Articles tagged with Discovery Research
Comprehensive exploration of living organisms, biological systems, and life processes across all scales from molecules to ecosystems. Encompasses cutting-edge research in biology, genetics, molecular biology, ecology, biochemistry, microbiology, botany, zoology, evolutionary biology, genomics, and biotechnology. Investigates cellular mechanisms, organism development, genetic inheritance, biodiversity conservation, metabolic processes, protein synthesis, DNA sequencing, CRISPR gene editing, stem cell research, and the fundamental principles governing all forms of life on Earth.
Comprehensive medical research, clinical studies, and healthcare sciences focused on disease prevention, diagnosis, and treatment. Encompasses clinical medicine, public health, pharmacology, epidemiology, medical specialties, disease mechanisms, therapeutic interventions, healthcare innovation, precision medicine, telemedicine, medical devices, drug development, clinical trials, patient care, mental health, nutrition science, health policy, and the application of medical science to improve human health, wellbeing, and quality of life across diverse populations.
Comprehensive investigation of human society, behavior, relationships, and social structures through systematic research and analysis. Encompasses psychology, sociology, anthropology, economics, political science, linguistics, education, demography, communications, and social research methodologies. Examines human cognition, social interactions, cultural phenomena, economic systems, political institutions, language and communication, educational processes, population dynamics, and the complex social, cultural, economic, and political forces shaping human societies, communities, and civilizations throughout history and across the contemporary world.
Fundamental study of the non-living natural world, matter, energy, and physical phenomena governing the universe. Encompasses physics, chemistry, earth sciences, atmospheric sciences, oceanography, materials science, and the investigation of physical laws, chemical reactions, geological processes, climate systems, and planetary dynamics. Explores everything from subatomic particles and quantum mechanics to planetary systems and cosmic phenomena, including energy transformations, molecular interactions, elemental properties, weather patterns, tectonic activity, and the fundamental forces and principles underlying the physical nature of reality.
Practical application of scientific knowledge and engineering principles to solve real-world problems and develop innovative technologies. Encompasses all engineering disciplines, technology development, computer science, artificial intelligence, environmental sciences, agriculture, materials applications, energy systems, and industrial innovation. Bridges theoretical research with tangible solutions for infrastructure, manufacturing, computing, communications, transportation, construction, sustainable development, and emerging technologies that advance human capabilities, improve quality of life, and address societal challenges through scientific innovation and technological progress.
Study of the practice, culture, infrastructure, and social dimensions of science itself. Addresses how science is conducted, organized, communicated, and integrated into society. Encompasses research funding mechanisms, scientific publishing systems, peer review processes, academic ethics, science policy, research institutions, scientific collaboration networks, science education, career development, research programs, scientific methods, science communication, and the sociology of scientific discovery. Examines the human, institutional, and cultural aspects of scientific enterprise, knowledge production, and the translation of research into societal benefit.
Comprehensive study of the universe beyond Earth, encompassing celestial objects, cosmic phenomena, and space exploration. Includes astronomy, astrophysics, planetary science, cosmology, space physics, astrobiology, and space technology. Investigates stars, galaxies, planets, moons, asteroids, comets, black holes, nebulae, exoplanets, dark matter, dark energy, cosmic microwave background, stellar evolution, planetary formation, space weather, solar system dynamics, the search for extraterrestrial life, and humanity's efforts to explore, understand, and unlock the mysteries of the cosmos through observation, theory, and space missions.
Comprehensive examination of tools, techniques, methodologies, and approaches used across scientific disciplines to conduct research, collect data, and analyze results. Encompasses experimental procedures, analytical methods, measurement techniques, instrumentation, imaging technologies, spectroscopic methods, laboratory protocols, observational studies, statistical analysis, computational methods, data visualization, quality control, and methodological innovations. Addresses the practical techniques and theoretical frameworks enabling scientists to investigate phenomena, test hypotheses, gather evidence, ensure reproducibility, and generate reliable knowledge through systematic, rigorous investigation across all areas of scientific inquiry.
Study of abstract structures, patterns, quantities, relationships, and logical reasoning through pure and applied mathematical disciplines. Encompasses algebra, calculus, geometry, topology, number theory, analysis, discrete mathematics, mathematical logic, set theory, probability, statistics, and computational mathematics. Investigates mathematical structures, theorems, proofs, algorithms, functions, equations, and the rigorous logical frameworks underlying quantitative reasoning. Provides the foundational language and tools for all scientific fields, enabling precise description of natural phenomena, modeling of complex systems, and the development of technologies across physics, engineering, computer science, economics, and all quantitative sciences.
The University of Minnesota Medical School is studying the epigenetic factors of low back pain using a five-year, $3.2 million grant. This research aims to identify new treatments targeting disc degeneration and chronic back pain.
Two UCF cancer researchers, Alicja Copik and Debbie Altomare, have received $100,000 grants from the Florida Breast Cancer Foundation to develop new treatments for breast cancer. They focus on enhancing natural killer cells to fight cancer and harnessing the body's immune system to create new therapies.
A team of scientists has successfully mapped the entire brain of Drosophila melanogaster, a fruit fly, using electron microscopy dataset and connectome analysis. The complete map will help researchers understand how different circuits work together to control behaviors like motor control, courtship, and decision-making.
Researchers have discovered that Listeria monocytogenes loses its cell wall and becomes round when entering a dormant state, making it undetectable by growth-based tests. Developing antibodies to detect dormant forms of the bacterium could lead to specific tests for better protection.
Researchers create a complex model of nematode worm behavior, accurately mimicking its movements and offering insights into animal behavior. The findings have significant implications for medical research, particularly in the study of movement disorders like Parkinson's disease, and could also improve robotics.
Researchers at Lehigh University have pioneered a method to create customizable ceramics using solid-state synthesis, enabling advances in electronics and energy conversion. The team aims to produce functional materials with tailored geometries that can be used in thermoelectric devices and other applications.
Researchers at the University of Nottingham uncover key regulators of malaria parasites' cell division, revealing NEK1 as a potential drug target. The study aims to find new therapeutic targets for controlling malaria transmission.
A new study published in Scientific Reports reveals the importance of foot movement in early infant development and interaction. By using machine and deep learning techniques, researchers found that AI can accurately classify five-second clips of 3D infant movements, with foot movements showing the highest accuracy rates.
Researchers from University of Texas at Arlington have identified 206 systems of interest for potential habitability, including one system where the planet is always situated in the HZ. The team analyzed data from NASA Exoplanet Archive and found F-type stars to be a promising case for life beyond Earth.
A Southwest Research Institute-led team has detected carbon dioxide and hydrogen peroxide on Charon's surface, revealing insights into the moon's geological processes and formation. The presence of these substances suggests that Charon's surface is altered by solar ultraviolet light and energetic particles.
The U.S. Department of Energy has selected Kate Petersen Mace as the project director for the High Performance Data Facility (HPDF), a first-of-its-kind project providing resources for data-intensive science. Mace will lead the team in developing transformational capabilities to serve the DOE community.
Rice engineers developed a new synthesis strategy for covalent organic frameworks (COFs) that can be used to trap gases, filter water and speed up chemical reactions. The approach enables faster production of COFs with superior crystallinity and high efficiency in breaking down harmful chemicals.
A new microscope-integrated OCT system has been developed to identify tumor margins during brain surgery, providing high-resolution images of subsurface anatomy. The system has shown promising results in clinical studies, with the potential to improve outcomes for neurosurgery procedures.
Researchers identify a homozygous SPAG9 gene mutation associated with intellectual disability, progressive cognitive decline, and heterogeneous brain abnormalities. The study provides a unique model for understanding disruptions in cellular transport mechanisms leading to neurodevelopmental and degenerative brain conditions.
In this study, researchers from Tokyo Institute of Technology found that hydrogen sulfide-dependent transcription factor YgaV regulates iron uptake dynamics in Escherichia coli. The team observed elevated intracellular H2S levels resulting in increased antibiotic resistance and upregulated genes involved in sulfur metabolism.
Leading researchers from Penn Medicine will showcase clinical trial results and new data on FLASH radiation therapy. The institution is one of the world’s leading academic medical centers, with a proud history of groundbreaking discoveries and innovations.
A team of researchers has made groundbreaking findings that suggest our cosmic neighborhood may be far larger than previously thought. The study, which analyzed the movements of 56,000 galaxies, reveals a potential shift in the scale of our galactic basin of attraction.
Researchers at Purdue University and NASA believe Ceres has a dirty ice crust and was once a muddy ocean world. The team used computer simulations to show that ice can be much stronger than previously predicted, contradicting the previous belief that Ceres was relatively dry.
The UT Arlington Neutrino Group has successfully identified the detector's neutrino interactions for the first time in a decade-long project. The group's work on the SBND experiment aims to study neutrino oscillation and search for evidence of a fourth neutrino, with the potential to redefine our understanding of the universe.
Astronomers using NASA's Hubble Space Telescope discovered that the blowtorch-like jet from a supermassive black hole at the core of a huge galaxy causes stars to erupt along its trajectory. The finding suggests that there is something missing from our understanding of how black hole jets interact with their surroundings.
A team of researchers at UMC Utrecht has identified 29 novel antibodies against the bacterium Klebsiella pneumoniae, an important cause of drug-resistant infections. The antibodies were found to interact with antigens on the bacterial surface and some act synergistically to neutralize the pathogen.
Researchers discovered that activating the pentose phosphate pathway makes antitumor CD8 T cells more likely to stay in an immature state, leading to better results in animal models and human organoids. This metabolic reprogramming strategy may enhance checkpoint inhibitor therapy by boosting a long-term supply of active cytotoxic T ce...
Researchers at the University of Virginia Health System have identified a crucial biological switch that regulates renin production in certain cells, allowing them to control blood pressure. This discovery provides important direction for future research into high blood pressure and cardiovascular disease treatment.
A new study suggests the hormone hepcidin may trigger psoriasis by causing iron overload in the skin. This excess iron amplifies the damaging effects of UV sunlight, leading to hyperproliferative chronic diseases like psoriasis. A potential treatment targeting hepcidin could improve treatment options for millions.
A recent study found that microwave drying enhances the release of eleutheroside E, a compound detected for the first time in lily bulbs. This method preserves key bioactive compounds and minimizes browning, making it an effective way to preserve the nutritional value of lily bulbs.
Researchers developed a noninvasive method to monitor postprandial cardiovascular health using spatial frequency domain imaging (SFDI). The technique effectively tracks diet-induced changes in cardiovascular physiology, revealing significant differences in tissue responses after consuming high-fat and low-fat meals.
Scientists identify PICALM as a key player in regulating glucose homeostasis and insulin signaling in adipocytes. Reduced expression of PICALM improves insulin sensitivity and glucose transport, holding promise for new therapeutic approaches for type 2 diabetes and obesity.
Researchers have developed a new method to detect melanoma using tumour-specific antibodies, which can accurately identify stage I and II melanoma patients. The study found that these antibodies showed high sensitivity and specificity in detecting melanoma, with an AUC value of up to 0.981.
A new study found that a high body roundness index over 6 years was associated with an increased risk of developing cardiovascular disease in adults older than 45. The study, published in the Journal of the American Heart Association, suggested that BRI may be a valuable predictor of cardiovascular disease risk.
Researchers from Xiamen University created a novel two-step enzymatic approach to synthesize diverse Ephedra-type alkaloids with improved yields and introduced new N-group modifications. They successfully tested various enzymes and imine reductases to optimize conversion rates and generate novel synthetic Ephedra-type alkaloids.
Researchers developed innovative technologies to increase lactoferrin production using synthetic biological systems, overcoming limitations in separating and purifying LF from milk. The new methods have the potential to meet market demand for LF in food, pharma, and cosmetics industries.
Researchers at Cold Spring Harbor Laboratory create a roadmap of how prostate cancer spreads throughout the body, showing that aggressive cells seed cancer's rare migrations to bones, liver, lungs, and lymph nodes. The new technology offers a clearer picture of cancer spread and could lead to more targeted therapeutics.
Researchers at Texas A&M University have developed a method to recharge cellular mitochondria using nanotechnology, potentially extending healthy lifespans and improving outcomes for patients with age-related diseases. The molybdenum disulfide nanoparticles stimulate mitochondrial regeneration, helping cells generate more energy.
The American Heart Association joins a $10 million grant from the Global Cardiovascular Research Funders Forum for international scientific research on cardiovascular health in women. The International Research Challenge aims to address significant gaps in research, diagnosis, and care for women worldwide.
Researchers have tested a combination of treatments in mice with lung cancer and shown that these allow immunotherapies to target non-responsive tumours. The combination therapy allows 'immune cold' tumours to respond to the body's own defences.
Researchers compared epigenetic changes across the genome in young adults who vaped, smoked or did not use nicotine products, finding a tumor-suppressor gene among the key findings. The study found substantial overlap in DNA methylation patterns between people who vaped versus those who smoked.
A new individualized risk prediction tool has been developed to predict the severity of heart disease in people suffering from Long QT syndrome. The test analyzes genetic mutations associated with the condition and can identify those at high risk of sudden cardiac death, allowing for tailored treatment.
Researchers are conducting a comprehensive health and nutrition examination study to assess the status of active-duty service members. The study will gather data on dietary intake, nutritional status, cardiovascular health, and other measures to guide evidence-based screening and intervention strategies for improving health in the mili...
Astronomers have discovered a 'weird' and unprecedented galaxy in the early Universe, with its gas outshining its stars. This phenomenon could provide clues about how galaxies evolved between the Big Bang and familiar galaxies.
A new study from Case Western Reserve University found that patients taking semaglutide had a significantly lower risk of opioid overdose compared to those on other anti-diabetic medications. The research suggests semaglutide could be a potential new treatment for opioid use disorder and preventing overdoses.
Scientists have discovered a new species of predatory flatworm in North Carolina and Florida, which has been detected in residential landscapes across the Southeast. The researchers found that the flatworm has brownish-black color and feeds on soft-bodied organisms like earthworms and slugs.
Researchers have identified James Fitzjames, a senior officer of Sir John Franklin's 1845 Northwest Passage expedition, using DNA and genealogical analyses. The identification was made possible by a DNA sample from a living descendant that matched the remains found on King William Island.
Researchers discovered that certain bacteria display communal behaviors protecting sensitive species from drugs, allowing them to grow normally in a community. The study found that high drug concentrations cause microbiome communities to collapse and cross-protection strategies are replaced by cross-sensitisation.
A new study reveals how psilocybin alters brain connectivity to alleviate symptoms of body dysmorphic disorder, potentially aiding treatment. Psilocybin strengthens neural connections between executive functions and emotionally salient stimuli, leading to improved BDD symptoms.
A PSU English professor is using a grant from the National Science Foundation to study one of the world's fastest and largest supercomputers, Aurora. The research aims to answer questions about how supercomputers work, their applications in science and industry, and their impact on the US's position in scientific advancement.
Researchers have identified eight novel genetic mutations in patients with CSF1R-Related Disorder worldwide, highlighting the prevalence of the disease and paving the way for future individualized treatment. The discovery also suggests that genetic and environmental factors may influence the disease.
A new, low-cost cathode material developed by Georgia Tech's Hailong Chen could transform the electric vehicle (EV) market and large-scale energy storage systems. The iron chloride (FeCl3) cathode costs a mere 1-2% of typical cathode materials and can store the same amount of electricity.
A recent study by the Wellcome Sanger Institute and GeneDx analyzed nearly 30,000 families with developmental disorders, revealing that known genes explain over 80% of cases caused by recessive genetic variants. The team identified several new genes associated with these conditions, providing answers for previously undiagnosed families...
Researchers found that colleges offer multimillion-dollar coaches instead of throwing money at student-athletes, leading to an arms race in athletics. The study revealed a significant correlation between head coach salaries and team recruitment success, with higher salaries associated with better teams and more victories.
A recent FAU study reveals that mesophotic corals can replenish declining shallow reef populations with strong genetic connectivity between shallow and deep zones. The research suggests that deeper corals could be a key source of genetic diversity for shallow reefs, providing valuable opportunities for recovery and restoration efforts.
A Virginia Tech research team has identified a molecular mechanism by which Shigella flexneri bacteria manipulate host molecules to ensure their survival. The study provides a new understanding of the infection pathway and its potential implications for preventing similar infections in other bacteria.
Researchers at MIT found that a two-dose schedule for an HIV vaccine can generate a strong response to the virus, outperforming a traditional seven-dose regimen. The first dose primes the immune system, helping it to produce antibodies more effectively when a larger dose is administered one week later.
Researchers at ETH Zurich have found an antidepressant, vortioxetine, effective against glioblastomas, a particularly aggressive brain tumor with no cure. The drug's ability to cross the blood-brain barrier and trigger a signalling cascade makes it promising for treating this deadly tumour.
A new study has identified key factors to build food resilience in Sub-Saharan Africa, including diversifying suppliers, empowering local farmers, and promoting sustainable practices. The proposed blueprint aims to enhance self-sufficiency and reduce reliance on external sources.
Researchers analyzed DNA in fecal samples to determine the diet of Alaska and southern resident killer whales. They found that both populations prefer salmon, but differ in when they switch to hunting other fish species. The study provides key insights into the delicate balance between regional abundance of different fish species.
UTHealth Houston researchers are exploring new pathways to treat Alzheimer's disease through multiple projects funded by the Texas Alzheimer's Research and Care Consortium. Studies aim to investigate ACSL4 gene, delirium's impact on disease progression, biological aging, and noninvasive diagnosis methods.
Researchers at the CNIC found that respiratory complex I possesses sodium transport activity essential for efficient cellular energy production. This discovery provides a molecular explanation for Leber's hereditary optic neuropathy and may have implications for other neurodegenerative diseases.
A study published in Nature Communications found that the MYC gene is a common culprit driving prostate cancer progression. The research reveals how MYC activation attracts immune cells to the tumor but later helps hide it from immune detection, making it undetectable.
A research team has successfully recreated wrinkle structures in biological tissue in vitro, revealing the mechanisms behind their formation. The study found that compressive forces and dehydration play a crucial role in wrinkle formation, mirroring aging skin effects.
A team of researchers discovered that twisting layers of a material can generate an electron-path-deflecting effect, controlling light and electrons in quantum materials. The phenomenon mimics the Coriolis force, where light is used to manipulate electrons, exhibiting new quantum behaviors.