Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
Lawrence J. Marnett's research focuses on identifying functional biochemical differences between COX-1 and COX-2, which play a crucial role in cancer development. The grant will support the development of more specific and effective drugs to prevent and treat cancer.
The Fogarty International Center has awarded a total of $15 million to support six new awards, three competing renewal awards, and 32 competing supplements for U.S. universities under the AITRP. The program focuses on building global HIV/AIDS research capacity and preventing HIV transmission in developing countries.
Scientists have made significant progress in understanding how birds regenerate their hair cells, a process that could lead to new treatments for human deafness. By studying the sequence of events involved in this process, researchers hope to develop strategies to prevent or reverse certain forms of hearing loss.
David Julius, PhD, has made a groundbreaking discovery about the capsaicin receptor, VR1, which mediates responses to painful stimuli. His work builds on the pioneering research of Edward R. Perl, who first identified nociceptors as responsible for pain perception.
Researchers at Duke University Medical Center have discovered a gene responsible for hereditary benign intraepithelial dyskeratosis (HBID), a rare eye disease primarily among the Haliwa-Saponi tribe. The gene causes a 'founder's effect,' leading to abnormal growths on mucosal linings, affecting vision and bloodshot eyes.
INEEL researchers discovered a way to make rare earth magnets more powerful and durable by tweaking their formula. By adding extra elements, they improved the temperature resistance and magnetic field strength of the magnets.
The NHLBI launched a $37 million genomic applications initiative to identify human genes relevant to heart, lung, blood, and sleep functions. The program aims to decipher individual gene functions and develop better prevention, diagnosis, and therapy methods.
Researchers at Memorial Sloan-Kettering Cancer Center discovered a way to protect ovaries from radiation and chemotherapy damage by 'knocking out' a particular gene. A compound called sphingosine-1-phosphate (S1P) has been shown to preserve ovarian function, allowing mice to continue producing eggs.
Researchers have discovered a potential new target for therapy by understanding how Onyx-015 works against cancer cells. The study suggests that the drug's effectiveness may be linked to p14 ARF, which could lead to the development of new cancer treatments.
A $1.1-million study led by LSU will examine marine life on offshore platforms for pharmaceutical value, while also investigating the potential for better glues and adhesives. The research aims to identify new treatments for diseases such as cancer and AIDS.
Scientists have identified a gene mutation on chromosome 22 that causes Spinocerebellar Ataxia Type 10 (SCA10), a neurodegenerative disorder associated with motor incoordination and epilepsy. The discovery may lead to preventative measures by identifying ways to prevent neuron death.
Researchers at Mayo Clinic have discovered a new gene, AXIN2, linked to colorectal cancer development. Mutations in this gene elevate Beta-catenin levels, contributing to the disease.
A Rutgers-led consortium has received a five-year, $25 million NIH grant to determine the structures and functions of proteins. The project aims to develop integrated technologies for high-throughput protein production and 3-D structure determination.
Researchers have discovered a virus with an armored coat made of interlocking rings of protein, similar to medieval chain mail suits. The discovery could lead to new designs for nanotechnology, as the unique structure allows for stability while maintaining mobility.
Researchers found that urban living increases the risk of asthma among black children in the US, while highly active antiretroviral therapy reduces TB and Mycobacterium avium complex infections in HIV patients. Prenatal corticosteroid treatment also boosts surfactant production in preterm infants with respiratory distress syndrome.
A national center for dietary supplement research will be established at Purdue University, combining expertise in plants and natural compounds with analytical technology. The center aims to understand the mechanisms of disease prevention and develop 'designer botanicals' to test their anticancer properties.
The Alliance For Cellular Signaling will map thousands of molecular interactions in cells using a collaborative approach. Researchers will publish data on the Internet immediately, enabling free access to enhance medical treatment discoveries.
Researchers have discovered a biological marker associated with depression in children, who produce less growth hormone than normal peers when given a specific hormone. This finding could give doctors an early warning system to treat children at risk for major depression before they develop the illness.
OHSU researchers discovered that bacteria like E. coli and Neisseria use pili to congregate into microcolonies before invading cells, which can lead to disease spread. The study provides strong data on the mechanism of bacterial movement, potentially leading to new treatments.
Researchers at Monterey Bay Aquarium Research Institute discover a novel light-absorbing pigment in oceanic bacteria, which can generate cellular energy using light. This finding suggests that a new type of microorganism is capable of harnessing light energy in the ocean's sunlit surface zone.
Scientists have discovered a new light-activated protein in surface water bacteria, which may represent a new mechanism for cycling carbon in the oceans. The protein, called proteorhodopsin, pumps ions across the cell membrane when exposed to light, generating energy for marine microbes.
The MACE-II experiment, launched on September 8 aboard the space shuttle Atlantis, will test techniques for predicting motion and controlling vibrations in zero gravity. With multiple months of testing, researchers will interact with the experiment remotely to refine its performance.
A recent study published in Thyroid journal found paclitaxel to have significant clinical activity against ATC, with 53% of patients showing improved survival time. The drug was infused continuously over 96 hours every three weeks for one to six treatments.
A $10 million-per-year project allows researchers worldwide to collaborate on studying cell signaling, with the goal of developing a 'virtual cell' for testing new drugs. The Alliance for Cellular Signaling (AFCS) will help understand the global properties of cellular signaling, leading to breakthroughs in medical research.
The study found that the Gz protein conveys signals from epinephrine, supporting the body's ability to stave off lethal blood clots and avoid strokes. The research also sheds light on human drug dependency and holds promise for the development of more effective painkillers, anti-depressants, and clot-busters.
Researchers at UCSD Institute of Molecular Medicine have discovered a new genetic pathway that plays a pivotal role in the onset of sudden cardiac death. The study found defects in genes controlling heart's electrical wiring may lead to ventricular arrhythmia and sudden death.
Two studies reveal that half of parents using donor insemination are not telling their children about their biological origins, putting them at risk. Meanwhile, a UK study of adults conceived through DI found they faced identity issues, feelings of abandonment and deceit within their families.
Researchers have found a pore-like hole in the membranes of red blood cells infected by Plasmodium falciparum malaria parasite. This discovery may lead to new treatments for malaria, a devastating disease that kills over one million people each year. The study provides a new target for potential new malaria treatments.
Researchers have found pore-like holes in red blood cells infected by Plasmodium falciparum, a deadly form of the malaria parasite. This discovery may lead to the development of new treatments for malaria, a widespread and devastating disease that affects over 40% of the world's population.
OHSU researchers have successfully recorded individual nerve cell transmissions for the first time, revealing how synapses enable cells to communicate. The study provides new insights into the mechanisms of neural communication and has potential implications for understanding neurological and mental diseases.
Chemists at the University of Georgia have developed a new approach to synthesizing key components of Heparin, a widely used anti-coagulant. This method could lead to novel ways to fight disease or improve human health by understanding the structure-function relationships of Heparin.
Researchers have discovered a protein called p110g that suppresses colorectal cancer growth in mice and human cell cultures. The absence of the protein leads to spontaneous development of colorectal cancer, while its presence stops tumour growth.
Virginia Tech researchers create supramolecular complexes with multiple capabilities, including new DNA binding properties and solar energy conversion potential. The complexes are formed by connecting metal-based molecules using polyazine ligands, allowing for the creation of diverse systems with unique properties.
The study identified 46 genes overexpressed in tumor endothelium, up to ten fold, and 33 genes expressed at significantly lower levels, revealing a different environment for tumor growth. The researchers believe endothelial cells are promising therapeutic targets to halt cancer cell growth.
A consortium of researchers found that isocitrate lyase (ICL) enables the tuberculosis bacterium to use fatty acids as energy. Disabling ICL crippled the bacterium in its persistent phase, suggesting a potential target for TB therapies. Current treatments are often ineffective due to the bug's ability to persist in the body.
A UBC research team led by Prof. Chris Overall discovered a protein that reduces inflammation and halts the flow of white blood cells. The discovery, published in Science, may lead to new treatments for chronic inflammatory diseases such as arthritis and lung disease.
Chemist David L. Van Vranken receives Arthur C. Cope Scholar Award for his studies of protein reactivity patterns, which have led to the development of new drugs targeting cancer and other diseases. His research has also shed light on the effects of aging and environmental factors on proteins in the body.
Columbia University researchers have identified a target molecule called RAGE that contributes to cellular damage in diseases like diabetes, cancer, and Alzheimer's. Blocking RAGE has shown promise in halting or reversing cellular damage in animal studies.
Researchers have identified the protein that transports glutamate, a key player in brain function, offering a potential new target for treating diseases such as Alzheimer's and Parkinson's. The discovery could lead to therapies that either reduce or increase glutamate release, depending on the specific condition.
A new study reveals that gadolinium zirconate is highly resistant to radiation, outlasting ceramic materials currently considered for plutonium disposal by millions of years. This finding makes it a leading candidate for the immobilization of plutonium, a nuclear contaminant with a long half-life.
A newly identified protein called palladin is being explored for its influence on biological processes including cancer spread and wound healing. Palladin appears to play a critical role in determining cell shape via the actin cytoskeleton, with different forms of the protein involved in tight adhesion and movement.
Deep breathing reduces adverse effects of methacholine on healthy lung function by 85%, potentially providing therapeutic options for asthmatics. The study suggests that deep breaths stretch lung tissue, releasing a protective chemical to keep airways open.
Researchers found that cortisol levels remained steady or rose in some people after discussing positive relationship history, despite expecting a decrease. Women who experienced this were more likely to be divorced from their husbands.
Researchers at UC Irvine have discovered a protein called calsenilin that can offset calcium imbalances in brain cells, which contribute to the development of early-onset familial Alzheimer's disease. This finding may lead to pharmaceutical therapies and preventive measures to halt the progression of this neurological disorder.
Scientists have successfully implanted the lens of a sighted fish into cavefish, resulting in the growth of a normal eye. This breakthrough may provide new avenues for understanding the genetic factors involved in eye growth and development, potentially leading to improved treatments for certain forms of blindness. Further research is ...
Researchers at CU-Boulder have discovered a second underwater church in the ancient port city of Aperlae, suggesting it was a magnet for pilgrims traveling to and from the Holy Land. The settlement, which likely supported around 1,000 people, featured multiple churches, public baths, and self-sustaining agriculture.
A study of over 5,000 children's stories found that girls with aggressive themes tend to exhibit behavioral problems at home and school. Researchers suggest engaging children in play to help them work through issues, rather than inhibiting it.
Researchers discovered a simple geometric explanation for protein spiral shapes, which could aid in understanding protein functions and structures. The finding uses mathematical ideas to optimize protein shape for maximum 'thickness,' leading to the natural occurrence of helical motifs in proteins.
A study found that antibodies in patients with primary Sjogren's syndrome bind to small nerve endings, blocking transmission and causing severe dryness of the eyes and mouth. Researchers hope to use this discovery to develop new treatments for autoimmune diseases.
A new study by researchers at Dartmouth College found that fertilized lakes in Ontario, Canada, exhibit unpredictable algal composition and abundance fluctuations from year to year. This unpredictability makes it challenging for lake managers to make accurate predictions for planning management and research efforts.
Researchers discovered how E. coli O157:H7 causes massive cell death in humans, leading to organ failure and death. The bacteria's verotoxins trigger programmed cell death through a Bcl-2 protein sequence, offering potential new treatments for food poisoning.
Researchers at University of Toronto have identified a common principle underlying brain cell death in neurodegenerative disorders. They propose a 'one-hit' model, where cells die after a single catastrophic event, rather than gradual damage over time.
Scientists have identified mating behavior in Candida albicans, a fungus long thought to reproduce only by splitting itself. This discovery promises to accelerate research into the fungus and enable researchers to better understand its biology and identify new drug targets.
Scientists at UCSF have identified a molecule, S1P, that guides the union of two primordial heart tubes in zebrafish embryos. This discovery sheds light on the critical role of S1P in human heart development and may provide insights into other cellular processes such as wound healing.
A team of scientists at Cornell University has discovered a genetic connection between the evolution of plump fruits and vegetables and the growth of human cancer cells. The study identified a single gene called ORFX that plays a key role in plant fruit development, similar to the human oncogene c-H-ras p21.
Scientists at the University of Illinois have discovered a way to spontaneously assemble chemicals into ribbon-like tubules that resemble bacterial cell walls. These micrometer-sized tubules have potential applications in drug delivery systems and as templates for synthesizing inorganic nanostructured materials.
Researchers at Rosetta Inpharmatics used Flexjet DNA microarray technology to analyze the role of changes in chromosome number on gene expression, showing large-scale biases that affect cellular processes. The study provides a novel tool for evaluating aneuploidy and its potential applicability to human cancer cells.
A team of scientists at UCSF has identified five proteins that trigger the immune system to attack cancer cells, marking them for swift destruction by NK cells. The discovery increases the number of known targets for drugs or vaccines to boost the immune system's natural cancer-fighting ability.
A new TB drug candidate, PA-824, has been shown to be effective against MDR strains of the bacteria. The compound, developed by PathoGenesis Corporation with assistance from NIAID's Laboratory of Host Defenses, works by preventing MTB from forming an important fatty acid component of its cell walls.
The Kaposi's sarcoma virus employs a novel strategy to evade the immune system by removing sentries on cell surfaces and shipping them for destruction. Researchers identified two viral genes that reduce MHC-1 proteins at the cell surface, allowing the virus to spread more widely.