Articles tagged with Clinical Research
Researchers demonstrate a model for developing probiotic therapies to modulate the microbiome by targeting intestinal biofilms and identifying beneficial microbial strains. The study showed positive effects in reducing GI symptoms and improving overall well-being in healthy individuals.
Researchers from UTSA and UT Health San Antonio are developing compounds that target the estrogen receptor-beta, which suppresses cancer growth. The goal is to identify a novel ER-beta agonist with potential as a therapeutic strategy for treating GBM in patients.
Researchers at the University of Maryland School of Medicine found that monoclonal antibody CIS43LS provided high levels of protection against controlled human malaria infection. The study's findings suggest that this treatment could be a potential game changer for deploying monoclonal antibody therapies in African countries.
A new study published in Journal of Diabetes Investigation found a significant link between self-stigma and suboptimal glycated hemoglobin (HbA1c) levels in adults with type 1 diabetes. The research highlights the importance of eliminating self-stigma in managing the condition.
Angelo J. Mariotti, the new Dean of LSU Health New Orleans School of Dentistry, has a track record of success in transforming dental education, increasing fundraising, and improving facilities. He aims to enhance faculty development and expand clinics to serve Louisiana's citizens for better oral health.
Researchers seek to reduce medical errors among patients with limited English proficiency by implementing three different translation approaches. The goal is to compare the effectiveness of telephone interpreter-based and in-person interpreter-assisted communication in reducing errors.
A higher rate of sudden infant death syndrome (SIDS) was observed among siblings of children who died of SIDS compared to the general population. Shared genetic and/or environmental factors may contribute to this clustering of SIDS, warranting consideration of family history in clinical assessments.
A recent study published in the Journal of Thrombosis and Haemostasis found that exertional dyspnea can be a misleading presentation of pulmonary embolism, affecting 32% of patients under 75. The Pulmonary Embolism Dyspnea Italian Study (PEDIS) highlighted the importance of evaluating young patients with severe respiratory fatigue for ...
A global study involving 5,869 patients from 50 countries found that 35% could not be successfully weaned from invasive mechanical ventilation. Researchers recommend a systematic approach to reduce weaning duration and improve survival rates, with higher sedation levels associated with delays in initiating weaning.
French researchers found that human and organizational factors negatively impact clinical decision support system use, whereas technological factors have a neutral effect. Despite benefits, PCPs report decreased efficiency due to increased workload, highlighting the need for developers to address these issues.
A nationwide study in Japan found that high-quality primary care attributes, including accessibility and continuity, significantly reduced hospitalizations. Researchers identified a reduction in total hospitalizations among participants with better primary care coordination and comprehensiveness.
Insufficient sleep during teenage years is linked to a higher risk of developing multiple sclerosis (MS). Short sleep duration and poor sleep quality are associated with a 40% and 50% increased risk, respectively. The study suggests that sufficient restorative sleep may be an important preventive factor against MS.
A study of 1,561 primary care patients found most preferred self-rooming for a safer waiting experience. Staff also overwhelmingly favored self-rooming, citing patient comfort and reduced isolation.
Researchers at Children's Hospital of Philadelphia have developed a custom-built application to automate the determination of engraftment after hematopoietic stem cell transplant. The tool has been shown to improve accuracy of reported engraftments, reducing errors in neutrophil and platelet engraftment reporting.
A potent plant toxin called albicidin has emerged as a strong new antibiotic candidate, effective in small concentrations and highly potent against pathogenic bacteria. Its unique mechanism targets the bacterial enzyme DNA gyrase, which is essential for cell function.
A combination of two novel immunotherapy drugs has shown promising clinical activity in treating patients with refractory metastatic colorectal cancer. The study found that 23% of patients had a tumor reduction, and the disease control rate was 76%. The treatment was well-tolerated, but adverse events were common.
A Dartmouth-led study found that team-based coaching significantly improves the risk of acquiring post-procedural acute kidney injury (AKI) when compared to other interventions. The Collaborative with Surveillance intervention reduced the odds of AKI by 46 percent, making it a promising approach to address this prevalent adverse event.
Researchers developed the Functional Assessment of Cancer Therapy – Radionuclide Therapy (FACT-RNT) questionnaire to identify key symptoms and side effects associated with radionuclide therapy. The tool aims to improve patient-centered care and guide treatment decisions for prostate cancer patients.
Biomarkers of bone turnover are essential for diagnosing and treating metabolic musculoskeletal diseases. The International Osteoporosis Foundation, IFCC, and ESCEO have collaborated to publish authoritative reviews on the use and interpretation of these biomarkers.
A UCSF study suggests people who identify as lesbian, gay, bisexual, transgender, or non-binary may have a higher risk of stroke at a younger age. Non-traditional stroke risks include HIV and syphilis infections.
A new personalized treatment for bile duct cancer has shown remarkable results, with patients surviving for up to two years when treated with the drug futibatinib. The Phase II clinical trial found that the drug was more effective at reducing tumor size and producing modest side effects compared to chemotherapy.
A recent study found that genomic testing can identify genetic causes of childhood hearing loss and provide critical information on its clinical characteristics. The researchers detected variants responsible for hearing loss in 43 different genes, and the severity of hearing loss varied by gene.
Researchers are launching a clinical trial testing azeliragon, a RAGE inhibitor, with chemoradiotherapy to re-sensitize brain tumours that resist radiotherapy. The trial aims to predict radioresistance in brain metastasis using liquid biopsy.
A new study found a direct link between hypospadias and epigenetic alterations, suggesting an environmental cause. Researchers identified a potential biomarker for early detection and better clinical management of the condition.
Researchers developed a new technique to analyze frozen tumor specimens, enabling the study of rare cancers and unique patient histories. This breakthrough increases the number and variety of tumor samples available for scientific analysis.
Researchers analyzed data from the VITAL trial and found that vitamin D supplementation increased biomarkers associated with vitamin D metabolism in people, regardless of their weight. However, these increases were significantly smaller in people with elevated BMIs, suggesting a blunted response to supplementation.
Patients with high fracture risk and complex medical conditions are less likely to receive osteoporosis treatment and have poorer health outcomes. The study highlights the need for a comprehensive treatment approach that considers the patient as a whole, rather than just focusing on individual diseases and treatments.
Researchers found that a pro-oxidant mixture of resveratrol and copper can inactivate cell-free chromatin particles, reducing chemotherapy toxicity. The treatment also showed promise in preventing aging and sepsis.
A team of researchers from Chung-Ang University evaluated three different MALDI-TOF MS approaches used in domestic clinical settings for the identification of molds. They compared the performance and diagnostic accuracy of the Bruker Biotyper, ASTA MicroIDSys, and Vitek MS instruments.
Researchers found that patients with low comorbidity groups who received more frequent phone calls had improved outcomes, including reduced mortality and longer hospital stays. The intervention involved regular calls from nurses to monitor patient response and address any unusual symptoms.
Researchers at the University of Bath show that separating patient preparation from operating theatre schedules can significantly improve theatre availability and reduce waiting times. The study found a 40% improvement in theatre idle times and benefits for patient waiting times when surgery procedures are reconfigured.
A new UK study led by psychologists at the University of Bath reveals that adults with high levels of ADHD symptoms are more likely to experience anxiety and depression than those with autistic traits. The study, published in Scientific Reports, uses innovative analytical techniques to confirm a strong link between ADHD personality tra...
Researchers have improved the FDA's equation for predicting drug interactions by addressing fundamental limitations and incorporating new models. The modified equation has shown a significantly increased accuracy of about 80%, which is expected to contribute to increasing the success rate of new drug development.
A freely available measure of autism symptoms can help screen for autism and monitor changes over time in symptoms. The Autism Symptom Dimension Questionnaire (ASDQ) was applied to 1,467 children and adolescents, including 104 with autism spectrum disorder, and found to be reliable and valid.
A phase II clinical study has found that nearly 50% of patients with inoperable locally advanced liver cancer can be cured using the tri-modality therapy. The 'Reduce and Remove' approach, which combines TACE, SBRT, and immunotherapy, results in a 90% two-year survival rate with minimal side effects.
A phase 2 clinical trial using boiled peanuts followed by roasted peanuts showed promising results in desensitizing 80% of children with peanut allergies. Treatment-related adverse events were reported in 61% participants.
Researchers at the University of Minnesota Medical School conducted a large clinical trial comparing two commonly prescribed generic drugs, chlorthalidone and hydrochlorothiazide. The study found that both medications were equally effective in preventing cardiovascular disease and non-cancer death, contradicting current clinical guidel...
Researchers discovered that pre-surgery immunotherapy significantly improved patient outcomes for locally advanced colorectal cancer. The treatment showed substantial longer survival benefits, including low recurrence rates, in patients with mismatch repair-deficient or microsatellite instability-high (dMMR/MSI-H) CRC.
A study shows that pharmacies can offer a safe starting point for patients with opioid use disorder, leading to higher rates of retention in treatment. The pharmacy-based model increases access to buprenorphine, a lifesaving medication, for diverse patient populations and promotes racial and economic equity.
A study from Japan found that variations in psychiatric diagnoses across different cultures can affect the efficacy of antipsychotics in clinical trials. Researchers analyzed data from 28 double-blind randomized trials and found that psychotic features were associated with varying therapeutic responses to antipsychotic medications.
Researchers have identified a new genetic pathway involved in regulating sleep from fruit flies to humans. The Pig-Q gene is associated with sleep regulation in both humans and animals, providing a novel insight into the genetics of insomnia.
Researchers found that letters successfully encouraged clinicians to check patients' prescribing records, leading to increased PMP search rates and persistent effects. The findings suggest a cost-effective evidence-based strategy for promoting safer prescribing practices through simple letter interventions.
Researchers have developed an innovative amputated human limb model to evaluate molecularly targeted fluorescent probes for human tissues. The model allows for controlled testing of imaging agents with zero risk to patients, improving the accuracy and safety of surgical procedures.
A survey of US neonatal nurse practitioner education programs found that underrepresented groups make up less than 20% of faculty and students. Despite disparities in NICU admissions, there is no significant difference in racial/ethnic composition between NNP faculty and students.
A new study published in BMJ Open found no significant difference between older and newer knee replacement implants six months after surgery. This is a breakthrough for patients, as it suggests that older designs with proven track records can provide similar patient-reported outcomes to more modern designs.
A USC study found that notifying clinicians about fatal opioid overdoses through letters from medical examiners reduces opioid prescribing over the next three months. The study shows these notifications have a lasting impact, with a 7% reduction in prescriptions after one year.
A new study by University of Texas Health Science Center at San Antonio shows that treatment for combat-related PTSD can be both fast and effective, with clinically significant reductions in symptoms in over 60% of patients. Long-term remission was observed in more than 50% after three weeks of outpatient therapy.
African patients with chronic hepatitis B face limited access to treatment due to inadequate guidelines. Researchers propose lower treatment thresholds and better adapted guidelines for the African population.
Researchers developed a genotype-first approach that traces genomic variants back to genetic disorders, discovering new relationships between genes and clinical conditions. This approach broadened traits and symptoms associated with known disorders and offered insights into newly described disorders.
The INCOG 2.0 guidelines provide critical updates to address issues in cognitive rehabilitation after traumatic brain injury, including the use of telerehabilitation tools to promote clinical implementation. The guidelines aim to close the evidence-practice gap and improve outcomes for individuals with TBI.
Researchers at HKUMed have established a baseline for gene expression profiles of amniotic fluid cells using RNA-sequencing, providing potential clinical utility for prenatal diagnosis. The study identified outliers in genes associated with structural congenital anomalies, offering new evidence for diagnosis.
A University of Cincinnati researcher is leading a study to examine the effectiveness of a stroke treatment for patients with a pre-stroke disability, which are often overlooked in clinical trials. The study, funded by PCORI, will enroll over 1,100 patients across the US and collect data on outcomes such as disability, function, and qu...
Researchers have made a breakthrough in precision oncology for patients with metastatic urothelial carcinoma, identifying that certain cell surface molecules decrease or are absent in these patients, making them resistant to the new drug enfortumab vedotin.
Researchers at MD Anderson Cancer Center have discovered a novel triple immunotherapy combination targeting checkpoints in T cells and myeloid suppressor cells, improving anti-tumor responses and survival rates in preclinical models of pancreatic cancer. The study found that neutralizing specific immunosuppressive mechanisms dramatical...
A new biomarker test, called BD-tau, can detect Alzheimer's disease neurodegeneration in blood samples with high accuracy. The test outperforms current methods and correlates well with CSF biomarkers, providing a valuable tool for improved diagnosis and clinical trial design.
A cost-effectiveness analysis of direct oral anticoagulants (DOACs) versus low-molecular-weight heparin (LMWH) for cancer-associated thrombosis found that DOACs are more medically effective and cost-effective. The most cost-effective DOAC, apixaban, was also shown to be the least costly anticoagulant.
The article explains how epigenetic changes are used to diagnose brain tumors, predict disease progression, and determine treatment efficacy. Epigenetic drugs have shown promising results in treating various types of leukemia and lymphoma, offering a new approach to cancer management.
Researchers developed a new epigenetic biomarker, GrimAge version 2, which leverages two DNAm-based estimators of plasma proteins to predict mortality risk. The study found that GrimAge 2 outperforms existing clinical biomarkers in predicting mortality across multiple racial/ethnic groups and associations with age-related conditions.
A study in Serrana, Brazil showed that mass vaccination reduced severe cases and death rates even while gamma and delta variants were circulating. Vaccination coverage reached 80% of the target population.
A new algorithm developed by researchers at Charité improves motor symptoms comparable to standard of care treatment, increasing efficiency in deep brain stimulation for Parkinson's disease. The study suggests a promising result for imaging-based algorithms to simplify clinical practice and improve therapeutic outcomes.