Research on depression and its treatment. Covers stress-response biology, ketamine and dopamine-targeting therapies, treatment-resistant cases, and brain mechanisms.
A new study from the University of Chicago Medicine challenges conventional notions about alcohol's effects in depressed people who drink excessively. Participants with AUD and depression reported feeling acute, sustained positive and rewarding alcohol effects similar to non-depressed counterparts.
A Maynooth University study found that 84% of Parkinson's patients struggle with sleep issues, linked to depression, independent living difficulties and a decline in quality of life. Sleep problems worsen the severity of 'OFF periods' and are a significant burden on quality of life.
A new study suggests that women at risk of postpartum depression may have characteristic levels of neuroactive steroids in their blood during pregnancy. Elevated progesterone levels and imbalances in its metabolism may be associated with an increased risk of PPD.
A preliminary study found that shorter protective caps at the end of chromosomes (telomeres) may be more likely to develop age-related brain diseases such as stroke, dementia, and late-life depression. Adopting healthier lifestyles could lower the negative effects of shorter telomeres.
A preliminary study presents a link between stroke and mental health challenges in children, highlighting the need for early intervention and screening. The analysis found that kids who have a stroke are at higher risk of developing anxiety, depression, and related physical symptoms.
Research highlights three vulnerable populations: racial and ethnic minorities, financially insecure individuals, and those with chronic health conditions. Depression is a significant factor in social isolation among these groups.
A new Cochrane review confirms that antidepressants reduce anxiety symptoms in GAD patients under trial conditions. However, there is limited data on long-term usage and its potential benefits and harms.
A study by ISGlobal found that exposure to cold temperatures was associated with increased internalizing problems, while heat exposure was linked to attention problems in adolescents. Psychiatric symptoms affect about one in seven adolescents worldwide, and climate change may exacerbate these conditions.
Researchers at McGill University discovered a novel brain mechanism that explains why bipolar patients alternate between mania and depression. A dopamine-based 'second brain clock' controls mood shifts, operating in tandem with the body's natural sleep-wake cycle.
A recent study found that positive affectivity contributes to higher physical activity levels and increased activity during the COVID-19 pandemic. In contrast, depressive feelings are associated with lower physical activity levels. Mental well-being plays a crucial role in maintaining a physically active lifestyle.
Researchers identify key brain signals prediction error and expected value to predict recovery potential in depression. They found unique brain activity patterns that could inform tailored therapy strategies, targeting specific symptoms of depression.
A recent study by researchers from the University of Toronto found that older adults who experienced parental divorce during childhood have a 60% higher odds of stroke. The study controlled for known risk factors and still showed a strong association between parental divorce and stroke.
Dog owners cite emotional, physical, and social benefits of dog ownership, but also costly responsibilities. While daily life benefits include improved exercise and stability, the biggest cost is often cited as veterinary expenses.
A study published in JAMA Pediatrics found that childhood obesity treatment can reduce the risk of serious health problems such as type 2 diabetes, hypertension, and dyslipidaemia in young adults. However, it did not have a lasting impact on depression and anxiety, which remained unchanged regardless of treatment outcomes.
A recent study found that effective pediatric obesity treatment is associated with lower incidences of mortality in young adulthood. The treatment was also linked to reduced long-term morbidity, such as type 2 diabetes, dyslipidemia, and hypertension.
A UConn study found that Black adolescent girls experience higher levels of hair dissatisfaction and related depression compared to their peers. The research suggests that targeted interventions, such as positive messaging about hair and texture, may help improve hair satisfaction and reduce depressive symptoms.
Research identifies IL-1R1-expressing neurons in key brain regions, including the somatosensory cortex and hippocampus, which regulate sensory processing, mood regulation, and memory. The study provides new insights into how inflammation contributes to sensory, mood, and memory disorders.
A pilot study found that qigong significantly decreases chronic low back pain in US military veterans, improving physical function and reducing sleep disturbance. The holistic practice also showed positive effects on PTSD, depression, anxiety, and social roles, highlighting its potential as a nonpharmacological treatment option.
A Swedish study found that topical steroid withdrawal (TSW) is characterized by symptoms such as redness, pain, and itching, often accompanied by sleep problems. The study aimed to understand the phenomenon of TSW, which many patients consider a cortisone dependence.
A new study reveals that delta opioid receptor agonist KNT-127 has a rapid and effective antidepressant effect with minimal side effects. The research highlights the molecular mechanisms underlying its action, including mTOR signaling pathways and Akt activation in the medial prefrontal cortex.
A global study has identified nearly 300 genetic links to depression, revealing the condition's impact on the brain and suggesting new treatment targets. The research, involving over five million people from 29 countries, highlights existing drugs that could be repurposed for depression treatment.
A new study analyzing US data from over 27,500 participants reveals that retirees show more signs of depression than working individuals, with binge drinking exacerbating the issue. Moderate drinking appears to have fewer depressive symptoms compared to abstaining completely.
The PEARLDIVER project aims to develop a Europe-wide research infrastructure to accelerate the discovery of effective treatments for depression. By building a shared platform, researchers can quickly assess the safety and efficacy of new and existing medications, allowing clinicians to make informed decisions about treatment options.
Researchers found that participants who received early therapeutic interventions were significantly less likely to develop clinical depression within the first year. The interventions, which typically lasted six to twelve sessions, reduced symptoms and lowered the risk of depression by 42% in the first six months.
A recent study by Columbia University's Mailman School of Public Health found that engaging in volunteering activities can significantly reduce the odds of depression in community-dwelling older adults. The study, which analyzed data from over 2,900 participants aged 65-79, also revealed that older adults with a negative history of dep...
Researchers developed an AI-based method to analyze CEO depression from vocal acoustic features in conference calls. The study found that CEOs with higher levels of depression tend to receive larger compensation packages and are more responsive to negative feedback.
A new study found that only 11% of children and young people received a clinical diagnosis of an emotional disorder from CAMHS. Only 44% had their referral accepted, highlighting delays in receiving help.
A new study published in PNAS found that sleep deprivation leads to memory control deficits, making it harder to suppress unwanted memories. REM sleep rejuvenates brain regions that support memory inhibition, reducing the likelihood of intrusive memories.
Two studies suggest that psilocybin-assisted psychotherapy can improve mental health outcomes for patients with cancer and alcohol use disorder, reducing symptoms of anxiety, depression, and obsessive thoughts, while also promoting lasting personality changes.
The January issue of the American Journal of Psychiatry explores the use of psychedelic medications in psychiatry, addressing basic pharmacology, clinical efficacy, and public health considerations. The series of articles aims to provide sufficient evidence for therapeutic strategies utilizing psychedelic drugs.
Neuroscientist Professor Raz Yirmiya reveals a vital link between inflammation and depression through groundbreaking research. His work suggests that both activation and suppression of the immune system can trigger depressive symptoms, highlighting the need for personalized treatment approaches.
A longitudinal cohort study found that older drivers with major depressive disorder demonstrated higher rates of hard braking, cornering, and unpredictability in their driving patterns. Tailored interventions are crucial for maintaining independence and ensuring driving safety among this population.
A study of Californian adults aged 19-89 found that growth mindset was associated with lower levels of depression and higher well-being. The research suggests that a growth mindset may help protect mental health during challenging times.
Researchers developed a preclinical model of brain stimulation therapy that enhances the brain's ability to process conflicting evidence. This improvement in cognitive flexibility could lead to more effective treatments for conditions like depression, ADHD, and addiction.
People with severe depression who received vagus nerve stimulation showed significant improvement in depressive symptoms, quality of life, and ability to complete everyday tasks after a year. Despite this, the therapy remains unaffordable for many patients due to high costs.
A new study from Uppsala University shows that an app can help parents who are mourning the loss of a child, reducing symptoms of prolonged grief and post-traumatic stress. The app provides four components: learning about grief, finding support, practical exercises, and a 'grief meter' to track feelings.
A new study published in the Journal of Medical Internet Research found that dancing improves both self-reported questionnaires and MRI brain scans in people with Parkinson disease. The study, conducted by York University researchers, showed a cumulative effect of dance classes on depression rates over 8 months.
Research published in PLOS ONE found that older adults in the U.K. are more likely to be repeatedly victimized by cybercrime, resulting in significant financial loss. This demographic is particularly vulnerable due to factors such as health conditions and social isolation.
A new NIH study has found that spending time in childcare does not significantly affect young children's mental health, even among those facing early adversity. The study followed over 2,000 parent-child pairs and found no link between hours spent in childcare and symptoms of anxiety, depression, or aggression.
Researchers found that a blunted response to reward feedback in teens predicts the first onset of depression, but not anxiety or suicidal ideation. This study contributes to understanding neural risk factors for mental health disorders and developing new methods to assess mental health risks.
Researchers from the University of Surrey found that vegetarians who consumed plant-based meat alternatives had a 42% increased risk of depression compared to those who refrained. However, they also found lower levels of inflammation and a reduced risk of irritable bowel syndrome (IBS).
A new study by Murdoch Children's Research Institute found that 64% of adolescents reported symptoms three or more times across their adolescent years. Girls were at increased risk and more likely to have a chronic course. Preventive strategies are urgently needed to address this public health problem.
Researchers at Université de Montréal's CRCHUM discovered that inhibiting a key brain enzyme can reduce body weight and improve physical activity in mice. The study suggests that targeting specific neuronal pathways in the brain could be crucial for fighting obesity and metabolic disorders.
A systematic review and meta-analysis of 96,000 adults found that higher daily step counts were linked to lower depressive symptoms. Further studies are needed to confirm the potential protective role of daily steps in depression.
Researchers at MUSC discover an RNA:DNA 'sandwich' plays a key role in how the brain interprets emotional experiences and brings about behavioral adaptations. The discovery could lead to better RNA therapies for treating brain disorders.
Increasing serotonin levels in the gut epithelium improves symptoms of anxiety and depression in animal studies, suggesting a new therapeutic approach. The study also highlights the risk of digestive issues in children exposed to antidepressants during pregnancy.
US veterans reported an average happiness level of 5.41, with higher happiness tied to greater sense of purpose and lower depressive symptoms. The study also found strong associations between optimism, emotional stability, and resilience and increased happiness in veterans.
A study by the University of Southampton found that police investigators of Child Sexual Abuse Material experience high levels of depression and anxiety, with feelings of betrayal by colleagues and institutions being a significant predictor. In contrast, feeling successful and supported at work can act as a powerful buffer to these out...
A randomized controlled trial examines the association between treatment expectancies and the relative efficacy of psilocybin versus escitalopram for major depressive disorder. The results suggest that psilocybin is more effective than escitalopram in treating depression.
A study from King's College London reveals that the dural sinuses and skull bone marrow act as a likely interface between the central and peripheral immune systems, suggesting a potential link between brain and body inflammatory signals. The research highlights areas of the skull that work as 'traffic lights' between the two systems.
A systematic review of 45 studies found inconsistent descriptions of psychotherapy sessions, making it difficult to replicate studies and compromise patient well-being. Researchers call for improved reporting standards to enhance the replicability, safety, and potential effectiveness of these therapies.
A study of 2,788 participants with impulse control disorder found that people with ICD are more likely to exhibit both overt and covert suicidal behavior. The study identified shared and specific risk factors for each type of behavior, including depressive symptoms and low self-direction.
JMIR Perioperative Medicine is launching a new theme issue exploring burnout among perioperative clinicians, including anesthesiologists and advanced practice providers. The call for papers aims to examine the critical issue of burnout within perioperative medicine.
Researchers have identified structural grey matter differences in the brains of women with a history of peripartum depression compared to those without. The study found that hormone fluctuations during pregnancy and childbirth may be key to understanding this condition.
A study found that psilocybin-assisted psychotherapy significantly reduced depression among clinicians providing front-line COVID-19 care. The treatment was more effective than a placebo, with participants experiencing greater reductions in symptoms over time.
A new Simon Fraser University study finds that antidepressants are associated with reduced genital sensitivity in 13% of users, compared to 1% of other psychiatric medication users. The study highlights the need for better patient education and warnings about potential side effects.
Researchers at UCSF found a brain signature of resilience in mice that suggests a new way to treat severe depression. Stress changes activity in the amygdala, distinguishing resilient from less resilient mice. By stimulating neurons, the team improved decision-making and reduced ruminating in less resilient mice.
Researchers identified iTBS over the left dorsolateral prefrontal cortex as the most effective method for treating adults with schizophrenia, improving negative and cognitive symptoms. The treatment approach was well-accepted and well-tolerated by participants.
Researchers found a strong link between depression and menstrual pain in a new study published in Briefings in Bioinformatics. Depression may be a cause of dysmenorrhea, rather than a consequence, according to the findings.
Researchers found that individuals with depression who engage in reflexive emotion regulation experience increased suicidal thoughts during daily stressful events. In contrast, adaptive responses to stress were observed when participants used reappraisal strategy.