Articles tagged with Clinical Research
Dr. Olugbenga Ogedegbe has been recognized for his pioneering research on health disparities, chronic diseases, and cardiovascular risk reduction, particularly among Black adults in the US. His work aims to reduce hypertension control and racial inequities in cardiovascular disease outcomes.
A small clinical trial led by the University of Houston demonstrates Riluzole's effectiveness in improving functionality in people with acute spinal cord injuries. The study used an SCI-specific biomarker to show how Riluzole reduces neuron cell damage and improves motor abilities.
Dr. Zainab Mahmoud received the 2023 Dr. Nanette K. Wenger Research Goes Red Award for her study identifying racial disparities in specific maternal cardiovascular outcomes. The analysis found higher rates of hospitalizations among Black women, highlighting the need for improved access to care and enhanced postpartum monitoring.
Dr. Marlene Rabinovitch, a renowned pediatric cardiologist, will receive the 2023 Research Achievement Award for her groundbreaking research on PAH treatment. Her discoveries have led to the identification of neutrophil elastase as a trigger for inflammatory responses and the potential use of immunosuppressant FK506 to restore lung blo...
A new study from Tulane University found that frequent salt consumption is associated with a higher risk of developing Type 2 diabetes. The study surveyed over 400,000 adults and found participants who regularly added salt had a 13% to 39% increased risk of developing the disease compared to those who never or rarely used salt.
The new department will expand and improve isotope research and production to meet the nation's growing need for critical isotopes. Cathy Cutler plans to leverage the Lab's nuclear physics accelerator infrastructure to develop novel isotopes and applications.
Dr. Marc A. Pfeffer will receive the 2023 Eugene Braunwald Academic Mentorship Award for his remarkable teaching and mentoring career, which has inspired numerous professionals in cardiovascular medicine. He is credited with directly mentoring 58 individuals throughout their careers.
A new study found that oral contraceptive pill users have a lower prevalence of major depression (4.6%) compared to former users (11.4%). The researchers suggest two possible explanations for the findings: removing concerns about unwanted pregnancy and survivor bias.
A new study by RCSI University of Medicine and Health Sciences found that boosting levels of a deficient protein improves survival rates for people with severe alpha-1 antitrypsin deficiency. The research, which tracked health data from over 600 patients, showed a clear survival benefit from augmentation therapy.
Dr. Schwamm, a neurologist at Yale School of Medicine, is recognized for his work on stroke systems of care and telestroke initiatives. He has improved patient outcomes and expanded access to care through his advocacy for telemedicine and digital health solutions.
A recent study presents exciting future possibilities for managing type 1 diabetes with the repurposed drug α-difluoromethylornithine (DFMO), which may reduce insulin dependency. The researchers have established preliminary safety of DFMO for individuals with type 1 diabetes, paving the way for innovative therapies.
A national-level study found that the median UVC dwell time was 7 days, and CLABSI incidence did not differ significantly between 0-7 days and 7-15 days. The study also highlighted high rates of antibiotic exposure without reduction in CLABSI rates, emphasizing the need for nuanced approaches to antibiotic administration.
A $4.7 million NIH grant will be used to train dental students and faculty, enhance mentoring, and conduct a clinical research study on Sjögren's disease. The grant aims to find an early biomarker for the chronic autoimmune disorder affecting four million Americans.
The 2023 Practitioner’s Toolkit for Managing Menopause offers updated guidance on assessing and treating women with menopausal health issues. The toolkit includes new advice on hormone therapies, bone health, and treatment guidelines, aiming to improve care for women globally.
Researchers at the University of Cincinnati Cancer Center found that SmartClips, a wireless localization method for breast tumors, is safe and effective. The devices reduce patient discomfort and improve surgery efficiency by allowing surgeons to locate tumors more accurately.
Researchers developed an environmental risk score to assess ALS risk and survival using a blood sample, associating several individual pollutants with disease risk. A mixture of pesticides in the blood significantly increased ALS risk, with those in the highest group having twice the risk as those in the lowest.
A recent study from Ohio State University Wexner Medical Center and colleagues found that Rumination-focused Cognitive Behavioral Therapy (RF-CBT) can reduce rumination in adolescents. The study also showed correlated shifts in brain connectivity, suggesting that RF-CBT can help young people break the painful mental loops that contribu...
Researchers from Universitatsklinikum Bonn have found that a loss of the structural protein ACTL7B blocks spermatogenesis in male mice, leading to infertility. The study suggests that mutations in the Actl7b gene could be a cause of male infertility in humans.
A large-scale study found that metformin can reduce weight gain and increase adherence to treatment in youth with bipolar disorder. The medication, typically used for Type 2 diabetes, was effective in preventing weight gain and showed promise as a potential solution to this common side effect of SGAs.
A new study validates Low-Pass Genome Sequencing (LP GS) as a robust and cost-effective alternative to Chromosomal Microarray Analysis (CMA) for prenatal diagnosis. LP GS detects six additional Copy Number Variations (CNVs) in cases with negative CMA results, highlighting the importance of sequencing depth in its detection sensitivity.
University of Alberta researchers have identified taurine as a key player in predicting poor clinical outcomes and treating long COVID. A predictive test and proposed supplement trial aim to minimize symptoms and improve patient outcomes.
A study published in Annals of Neurology found that receiving clot-busting drug treatment in a mobile stroke unit (MSU) increases the likelihood of averting strokes and complete recovery compared to standard hospital emergency care. Patients treated by an MSU had faster treatment times, with nearly one-third recovering within 24 hours.
A year-long clinical trial found sustained remission of polymyalgia rheumatica in 28% of patients taking sarilumab, compared to 10% of those on placebo. The treatment showed promise in reducing relapse and improving outcomes for patients tapering their steroid medication.
Researchers found changes in microglial cells, a specialized subset of immune cells, that may worsen schizophrenia risk in adolescents. The study, published in Nature Communications, suggests that THC exposure during adolescence can lead to long-lasting negative effects on brain development and function.
Researchers have discovered that genetic ancestry influences the biology of normal breast tissue and how it factors into the development of aggressive breast cancers. PZP cells, naturally higher in Black women, can influence cancer cell behavior and growth.
Researchers developed the SOMMA Vigor to Frailty Score to rank older adults from 0 (vigorous) to 12 (frail), predicting their resilience to stress. Patients on the high end of the continuum are up to 31 times more likely to have functional limitations.
A global platform study has released results on the use of simvastatin to treat severely ill patients with COVID-19, showing a high probability of improving outcomes. In contrast, high-dose vitamin C was found to be ineffective and potentially harmful in critically ill patients, suggesting its use should be discontinued.
Tongxinluo significantly improved 30-day and 1-year clinical outcomes in STEMI patients, according to a randomized clinical trial. Further research is needed to understand its mechanism of action.
Atrial fibrillation patients undergoing TAVR with the Watchman device had similar outcomes to those receiving medical therapy or blood thinners after TAVR, according to a Cleveland Clinic-led trial. The study found no differences in all-cause death, stroke, and major bleeding between the two groups.
A Michigan Medicine-led study reveals that older adults from distressed communities are less likely to attend cardiac rehabilitation after coronary revascularization. The study found that only 26% of patients from these areas used cardiac rehab, compared to 46% from prosperous areas.
The partnership aims to reduce disparities in cancer research and drug development through collaborations, resources, and training programs. Key projects will focus on breast and pancreatic cancers, particularly luminal B breast cancers disproportionately affecting women of African descent.
Researchers found that apoptotic cells induce apoptosis in neighboring hair follicle cells during the regression cycle. The study proposes a mathematical model of the hair follicle regression cycle, which suggests that the dermal papilla plays an essential role in initiating apoptosis.
A study by Medical University of Vienna found that AI algorithms in smartphone applications perform well in diagnosing pigmented skin lesions, but are outperformed by doctors in treatment decisions. The 7-class algorithm showed equivalent diagnostic accuracy to experts, while the ISIC algorithm performed worse.
A retrospective cohort study found that Black, lower SES, and publicly insured teens are at higher risk of major complications after scoliosis surgery. These disparities also affect pre-operative care, including rates of brace prescription and second opinions.
Researchers from Drexel University's Autism Institute found that most TikTok videos providing information on autism were inaccurate or overgeneralized. Healthcare professionals' content was more likely to include accurate information, while personal experience-based videos were not coded in the study.
Researchers at Ohio State University Wexner Medical Center are testing a novel diagnosis and treatment combination for painful diabetic neuropathy using spinal cord stimulation and small fiber nerve activity measurement. The approach has the potential to provide effective pain relief and potentially reverse neuropathy reversal.
Researchers found that neighborhoods with better socioeconomic and educational opportunities had lower rates of asthma-related emergency department visits among children under five years old. This suggests that improving social determinants of health in areas with high asthma morbidity may help reduce childhood asthma rates.
Scientists at UNSW Sydney have created a new material that can mimic human tissue, fight bacteria, and heal itself. The hydrogel material is made from simple peptides and has implications for biomedical research, medicine, and manufacturing technology.
Researchers at Penn Medicine have received a $10 million grant to develop a new strategy for preventing breast cancer recurrence by targeting dormant tumor cells. In a phase II clinical trial, the team successfully cleared dormant cells from over 80% of patients, offering a promising proof-of-concept for this approach.
An international team recorded real-time chemical activity in the human brain using clinical electrodes, providing insights into the brain's chemistry and its implications for various medical conditions. The groundbreaking methodology has opened a window to never-before-seen brain activity.
A clinical trial has shown that combining chemotherapy with immunotherapy nivolumab significantly improved outcomes in patients with advanced bladder cancer. The study found nearly twice as many patients with no evidence of disease after treatment, and a median complete response of 37.1 months.
Postoperative wound infections in the head and neck region are common complications, with risk factors including age, smoking, and comorbidities. Aseptic operating conditions and peri/postoperative antibiotics can help minimize infection rates.
Research found that curling irons and curlers were the most common causes of burn injuries, affecting 68% of injured children under 10. Most injuries occurred at home without hospitalization required.
Researchers found that patients who recorded more than 7,500 steps per day before surgery had a 51% reduced odds of experiencing postoperative complications. The study analyzed health data from 475 participants using Fitbit devices and found that chronic physical activity habits were associated with better surgical outcomes.
Researchers identify cytotoxic CD4+ tissue-resident memory T cells as potential asthma triggers, particularly in older male patients. These cells can cause severe inflammatory responses and make treatment challenging.
Researchers develop a novel iNKT cell therapy approach using canine models, demonstrating improved survival and longer therapeutic effect. The platform could potentially treat human cancers with reduced risk of relapse and increased efficacy.
Researchers from Nemours Children's Health present studies on body image, sports attrition, social determinants, and obesity, highlighting fresh approaches to keeping children healthy. Dr. Steven Selbst receives the prestigious Jim Seidel Distinguished Service Award for emergency medicine contributions.
New studies from UCLA Health found that measuring pupil response to light before TMS treatment correlates with improved depression symptoms. Pupil size reflects activation of the autonomic nervous system, which is negatively impacted in people with depression. Researchers discovered a significant association between baseline pupil cons...
Research reveals nearly 80% of emergency department encounters involving transgender or gender diverse youth ages 10 and older screened positive for suicide risk. The majority of those who identify as transgender or gender diverse screened positive for suicidal ideation.
A retrospective analysis of pediatric sepsis deaths found Black children were 2.5 times more likely to die from sepsis, with an overall mortality rate of 1.65% compared to 1.27% for white children. The study highlights the need to identify factors contributing to racial disparities in sepsis outcomes.
A new neighborhood-based care model has been shown to be effective in treating hepatitis C among injection drug users and those experiencing homelessness. The study found that 92% of participants had undetectable levels of the virus after treatment, with 84% achieving sustained virologic response.
A survey by the American Academy of Pediatrics found that nearly 70% of teenagers are comfortable being asked about their sexual orientation and gender identity during medical visits. This study emphasizes the need for diverse avenues of communication to foster an inclusive healthcare environment.
A new hormone replacement therapy, Pulsatility, has shown promising results in improving symptoms and quality of life for patients with adrenal insufficiency conditions. The treatment, which delivers hydrocortisone in a pulsatile pattern, decreased fatigue by 10% and improved mood and energy levels by 30%.
A retrospective study found that research staff of the same race or ethnicity as patients increased consent rates by 65.1% compared to those of a different race or ethnicity. Employing diverse research teams can improve trust and engagement among potential study participants, according to researchers.
A new cancer immunotherapy that targets two immune-evading tumor tactics has shown promising results in an early clinical trial. The drug, tebotelimab, blocks both PD-1 and LAG-3 proteins, leading to a double-digit response rate in patients with advanced solid tumors or blood cancers.
The WVU School of Medicine and Benjamin M. Statler College of Engineering and Mineral Resources will support clinical trials and engineering technology development. The project aims to improve care and rehabilitation for people with neurological disorders through novel physician-engineer programs and human research.
A new electronic health record documentation tool has been shown to improve the accuracy and completeness of clinical documentation for patients undergoing treatment for epilepsy. This tool enables medical providers to identify patients who are failing treatments earlier, allowing for rapid optimization of positive outcomes.
A potential treatment for Haemolytic Uraemic Syndrome (HUS) has been discovered by an international team of scientists. The breakthrough found that inhibiting the complement pathway early on can successfully treat STEC-HUS, a devastating disease that can lead to life-long dialysis and death in children.
Recent studies suggest that probiotics may offer a protective effect against hypertension, but the exact mechanisms are unclear. A new study identifies two probiotic strains, Bifidobacterium lactis and Lactobacillus rhamnosus, as promising treatments for high blood pressure.
A new study found that racial and ethnic disparities persist in access to chiropractic care and physical rehabilitation for adults with low back pain, with Hispanic adults being less likely to use these services. The study also found that policy changes are needed to address these gaps in access, particularly in underserved communities.