Articles tagged with Clinical Research
A case of echovirus 11-induced hepatitis in Italian male twins has been reported, showing a close genetic relation to strains found in France among neonates. The study highlights the importance of rapid recognition and timely treatment to ensure survival, and suggests potential host genetic predisposition in male and twin categories.
The TCT 2023 Program Guide features four days of innovation and cutting-edge science in interventional cardiovascular medicine. The event marks 35 years of leading the field and will gather top researchers and clinicians to present evidence-based research.
Researchers from McGill University and Ontario Tech University examine the drivers of specialty drug diffusion. They propose a framework that suggests clinical studies affect the diffusion through a multi-stage scientific evidence production process. The study finds that marketing activities have no significant effect on prescriptions.
A patient with kidney cancer overcame several metastases with temsirolimus, leading researchers to identify key mutations that make this treatment effective. The study found that patients with USP9X mutations have altered autophagy and respond better to temsirolimus.
Researchers developed a noninvasive diagnostic test to identify intact sperm in infertile men with nonobstructive azoospermia. The test uses protein biomarkers AKAP4 and ASPX to visualize well-developed sperm, potentially increasing success rates for surgical sperm extraction. This breakthrough may lead to new male birth control drugs ...
Researchers at UCL have developed base-edited T-cells that can fight leukemia, showing promise in a NHS clinical trial. Three patients with relapsed T-cell leukaemia were treated with the cells, with one patient experiencing complete remission after just four weeks.
Researchers found that psychedelic drugs such as LSD, psilocybin, and MDMA reopen critical periods in mice, enabling them to learn from their social environment. The length of time the critical period stayed open varied among drugs, with some lasting up to four weeks.
Researchers from Medical College of Wisconsin found that older breast cancer survivors, particularly those exposed to chemotherapy, showed greater epigenetic aging than their same-aged peers without cancer. This acceleration in biological aging may be associated with worse functional outcomes and quality of life for these patients.
The Ontario Institute for Cancer Research (OICR) has awarded six research teams with two-year funding to pursue innovative cancer treatments and technologies. The projects focus on personalized medicine, accessible genetic testing, and improving patient engagement.
A study analyzed emoji and emoticon use in secure clinical texting systems, finding they primarily convey new and interactionally significant information. The results suggest that emoji use may not undermine professionalism as much as initially thought.
Researchers have made progress in generating stem cell-derived beta cells, but current methods are costly and labor-intense. A recent study has found a simple method to address these issues, enhancing maturation and functionality of sBCs.
The ASHP Summer Meeting presented research on clinical pharmacists' impact on type 2 diabetes treatment intensification with GLP-1 receptor agonists. A study found 85% of patients received care from clinical pharmacists had their medication titrated to the first effective dose, compared to 12.5% without pharmacist involvement.
A new study published in Aging-US has identified the p53-p16/RB-E2F-DREAM complex as a critical regulator of cellular senescence. The researchers found that this complex represses multiple target genes involved in cell cycle regulation, DNA repair, and chromatin structure, leading to the stability of the senescent arrest.
The FDA has issued a Biomarker Letter of Support for four novel biomarkers identifying drug-induced pancreatic injury. These microRNAs will enhance the detection of acute drug-induced pancreatic injury (DIPI) in phase 1 clinical trials, improving safety and accuracy.
Researchers suggest that multifactorial prediction models could enhance dementia risk estimation. Current dementia risk scores are found to have limited clinical utility for estimating 10-year dementia risk.
A West Virginia University study found that over half of surveyed faith community nurses and leaders reported moderate-to-high stress and compassion fatigue. The researchers recommend team-based approaches to support these individuals, emphasizing the importance of recognizing burnout and promoting self-care.
Research identifies beneficial changes in immune system during pregnancy, which can lead to new treatment strategies for MS. Women with MS experience a 70% decrease in relapses during the last third of pregnancy, possibly due to epigenetic changes and hormone regulation.
A new study published in JNCCN found that taking alectinib, a medication for advanced lung cancer, with a full breakfast or lunch resulted in higher drug concentrations than with a low-fat breakfast. This could impact treatment efficacy and survival rates for patients.
A study found that even insured patients with diabetes use crowdfunding platforms like GoFundMe to cover excess medical expenses, including uncovered co-pays and life-saving care. Researchers urge policymakers to consider these needs when developing affordable diabetes care policies.
A study has identified a potential treatment target for prostate cancer that is resistant to hormone therapy, a protein modification involving TRAF4. The researchers found that TRAF4 promotes the spread of cancer and may be associated with a new treatment option for patients.
A new study from Boston Medical Center found that implementing a streamlined process for urgent cesarean deliveries improved infant Apgar scores, particularly for Black and Hispanic infants. The study reduced decision-to-incision time by 64% among all patients, with the largest improvements seen in Black and Hispanic patients.
Researchers have identified LP-284 as a novel acylfulvene compound with anti-tumor activity against non-Hodgkin's lymphoma. The compound exerts nanomolar potency in 15 NHL cell lines and prolongs survival of mantle cell lymphoma xenograft mice, making it a potential therapeutic option for patients with HR or TC-NER deficiency.
The American Heart Association invites researchers to compete in a data challenge to better understand how lipoprotein(a) levels impact cardiovascular disease and stroke risk. The winning project can receive a $40,000 cash prize.
A statewide pay-for-performance intervention based on Choosing Wisely reduced rates of inappropriate antibiotic prescriptions for acute respiratory tract infections from 43% to 25%. This reduction occurred without measurable harms at safety-net hospitals serving disadvantaged patients.
A new study published in JMIR Cardio reveals the potential of AI-QCA in analyzing coronary angiography, providing accurate measurements of coronary stenotic lesions similar to IVUS. This technology has the potential to improve patient outcomes and support clinical decision-making.
Research by West Virginia University professor Sean Tu found that orphan drugs earn pharmaceutical companies almost as much as those marketed to the general public. The Orphan Drug Act incentivizes companies with tax credits, longer patent exclusivity, and easier FDA review for treating rare diseases.
Researchers at MD Anderson Cancer Center develop new methodology to analyze earliest precursor stages of multiple myeloma, revealing substantial genomic and transcriptional heterogeneity. The study identifies potential therapeutic targets and biomarkers for high-risk patients.
Winship Cancer Institute has received renewal of its National Cancer Institute-designated Comprehensive Cancer Center designation, solidifying its position as Georgia's only NCI-designated Comprehensive Cancer Center. The designation recognizes Winship's strong research programs, robust shared resources, and first-rate scientists.
Researchers at NYU Abu Dhabi identified microRNAs associated with a weakened immune response and ICU admission. The study provides new insights into how patient genetic makeup affects disease severity and offers potential biomarkers for disease monitoring.
The Shape Up! Keiki research study aims to create a better way to measure and describe health from body shape, focusing on identifying obesity risks in young children. Participants aged 5 years or younger will be compensated $200 for their time.
A survey study found that patients with health insurance, a primary care provider, and ongoing health needs are more likely to use online patient portals. Portal users tend to have higher levels of education and live in urban areas, while non-users cite lack of awareness and technical issues as reasons for not using the platforms.
Researchers from Universitat de Barcelona and Universitat Internacional de Catalunya discuss the non-receptor protein tyrosine kinase Src as a good example of an oncogene. Targeting the Src N-terminal regulatory element (SNRE) has potential as oncotargets to inhibit Src activity only in cancer cells.
Researchers found that rare brain tumor patients struggle to access therapy and experience devastating psychological impact after diagnosis. The study calls for improved mental health services and specialized support for these patients.
A retrospective study found a 24% response rate to Docetaxel among patients with stage IV non-small cell lung cancer who experienced progression on immunotherapy. The median progression-free survival was 3 months, suggesting chemotherapy may still play an important role in treatment after immunotherapy failure.
The Tufts Clinical and Translational Science Institute has received a $78.4 million NIH grant to accelerate the translation of laboratory and medical research into clinical use. The grant will support efforts to improve health and increase health equity, with a focus on addressing health disparities.
A new observational study published in BMJ Open found that long Covid can have a devastating effect on daily lives, with fatigue impacting social activities, work, and relationships. The study's findings suggest that long Covid can leave people with worse fatigue and quality of life than some cancers.
A new study found an association between lower extremity spasticity and cryptorchidism treatment in boys with cerebral palsy. Boys with more severe spasticity were especially likely to have had the surgery, suggesting a potential link between affected muscles and testicle development.
The Montefiore Einstein Cancer Center received a $2.9 million grant to train physicians and scientists to conduct clinical and translational oncology research, focusing on addressing health inequities in the Bronx. Scholars will engage in interdisciplinary research projects with community outreach and engagement.
Researchers at NYU Grossman School of Medicine have developed an AI tool called NYUTron that can accurately estimate patients' risk of death, length of hospital stay, and other factors important to care. The tool achieved impressive results in predicting readmission rates, improving upon standard methods by up to 7%.
A recent study published in The Journal of Orthopaedics found that patients who underwent partial meniscectomy using a needle arthroscopic technique experienced significantly less pain and improved patient-reported outcomes at two weeks after surgery. However, differences were not sustained at six weeks.
A survey of clinician-researchers found concerning rates of sexual harassment and negative perceptions of climate in academic medicine, with a significant impact on mental health. Minoritized groups were disproportionately affected, highlighting the need for ongoing efforts to transform culture.
Researchers from Mount Sinai Health System presented new findings on the impact of customized lighting on inpatient sleep, a machine-learned combination of ventilatory, hypoxic, and arousal burdens, and the effects of obstructive sleep apnea and insomnia on cognitive impairment. The studies aim to improve sleep timing and duration, dia...
A recent study from Michigan Medicine suggests relief may be possible for individuals with tinnitus, a condition characterized by ringing or hissing sounds. The innovative bi-sensory treatment device improved quality of life and reduced tinnitus loudness in nearly 70% of participants.
A new targeted therapy drug vorasidenib has been shown to extend treatment time without worsening glioma in people with IDH1 and IDH2 mutations. The study suggests a possible new treatment option for slow-growing but deadly brain tumors, delaying chemotherapy and radiation.
A phase I study found significant clinical benefit of the ADC luveltamab tazevibulin in patients with recurrent ovarian cancer expressing high levels of folate receptor alpha, with an overall response rate of 37.5% and a 44% response rate at higher doses.
UofL researchers, led by Jun Yan, will investigate the causes of immune system overresponse in COVID-19 patients, leading to severe lung disease and death. They aim to develop methods to predict, prevent or control this response with potential treatments for other conditions.
The study found that the immune response to spinal-cord injuries is impaired in older individuals, leading to weaker cell responses and reduced recovery. The researchers identified an essential role for the meninges surrounding the spinal cord in mounting the immune response, paving the way for new therapeutic approaches.
In a multicenter trial, pirtobrutinib demonstrated reversible and effective inhibition of defective B-cells in patients with poor survival prognosis. Over half of patients responded to the drug, with a median duration of response of 21.6 months.
Researchers have developed a custom OCT setup that incorporates a vertical cavity surface emitting laser (VCSEL) diode, which could increase access to OCT imaging and help catch eye problems early. The system performed well in imaging the eye of a healthy volunteer and showed potential for use in biometric eye scanner systems.
The SISAQOL-IMI Consortium establishes an international consensus on patient-reported outcomes in cancer trials, aiming to improve the use of PROs. The new standards will enhance patient involvement and ensure the relevance of recommendations to the patient community.
A randomized trial found that ultrasound diagnosis of forearm fractures in children resulted in similar recoveries and reduced the need for follow-up x-rays. The study suggests using bedside ultrasounds could alleviate hospital waiting times and costs, benefiting rural areas with limited access to healthcare.
Researchers found that ropinirole is safe and effective in slowing ALS progression, with patients showing improved physical activity and muscle strength after treatment. The study suggests that the method of growing motor neurons from patient-derived stem cells could be used to predict a patient's response to the drug.
Researchers at UBC Okanagan found that a low-carb breakfast can significantly reduce blood sugar swings and improve glucose control. Participants who followed a low-carb breakfast plan showed lower glycemic variability and some were able to reduce their glucose-lowering medication.
The study found that people younger than age 50 with colorectal cancer had lower levels of citrate and differed in protein and carbohydrate metabolism compared to older patients. Red meat consumption and sugar intake are potential risk factors for young-onset colorectal cancer. Higher levels of 4-hydroxyhippuric acid correlated with im...
A retrospective case-matched study found prism adaptation therapy (PAT) to be beneficial for treating both right- and left-sided spatial neglect. PAT showed improvements in neglect symptoms for patients with right-sided neglect, suggesting greater potential benefits compared to those with left-sided neglect.
Researchers presented findings on pembrolizumab for brain metastases, virtual mind-body interventions for post-treatment survival, and dynamic HER2-low status in triple negative breast cancer. The studies aim to improve treatments and outcomes for patients with cancer.
Researchers argue that technology-based solutions often fall short of addressing human-based challenges to teamwork in healthcare. Integrating insights from organizational science research could reveal useful levers for amplifying teamwork necessary for patient care.
Researchers have identified 16 genes associated with an increased risk of Spontaneous Coronary Artery Dissection (SCAD), a type of heart attack primarily affecting young to middle-aged women. The study also found that patients with SCAD have some genetic protection from the risk of conventional coronary artery disease.
Biomedical engineers at UTS have developed an intervertebral disc-on-a-chip, a precision-engineered toolbox for low back pain studies. The device simulates the complex mechanobiology of native tissue, enabling accurate evaluation of experimental methods for treatment or regeneration.
Researchers developed a novel endoscopic imaging system with a bioinspired sensor that can detect multiple fluorescent probes, enabling more accurate fluorescence-guided cancer surgery. The system showed improved spatial resolution and sensitivity in detecting tumors, paving the way for the adoption of multi-tracer FGS.