Articles tagged with Discovery Research
The TGN1412 trial's failure led to serious adverse events in healthy volunteers. A review of the available data revealed essential information was absent from the research file, concluding that the compound was unsuitable for administration without additional pre-clinical experiments.
A molecule called TBK-1 helps keep cancer cells alive, and blocking it may be a promising approach to treating cancer. Researchers at UT Southwestern Medical Center found that TBK-1 is essential for cancer cell survival, even though its normal function is in the immune response.
The NIH has launched a national consortium to transform clinical research, enabling the development of new treatments more efficiently and quickly. The initiative aims to improve medical care by applying scientific advances to real-world practice, particularly in underserved populations.
A large collaborative effort has made publicly available genetic data for Parkinson's research, providing new opportunities for future studies. The data includes genotypes from hundred of patients and healthy controls, which may help identify common genetic variability that results in minor and moderate risk for disease.
Researchers created a 'Poverty Atlas' using geographic information system applications to visualize poverty-related indicators. The maps provide a visual context for understanding the connection between poverty and geography, including factors like climate, soil fertility, and access to transportation networks.
A new generation of cartographers is emerging, thanks to innovative software programs that simplify map-making tasks. Dr. Mark Harrower's tools, such as Color Brewer and Map Shaper, empower users to create accurate and visually appealing maps, bridging the gap between scientific validity and artistic expression.
Researchers at Iowa State University are working on a project to improve the performance of thin-film solar cells by 40-50% using non-crystalline silicon wafers. The discovery could result in several patents and give companies like PowerFilm Inc. a significant advantage in the market.
Scientists used holotomography to study arabidopsis seed's internal structures, discovering a network of voids that may store oxygen for efficient germination. The technique reveals the seed's three-dimensional organization and circulation system, opening new research avenues.
Researchers at MIT use sound waves to identify pockets of natural gas and oil in fractured rocks, offering a new method for finding sweet spots. By combining data from seismic surveys and microseismic events, the team aims to improve the accuracy of hydraulic fracturing, potentially unlocking a larger share of US gas reserves.
Researchers at the University of Cambridge discovered that African pied babbler adults continue to care for their young after they stop feeding directly. The parents call the inexperienced fledglings to areas with readily available food, improving their foraging success rate.
A revised dinosaur census by University of Pennsylvania scientist Peter Dodson estimates that 71% of discoverable genera are still awaiting discovery. The researchers predict that new discoveries will decline sharply in the early 22nd century, but a child born today can expect a fruitful career in dinosaur paleontology.
Research finds British Army wives more resilient than their husbands in military life, with 88% wanting them to stay after deployment. Despite work-life tensions, wives prioritize financial security and feel better equipped to cope than husbands.
Researchers at Purdue University have discovered that nanocantilevers, coated with antibodies, attract different densities of proteins depending on their length. This phenomenon could lead to the development of advanced sensors capable of detecting minute quantities of contaminants.
A newly discovered enzyme inhibitor identified by researchers looking for pest controls may provide pain relief for arthritis and inflammatory diseases sufferers. The finding, hailed as the most important discovery in inflammation in over a decade, reduces side effects associated with painkillers like Vioxx.
A study found that healthcare providers are more accepting of male patients' gay identities compared to female patients, resulting in better care experiences for men. The research highlighted the importance of disclosure in providing high-quality healthcare, as non-disclosure can negatively impact health outcomes.
Researchers discovered that PARL plays a key role in initiating apoptosis in mitochondria, leading to faster cell death and increased risk of diseases like Parkinson's. The study used 'knock-out' mice that lacked PARL, showing that the protein is essential for protecting cells from controlled cell death.
A new lemur species has been named Microcebus mittermeieri in honor of Conservation International President Mittermeier. The discovery was made by researcher Mireya Mayor and her team, highlighting the importance of protecting Madagascar's vital lemur habitat.
Nearly 20% of Canadians work on weekends, mostly in the service sector, with most being female due to part-time and temporary job trends. The unsocial schedule can lead to stress, physical and mental health problems, and decreased productivity.
Researchers found SIVcpz infection in up to 35% of chimpanzees in West Africa, allowing for genetic comparisons between HIV-1 and its simian counterpart. The study provides insights into the origins of HIV-1 and how it made the jump from animals to humans.
Researchers have discovered an extensive system of deepwater coral reefs off Miami and Bimini, which are likely to harbor diverse marine life. The newly mapped areas will be explored using submersibles and autonomous underwater vehicles to assess their ecological importance and search for pharmaceutical compounds.
Researchers will test 400,000 SNPs in 552 patients to clarify the role of genes in sporadic ALS. The study's results could strongly shape the search for a cure if it finds gene associations or suggests an environmental cause.
Scientists have discovered a new mechanism for the formation of insulin crystals, which is crucial for understanding diabetes. The discovery, made by University of Houston researchers, provides insight into how insulin molecules attach to crystals and could lead to breakthroughs in various fields.
The National Institutes of Health (NIH) has launched a $71 million effort to investigate rare diseases affecting fewer than 200,000 persons in the US. The Clinical Research Consortium Network (RDCRN) aims to develop personalized treatments and prevent complications through genetic research.
A gene called caspase-12 is found in around 20% of people of African descent, but was lost from other ethnicities 60,000 years ago. Researchers hope to develop treatments that may strengthen the immune system of those carrying the gene.
A new study by Salk researchers reveals a previously unknown connection between the neural pathways responsible for color and fine detail perception and those involved in motion processing. This discovery challenges the long-held assumption that sensory information about color is relatively unimportant for detecting moving objects.
A new statistical technique identified a single nucleotide polymorphism (SNP) associated with obesity risk in 10% of studied populations. The variant, near the INSIG2 gene, was found to increase BMI measurements and was replicated in four independent populations, including families and non-related subjects.
A new clean-up strategy using phytoremediation has been discovered, allowing plants to transport environmental arsenic from roots to shoots. This breakthrough could help clean up thousands of sites worldwide where arsenic poses serious health risks.
A statewide study in Wisconsin found that unbelted crash occupants represented 68% of patients dying in emergency departments. Unbelted survivors were more than twice as likely to be admitted to the hospital and suffer moderate to severe injuries. The study also linked seatbelt non-use to higher ED bills and economic costs.
A new human retrovirus, XMRV, has been found in patients with a rare type of prostate cancer, suggesting a possible link between the virus and cancer development. The discovery was made using a microarray-based screening method and found that prostate cancers with specific genetic mutations were more likely to harbor XMRV infection.
Phagocytosis, a key part of the immune system, depends on macrophages to remove particles from the body. Researchers at UCSB found that particle shape, not size, is more important in this process. This discovery could lead to the design of drug carriers that can be retained by the body for longer periods and vaccines that stimulate rap...
The NIH is supporting a collaborative neuroimaging research network that brings together researchers at 14 institutions to develop and test interdisciplinary techniques for integrating fMRI efforts. The project aims to improve calibration of imaging equipment, develop robust protocols for cognitive assessment, and analyze resulting data.
The University of Vermont's Proctor Maple Research Center has opened a research building to study the impact of new maple syrup technologies on flavor and chemistry. The facility allows for simultaneous testing of up to four evaporators, providing objective data on the effects of air injectors and other equipment.
Los Alamos scientists uncover new relationship between magnetism and unconventional superconductivity in complex materials. They demonstrate that magnetism can be made to reappear in the presence of an applied magnetic field, expanding our understanding of high-temperature superconductors.
A 'shuttling' protein, ATF2, previously confined to the nucleus of healthy cells, has been found to shuttle between the nucleus and cytoplasm in cancer cells. This shuttling is controlled by the presence of another protein, c-Jun, and may play a key role in cancer's resistance to treatment.
A Florida Institute of Technology faculty member has received a $360,000 grant to explore the origin of mass through high-energy physics research. The grant supports the CMS project, a massive particle detector experiment at CERN's Large Hadron Collider.
A research team led by Yuichiro K. Kato has made a significant breakthrough in understanding the spin Hall effect, a phenomenon that had defied experimental detection for 33 years. The team's discovery has the potential to lead to new applications in sensing technologies, quantum computing, and quantum communication.
Researchers at U of MN develop novel method to assess dynamic brain network interactions using magnetoencephalography (MEG). This breakthrough allows for better evaluation of brain function in diseases like Alzheimer's and monitoring treatment effects.
Researchers at Rensselaer Polytechnic Institute have successfully synthesized hundreds of milligrams of heparin using engineered enzymes and co-factor recycling. This breakthrough could enable the widespread use of synthetic heparin in human medical treatments, reducing reliance on animal-derived products.
A recent study published in Chemical Senses found that the sense of smell is dependent on body position. Researchers at McGill University exposed participants to different concentrations of rose odor while sitting or lying down and discovered a significant decrease in sensitivity to smell when in a supine position.
Johns Hopkins engineers discover that metallic glass atoms form unique Kasper polyhedra, joining together in clusters and forming cavities. This breakthrough advances materials science knowledge and paves the way for intelligent design techniques to create materials with precise mechanical characteristics.
Despite having more free time, women experience a 'family penalty' from childcare and housework responsibilities. A study found that married women with children feel 2.2 times more rushed than single, childless women.
A UAB research team has discovered a new type of construction in Peru, featuring yards built with stone walls where people worked on agriculture and crafts. The buildings date back to the first millennium BC and have been found to contain evidence of large-scale agricultural processing and craftsmanship.
A year-long study using functional Magnetic Resonance Imaging (fMRI) technology has localized a small area in the occipital lobes of the brain responsible for generating visual awareness. This breakthrough discovery clarifies how our brains process visual information and recognize stimuli as visible.
The Purdue-IUSM team will focus on three areas: intelligence analysis, emergency planning, and healthcare monitoring. They aim to create a comprehensive picture of information for decision-makers using advanced visualization tools.
A recent study found that glaciers in Pacific North America underwent a regionally-extensive expansion during the first millennium AD, contradicting previous assumptions about past glacier activity. This discovery suggests that regional climate cycles have cycled from warmer to colder intervals several times over the last 10,000 years.
UI researchers discovered a giant star orbiting a 'medium-sized' black hole every 62 days, indicating the star's enormous size and brightness in X-rays. This finding may help confirm a class of black holes with masses between 100 and 10,000 solar masses.
Researchers at McMaster University have successfully sequenced the woolly mammoth genome, providing a new understanding of evolution and allowing for the potential recreation of extinct hybrid animals. The discovery has significant implications for fields such as conservation and genetics.
The discovery of p63, a death-promoting protein for nerve cells, may lead to new treatments for neurological and neurodegenerative disorders. The research also highlights the need for further funding in neuroscience research.
Researchers at the University of Kentucky have discovered a way to significantly reduce the power consumption of transistors in computer chips by applying rapid thermal processing directly on gate insulators. This technique can improve the insulating qualities of gate insulators, reducing direct tunneling current by up to 100,000 times.
A new study found that men's body image improved as much as women's in a 12-week strength training program, but for different reasons. For men, it was related to perceived changes in their bodies, while for women, it was tied to both perceived and real physical improvements, including increases in weight lifted at the gym.
Researchers identified a significant increase in stroke risk after heart attack, with risks remaining high for up to three years. The study highlights the importance of monitoring patients and implementing preventative measures such as medication adherence, smoking cessation, and healthy lifestyle habits.
Researchers investigated whether music training enhances multisensory processing, particularly sound localization in conductors. The study found that conductors outperformed musically untrained subjects in combining auditory and visual cues.
Research shows lead may cause additional long-term health problems, disrupting immune cells that fight off pathogens. An estimated 434,000 US children under age 5 have elevated lead levels in their blood.
Researchers have confirmed that Gigantopithecus blackii, a gigantic ape weighing up to 1,200 pounds and measuring 10 feet tall, roamed the same region as early humans in southern China. The species is believed to have co-existed with humans during a time of major evolutionary change.
Researchers at Stanford University School of Medicine have discovered the appetite-suppressing hormone obestatin, which could clear up confusion over how hormones regulate appetite. Obestatin's effects on laboratory animals suggest it may be a key to developing effective treatments for obesity.
Researchers at The Wistar Institute have identified a novel multi-protein complex called the Integrator that plays a central role in processing small nuclear RNAs. This complex, which consists of at least 12 subunits, appears to bind to both CTD and specific genes coding for snRNAs.
A new report from ICSU recommends establishing an international scientific data forum to promote coordinated data collection and distribution. The report identifies key challenges, including inadequate legal frameworks, preservation, and archiving of data, which exacerbate inequities between scientists in rich and poor nations.
Researchers detected 'milky seas' in the northwest Indian Ocean using satellite data from the Defense Meteorological Satellite Program. The glowing waters were found to last at least three nights and span an area roughly the size of Connecticut, with boundaries matching surface ship reports.
A USC study of over 12,250 patients found that those treated at level I trauma centers had nearly a 20% lower mortality rate than those at level II centers. Patients also had better functional outcomes and were less likely to be severely disabled after discharge.
The NIH has secured contracts with Deltagen Inc. and Lexicon Genetics Incorporated to provide researchers with extensively characterized lines of knockout mice, featuring disrupted genes. This comprehensive resource will greatly accelerate efforts to explore gene functions in health and disease.