Articles tagged with Clinical Research
Researchers found that physical activity can prevent cancer recurrence in stage III colon cancer patients by lowering the recurrence rate within the first year of treatment. This association persisted for approximately three years after surgery, suggesting a long-term survival benefit.
A recent survey found that patients overwhelmingly support receiving test results immediately, even if their provider has not yet reviewed them. Most respondents (90%) preferred receiving results through the patient portal as soon as they were available, and nearly all (96%) indicated a preference for timely release.
Researchers develop unsupervised machine learning algorithm to classify osteosarcoma at diagnosis based on gene expression modules. This approach enables personalized treatment strategies for osteosarcoma patients.
A new way to identify higher-risk groups of older surgical patients can help surgeons make better care decisions and compare hospital performance. The new definitions label fewer patients as multimorbid and specify high-risk comorbidity combinations, which contribute to patient risk.
A multicenter study found that patients with cystic fibrosis can safely take a dual combination of CF modulator drugs for four years while maintaining previously achieved clinical improvement. This breakthrough therapy has improved the quality and length of patients' lives, with some even seeing a 15% increase in lung function.
Isabelle B. Cooperstein, a PhD candidate, receives the 2023 David L. Rimoin Inspiring Excellence Award for her work on rare disease diagnosis tools. Her research aims to create accessible diagnostic solutions using Human Phenotype Ontology and sequencing data.
The ATS 2023 International Conference Program is now available, offering dynamic scientific programming on pulmonary, critical care, and sleep medicine topics. Attendees can build their daily schedule using the program itinerary and access a series of presentations featuring innovators in the field.
Researchers from China conducted a comprehensive review of dual therapy (DT) for H. pylori eradication, highlighting its high efficacy and patient compliance with minimal adverse events. High-dose DT administered over 14 days has emerged as the most effective treatment option.
A clinical study published in the European Heart Journal found that ghrelin increases the heart's pump capacity in patients with heart failure, improving cardiac output by 28% after two hours of treatment. The treatment also showed a 10% higher pump capacity at follow-up.
Researchers have successfully printed flexible electronics using polypyrrole and demonstrated its compatibility with living organisms, paving the way for patient-specific implants. The technology has potential applications in real-time health monitoring and treating conditions like epilepsy or pain.
A remote hypertension program, operated by Mass General Brigham, successfully supported patients through the COVID-19 pandemic in achieving their blood pressure goals. Participants who enrolled during the pandemic reached and maintained their goal blood pressures an average of two months earlier than in the pre-pandemic period.
Recent review article discusses clinical development in long-acting growth hormone (LAGH) therapy, which mimics natural GH release patterns. LAGH therapies reduce daily injection burden, improving patient compliance and treatment outcomes.
Researchers at University of Technology Sydney have successfully created personalized 'bio-inks' from patients' own stem cells, which are then used to 3D-print cardiac tissues to repair areas of dead tissue. This technology shows promise in treating heart failure and may reduce the need for expensive and traumatic heart transplants.
A study published by the European Association of Urology defines 'growers' and 'showers' as men whose penises increase in size by more than 56% when erect, compared to flaccid states. The researchers found that most men fell into a 'grey zone', with only 24% classified as growers and 25% as showers.
A survey of over 1000 patients found that two thirds prefer a urologist of their own gender, but in certain situations, both men and women choose a female doctor. Patients with painful conditions are more likely to opt for a female urologist.
Dr. Natasha Kekre, a University of Ottawa associate professor and hematologist, has secured millions in funding and published numerous peer-reviewed papers on CAR-T cellular therapies for cancer treatment. Her work has advanced the immunotherapy field in Canada and made her an expert in cancer immunotherapies.
The March issue of CHEST journal features 44 articles on topics such as asthma, critical care, and sleep medicine. The journal also includes complementary web resources, including visual abstracts.
Researchers at Wake Forest University School of Medicine aim to improve hemodialysis quality with an individualized approach, tailoring treatments to each patient's unique medical needs. The project aims to reduce mortality and improve health-related quality of life for patients treated with hemodialysis.
Researchers at Linköping University found that C-reactive protein has a beneficial function in systemic lupus erythematosus, reducing interferon activity and promoting milder disease. The study's findings suggest new treatment strategies to reduce immune complexes and elevated interferon levels.
A recent study found that spinal manipulation is a gentle therapy used to treat low back pain in patients after previous lumbar spine surgery. The study, published in Chiropractic & Manual Therapies, compiled data from over 100 patients and reported most cases were done using a potentially gentler method.
The magrolimab plus azacitidine regimen resulted in a complete response rate of 33% and partial response rate of 75%. Patients with TP53 mutations showed improved overall survival rates compared to previous studies.
A study found that Spp24 inhibits osteosarcoma tumor cell proliferation, invasiveness, and promotes apoptosis. It achieves this by neutralizing bone morphogenetic protein 2.
A new approach by the Medical University of South Carolina aims to increase clinical trial participation, especially from diverse populations. By making patients eligible for research opportunities by default, while allowing opt-out, the team saw a significant increase in potential participants.
A large study found that individuals with atrial fibrillation had a modestly elevated risk of developing dementia, particularly in younger adults and those without chronic kidney disease. The risk was higher in younger adults and those without chronic kidney disease, but did not substantially vary across sex, race, or ethnicity.
Researchers develop a novel combination therapy using mitoxantrone and vancomycin to treat vancomycin-resistant Enterococcus faecalis (VRE) infections. The therapy stimulates the host immune system, accelerating wound healing and killing bacteria more effectively.
The Patient-Centered Outcomes Research Institute (PCORI) has selected Cleveland Clinic for a nationwide initiative to improve how healthcare systems translate research findings to clinical practice. The initiative aims to reduce the time it takes to move discovery in research to new treatments, with an estimated lag of 17 years.
A new study published in Scientific Reports found that individuals who synchronize their pupil dilation patterns to a simple rhythmic beat also exhibit higher levels of synchrony with other minds, such as attending to the same story. This suggests an underlying mechanism uniting different forms of synchrony.
New research analyzed data on 8,007 patients with stage I–III breast cancer to predict recurrence risk based on cancer stage and receptor status. Patients with certain receptor combinations had higher or lower risks of recurrence at different stages.
A new cutaquig study found that increasing infusion volume per site resulted in a reduction of injection sites, while increasing infusion rates decreased infusion duration. The research also showed that dosing every other week demonstrated equivalency to trough levels with weekly dosing.
High-dose anticoagulation reduces intubations and deaths by 30% in hospitalized COVID-19 patients, especially those with ARDS. The study found a significant reduction in mortality and need for ICU care among patients treated with therapeutic anticoagulation.
A new type of planning document called the multidisciplinary rounding plan (MDRP) offers relevant information for use in patient care, compared to traditional nursing care plans. The MDRP provides more concrete, patient-specific information and is written in a plain-speech style.
A virtual care team consisting of physicians and pharmacists improved the adoption of life-saving therapies in patients with heart failure, leading to increased use of evidence-based treatments and better patient outcomes. The strategy was safe and effective, with comparable length of stay and safety events between the groups.
A novel deep brain simulation approach has been developed to treat intractable epilepsy, with the potential to be a safer and more effective treatment than conventional methods. The sequential narrow-field stimulation method accurately detects seizure onset and alleviates symptoms while minimizing side effects.
A new UNCG study confirms that SARS-CoV-2 destroys the antioxidant activity of key human selenoproteins, weakening immunity and enabling virus replication. The findings suggest investigating selenium supplementation and dietary sulfur compounds as potential symptomatic treatments for COVID patients.
Researchers discovered that quiescent ovarian cancer cells secrete follistatin, which induces resistance in neighboring cells and worsens survival rates. Targeting this protein may improve chemotherapy response and boost survival in patients with aggressive ovarian cancer.
A new study found that military veterans are at higher risk of developing human papillomavirus (HPV)-related cancers due to low vaccination rates. The study suggests that 'catch-up' HPV vaccination campaigns are needed to boost vaccination rates among veterans and reduce deaths from these largely preventable cancers.
Research on caregiving after neurotrauma and neurological disability emphasizes the need to address unmet caregiver needs, which can impact the quality of care provided. Studies found that brain injury caregivers experience higher burden, decreased physical and neuropsychological functioning, and lower mental health.
A study published in Brain, Behavior and Immunity found that pregnant women with anxiety have higher levels of cytotoxic T cells and different immune marker activity compared to those without anxiety. This suggests a biological link between anxiety and the immune system during pregnancy and postpartum.
The use of AI is improving diagnostic accuracy for digestive cancers, but challenges in data sharing and standardization hinder its widespread application. Researchers surveyed recent applications of AI to these deadly cancers, finding that AI can automate complex processes and detect patterns not visible to humans.
Researchers at the University of Sheffield's Institute of Translational Neuroscience have discovered a novel way to block the transportation of mutant RNA and toxic repeat proteins that lead to the death of nerve cells in most common forms of motor neurone disease (MND) and frontotemporal dementia (FTD). Using a peptide, they found tha...
The NCCN Annual Conference will debut a new hybrid format featuring in-person events at a new venue, allowing for hallway conversations and networking opportunities. The conference will also showcase more than 100 abstract poster presentations on various oncology-related categories.
A recent study found that public investment in critical research contributed significantly to the development of mRNA COVID-19 vaccines. The US government invested at least $337 million in research over 35 years, including basic science and vaccine development.
Researchers at University Hospitals Cleveland Medical Center discovered that S-nitrosohemoglobin senses areas with insufficient oxygen and restores blood flow for oxygenation. This breakthrough opens up a new line of drug development to correct poor tissue oxygenation, including peripheral artery disease and sickle cell disease.
A clinical study by Indiana University School of Medicine researchers found that oral verapamil can improve pancreatic beta cell function in children with new-onset type 1 diabetes, with a 30% increase in insulin secretion over the first year. The trial involved 88 participants and was published in JAMA.
Using a dual-source CT scanner eliminates the need for beta-blockers and decreases nondiagnostic examinations, resulting in shorter CT completion times. The study found no difference in ED length of stay but demonstrated significant benefits in reducing nondiagnostic examinations.
Researchers at UTHealth Houston received $15 million in NIH BRAIN grants to study brain processes related to speech, epilepsy, and reading. A new minimally invasive device will be developed to record brain activity during speech, while another project aims to disrupt seizures using neuromodulation.
A study published in the American Journal of Critical Care found that a single trained observer serving as a checklist prompter can accurately assess whether multidisciplinary rounds addressed key elements of the ABCDEF bundle. This approach enables customized, shorter checklists to streamline workflows and improve patient care.
Patients with stage IIIB-IV melanoma who received neoadjuvant pembrolizumab had a significantly lower risk of cancer recurrence compared to those receiving adjuvant therapy only. The study found improved event-free survival rates in the neoadjuvant group, suggesting that starting immunotherapy before surgery generates better outcomes.
A phase 2 clinical trial shows that treating resectable stage 3 and 4 melanoma patients with pembrolizumab both before and after surgery greatly improves outcomes compared to pembrolizumab given only after surgery. This approach resulted in significantly longer event-free survival rates.
A recent study found that bacterial co-infection in COVID-19 patients significantly increased the risk of death, intensive care unit admission, and mechanical ventilation. The study reviewed 13,781 COVID-19 inpatient encounters and identified laboratory trends associated with COVID-19 bacterial co-infection.
This special supplement from Annals of Family Medicine highlights the work of six HRSA-funded academic units focused on advancing health care equity and improving primary care practices. The articles cover topics such as workforce training, mental health care seeking, socioeconomic issues, and whole-person oriented healthcare.
A study analyzing over 12,000 patients found that transesophageal echocardiography-guided transcatheter structural cardiac interventions were associated with a major complication rate of 3.6%. The most frequently reported complication was gastrointestinal bleeding.
William L. Lombardi, MD, receives the TCT Geoffrey O. Hartzler Master Operator Award for his technical excellence and leadership in complex coronary disease therapies. He is recognized for developing novel CTO techniques and technologies to improve patient outcomes.
The American Roentgen Ray Society (ARRS) has awarded four radiologists with the 2023 Resident/Fellow in Radiology Awards for their exceptional research, education, and administrative work. Drs. Elliot T. Varney, Vincius Alves, Luca Pasquini, and Pallavi Srivastava will present their research findings at the upcoming ARRS Annual Meeting...
A new cell therapy has demonstrated significant benefits in improving the heart's pumping ability and reducing the risk of cardiovascular death, heart attack, or stroke in patients with chronic heart failure. The therapy, using mesenchymal precursor cells (MPCs), also showed a strong signal in reducing inflammation and improving microv...
Researchers re-examine molecular characteristics of WNT-subgroup patients to identify optimal treatment strategies for low-risk medulloblastoma. Key findings suggest that therapy-related late toxicity remains a concern, despite comparable survival rates between children and adolescents with this disease subtype.
Research identifies bovine meat and milk factor protein expression as possible cause of colorectal cancer. Monitoring Rep expression and inflammation in tissues may help identify individuals at risk. Early detection could offer new options for preventive and therapeutic intervention.
Researchers discovered that frail patients who received additional support before and after surgery were 18% less likely to die within a year. By connecting these patients with medical professionals and resources, they can make healthy lifestyle changes and receive guidance on managing their condition without surgical intervention.
Researchers have identified novel host protease determinants that facilitate SARS-CoV-2 entry, including membrane-type matrix metalloproteinases (MT-MMP) and ADAM families. Inhibiting these proteases may provide a new treatment strategy against the Omicron variant.
A new analysis reveals that convalescent plasma can be used to prevent hospitalizations and save lives in COVID-19 patients. Early treatment with high doses of antibodies significantly reduced hospitalization rates by up to 50%. The study provides a roadmap for using convalescent plasma as an effective therapy for future pandemics.