Articles tagged with Life Span
Long-lived organisms exhibit better DNA maintenance, stress resistance, regenerative capacity, and stem-cell populations compared to shorter-lived species. Comparative genomic studies have identified longevity-associated pathways, including apoptosis, protein homeostasis, and oxidative-stress resistance.
Researchers found that gut bacteria-derived polyamines, including putrescine and spermidine, contribute to extended lifespan in fruit flies. The study used genetically engineered E. coli to investigate the specific contribution of polyamines to host lifespan, revealing a sex-dependent effect with males living longer than females.
Research reveals that targeting insulin/IGF-1 signaling pathway in C. elegans extends male lifespan by 446% and improves reproductive healthspan, with whole-body degradation required for reproductive benefits. The study highlights the importance of coordinated effects across multiple tissues and physiological systems.
The study found that Indy gene reduction is associated with lower bacterial load and higher bacterial diversity in aging fruit flies compared to controls. Reduced Indy activity also linked to improved intestinal homeostasis, reduced oxidative stress, and maintenance of gut integrity.
Researchers found that GLP-1 treatment improved muscle and cognitive function, and reduced hallmarks of natural aging in older mice. The treatment also extended lifespan by nearly 100 days, suggesting a potential therapeutic route for slowing physiological aging.
Researchers identified a compound, PF-04457845, that slows ALS progression in mice, with potential as a therapeutic option. The compound targets N-acyl taurines, which correlate with ALS progression, and has been proven safe in humans.
Cyclin D1, a protein linked to cancer, paradoxically promotes chronic inflammation in non-proliferating senescent cells, which can lead to age-related disease. Research suggests that targeting cyclin D1 may be a promising strategy to reduce inflammation and promote healthier aging.
A study led by Albert Einstein College of Medicine found that children of centenarians live longer and have lower risks of cardiovascular disease and hypertension. The research, analyzing data from three geographically diverse studies, suggests that inherited biological factors beyond lifestyle contribute to exceptional healthy aging.
A new review suggests metformin's interactions with multiple hallmarks of aging, including cellular energy balance, nutrient-sensing pathways, and epigenetic regulation. The study identifies strong evidence for metformin's effects on aging biology, including improved insulin sensitivity and reduced oxidative stress.
Researchers found that longer-lived bats have higher levels of cancer-fighting genes and an immune system that can mount an overwhelming attack against infectious organisms and cancer. This discovery suggests that understanding one will help scientists understand the other.
The 13th Aging Research and Drug Discovery Meeting (ARDD) 2026 will bring together leading researchers, clinicians, and industry experts to advance aging research and accelerate age-related disease interventions. Aging is proud to support ARDD as a media partner, promoting the event through its digital and social media channels.
Researchers reviewed grant data from 2015-2022, supporting investment in a strong evidence base for obesity and cancer research. Key areas of focus include obesity's impact on cancer treatment and survivorship, as well as disparities in cancer outcomes.
Researchers from Tohoku University and the University of Tokyo developed super exosomes that target senescent cells, improving frailty and physical performance in aged mice. The technology has potential applications in healthy aging, cognitive function, and reproductive medicine.
Misha Blagosklonny's work challenged traditional paradigms in aging biology, proposing that persistent growth-promoting signals drive age-related pathology. His hyperfunction theory integrates evolutionary concepts with molecular pathways, offering a comprehensive framework for understanding aging.
A new research perspective proposes that developmental and growth programs continue operating beyond their beneficial period, driving aging. Programmatic mechanisms of aging are supported by evidence from animal models and experimental observations.
A recent review suggests that consuming less protein could have greater health benefits and potentially extend lifespan. The review highlights the role of fibroblast growth factor 21 (FGF21) in slowing aging by improving metabolism, reducing cellular damage, and preserving healthy cell function.
Researchers found that lifelong PQQ and IPQ supplementation in senescence-accelerated mice reduced mortality risk during midlife and delayed aging progression. Middle-aged mouse supplementation also improved age-related muscular dysfunction. The study suggests a potential healthspan extension benefit of these compounds.
A global study led by NUS Medicine found that Singaporeans have the highest life expectancy and healthy life expectancy, but a growing number of years are spent in poor health. The morbidity gap has widened globally, with people spending more years lived with illness or disability.
A new Global Burden of Disease study found that people are spending more years living with chronic disease and disability as global life expectancy increases. The analysis revealed that high-income countries face the widest morbidity gaps, while women consistently live longer but spend more years in poor health.
Researchers found that preserving peroxisomes preserves mitochondrial health during aging by maintaining long, interconnected mitochondrial networks and reducing oxidative stress. The study identifies peroxisome homeostasis as a promising area for future aging research.
A comprehensive systematic review clarifies life expectancy across rare progeria disorders, revealing striking differences among subtypes. The analysis demonstrates that patients with Hutchinson-Gilford progeria syndrome have a median survival of 16 years, while those with mandibuloacral dysplasia type B have a median survival of 37 ye...
Researchers found that a 12-week lifestyle program combining exercise guidance, dietary counseling, and daily yogurt consumption significantly slowed DunedinPACE, an epigenetic measure of biological aging. The intervention resulted in a modest but statistically significant slowing of the pace of aging, corresponding to a 2.2% reduction.
A study of 585 older adults found that different patterns of depressive symptoms are associated with disability-free survival, differing between men and women. Stronger feelings of 'worthlessness' were a significant risk factor for men, while 'anxiety' was a bigger risk factor for women.
A US-based longitudinal study found that Black fathers have lower all-cause mortality rates by middle age compared to nonfathers. The association was not observed in White fathers, highlighting racial differences in health outcomes of fathers.
A new study found that DNA methylation aging biomarkers, such as GrimAge2 and DunedinPoAm, significantly mediate the relationship between social disadvantage and mortality risk. The findings suggest that epigenetic aging measures capture the cumulative effects of multiple social and environmental stressors.
The editorial highlights the growing importance of public health interventions to extend healthspan alongside lifespan. Key findings include the need for integrated strategies addressing environmental, metabolic, social, and behavioral exposures that accelerate biological aging and increase vulnerability to chronic disease. The authors...
A Chinese endoscopy-screened cohort study found that genetic risk and lifestyle factors independently contribute to upper gastrointestinal cancer risk. Integrating genetic risk with lifestyle information may improve risk stratification and identify individuals most likely to benefit from screening and prevention.
Screening with a PSA blood test reduces prostate cancer deaths by approximately 2 for every 1,000 men screened. The review found that 500 men would need to be invited to screening to prevent one prostate cancer death.
The BHARAT study, led by the Indian Institute of Science, is a groundbreaking initiative that integrates clinical, molecular, lifestyle, and environmental data from diverse demographic groups in India. The study aims to develop population-specific biological aging signatures and predictive models tailored to Indian populations.
The 12th ARDD meeting emphasized the importance of reversing biological age and identifying molecular mechanisms that can be targeted to modify them. Researchers presented new biomarkers and AI-designed proteins to develop novel therapeutics, with a focus on integrated, multi-targeted therapeutic strategies.
A new study published in Aging-US found that plant-based dietary patterns are associated with slower epigenetic aging. The research analyzed data from two large cohorts and found that higher intake of plant foods was linked to decelerated biological aging.
A multi-phase clinical study will examine dosing, safety and long-term effects of rapamycin in older adults to guide future research on extending health span. Researchers aim to establish evidence-based guidance for the drug's use and move beyond speculation.
A new metabolic theory proposes that a decline in glycolytic ATP production is the fundamental mechanism limiting lifespan. Species with an optimal rate of decline survived, suggesting that maintaining a stable glycolytic flux may support repair processes and tissue regeneration. The authors propose testing this hypothesis through expe...
The 'SWISS100' study identified 37 proteins in centenarians' blood whose profile appears linked to slower ageing, with remarkably low oxidative stress markers. Centenarians also show profiles surprisingly close to those of younger individuals, particularly with youthful expression levels of regulatory proteins of the extracellular matrix.
Lifespan-extending treatments and dietary restriction have increased variance in age-at-death in vertebrates, failing to 'square the survival curve'. The findings highlight that current interventions do not equally benefit all individuals, leading to a biological lottery.
The Barshop Institute will conduct the VITAL-H trial, evaluating the repurposing of FDA-approved medications to delay age-related health decline in generally healthy middle-aged adults. The trial aims to preserve everyday abilities during a critical window of midlife aging.
A cohort study of St. Louis adults found that heightened cumulative lifespan stress and elevated inflammation were associated with shorter survival among Black participants. The findings highlight the need for policies addressing structural racism and treatments reducing inflammation to reduce mortality disparities.
Research published in BMJ Medicine found that a mix of different types of physical activity may be best for prolonging the lifespan. Variety rather than total quantity alone is linked to a lower risk of death, with some activities associated with a 15% lower risk of death from all causes.
Research led by University of Notre Dame biologist Jason Rohr found that chronic exposure to the insecticide chlorpyrifos causes fish to age faster at the cellular level, leading to accelerated aging and reduced lifespan. The study suggests that low-level exposures can silently accumulate damage over time.
A new study shows that chronic low-dose pesticide exposure reduces the life span of wild lake fish in China by accelerating physiological aging. Fish from pesticide-impacted lakes exhibited shortened telomeres and truncated population structures, dominated by younger individuals.
The study found that women with two to three children tend to live the longest, while those with an above-average number of children have shorter lifespan. Pregnancies between ages 24 and 38 were also linked to more favorable aging patterns.
A comparative study of 117 mammal species found that reproductive suppression increases lifespan by an average of ten percent. The study suggests that blocking reproduction allows more energy to be directed towards longevity, with significant effects observed in various mammalian groups.
A new study published in Nature found that contraception and castration increase life expectancy in both males and females. In males, castration extends lifespan, while in females, various forms of sterilization are associated with increased life expectancy due to reduced energetic costs of pregnancy and lactation.
Researchers found that the tenascin-C protein promotes a thriving community of functional muscle stem cells needed for efficient muscle regeneration. Aging reduces skeletal muscle regeneration due to lower levels of TnC and impaired muscle stem cell function.
Researchers argue that widely used proxies for aging may conflate genuine modifications with simpler effects on physiology. Targeting specific pathologies can extend lifespan without slowing aging process. Historically, increased human lifespan was primarily driven by reduced infectious disease mortality, not a fundamental slowing of a...
A European consortium developed a new decision-making framework to predict COPD exacerbation severity and prognostic risk, integrating three key factors: baseline health status, event intensity, and triggers. This framework, known as BAt model, aims to guide treatment strategies and improve consistency across clinical settings.
A study by University of California, Riverside scientists found that alternative RNA processing, or
Lung cancer screening has the potential to prevent 3 times more deaths and gain 3 times more life-years than current levels. Increasing awareness and accessibility of lung cancer screening could lead to wider adoption.
A new study found that high tyrosine levels are associated with a shorter lifespan in men, while phenylalanine showed no such link. The researchers suggest that dietary adjustments, such as protein restriction, could help reduce tyrosine levels and support healthier aging.
Premature mortality among adults aged 18-64 increased by over 27% between 2012 and 2022, with racial disparities widening substantially. Despite contributing to Medicare, Black individuals are less likely to live long enough to reach the qualifying age for coverage, resulting in unrealized benefits.
Anthropologist Michael Gurven challenges youth-obsessed culture by exploring aging's physiological and societal aspects, asserting that evolution designed humans to live at least seven decades. Multigenerational cooperation played a key role in the evolution of a post-reproductive life stage.
A significant genetic correlation has been identified between childhood cognitive function and parental longevity, providing molecular evidence for the connection. The study found that shared genetic factors influence both early cognitive abilities and lifespan, with a genetic correlation of 0.35.
Stroke survivors' lived experiences reveal key factors that shape their physical and emotional wellbeing during recovery. The study highlights the importance of integrating lived experiences in stroke research to improve care models.
Researchers found that quitting smoking more than doubles survival time among patients with advanced cancers. The study shows the benefits of integrated smoking cessation interventions into cancer treatment plans.
A recent analysis found that former inmates report worse health than non-incarcerated peers, even years after release. The study, published in the Journal of the American Geriatrics Society, suggests that clinicians consider screening for incarceration history and connecting patients to supportive services.
A study by Max Planck Institute for Evolutionary Anthropology found that women generally outlive men, with females living 12% longer on average in most mammals. This gap is attributed to genetic differences, reproductive strategies, and parental investment, which provide a survival advantage to females.
Researchers found that a combination of oxytocin and an Alk5 inhibitor significantly extended the lifespan and healthspan of frail, elderly male mice, but not female mice. This dual-drug approach reduced chronic inflammation and tissue damage, leading to improved physical endurance and memory in males.
Rates of alcohol-induced deaths in the US nearly doubled between 1999 and 2024, reaching a record high in 2021. The largest increase was among females aged 25-34, with mortality rates rising by 255%.
A new perspective suggests that food-derived signals can modulate biological aging by influencing lifestyle choices such as diet, physical activity, and sleep. Targeted nutritional approaches have been shown to slow down aging and preserve cognitive function, highlighting the potential of precision nutrition interventions.
A new study by University of Wisconsin-Madison researchers found that life expectancy gains made in high-income countries have slowed significantly since the first half of the 20th century. As a result, none of the generations born after 1939 will reach 100 years of age on average.