Articles tagged with Clinical Research
Research published in Developmental Medicine & Child Neurology reveals a link between maternal diabetes and neurodevelopmental disorders such as autism, ADHD, and intellectual disability in children. Type 1 and type 2 diabetes were associated with increased risks of these conditions, while gestational diabetes was linked to autism spec...
A new Northwestern Medicine study found that all U.S. OB-GYN subspecialties lack racial and ethnic representation in clinical trials and research publications. This absence has negative consequences, including biased tools for diagnosing endometrial cancer and unacceptably low sensitivity in the Black female population.
The use of 3D-patient tumor avatars (3D-PTAs) is crucial for guiding treatment decisions in precision oncology. These avatars, including patient-derived organoids, 3D bioprinting, and microscale models, can accurately depict a tumor with its microenvironment, enabling the testing and prediction of therapeutic drug efficacy.
A new study found that older heart failure patients who feel they have lost their social role amongst friends and family are more likely to suffer poor clinical outcomes. The study highlights the need for a management program that includes a social approach to care, as social frailty is linked to worse outcomes.
A new study found that music therapy resulted in clinically significant reductions in pain and anxiety for patients with cancer and sickle cell disease. Patients with SCD who received music therapy also reported significantly higher pain and anxiety at baseline compared to those without SCD.
A new study from University of Limerick has found that loneliness and social isolation increase the risk of premature death for individuals with cardiovascular disease. The research, which examined data from around the world, highlights the importance of addressing these factors in the treatment of cardiovascular disease.
The study estimated that the NCI-funded NCTN trials have added at least 14.2 million life-years to cancer patients in the US, representing a cost of $326 per year. The trials have had a significant impact on clinical care, with 87.7% of their findings cited as evidence in guidelines and package inserts.
Researchers at the University of Montreal discovered a key mechanism in muscle regeneration, enabling targeted therapies for diseases like muscular dystrophy. By biasing the conformation of a protein called ELMO2, they improved muscle fusion and regeneration in mouse models.
A recent study found that many young cancer survivors decline HPV vaccination due to concerns about safety, importance, and timing. The research aims to address these concerns and provide health care providers with messaging tools to encourage survivors to receive the vaccine.
The American Roentgen Ray Society has awarded the 2023 ARRS Gold Medal to Dr. Bernard F. King, Jr., MD, FACR, FSAR, in recognition of his distinguished service to radiology. Dr. King has made significant contributions to the field, including the development of contrast media recognition and treatment protocols.
Researchers at HKUMed identified a new type of nasopharyngeal carcinoma associated with EBV and immunosuppression in the tumor microenvironment. Global DNA hypermethylation was found to be a critical step in NPC pathogenesis, while global DNA hypomethylation may lead to immune evasion.
A recent study discovered a link between soluble urokinase plasminogen activator receptor (suPAR) and the development of atherosclerosis, a hardening of arteries that affects over a billion people worldwide. SuPAR was found to cause inflammation in blood vessels, leading to cardiovascular events and increasing risk of heart disease.
The December issue of CHEST journal features articles on COVID-19 lessons learned and future pandemic preparedness. The journal also explores various topics in chest medicine, including asthma, critical care, and sleep medicine.
A recent study suggests that stimulating the intersection of two particular brain networks correlated with better patient outcomes than stimulating nearby sites for patients with Alzheimer's disease. Cognitive improvement was associated with DBS to the direct interface between the fornix and bed nucleus of the stria terminalis.
Researchers developed a laser-based approach to perform microbiopsies, enabling fast, painless tissue sampling with minimal damage. The novel technique uses laser ablation to extract tiny tissue volumes, which can be analyzed using virtual H&E imaging and other techniques in minutes, not hours.
A study found that joint replacement prices are not associated with quality of care, but rather with the type of insurer. The study analyzed publicly available data from 18 hospitals in California and found significant price differences between different payer types.
The Cleveland Clinic is developing a stem cell treatment for complex regional pain syndrome, a debilitating disease that causes chronic pain, using human mesenchymal stem cells (hMSC). The research has long-term potential for providing patients an alternative to addictive opioid treatments.
Researchers describe results using cladribine-based combination epigenetic and immunotherapy in MCL, achieving an increased overall survival greater than 40 months with durable remissions without relapse for longer than 5 years. The approach is promising in the treatment of MCL and potentially other previously treatment-refractory canc...
A new study published in Hypertension suggests that lipoprotein(a) cholesterol may affect the relationship between hypertension and cardiovascular disease risk. The study found that people with high levels of lipoprotein(a) and hypertension had a 24% higher risk of cardiovascular disease compared to those without hypertension.
Researchers found that simultaneously targeting two signalling switches can severely inhibit tumour angiogenesis, cancer growth and metastasis in multiple models of cancer. This approach has the potential to restrict a cancer's ability to escape therapy by rapidly destroying the VEGF receptor when both receptors are targeted.
A recent study led by Stefan Seidel found that light therapy significantly improves fatigue symptoms in Multiple Sclerosis patients, with measurable improvements observed after just 14 days of use. The study used objective measurements to rule out sleep disorders, which are common comorbidities with fatigue in MS patients.
As people age, their health care needs become more complex, making it essential to consider anatomical and functional changes when diagnosing and treating ACS. An individualized and patient-centered approach is best for older adults, considering coexisting conditions and input from multiple specialists.
Researchers from The Mount Sinai Hospital found that talquetamab, a bispecific antibody, was successful in killing multiple myeloma cells in over 70% of patients. This therapy directs the immune system to target cancer cells and has shown promise even for those who have resisted all other treatments.
Current tobacco and electronic nicotine delivery systems use associated with increased risk of bleeding after brushing or flossing. Longitudinal studies highlight the importance of tobacco cessation counseling in clinical practice.
The University of Birmingham has developed a validated symptom burden questionnaire for Long COVID, which can now be translated into hundreds of languages. The questionnaire, called SBQ-Long COVID, aims to capture the complexities of Long COVID and develop or test new treatments.
A new American Heart Association scientific statement highlights the potential benefits and risks of complementary and alternative therapies for heart failure. The statement advises healthcare professionals to discuss CAM use with patients, monitor medication interactions, and consider pharmacists' consultations.
Dr. Keith Chan joins Houston Methodist to enhance chemoimmunotherapy responses in bladder cancer, while also expanding research into pancreatic and skin cancers. He will lead translational research and mentor next-generation cancer researchers.
A recent study found that pregnant subsistence farmers in The Gambia experience physiological strain due to heat stress exposure, leading to raised foetal heart rates and slower blood flow. The research highlights the need for effective interventions to protect these women and reduce adverse birth outcomes.
Persistent pain was common among US adults aged 65+, with declines in physical function (64% persistent pain, 59% intermittent) and well-being (48% persistent pain, 45% intermittent). Cognitive decline was not significantly affected. The study highlights the importance of access to effective treatment for persistent pain in older adults.
A study published in the Journal of Dentistry found that patients with unexplained brain abscesses were three times more likely to have oral bacteria present. The researchers also discovered significantly higher counts of Streptococcus anginosus, a bacterium linked to dental abscesses and infections in internal organs.
Researchers have identified three new genes, SHMT1, FAM120B, and ICA1L, and their expressed proteins that may be involved in the development of multiple sclerosis. The study provides new insights into the mechanisms underlying the disease and prioritizes promising targets for future therapy research.
The Cochrane review analyzed data from 41 randomized controlled trials of 12 different COVID-19 vaccines, involving 433,838 people worldwide. The review found that most vaccines reduced the risk of COVID-19 infection and severe disease, with few reported side effects.
A new antimalarial drug, tafenoquine, is found to require a higher dose of 450mg to achieve cure rates of 85% compared to the current 300mg dose of 70%. The study suggests that the single-dose tafenoquine is not as effective as optimal primaquine treatment in preventing vivax malaria relapses in all endemic regions.
Researchers have identified three new subtypes of glioblastoma, a type of brain cancer, based on the presence of specific non-cancer cells. These subtypes may help identify targeted therapies, such as immunotherapies, for improved patient outcomes.
The American Heart Association has added a new $4 million grant to its $24 million Strategically-Focused Research Network (SFRN) on the Science of Diversity in Clinical Trials. The new center, led by researchers at Johns Hopkins University and Morgan State University, aims to identify ways to increase participation and recruitment of p...
A recent study published in Mayo Clinic Proceedings found that people who are physically fit have a lower risk of needing prescription sleeping pills. The research, based on data from Norway's HUNT study, suggests that being in good physical shape can help improve sleep quality.
Research suggests that long-lasting insecticidal malaria nets lost their effectiveness after just one year in Burundi, contradicting the recommended replacement every 3 years. The study found that malaria incidence rose again after two years, highlighting the need for continued epidemiological monitoring and improved resource allocation.
Researchers analyzed a child's genetic data to identify novel mutations in the GTF3A gene, which impair the innate immune response. The study found that these mutations make cells more susceptible to HSV-1 infection and loss of antiviral immune response.
Researchers developed a new method to detect lung cancer using machine learning and statistical techniques, identifying 7 specific volatile organic compounds in breath samples. This breakthrough could lead to earlier diagnosis and improved treatment outcomes for patients.
A survey by UCI MIND found that media coverage of the FDA's decision made people less willing to volunteer for Alzheimer's pharmaceutical trials. The study highlights the powerful influence of media coverage on scientific research and emphasizes the need for diverse populations in clinical trials.
A large US study found that excess oxygen during surgery is associated with a higher risk of kidney, heart, and lung injury. The study of over 350,000 patients suggests that liberal use of oxygen may be harmful to the body's cells and tissues.
Research reveals that individuals with autism have normal pain thresholds but increased sensitivity to painful stimuli. This study's findings suggest the need for increased awareness and early treatment to improve quality of life for autistic individuals.
Researchers at Karolinska Institutet found that internet-delivered anonymous cognitive behavioural therapy (CBT) significantly reduced the viewing of child sexual abuse material. The study, published in Internet Interventions, shows promise for a feasible and effective treatment approach.
Researchers found that buprenorphine use was associated with better outcomes for the baby, including lower risk of preterm birth, small size for gestational age, and low birth weight. The study suggests increasing access to buprenorphine treatment among pregnant individuals with opioid-use disorder.
A pilot study found that nearly half of patients treated with aflibercept could safely stop eye injections without vision loss, while only 17% of those on bevacizumab were able to do so. The findings suggest that matching patients with the right therapy may reduce the need for lifelong treatment.
Researchers developed a new continuity of care measure to track clinician/patient relationship quality in family medicine. Higher CoC scores correlate with decreased emergency department visits, suggesting its potential to shape healthcare behaviors.
Researchers at the University of Waterloo have identified a new method for scheduling radiation therapy that could be up to 22% more effective at killing cancer cells. The algorithm takes into account the differing radiation resistances of stem cells and non-stem cells, allowing doctors to predict how a tumour will respond to treatment.
A recent study found that cannabis studies are often reported in positive terms in the media regardless of their results. The analysis of 20 studies involving 1,500 individuals showed a moderate to large placebo response, where pain was rated as being significantly less intense after treatment with placebo.
A study found that individuals with blood group Rh(D) have a higher risk of contracting parvovirus, which causes fifth disease. The study screened over 160,000 blood donors in Germany and found all infected persons belonged to the Rh(D) blood group.
A trial found that extending anti-clotting treatment after a blood clot in the lower leg reduced further clot risk up to two years. Rivaroxaban administered for three months effectively and safely reduced venous thromboembolism compared to six weeks of treatment.
A new study published in Clinical Gastroenterology and Hepatology found that nearly 1 in 7 Americans experience bloating on a weekly basis. Women were more than twice as likely as men to report feeling bloated, and lifestyle changes, such as exercise and dietary modifications, can help manage symptoms.
A new study explores the value of 'trash data' from cancer genome sequencing, identifying new strategies to uncover previously unexplored information. The researchers found that genomic and transcriptomic data contain relevant information that can help elucidate carcinogenesis and discover putative biomarkers with clinical applications.
Men with metabolic syndrome had nearly four-fold higher risk of developing gout compared to those without MetS. Recovery from MetS reduced incident gout risk by nearly half.
A study published in Oncotarget found that APOE genotype is associated with the presence and severity of cancer treatment-related side effects and symptoms, as well as the response to exercise-based interventions in cancer survivors. ApoE4 carriers showed a lower fall rate after exercise intervention compared to non-carriers.
Researchers at the University of Gothenburg found that using warmer brain irrigation fluid can halve the number of repeat operations needed to remedy bleeding under the cranium. This method involves replacing room temperature irrigation fluid with body temperature fluid, resulting in a significant reduction in surgical interventions.
Research findings suggest that skewed X chromosome inactivation may indicate increased risk of developing chronic diseases, including cardiovascular disease and cancer. XCI-skew is a measure of how many cells in a tissue inactivate the same parental X chromosome.
A pooled data analysis of 10 randomized controlled trials involving 1040 women found that acupuncture significantly relieved pain during pregnancy, improved physical function, and quality of life. The therapy was also found to be safe, with no observable major side effects for newborns.
A new study analyzed tumor biopsies from patients with newly-diagnosed germinal center B cell lymphoma and found that CREBBP mutations were associated with lower disease-free survival rates. The researchers identified CLMA as a practical tool to translate experimental findings into clinical applications.
Researchers used wearable activity trackers to derive health metrics, including heart rate distribution and walking frequency, that correlated with clinically measured parameters. These findings suggest that activity-tracker data can identify surrogate markers of disease severity, enabling remote monitoring and potential personalized t...
Researchers demonstrate a new way to deliver medication to malignant brain tumors in mice, using a modified peptide that can penetrate the blood-brain barrier. The study shows promising results, with a 50% increase in survival rate for treated mice, and offers hope for future treatment breakthroughs.