Life Span
Articles tagged with Life Span
Screening modestly reduces prostate cancer deaths
Large-scale multi-omics study aims to decode aging in the Indian population
Global experts highlight path toward actionable interventions in human aging
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
Plant-based dietary patterns linked to slower epigenetic aging
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
UT Health San Antonio launches clinical trial to study rapamycin and healthy aging
A multi-phase clinical study will examine dosing, safety and long-term effects of rapamycin in older adults to guide future research on extending health span. Researchers aim to establish evidence-based guidance for the drug's use and move beyond speculation.
Next-generation metabolic theory suggests glycolytic ATP decline may limit lifespan
A new metabolic theory proposes that a decline in glycolytic ATP production is the fundamental mechanism limiting lifespan. Species with an optimal rate of decline survived, suggesting that maintaining a stable glycolytic flux may support repair processes and tissue regeneration. The authors propose testing this hypothesis through expe...
Barshop Institute to receive up to $38 million from ARPA-H, anchoring UT San Antonio as a national leader in aging and healthy longevity science
The Barshop Institute will conduct the VITAL-H trial, evaluating the repurposing of FDA-approved medications to delay age-related health decline in generally healthy middle-aged adults. The trial aims to preserve everyday abilities during a critical window of midlife aging.
Centenarians' blood sheds light on the mechanisms of longevity
The 'SWISS100' study identified 37 proteins in centenarians' blood whose profile appears linked to slower ageing, with remarkably low oxidative stress markers. Centenarians also show profiles surprisingly close to those of younger individuals, particularly with youthful expression levels of regulatory proteins of the extracellular matrix.
Lifespan-extending treatments increase variation in age at time of death
Lifespan-extending treatments and dietary restriction have increased variance in age-at-death in vertebrates, failing to 'square the survival curve'. The findings highlight that current interventions do not equally benefit all individuals, leading to a biological lottery.
Cumulative lifespan stress, inflammation, and racial disparities in mortality between black and white adults
A cohort study of St. Louis adults found that heightened cumulative lifespan stress and elevated inflammation were associated with shorter survival among Black participants. The findings highlight the need for policies addressing structural racism and treatments reducing inflammation to reduce mortality disparities.
Mix of different types of physical activity may be best for longer life
Research published in BMJ Medicine found that a mix of different types of physical activity may be best for prolonging the lifespan. Variety rather than total quantity alone is linked to a lower risk of death, with some activities associated with a 15% lower risk of death from all causes.
Long-term pesticide exposure accelerates aging and shortens lifespan in fish
Research led by University of Notre Dame biologist Jason Rohr found that chronic exposure to the insecticide chlorpyrifos causes fish to age faster at the cellular level, leading to accelerated aging and reduced lifespan. The study suggests that low-level exposures can silently accumulate damage over time.
Chronic low-dose pesticide exposure reduces the life span of wild lake fish, China-based study shows
A new study shows that chronic low-dose pesticide exposure reduces the life span of wild lake fish in China by accelerating physiological aging. Fish from pesticide-impacted lakes exhibited shortened telomeres and truncated population structures, dominated by younger individuals.
Number and timing of children linked to biological aging
The study found that women with two to three children tend to live the longest, while those with an above-average number of children have shorter lifespan. Pregnancies between ages 24 and 38 were also linked to more favorable aging patterns.
Contraception and castration increase lifespan in mammals
A comparative study of 117 mammal species found that reproductive suppression increases lifespan by an average of ten percent. The study suggests that blocking reproduction allows more energy to be directed towards longevity, with significant effects observed in various mammalian groups.
Contraception and castration linked to longer lifespan
A new study published in Nature found that contraception and castration increase life expectancy in both males and females. In males, castration extends lifespan, while in females, various forms of sterilization are associated with increased life expectancy due to reduced energetic costs of pregnancy and lactation.
Protein puppeteer pulls muscle stem cells’ strings
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
Conquer the diseases of aging and humans could live far longer than we think, scientists propose
Researchers argue that widely used proxies for aging may conflate genuine modifications with simpler effects on physiology. Targeting specific pathologies can extend lifespan without slowing aging process. Historically, increased human lifespan was primarily driven by reduced infectious disease mortality, not a fundamental slowing of a...
European consortium together transforming future of COPD care
A European consortium developed a new decision-making framework to predict COPD exacerbation severity and prognostic risk, integrating three key factors: baseline health status, event intensity, and triggers. This framework, known as BAt model, aims to guide treatment strategies and improve consistency across clinical settings.
New clues to why some animals live longer
A study by University of California, Riverside scientists found that alternative RNA processing, or
Lung cancer deaths prevented and life-years gained from lung cancer screening
Lung cancer screening has the potential to prevent 3 times more deaths and gain 3 times more life-years than current levels. Increasing awareness and accessibility of lung cancer screening could lead to wider adoption.
High tyrosine levels linked to shorter lifespan in men
A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
Racial disparities in premature mortality and unrealized Medicare benefits across US states
Premature mortality among adults aged 18-64 increased by over 27% between 2012 and 2022, with racial disparities widening substantially. Despite contributing to Medicare, Black individuals are less likely to live long enough to reach the qualifying age for coverage, resulting in unrealized benefits.
Aging as evolutionary success
Anthropologist Michael Gurven challenges youth-obsessed culture by exploring aging's physiological and societal aspects, asserting that evolution designed humans to live at least seven decades. Multigenerational cooperation played a key role in the evolution of a post-reproductive life stage.
Genetic link discovered between childhood intelligence and parental longevity
A significant genetic correlation has been identified between childhood cognitive function and parental longevity, providing molecular evidence for the connection. The study found that shared genetic factors influence both early cognitive abilities and lifespan, with a genetic correlation of 0.35.
Research Spotlight: Mapping overlooked challenges in stroke recovery
Stroke survivors' lived experiences reveal key factors that shape their physical and emotional wellbeing during recovery. The study highlights the importance of integrating lived experiences in stroke research to improve care models.
It’s never too late for those with cancer to quit smoking
Researchers found that quitting smoking more than doubles survival time among patients with advanced cancers. The study shows the benefits of integrated smoking cessation interventions into cancer treatment plans.
Does prior incarceration contribute to poor health later in life?
A recent analysis found that former inmates report worse health than non-incarcerated peers, even years after release. The study, published in the Journal of the American Geriatrics Society, suggests that clinicians consider screening for incarceration history and connecting patients to supportive services.
Why women live longer than men
A study by Max Planck Institute for Evolutionary Anthropology found that women generally outlive men, with females living 12% longer on average in most mammals. This gap is attributed to genetic differences, reproductive strategies, and parental investment, which provide a survival advantage to females.
Sex-specific effects found in new anti-aging therapy for elderly mice
Researchers found that a combination of oxytocin and an Alk5 inhibitor significantly extended the lifespan and healthspan of frail, elderly male mice, but not female mice. This dual-drug approach reduced chronic inflammation and tissue damage, leading to improved physical endurance and memory in males.
Rates of alcohol-induced deaths among the general population nearly doubled from 1999 to 2024
Rates of alcohol-induced deaths in the US nearly doubled between 1999 and 2024, reaching a record high in 2021. The largest increase was among females aged 25-34, with mortality rates rising by 255%.
New perspective outlines how food-derived signals can modulate biological aging
A new perspective suggests that food-derived signals can modulate biological aging by influencing lifestyle choices such as diet, physical activity, and sleep. Targeted nutritional approaches have been shown to slow down aging and preserve cognitive function, highlighting the potential of precision nutrition interventions.
New research reveals longevity gains slowing, life expectancy of 100 unlikely
A new study by University of Wisconsin-Madison researchers found that life expectancy gains made in high-income countries have slowed significantly since the first half of the 20th century. As a result, none of the generations born after 1939 will reach 100 years of age on average.
Cohort life expectancy is no longer rising as quickly
Researchers based calculations on six different methods and found life expectancy for those born between 1939 and 2000 is rising more slowly. The rate of increase slowed by 37-52% depending on the method used, with forecasts indicating none of these cohorts will reach 100 years of life expectancy.
Study in twins links childhood environment to epigenetic aging and cognitive decline
A new research paper found that epigenetic aging is linked to cognitive decline in midlife, with twins experiencing a larger drop in IQ scores if they had grown up in families with lower socioeconomic status. This study provides new evidence for the impact of childhood adversity on brain aging.
Global estimates of lives and life-years saved by COVID-19 vaccination during 2020-2024
A comparative effectiveness study estimates that COVID-19 vaccinations averted 2.5 million deaths during 2020-2024, with the majority of benefits secured for older adults within this age group.
Defining lifetime risk thresholds for breast cancer surgical prevention
A new study finds that risk-reducing mastectomy is cost-effective for women aged 30-55 with a lifetime breast cancer risk of 35% or higher. The findings have significant clinical implications, suggesting that RRM could expand access to the procedure beyond BRCA1/BRCA2/PALB2 pathogenic variant carriers.
Being consistently physically active in adulthood linked to 30–40% lower risk of death
A pooled data analysis of 85 studies found that consistently physically active adults had a 30–40% lower risk of death from any cause. Increasing physical activity levels also resulted in a 20–25% lower risk of death, with switching to an active lifestyle at any point extending lifespan.
New research in JNCCN offers reassurance about localized prostate cancer prognosis
A study of 62,839 people diagnosed with non-metastatic prostate cancer in Sweden found that those treated according to NCCN Guidelines were likely to survive their cancer for their remaining life-expectancy. Those with low- and intermediate-risk cancer were six times more likely to die of other causes than prostate cancer.
Shorter telomeres linked to increased risk of age-related brain diseases
Research from Mass General Brigham found that individuals with shorter telomeres and less optimal lifestyle choices are at greater risk for stroke, dementia, and late-life depression. However, those with healthier lifestyles showed no increased risk, suggesting a potential mitigation effect.
Scientists develop new blood-based proteomic score to predict healthspan and disease risk
Researchers developed a blood-based proteomic score to predict healthy aging and age-related diseases. A lower score is associated with higher mortality and disease risk, offering a powerful tool for understanding biological aging.
Iowa State researchers find key factor linking longer maturation to longer life in fruit flies
A recent study by Iowa State University researchers found that fruit flies missing a crucial developmental hormone, PTTH, live up to 30% longer due to reduced inflammaging. The connection between developmental timing and lifespan in fruit flies could be a useful model for studying human longevity.
Can engaging in social activities prolong life?
A study of 2,268 US individuals aged 60+ found strong association between social activities and low 4-year mortality risk. High social engagement, such as charity work and sports participation, was significantly linked to reduced risk of dying.
Road traffic accidents leading cause of pet cat deaths in the UK, Bristol Cats study finds
New research by the University of Bristol and Cats Protection reveals that road traffic accidents are the leading cause of death in UK pet cats under 8 years old. The study found that younger cats are at higher risk of death due to RTAs, while older cats are more likely to die from disease-related causes.
New research reveals nature’s secret to healthy longevity
Researchers from Bar-Ilan University discovered a link between protein modifications and extended lifespan in long-lived mammals. The study identified posttranslational modifications associated with increased resilience against age-related diseases, such as cancer and diabetes.
SwRI receives $3.2 million DARPA contract to predict life of AM components
Researchers will use sensors and software to predict AM part lifespan, enabling cost savings and extending part life. The project aims to improve Darwin software to provide detailed insights into manufacturing processes.
Even the richest Americans face shorter lifespans than their European counterparts, study finds
A study by Brown University researchers found that Americans across all wealth levels have poorer survival rates than Europeans. The gap between rich and poor in the US is larger than in Europe, contributing to lower life expectancy.
Hidden virus harboured by fruit flies may influence experimental accuracy
A new study reveals that the presence of Nora virus in laboratory strains of Drosophila fruit flies can increase their sensitivity to bacterial infection and limit their lifespan. Flies with persistent viral infections have higher stem cell growth rates, making them more susceptible to secondary pathogenic infections.
UTA takes lead with mobile lab to address rural health care crisis
The University of Texas at Arlington has launched a new Mobile Simulation Lab to tackle workforce and training challenges in rural areas. The lab, equipped with advanced patient manikins and simulation bays, will provide specialized training for local healthcare providers to expand their expertise.
Tapuy rice wine fermentation yields possible anti-aging superfood
Filipino researchers found a way to enhance tapuy lees for high polyphenol content and antioxidant activity, extending test animal lifespan and health. The study suggests repurposing tapuy lees as a health food to combat aging and oxidative stress-related diseases.
Breakthrough nano-spring technology boosts battery durability and energy density
Researchers developed a 'nano-spring coating' technology to increase the lifespan and energy density of EV batteries. The technology, featuring multi-walled carbon nanotubes, absorbs strain energy generated from charging and discharging, preventing cracks and improving stability.
Does exercise really extend life? Finnish twin study offers new insights
A Finnish twin study investigated the relationship between long-term leisure-time physical activity and mortality, finding that moderate activity offers a 7% lower mortality risk. The study also found no additional benefit from high levels of physical activity in reducing mortality risk.
Birds’ high blood sugar defies ageing expectations
A large-scale comparative study reveals that some birds have evolved mechanisms to resist protein glycation, a process causing cellular damage from high blood sugar levels. This challenges conventional wisdom on metabolism and ageing in birds.
The Exercisers: Appearance is more important than physical health
A new study from Tel Aviv University used AI tools to discover that 23.9% of people exercise to improve their appearance, while 18.9% prioritize physical health and 16.9% for mental well-being. The study also identified effective strategies for maintaining physical fitness, including creating exercise habits.
Mizzou researchers identify first-ever neurotherapeutic to address muscle weakness
Researchers at the University of Missouri have identified a small molecule drug that targets a specific serotonin receptor, showing promise as a treatment for sarcopenia. The study suggests that this neurotherapeutic can improve muscle strength by activating motor neurons to fire more effectively.
Better semen quality is linked to men living longer
A large study of nearly 80,000 men found that those with better semen quality lived two to three years longer than those with poorer semen quality. The research suggests that poor semen quality may be an indicator of underlying health issues, and could potentially detect early signs of disease.
Dental implants still functional after forty years
A recent study from the University of Gothenburg found that dental implants continue to function well after nearly forty years. The implants, developed by Professor Per-Ingvar Brånemark, have been shown to remain stable and integrate with bone over an extended period.
Scientists crack the code to longer-lasting perovskite solar technology
Researchers have discovered a way to trap iodine in perovskite solar cells using alumina nanoparticles, enhancing lifespan and stability. The modified solar cells maintained high performance for over two months under extreme conditions.
Move more, age well: Prescribing physical activity for older adults as a recipe for healthy aging
A review article discusses the importance of physical activity in preventing disease and improving functional independence among older adults. Higher levels of physical activity are associated with improved cognition, mental health, and quality of life, and can potentially add years to an individual's life.