks.
A long-term study found that changes in core autism characteristics are related to the development of mental health challenges during elementary school years. Restrictive and repetitive behaviors may help reduce anxiety for autistic individuals.
The American Academy of Pediatrics hosted its 2023 National Conference & Exhibition in Washington, D.C., presenting original research on topics such as the national opioid crisis, obesity prevention, and mental health challenges. The AAP also released two new policy statements: one proposing bold reforms in Medicaid and CHIP, and anoth...
Research found that young children's immune systems produce protective antibodies at high levels for up to 300 days after infection. Unlike adults, children have high levels of inflammatory cytokines in their noses but not in their blood, potentially explaining the mildness of COVID-19 in this age group.
A study involving 119,606 Chinese newborns found that concurrent hearing and high-throughput genetic screening significantly enhances congenital hearing loss management. The detection rate of certain gene mutations was also reported, highlighting the importance of considering multiple factors for accurate diagnosis.
A new trial combining an Alzheimer's medication with two other drugs may amplify its effects and arrest disease progression. The trial, funded by a $150M grant, will recruit 900 participants with early-onset Alzheimer's.
A clinic-based community program improved food security scores, healthy eating behaviors, and depression scores in a vulnerable, food-insecure population. The Geaux Get Healthy Clinical Program provided comprehensive education and access to resources, leveraging community partnerships.
TTUHSC researchers received funding for pilot studies on photothermal tumor therapy, clear cell renal cell carcinoma, and colorectal cancer screening in underserved areas. The grants support the purchase of a cell sorter and address regional health disparities.
A new study published in JNCCN found that intensive local-regional treatment to remove as much tumor as possible did not significantly impact overall quality of life for patients with metastatic colorectal cancer. However, the treatment was associated with a higher risk of adverse events.
Researchers at Johns Hopkins have published a guide for prioritizing the next steps in completing the human genome catalog. The study highlights the importance of cataloging non-coding RNA genes and enhancing databases of gene variations that cause illness and disease.
A new AI software has achieved a 100% detection rate for melanoma, significantly improving skin cancer detection accuracy. The software correctly identified 99.5% of all skin cancers and 92.5% of pre-cancerous lesions, with potential to reduce face-to-face consultations and enhance dermatology triage.
Researchers discovered that inhibiting the BRAF/EGFR/MEK pathway significantly reduced cancer stemness and drug resistance in primary colorectal cancer cells. The study also identified a triple combination treatment against BRAF, EGFR, and MEK as a promising approach to block these activities and develop effective treatments.
A team of NYU researchers developed a vocal reconstruction technology that recreates the voices of patients who have lost their ability to speak. By analyzing brain recordings, they disentangled the intricate processes of feedback and feedforward during speech production.
A new study finds that faces with acne, especially adult female acne, are perceived as less attractive, trustworthy, confident, successful, dominant, and happy. The study also highlights the emotional and psychological burden experienced by individuals with acne.
A new clinical trial has shown that infusing immune cells from living donors into recipients before transplantation may reduce the need for lifelong immunosuppressant medication. The treatment involves infusing donor-derived regulatory dendritic cells, which help the recipient's immune system distinguish between foreign and self-cells.
Researchers tested the feasibility of using locally run LLMs like Vicuna-13B to label key findings in chest X-ray reports while preserving patient privacy. The results showed moderate to substantial agreement with non-LLM computer programs, suggesting that these models can be a viable option for AI research.
A University of Massachusetts Amherst team demonstrates a protein antigen from a childhood vaccine can be delivered into malignant tumor cells to refocus the immune system against cancer. The bacteria-based intracellular delivering system shows promise in treating pancreatic, liver, and metastatic breast tumors.
A new study found that hybrid closed-loop technology significantly improved maternal blood sugars in pregnant women with type 1 diabetes. Women who used the technology spent more time within the target range for pregnancy blood sugar levels, gained less weight, and had fewer complications.
A large multi-state study found that mupirocin ointment is highly effective at preventing Staphylococcus aureus infections in critically ill patients, outperforming an antiseptic solution. The study involved over 800,000 ICU patients in 137 hospitals and showed a durable benefit from mupirocin.
Researchers at the University of Virginia Health System are developing computer models to better understand the cellular processes and gene activity of multi-drug resistant bacteria Staphylococcus aureus and Pseudomonas aeruginosa. The goal is to identify vulnerabilities in these bacteria and advance the development of new treatments.
Researchers at Mount Sinai Hospital developed an algorithm called HistoAge that predicts age at death based on human brain tissue specimens using artificial intelligence, revealing insights into aging mechanisms and neurodegenerative diseases like Alzheimer's disease.
Researchers have developed STARVar, an artificial intelligence-powered method that leverages diverse data sources to identify genetic variants associated with diseases. The tool prioritizes genomic variants based on real-world patient symptoms, providing a more nuanced understanding of clinical presentations.
Researchers discovered the STAT3 signaling pathway as a potential target for treating H3K27M-mutant diffuse midline gliomas (DMGs), a uniformly lethal central nervous system malignancy. The current standard of care, including palliative radiation and chemotherapy, remains ineffective in this disease.
A new blood test called OvaPrint TM detects specific nucleic acids in the blood, distinguishing between cancerous and benign pelvic masses with high accuracy. The test has the potential to improve treatment outcomes by identifying the best surgical approach for patients with a pelvic mass.
A new study shows that XEN1101 can reduce seizure frequency by more than 50% in some patients and sometimes eliminate seizures altogether. The medication, a potassium-channel opener, boosts the flow of potassium out of nerves to stop them from firing.
A new study led by UCL researchers finds that integrated health care for chronic high-burden conditions like diabetes and hypertension is feasible and cost-effective. The study showed that integrated care was associated with high levels of retention in care, no adverse effect on viral suppression among people with HIV, and cost-saving ...
A recent study found that integrated clinics can improve health outcomes and reduce costs for patients with multiple chronic conditions. The INTE-Africa study showed that retention rates were close to 90% and viral suppression rates remained unchanged, highlighting the benefits of integrating HIV and non-communicable disease care.
Post-Acute Sequelae of COVID-19 research aims to track long-term health symptoms in survivors. A $3.7 million grant will support the development of self-supervised deep learning technologies to recognize post-COVID lung progression phenotypes.
A new national ALS research consortium, Access for All in ALS, has been launched with a $16.7 million NIH award. The consortium will include 34 clinical sites nationwide and generate a longitudinal biorepository linked to detailed clinical information.
Researchers developed a low-cost, ultrasensitive blood test to detect a highly specific biomarker for multiple common cancers. The test showed promise for early cancer detection and disease monitoring, detecting levels of the biomarker in the blood of patients with many types of cancers.
Researchers at Memorial Sloan Kettering Cancer Center developed an open-source computational method, Spectra, to analyze single-cell transcriptomic data. The algorithm identifies functionally relevant gene expression programs and is well-suited for studying large patient cohorts.
Researchers found that former football players with medical and mental health conditions like depression and anxiety are at higher risk of receiving an unverified CTE diagnosis. The study highlights the need for accurate diagnoses and access to proven treatments.
Researchers developed a promising strategy to reduce adverse reactions to nanoparticles by using complement inhibitors. The study showed that regulators being studied effectively inhibited complement activation by nanoparticles in human serum in vitro and animal models.
The Keck School of Medicine of USC has received a $2 million grant from the California Institute of Regenerative Medicine to further enhance its cutting-edge cGMP Laboratory. The funding will support the adoption of advanced technologies, including an electronic quality management system and optimized cell therapy manufacturing processes.
A UCLA-led team has discovered the nerve supply that activates brown adipose tissue, a potential key to treating obesity. The study found nerve branches in all eight cadavers dissected, which may lead to using nerves to stimulate BAT activity for weight loss.
A research team has developed a technology that selectively targets and eliminates aging cells, contributing to various inflammatory conditions. This approach represents a new paradigm for treating age-related diseases with minimal toxicity concerns.
A research team has identified a link between calcium imbalances and the progression of brain damage in children with rare genetic conditions. They found that stabilizing calcium levels could be a target for new treatments to prevent further deterioration.
A study by Columbia University Mailman School of Public Health found a significant association between attention-deficit/hyperactivity disorder (ADHD) and crash risk among older adult drivers. Older adults with ADHD were more than twice as likely to report traffic tickets and vehicular crashes compared to their counterparts without ADHD.
Researchers developed a calculation to identify moderate aortic stenosis patients at higher risk of mortality. The study found that low mean arterial pressure is associated with higher mortality in all patient subgroups.
Research published in European Journal of Neurology indicates that COVID-19 and COVID-19 vaccination have negligible effects on migraine severity. Among participants who reported worsening migraines, those infected were 2.5-times more likely to be concerned about migraine worsening than those vaccinated.
A study published in Diabetes Care found that obesity, hypertension, and dyslipidemia alter cardiac energy production by interfering with metabolic substrate uptake. The research reveals early changes in apparently healthy middle-aged individuals, highlighting the importance of identifying mechanisms involved in heart disease onset.
University of Minnesota researchers identified top-performing primary care practices that deliver high-quality diabetes care through proactive patient outreach. These practices prioritize good communication and engagement with patients, fostering a strong doctor-patient relationship essential for overall health.