Articles tagged with Clinical Research
The study aims to test two interventions to lower blood pressure in stroke survivors, including telehealth and in-person clinic management. Over 1,550 participants will be enrolled, with a focus on under-represented populations at higher risk for recurrent stroke.
A recent study assessed ChatGPT's accuracy in identifying common allergy myths. The AI model correctly identified myths as true or false with an overall accuracy rate of 91%, with some myths being more accurate than others.
A Pitt University study found that individuals with higher education levels are less likely to experience cardiovascular disease events later in life. On average, those with less than a high school education were 1.4-1.7 times more likely to have a heart attack or stroke compared to college graduates.
A Mayo Clinic study found patients with lower extremity lymphedema had twice the risk of developing skin cancer, including basal cell carcinomas and squamous cell carcinomas. Regular skin cancer screenings are crucial for these patients as early detection is critical.
A new study published in BMJ Mental Health reveals that people with severe mental health issues are almost twice as likely to experience multimorbidity, a combination of chronic diseases. The research emphasizes the urgent need for a comprehensive and integrated approach to address this critical issue.
A study tracked skin temperature in 600 participants for six months, finding that individual differences were more significant than sex-based variations. The team used wearable devices to monitor skin temperature and found patterns consistent with menstrual cycles in women.
A new study finds that people with antibodies to common foods like dairy and peanuts are at a higher risk of cardiovascular-related death. The research suggests that these subtle immune responses may lead to inflammation and contribute to heart disease over time.
A new study found that electric toothbrushes significantly reduce plaque and gingivitis in young children aged 3-10. The research showed that electric toothbrushes are more effective than manual toothbrushes in reducing these dental issues, with whole mouth plaque reduction increasing by up to 55.7% in younger children.
Researchers analyzed over 314,000 cells from rheumatoid arthritis tissue to define six types of inflammation involving diverse cell types and disease pathways. The findings shed new light on the cellular causes of RA, potentially informing targeted and effective therapeutic approaches.
A recent study published in eClinical Medicine found that the GB510/AS03 vaccine elicited a stronger antibody immune response against the ancestral SARS-CoV-2 strain compared to ChAdOx1-S. The vaccine demonstrated robust safety and efficacy, with no significant safety concerns identified.
UArizona researchers are conducting a four-year clinical trial to investigate the effectiveness of angiotensin 1-7 as a potential treatment for TBI. The study aims to address the underlying inflammatory reaction that drives long-term effects of TBI.
A longitudinal study found that nine-to-10-year-old children who drink daily caffeinated soda are twice as likely to try alcohol within a year. Daily caffeine intake is associated with low working memory and high impulsivity, recognized risk factors for substance use disorders.
Patients with HER2-positive breast cancer that has spread to other parts of the body survive for longer if treated with pyrotinib. The new drug targets proteins involved in HER2-positive breast cancer and shows a 22% reduction in risk of death compared to lapatinib.
Dr. Glenn Flores has been recognized for his significant contributions to advancing child and adolescent health, well-being, and equity through quality improvement, advocacy, and research. His work aims to eliminate disparities and foster equity for underserved children and families.
A study of 2,458 children found that genetic predisposition to insomnia affects sleep patterns, including frequent awakenings and difficulty initiating sleep. The research suggests a lifelong 'poor sleeper' trait, emphasizing the importance of early recognition and prevention.
A study published at ACR Convergence 2023 found that patients with acute calcium pyrophosphate deposition disease have a doubled risk of fractures. The researchers analyzed data from over 1,100 patients and compared them to matched comparators without the disease.
A significant increase in premature babies born at 22 weeks receiving respiratory life support has been observed in England and Wales following changes to national guidance. Overall survival remains low, but the proportion of these babies surviving to discharge has increased.
Researchers at the University of Leicester have received a significant financial boost to advance their cancer treatment research. The team will investigate 'liquid biopsies' to reveal vital clues about cancer genetic makeup, aiming to predict how cancer changes and which treatment works best for individual patients.
A study at ACR Convergence 2023 found that hydroxychloroquine lowers the risk of nonalcoholic fatty liver disease in rheumatoid arthritis patients, particularly in women and men under 50. The medication may exert its effect through increased adiponectin levels, a hormone inversely linked to insulin resistance and inflammation.
Researchers developed a method to measure transepidermal water loss to detect anaphylaxis before epinephrine injections are necessary. The study showed that skin water loss increases before anaphylaxis occurs and can predict food challenge outcomes.
Researchers at Gwangju Institute of Science and Technology developed metal-enhanced fluorescence probes for rapid and accurate detection of influenza viruses. The probes showed high sensitivity and specificity, detecting the virus even at low concentrations, with a remarkable accuracy of over 99%.
Better education for cat owners and veterinarians is key to reducing antimicrobial use, which contributes to rising resistance. The study's findings highlight the need for faster, cheaper diagnostic testing and better training of pet owners and vets.
Researchers at Texas A&M University have found a correlation between flavonoid compounds and reduced endometriosis symptoms. Flavonoids like Quercetin and Kaempferol show promise in easing inflammation, with studies suggesting they may help suppress the symptoms of inflammatory diseases like endometriosis.
Researchers developed a deep learning system to detect and predict joint space narrowing and erosions in hand radiographs of RA patients. The AI model achieved over 90% accuracy in detecting joints, but its performance may be lower than human radiologists for wrist joint analysis.
A clinical study found that a ketogenic diet can improve kidney function in patients with hereditary polycystic kidney disease. After three months, positive changes were seen in key parameters, with no unexpected side effects.
A new study reveals a link between the removal of the FGFR1 protein's extracellular domain and a significant decrease in tumour volume. This finding offers a potential new avenue of treatment for patients with squamous cell carcinoma of the lungs, who have shown limited success with current therapies.
A new study published in Radiology shows that patients diagnosed with lung cancer via CT screening have a 20-year survival rate of 81 percent, significantly higher than the average five-year survival rate for all lung cancer patients. Early detection through routine screening can lead to a cure if found early.
A new rheumatology training program for Native American primary care physicians has expanded its reach to tribes in 15 states. The program, which includes virtual classes and case-based discussions, aims to improve diagnosis and management of rheumatoid arthritis, but faces challenges due to mistrust of accessing private health records.
A study of 144 Covid survivors found that women with elevated inflammatory biomarkers during the acute phase were more likely to experience lingering symptoms like fatigue, breathlessness, and sleep disturbance. This research sheds light on a potential link between inflammation and persistent Long Covid symptoms in women.
The RAND Corporation has received a $6 million federal grant to support innovative research center for complementary and integrative health institutions. The new REACH Center will enable these institutions to submit more competitive research grants, increase collaboration, and build infrastructure.
A new study has found that tumor necrosis factor inhibitors, commonly used for inflammatory arthritis, are not associated with poor pregnancy outcomes. Women who continued treatment had lower risks of severe infections postpartum compared to those who stopped. The results provide reassuring data on the use of TNF blockers during pregna...
Researchers have developed a novel noninvasive method to assess nutrient absorption and diagnose feeding intolerance severity in preterm infants. The precision exfoliomic approach captures gene expression information from intestinal cells released into the fecal stream, allowing for precise diagnosis without invasive testing.
The Southwest-Midwest Pediatric Device Innovation Consortium has supported over 200 pediatric device innovators and companies, developing several devices in the past five years. The consortium's portfolio includes real-world evidence research projects using digital tools for collecting and analyzing patient data.
Researchers at CU Anschutz Medical Campus and Johns Hopkins University found that hundreds of ketamine clinics make false or misleading statements about their treatments. The study highlights the need for accurate and balanced information about potential risks and benefits of these therapies, especially given the high financial costs i...
A study published in Oncotarget reveals that HER2 mutant alleles play a crucial role in determining treatment response to neratinib and poziotinib. Researchers found that individual HER2 mutant alleles have distinct effects on therapeutic efficacy, suggesting new targets for breast cancer therapy.
Researchers developed personalized risk equations using AI to identify individuals at high risk of sudden cardiac death. The analysis found that AI was able to accurately predict sudden cardiac death in over one-fourth of all cases, highlighting the potential for AI to revolutionize prevention strategies.
A new study finds that higher cardiovascular health is associated with decelerated biological aging, as measured by phenotypic age. Greater adherence to all Life's Essential 8 metrics can slow down the body's aging process and have numerous benefits.
Research highlights significantly higher heart attack death rates among American Indian and Alaska Native adults, particularly at younger ages. The study suggests that factors like limited healthcare access, socioeconomic conditions, and restricted health insurance coverage may contribute to these disparities.
A large US study found that persistent tobacco use and prediabetes significantly increase the risk of stroke in young adults without other cardiovascular risk factors. Quitting smoking is crucial for preventing stroke and heart disease, especially among those with prediabetes.
A six-month produce prescription program improved hemoglobin A1c levels, indicating better blood sugar control. Participants also showed improved food security and nutrition security.
Researchers from Incheon National University create gelatin patches that generate molecular oxygen to accelerate wound healing. The new hydrogels demonstrate improved coagulation, blood closure, and neovascularization in both in vitro and in vivo experiments.
Two preliminary studies presented at American Heart Association’s Scientific Sessions 2023 found a potential association between regular marijuana use and an increased risk of heart failure, heart attack, and stroke. Daily marijuana use was associated with incident heart failure in a study involving over 150,000 adults in the US.
Research highlights racial disparities in cardiac arrest survival among children, with Black children facing poorer outcomes. The study's findings have implications for increased resources for CPR programs in higher-risk communities.
Researchers found that patients with elevated NfL levels had a 91% higher risk of worsening disability with relapse within a year, and a 49% higher risk without relapse nearly two years later. The study suggests that interventions may prevent worsening symptoms by targeting nerve cell death.
Research highlights the association between traumatic events and insufficient/excessive sleep duration in US children. The analysis of over 100,000 children found that traumatic events magnify the adverse effects of poor sleep on cardiovascular health.
A new neural circuit has been discovered in the brain that produces a strong sense of discomfort when activated. The study found that the subthalamic nucleus, which controls voluntary movements, also plays a role in the development of depression.
Researchers discovered that patients with FSGS who received sparsentan treatment experienced improved kidney function and reduced proteinuria, a key indicator of kidney damage. The study suggests sparsentan may be a potential new treatment option for the disorder, offering hope for patients affected by FSGS.
Researchers describe the use of ripretinib and repeated surgical resection in a patient with recurrent GIST harboring a KIT exon 11 mutation. The treatment led to extended clinical benefit, outperforming current reported data from ripretinib clinical trials.
A new study by UC San Francisco found that poor sleep is significantly associated with a 15% greater risk of experiencing atrial fibrillation the next day. The researchers suggest strategies like going to bed at a reasonable time, avoiding alcohol and caffeine before bedtime, and exercising regularly to improve general sleep quality.
A new study by Anglia Ruskin University and University of Oxford highlights the lack of clinical research on severe sight impairment (SSI) among working-age individuals in the UK. The study finds that inherited retinal disorders, such as IRDs, are under-researched despite being a leading cause of SSI certifications in this population.
Researchers at the German Center for Infection Research have developed effective antibodies against Pseudomonas aeruginosa, a major challenge in healthcare systems worldwide. These monoclonal antibodies target the pathogen's type III secretion system and show promise as a highly potent treatment option for acute and chronic infections.
A vaginal film designed to dissolve in 30 days is being tested for its feasibility and acceptability as a potential HIV prevention method for women. The study will enroll 100 women and assess the comfort, usability, and safety of two prototype films with different shapes.
A recent study analyzing global and national trends of atherosclerosis found an increasing trend in incidence from 1990 to 2019, driven by adults aged 20–54. The burden of the disease is particularly concerning in low- and middle-income countries, where it is rising significantly due to lifestyle factors and aging populations.
A specific nucleotide metabolite called GTP controls responses to radiation and chemotherapy in an unexpected way. Increasing GTP levels makes cells resistant to treatment, while lowering them makes cells more sensitive.
Researchers at the University of Arizona Health Sciences received a $13.1 million grant to study how to improve immune defense in older people. The goal is to create interventions that can help combat age-related decline in T cells, leading to better health outcomes and reduced healthcare expenses.
Dr. Alan Jobe, MD, PhD, is recognized for his pioneering work in neonatal lung diseases, advancing the field of bronchopulmonary dysplasia research. The APS John Howland Award acknowledges his commitment to improving global health outcomes, particularly in low-income countries.
The American Heart Association will present Dr. Pradeep Natarajan with the 2023 Joseph A. Vita Award for his groundbreaking research in genetic analysis of cardiovascular disease risk and discovery of new genes responsible for coronary artery disease. His work is propelling the future of preventive cardiovascular medicine.
Dr. Yibin Wang will be recognized for his commitment to learning more about the genetic, molecular and cellular mechanisms behind cardiovascular disease. His research has directly contributed to many clinical studies and new trials for heart diseases.
A new study reveals that women with atrial fibrillation (AF) have comparable outcomes to men when undergoing pulsed field ablation (PFA), a safer and more precise procedure. The results show improved AF recurrence rates in women after PFA, making them an eligible candidate for this life-enhancing treatment.
Researchers found that FAAH inhibition reduced breast cancer growth in immunodeficient mice and induced apoptosis of breast cancer cells. The combination of FAAH inhibitors and endocannabinoids was the most effective treatment approach.