MIT study shows genetic link for schizophrenia
A recent MIT study reveals a genetic link between gene mutations and schizophrenia, focusing on the calcineurin system as a potential target for future treatments.
Schizophrenia
Articles tagged with Schizophrenia
Study reveals value of schizophrenia-related gene variation
Researchers have identified a genetic variation associated with a mild form of schizophrenia, which also confers improved overall survival. The HOPA12pb gene variation affects dopamine-releasing neurons and may hold the key to developing new treatments for schizophrenia and other related illnesses.
Possible genetic link to schizophrenia identified
Research reveals genetic variation in the DARPP-32 gene linked to improved cognitive performance and increased risk of schizophrenia. The study's findings suggest a possible genetic connection between the protein and frontostriatal brain structure and function.
Common gene version optimizes thinking -- but with a possible downside
A common gene variant is found to optimize brain function and improve thinking abilities, but also increases the risk of developing schizophrenia. The study suggests that this variant may have a paradoxical effect when combined with impaired prefrontal cortex function.
Scientists identify gene that may indicate predisposition to schizophrenia
A study published in The American Journal of Human Genetics identifies the chitinase 3-like 1 gene as a potential risk factor for schizophrenia. Genetic variations in this gene were found to be associated with schizophrenia, suggesting that genes involved in biological response to adverse conditions may play a role in predisposition.
High risk of chronic health conditions plagues those with schizophrenia
Research found that individuals with schizophrenia are more likely to have multiple chronic health conditions, including cardiovascular and neurological diseases. A third of those with schizophrenia had three or more physical health conditions, highlighting the need for integrated care.
Changes in brain density can help predict schizophrenia
A study found that monitoring grey matter density over time using brain scans could help early detection of individuals at risk for schizophrenia. The results showed a correlation between reduced grey matter density and increased risk of developing the condition.
New anti-psychotic drugs no better than older, cheaper ones
A study found that schizophrenia patients respond equally well to older psychiatric drugs as newer, costlier alternatives. The NHS-funded trial revealed little benefit from switching to second-generation anti-psychotics despite their higher market share.
Older medication may be more cost-effective for some patients with schizophrenia
A new study suggests that older antipsychotic medication perphenazine is less expensive and equally effective as newer medications for treating schizophrenia. The study, funded by the National Institutes of Health, found that total monthly health costs were up to 30% lower for patients taking perphenazine compared to those taking secon...
Biomarkers for psychosis
Researchers have identified characteristic changes in cerebrospinal fluid that may serve as biomarkers for psychosis, including schizophrenia. These findings suggest a potential new approach to understanding and treating these conditions.
USC groups present at Neuroscience 2006
Researchers at USC have made significant discoveries in the fight against Alzheimer's disease. A study found that hormone replacement therapy may lower Alzheimer's risk by as much as 50 percent in younger women. Additionally, a new treatment approach for ALS and Parkinson's disease has shown promising results, with exercise interventio...
Second-generation antipsychotic medications appear to offer little advantage over older drugs
A study found that second-generation antipsychotic medications do not offer significant benefits compared to older first-generation antipsychotic drugs for patients with schizophrenia. The findings contradict the widely held perception that second-generation agents are safer and more effective.
Genetic links to schizophrenia focus of international study
An international team, led by UCLA's Roel Ophoff, is conducting a four-year study on schizophrenia that will analyze the human genome of approximately 850 Dutch patients and 750 control subjects to pinpoint related genes. This approach aims to separate false clues from true genetic variants associated with the disorder.
Survey: Caregivers of people with mental illness say treatment disruption has serious consequences
The survey reveals that caregivers experience devastating consequences, including relapse, hospitalization, and financial strain. Caregivers also emphasize the importance of effective medication and long-term care to maintain their loved ones' overall well-being.
National study compares delivery methods of schizophrenia medicines
A new five-year study will determine whether biweekly physician visits and injectable drugs can improve medication compliance among schizophrenia patients. Researchers are comparing the effectiveness of injectable risperidone microspheres to standard oral antipsychotics.
UCLA study uncovers new risk factor for schizophrenia
A new risk factor for schizophrenia has been identified by UCLA scientists, with infants having a specific immune gene that closely resembles their mothers' being more likely to develop the disease. The study suggests that this genetic match may increase fetal susceptibility to schizophrenia, particularly in females.
Research team to analyze brain changes in schizophrenia
A Wake Forest University research team is analyzing brain changes in individuals with schizophrenia and bipolar disorder to better understand the diseases. They are comparing post-mortem brain tissue with normal tissue, focusing on the temporal lobe's structures involved in learning and memory.
Exposure to toxins reduces the effectiveness of immunisation and more
Researchers found that children exposed to polychlorinated biphenyls (PCBs) receive lower antibody protection after vaccinations. The study suggests that reducing exposure to chemicals that harm immune systems is crucial for young children.
Study aims to identify schizophrenics at risk for type 2 diabetes
Researchers explore the connection between schizophrenia and an increased risk of developing type 2 diabetes. They aim to identify patients at high risk and develop more effective treatment plans.
Study finds gene related to brain development and function plays causal role in schizophrenia
A new study found that variations of the OLIG2 gene are strongly associated with schizophrenia. The gene plays a crucial role in myelin production and is coordinated with other genes involved in myelination and schizophrenia development. This causal link may help researchers develop new therapeutic targets for the debilitating illness.
Association between famine and schizophrenia may yield clues about inherited diseases and conditions
Research suggests that folate deficiency during pregnancy can cause genetic mutations leading to schizophrenia, challenging the conventional wisdom on psychiatric disorders. The study of two major famines in the 20th century supports a theory of medical genetics where multiple genetic mutations contribute to diseases.
Our grip on reality is slim, says UCL scientist
A study by UCL scientists found that people's brains struggle to distinguish between real and imagined events, leading to hallucinations in schizophrenia. The researchers used fMRI scans to observe brain activity while participants remembered whether words had been seen or imagined.
Studies suggest new brain protein may help in treating schizophrenia, insomnia and anxiety
Research on neuropeptide S suggests it can reduce biochemical and behavioral symptoms of schizophrenia, while also alleviating anxiety and promoting wakefulness. The study's findings indicate the NPS receptor could be a target for developing novel antipsychotic drugs.
Altered activity in receptor pair points to further complexity in schizophrenia pathology
Researchers discover altered activity in NRG1-erbB4 and NMDA receptor pairs, suggesting a relationship between the two and contributing to schizophrenia symptoms. The study's findings provide new insights into the molecular mechanisms underlying the disease.
Manchester academic to tell conferences: Child abuse can cause schizophrenia
A new theory suggests that two-thirds of people diagnosed with schizophrenia have suffered physical or sexual abuse, making it a major cause of the illness. The research argues that trauma, not just genetic predisposition, contributes to schizophrenic symptoms.
Study shows schizophrenia limits understanding of body language
A study led by University of Iowa researchers found that people with schizophrenia struggle to understand body language, including facial expressions and non-verbal cues. Even those with mild symptoms and taking medication, they have difficulty extracting information from these socially relevant clues.
Onset of psychosis may be delayed by medication
Researchers found that medication may delay the onset of psychosis in schizophrenia patients, leading to improved treatment outcomes and reduced symptoms. The study suggests that early recognition and treatment can help prevent or delay the development of full-blown psychosis in individuals with prodromal symptoms.
First recipient of the Vanderbilt Prize in Biomedical Science named
Dr. Andreasen, a leading expert on schizophrenia, receives Vanderbilt Prize for Biomedical Science for her groundbreaking research and mentorship of women in science. The award includes a $25,000 prize and establishes a scholarship to support a promising M.D./Ph.D. candidate.
Feinstein researchers identify intelligence gene
Researchers found a specific pattern of DNA sequence variations in the dysbindin gene associated with impaired cognition and intelligence. The study suggests dysbindin influences variation in human cognitive ability, but only explains a small proportion, about 3 percent.
Hospitalized patients with schizophrenia more likely to have medical and surgical complications
Researchers found that hospitalized patients with schizophrenia are more likely to experience serious infections, respiratory failure, and sepsis compared to those without the condition. The study suggests that improved quality of care could help mitigate this increased risk.
Engineered mouse mimics cognitive aspects of schizophrenia
Researchers created a genetically altered mouse strain with overexpressed dopamine receptors in the striatum, which showed specific cognitive deficits similar to human schizophrenics. The study suggests that cognitive symptoms may arise from subtle genetic differences in the dopamine receptor gene.
Mice with defective memory may hold clues to schizophrenia
Researchers created mice with a genetic defect that affects learning and memory, mirroring symptoms of schizophrenia. The animals struggled to adapt to new environments and scents, highlighting potential treatments for the mental health disorder.
One third of patients who stop treatment for schizophrenia early do so due to poor response
A study of 1627 patients found that 53% stopped treatment early, with 36% citing ineffective treatment or worsening symptoms. Patients who experienced an early response to medication were 80% more likely to complete treatment, highlighting the importance of early symptom control and discussing treatment expectations.
$1.75 million NHMRC grant for a world first – the Australian Schizophrenia Research Bank (ASRB)
A $1.75 million grant will establish the Australian Schizophrenia Research Bank, a nationally coordinated facility to support schizophrenia research. The bank will provide access to comprehensive, cross-referenced data on over 3,000 participants with schizophrenia and their families.
Disruption of gene interaction linked to schizophrenia
Studies using a laboratory model of PRODH deficiency demonstrate the role of COMT in compensating for overactive dopamine signaling, which contributes to schizophrenia symptoms. The findings show that disruptions in gene interaction, particularly between PRODH and COMT, play a crucial role in the development of schizophrenia.
Imaging shows similarities in brains of marijuana smokers, schizophrenics
Researchers found that repeated exposure to marijuana was related to abnormalities in the development of the arcuate fasciculus, a bundle of fibers connecting language and auditory functions. Longitudinal studies are needed to determine whether these changes in the brain are permanent or change over time.
Scientists move forward understanding of schizophrenia
Researchers have identified a new genetic link between PDE4B and DISC1 genes and mental illness, shedding light on the root causes of schizophrenia. The discovery suggests a potential new way of thinking about developing better treatments for this debilitating disease.
UCLA scientists report promising new molecular approach to fighting schizophrenia
Researchers discovered sequence variations in the DISC1 gene that predict schizophrenia, neurocognitive deficits, and brain structure abnormalities. The study's findings offer hope for developing a treatment that can prevent or fix the protein's function.
Penn researchers utilize MRI for early diagnosis of schizophrenia
Researchers at Penn have developed a new method using high-dimensional shape transformations to identify unique structural brain characteristics in schizophrenia patients. The study demonstrates the potential for early detection and prevention of the disease through MRI analysis.
Web Forum launched for schizophrenia researchers
The Schizophrenia Research Forum is a new online platform that aims to accelerate discovery by connecting researchers, experts, and clinicians. The site features interactive forums, live chats with leading scientists, and a searchable database of schizophrenia-related papers.
Schizophrenia: Delusion without illusion
Researchers found 12 out of 15 participants with chronic schizophrenia made more accurate judgments than the best performer among a control group of non-schizophrenic volunteers. The study suggests that contextual processing may be less effective in schizophrenic brains, possibly due to insufficient inhibition.
Stanford study reveals genetic trigger behind some schizophrenia cases
A Stanford study reveals that a single copy of the low-activity COMT protein may be a major risk factor for the development of schizophrenia or related psychotic disorders in children with a chromosome 22 deletion. This genetic variation can lead to an increased drop in verbal IQ, expressive language skills, and prefrontal cortex volume.
Teens with deletion syndrome confirm gene's role in psychosis
A study finds that youth with the 22q11.2 deletion syndrome and a specific COMT gene variant exhibit significant cognitive decline and psychosis, with excessive dopamine levels contributing to these effects. The study implicates the COMT gene in schizophrenia development, highlighting its potential role in information processing distur...
Neural development protein disproved as marker for schizophrenia
A recent study contradicts earlier research suggesting that the neural development protein Oct-6 could be a marker for schizophrenia and bipolar disorder. Contrary to previous results, researchers found no difference in Oct-6 protein or mRNA expression between patients with these disorders and healthy individuals.
Collaborations yield new discoveries in psychiatric genetics
Researchers at Rutgers University have made new findings linking genetic variants to susceptibility to autism and schizophrenia. The study suggests that a mutated form of the EN2 gene may contribute to up to 40% of autism cases, while another gene called CAPON has been implicated in schizophrenia.
NIMH study to guide treatment choices for schizophrenia
The CATIE study found that while newer medications have no substantial advantage over older antipsychotics, individual differences in patient response to these drugs remain crucial. Patients on olanzapine tended to stay on the medication longer but experienced increased side effects such as weight gain and metabolic changes.
Yale study reconciles two models of schizophrenia
A new Yale study reconciles two long-standing models of schizophrenia: the dopamine hypothesis and the PCP Model. Researchers found that drugs like ketamine, which block glutamate receptors, produce a more complete schizophrenia-like state than amphetamine.
Postmortem data support link between gene and schizophrenia
A study has found a significant connection between the CAPON gene and schizophrenia, with brain samples from patients showing higher levels of the short form of the protein. This increase was predominantly seen in individuals with variants of the CAPON gene previously linked to schizophrenia.
Odd behavior and creativity may go hand-in-hand
A new study published in Schizophrenia Research found that individuals with schizotypal personalities are more creative than normal or fully schizophrenic people. They also use the right side of their brains more heavily to access creativity. This is supported by research showing a disproportionate number of schizotypes and schizophren...
UC to study why minorities with mood disorders face dangerous misdiagnosis
A four-year multicenter study will examine why minorities face dangerous misdiagnoses for mood disorders, leading to excessive antipsychotic drug use among African-Americans. The research aims to identify underlying reasons and develop new education techniques to improve diagnosis and treatment plans.
New hope for schizophrenia sufferers
Researchers found a disrupted brain wave pattern in patients with schizophrenia, which may help understand attention deficits. The study aims to develop a biological test to distinguish patients with schizophrenia from those with bipolar disorder.
Prenatal exposure to famine increases risk of schizophrenia
A study found that prenatal exposure to famine in China's Wuhu region increased the risk of schizophrenia in later life. Birth rates dropped significantly during the famine years, and the risk of developing schizophrenia increased among those born during this time.
Brain function in schizophrenia can improve with support, holds promise for cognitive rehabilitation
A new study from Washington University in St. Louis shows that people with schizophrenia can remember things just as well as healthy subjects with proper cues and memory aids. The research suggests a new way to understand the cognitive problems underlying schizophrenia, offering hope for more effective cognitive rehabilitation programs.
The building blocks of schizophrenia and drug addiction
A study at McGill University investigates the links between brain behavior, neurochemistry, and molecular biology in relation to mental disorders. The researchers aim to develop diagnostic tools, treatment, and prevention strategies for conditions like schizophrenia.
Is it me… or my genes?
Edwin Rydberg wins prestigious EMBO Science Writing Prize with his essay Through The Illusions, exploring the link between DNA changes, smoking and schizophrenia. His work showcases a fascinating combination of factors, inspiring new research in popular science writing.
The self's broken border: Tracing the role of agency attribution in schizophrenia
Researchers found a correlation between delusion strength and 'world motion' perception in schizophrenia patients. This supports the view that delusions may be caused by an inability to attribute agency to sensory experiences.
Richer nations at more risk of schizophrenia
A comprehensive survey of schizophrenia rates around the globe debunks a popular textbook definition that the disorder affects 10 in every 1000 people. The study reveals the incidence and prevalence of schizophrenia varies greatly between regions, with poorer countries having more women affected than men.
Large survey suggests schizophrenia less prevalent than textbooks say
A comprehensive analysis of 1,721 estimates from 188 studies covering 46 countries found schizophrenia is more common in developed countries but overall less common than thought. The study revealed that immigrant populations have higher rates of the disease than native-born individuals.
New Seroquel data show significant improvement in compliance and cognition in schizophrenia
SEROQUEL demonstrates a higher compliance rate compared to risperidone and olanzapine, with significant improvements in cognitive function, including working and verbal memory, while also offering a superior side effect profile.
Cognitive function and compliance with Seroquel® examined in separate studies in schizophrenia
A study examined the effect of SEROQUEL on cognitive function in patients with schizophrenia, showing improved overall cognition. Another analysis found that patients taking atypical antipsychotics had better treatment compliance compared to those taking conventional antipsychotics.