The lack of synergy between academia and industry in drug discovery hinders the development of effective treatments. Researchers discuss why many therapeutic molecules fail to reach clinical trials despite pre-clinical efficacy.
A comprehensive database of invasive plant impacts in Europe has been created, featuring 266 peer-reviewed publications and 4,259 field studies. The dataset highlights the widespread effects of invasive species on native ecosystems, including impacts on plants, animals, and microbes across various trophic levels.
Researchers are exploring 'priming, shaping, and polishing' techniques to develop an HIV vaccine targeting rare immune cells that produce broad-neutralizing antibodies. The Amsterdam UMC-led project aims to create an effective vaccine for low- and middle-income countries with a €4.5m grant.
A recent study suggests that many nocturnal Strepsirrhines live in pairs of males and females, challenging the long-held assumption that these primates are solitary. Researchers found that pair-living was the most common social organization among ancestors 70 million years ago.
Recent studies published in the Tuberculosis journal reveal the earliest confirmed presence of tuberculosis' causative agents in human remains, pushing the timeline back by tens of thousands of years. Researchers have also discovered evidence of TB infection in Neanderthal specimens from Hungary, dating back over 32,000 years.
A recent VCU-led study found that rising temperatures can make it harder for dragonfly nymphs to control mosquito larvae populations. As a result, there could be nearly twice as many mosquito larvae reaching adulthood in warmer temperature pools.
A small molecule drug compound has shown promise in treating multiple sclerosis by targeting the glutamate system, reducing MS-like symptoms and repairing damaged myelin. The results come from a CAMH-led pre-clinical study published in Science Advances.
Researchers analyzed 13,000 hours of audio data from Okinawan forests before, during, and after typhoons, finding that ecosystems responded differently than expected. The study suggests that developed sites were more resilient to extreme weather than anticipated, but climate change may push these ecosystems to their limits.
Researchers used psychoacoustics to analyze sound frequencies and clarity at the ancient Greek sanctuary of Zeus, revealing that hillside spectators could hear sounds from the hippodrome. The method provides a unique perspective on ancient societies' organization and activity, but its results should be interpreted with caution.
Dr. Sonia Hernández's recent publication in the Journal of American History explores the complex histories of violence, gender, and power dynamics along the US-Mexican border region from 1900-1913. Her research centers on the testimonies of Mexican-origin women, shedding light on complicated gendered negotiations with state agents.
A brain-computer interface (BCI) has been successfully used to restore control of home devices for a patient with ALS, allowing the individual to navigate a communication board and smart devices without recalibration. The BCI device was implanted on the surface of the brain areas responsible for speech and upper limb function, enabling...
Researchers at Kyoto University have found three new species of animals living together in harmony with worms in dead coral rocks. The discovery highlights the importance of community structure and biodiversity patterns in cryptofauna, suggesting that symbiotic relationships are omnipresent in the ocean.
Purdue University scientists examine the bio-impact of toxic chemical cocktails in the environment, finding reduced growth in tadpoles exposed to PFAS mixtures. The study highlights the need for research on mixture toxicity in aquatic organisms, as each chemical interacts with others in complex ways.
An international team sequenced nearly 4,000 Darwin's finches' genomes to understand evolutionary change in natural populations. The results showed that only a few genetic loci explain variation in the beak of the finch, with genes transferring between species contributing to adaptation.
Scientists have developed a nonrelativistic and nonmagnetic mechanism for generating terahertz waves, harnessing the electrical anisotropy of two conductive oxides. This approach produces signals comparable to commercial terahertz sources and offers a high terahertz conversion efficiency.
Research suggests that psilocybin can lead to lasting reductions in depression symptoms by increasing openness to experience and promoting brain network flexibility. Clinical trials have demonstrated positive effects of psilocybin in treating psychiatric disorders, including major depressive disorder and treatment-resistant depression.
Researchers found a 5% sodium hydroxide solution successfully turns live Lebbeck mealybug specimens green, identical to the 10% potassium hydroxide solution. The new alternative is less corrosive, more water soluble and less expensive.
The study found that rising testosterone levels trigger full song development and territorial behavior in thrush nightingales. Full songsters were never found to settle close to each other, while plastic songsters settled close to both full and plastic songsters, indicating a connection between song and territoriality.
The study found that local communities in coastal Ecuador depend less on tagua trees today than their grandparents did, but still use them for cultural and supporting services. The research highlights the importance of conservation efforts to protect these ecosystem services.
A new study from the University of Notre Dame recommends building water projects that allow community collaboration, reducing distances and increasing equity. The research team created a unique dataset to optimize locations and found that community collaboration models outperform traditional methods.
Forensic scientists at West Virginia University have developed a systematic approach to compare pieces of trace evidence, including duct tape, using a novel method. The technique evaluates fracture edges and demonstrates physical fit, providing a foundation for evaluating error rates and improving accuracy in crime scene investigations.
A University of Illinois Chicago-led study investigates the aftermath of the East Palestine chemical spill, collecting data on residents' experiences and communication from authorities about water quality. The project aims to improve disaster response and provide new findings on the relationship between people and critical infrastructure.
Researchers found Amazon dark earth boosts tree growth by twice to five times normal height with 20% ADE and three to six times with 100% ADE. The soil also contains more nutrients, including phosphorus, and has a higher pH. Biotech applications aim to replicate these characteristics without requiring the finite resource.
Researchers at WVU's forensic lab discovered how organic and inorganic compounds in gunshot residue differ in their persistence on surfaces and transfer. This breakthrough allows crime scene investigators to distinguish between 'greener' and traditional ammunition, enabling faster and more informed decisions at crime scenes.
A study by the Netherlands Institute of Ecology found that great tits are struggling to adapt their breeding timing to cope with climate change, leading to a decline in population numbers. The researchers used innovative methods to speed up evolution and predict the impact of climate change on natural selection.
A Virginia Tech study found that hellbender fathers are more likely to eat their eggs in deforested areas, leading to a drastic increase in filial cannibalism. The research suggests that protecting and re-establishing forest cover around streams is crucial for the species' survival.
A study by Flinders University researchers found that short exposure to wind farm and road traffic noise triggers a small increase in waking from slumber, fragmenting sleep patterns. However, wind farm noise wasn't more disruptive to sleep than road traffic, which was slightly more disruptive at higher audio levels.
Researchers from the University of Arkansas found that organic sweetpotato growers can improve yields by selecting top-performing cultivars and using winter cover crops. The study also showed benefits for conventional production systems, as limited herbicides are available for weed management in sweetpotatoes.
Soil microbiology research increasingly relies on big data, with experiments moving from labs to fields. Discrepancies between lab and field studies impact policies due to inconsistent results. Bridging the gap requires interdisciplinary collaboration to improve upscaling of soil microbiology research.
A recent study by Sara Valentini and colleagues at Bocconi University found that consistency between online content and the values associated with a brand increases rebroadcasting frequency. Posts containing price promotions also perform well when aligned with the brand's identity, with followers being 109% more likely to share them.
Researchers at North Carolina State University found that adding nonanal, a chemical used in perfumes, to a pheromone blend increases its effectiveness in mimicking female fall armyworm calls. The discovery could help farmers detect and control fall armyworm populations more effectively.
Researchers have developed a novel autonomous, submersible, 3D holographic microscope and imaging system to study marine particles and plankton in their natural environment. The AUTOHOLO system achieved 90% accuracy in detecting red tide blooms at varying concentrations, enabling near real-time monitoring and tracking of bloom phases.
A Swansea University research study has evaluated the long-term environmental impacts of different Japanese knotweed management methods. The study found that glyphosate-based foliar spray control is the most sustainable approach, using the least materials and having the lowest economic costs.
A recent study by Xi'an Jiaotong-Liverpool University found that ethnic minority parents in Inner Mongolia prefer evidence-based knowledge on family education tailored to their local environment and culture. They sought information on how geographical features like the geomagnetic field influence children's growth and well-being.
Scientists have discovered a new virus that can kill antibiotic-resistant bacteria, including Pseudomonas aeruginosa. The virus, named Fyn8, was found in local creeks near the University of Southern Denmark campus and has been fully sequenced.
Researchers used unconventional methods to study fruit fly phenotypes, finding that loss of epigenetic mark led to changes in behavior, gene expression, metabolism, and offspring production. This knowledge can aid in predicting ecological patterns of change in wild animal populations.
Researchers from Northwestern University have developed a new biosensor device that accurately detects toxic levels of fluoride in water, allowing for easy use outside of a lab. The device has been field-tested in rural Kenya, showing excellent accuracy and usability results.
Scientists from Okayama University used environmental DNA (eDNA) to survey the distribution and population density of the endangered bitterling fish in Japan. They found that eDNA concentrations vary according to the downstream channel distance, providing a reference for conservation surveys.
A new study found a negative relationship between honey bee abundance and wild bee species richness, with small species being most affected. The research suggests that honey bee population increases may be threatening local wild bee communities in urban areas.
Researchers found that giving donors control over charitable project allocation increases donations and loyalty. Donors who value agency are more likely to be loyal, active, and generous, increasing fundraising effectiveness.
Researchers found that salmon carcasses can cause wildflowers to grow bigger and produce more seeds, shedding light on the impact of climate change on rivers and streams. The study, published in Royal Society Open Science, extends previous knowledge about nitrogen isotopes and their connection to plant growth.
Researchers discovered host proteins APOBEC3 can aid HIV's latency, a major hurdle to cure research. The finding raises questions about the role of these proteins and potential ways to block their activity to inhibit viral persistence.
A study found that nearly half of Russian university graduates with higher education do not work in their field of study, resulting in a salary reduction of 7-14%. The researchers discovered that those who studied general fields like pedagogy and IT are more likely to experience horizontal mismatch.
Researchers highlight recent progress in organotypic models, which offer a balance between the accessibility and control of in vitro context. These models have been used to study various aging-related phenotypes, including skin, gut, and skeletal muscle, providing valuable insights into the underlying mechanisms.
Researchers analyzed coyote diets and movement in Cape Breton Highlands National Park to determine why a lone hiker was attacked. The study found that coyotes relied on moose due to resource scarcity, adapting their behavior to exploit this unusually large food source.
A quarter-mile segment of the Klamath Geo Trail was successfully resurfaced using volcanic ash from Mount Mazama, demonstrating its potential as a more sustainable and locally sourced pozzolan. The surface treatment improved firmness and stability, making it accessible to people with mobility devices.
The study analyzed experimental parameters, nanomaterial types, and plant exposure duration. It found that many studies lacked positive controls and had short durations compared to crop lifecycles.
Researchers created a Facebook-like prototype platform, called Trustnet, where users rate posts as accurate or inaccurate before sharing. This approach showed that people effectively assess misinforming posts and share their assessments with others.
Researchers at University of Jyväskylä used machine learning to predict ACL injuries in elite athletes but found a low overall accuracy rate. The study analyzed the largest data set ever collected and provided valuable insights into the challenges of predicting injuries in individual athletes.
Research has found that former Scottish international rugby union players are at a significantly increased risk of developing neurodegenerative diseases, including dementia and motor neurone disease. The study's findings suggest that strategies to reduce head impact and traumatic brain injury in all sports are necessary.
SourceBMJ Group·JournalJournal of Neurology Neurosurgery & Psychiatry·TypeObservational study·DateOct 4, 2022
Researchers found that a common autism screening test consistently excludes more women than men from research studies, creating a 'leaky pipeline' for diagnosis and treatment. This bias is attributed to the test's origins in male-dominated samples, which may not accurately capture female phenotypes.
A study of wild baboons in southern Kenya found that most carry traces of hybridization in their DNA, with about a third of their genetic makeup coming from another species. However, new genetic evidence reveals that some borrowed genes came at a cost, affecting the hybrids' survival and reproduction.
Researchers from the University of Turku have described seven new species of tropical ferns, including six from the genus Danaea and one from Dennstaedtia. The newly discovered species range from 20cm to 2m tall and offer insights into the biodiversity of Amazonian rainforests.
A new species of giant keelback slug, Limax pseudocinereoniger, has been discovered in Montenegro's Tara Canyon by an international team of citizen scientists. The slug, which can grow up to 20 cm in length, was identified through DNA analysis and anatomical differences from a similar species.
Researchers developed a hot-carrier multijunction solar cell that maintains high conversion efficiency with nonoptimal materials, expanding the scope of candidate designs. The novel architecture showed superior resilience to design imperfections, widening the range of suitable materials and operating conditions.
A new study examining body-worn camera use in Phoenix found that departmental policy is a crucial factor in determining activation rates. The study revealed that policies confining, structuring, and checking officer discretion significantly impact decisions on turning on the cameras.
A new project led by INRS will assess how living organisms respond to reduced pesticide use, focusing on soil and water health. The study aims to provide a clear understanding of the benefits and limitations of reducing pesticide use in sustainable farming.
Scientists have partnered with park rangers in Ecuador to monitor butterfly populations, which serve as an indicator of ecosystem health. This approach aims to provide a more comprehensive understanding of biodiversity changes over time, addressing the limitations of traditional conservation methods.
A study published in Current Biology found that people share similar odour preferences regardless of cultural background. The researchers discovered that the structure of the odour molecule determines whether a smell is considered pleasant or not.
A recent study led by the University of Zurich found that well-integrated male dolphins with strong social bonds to many alliance partners produce the most offspring. The researchers analyzed 30 years of behavioral data from 85 male dolphins and used genetic data to conduct paternity analyses for more than 400 dolphins.