Articles tagged with Schizophrenia
A study at McGill University investigates the links between brain behavior, neurochemistry, and molecular biology in relation to mental disorders. The researchers aim to develop diagnostic tools, treatment, and prevention strategies for conditions like schizophrenia.
Edwin Rydberg wins prestigious EMBO Science Writing Prize with his essay Through The Illusions, exploring the link between DNA changes, smoking and schizophrenia. His work showcases a fascinating combination of factors, inspiring new research in popular science writing.
Researchers found a correlation between delusion strength and 'world motion' perception in schizophrenia patients. This supports the view that delusions may be caused by an inability to attribute agency to sensory experiences.
A comprehensive survey of schizophrenia rates around the globe debunks a popular textbook definition that the disorder affects 10 in every 1000 people. The study reveals the incidence and prevalence of schizophrenia varies greatly between regions, with poorer countries having more women affected than men.
A comprehensive analysis of 1,721 estimates from 188 studies covering 46 countries found schizophrenia is more common in developed countries but overall less common than thought. The study revealed that immigrant populations have higher rates of the disease than native-born individuals.
A study examined the effect of SEROQUEL on cognitive function in patients with schizophrenia, showing improved overall cognition. Another analysis found that patients taking atypical antipsychotics had better treatment compliance compared to those taking conventional antipsychotics.
SEROQUEL demonstrates a higher compliance rate compared to risperidone and olanzapine, with significant improvements in cognitive function, including working and verbal memory, while also offering a superior side effect profile.
A study by Columbia University found a potential link between maternal toxoplasmosis gondii infection and an increased risk of schizophrenia in adult offspring, particularly those with high antibody titers. The researchers suggest that inflammation may be the underlying mechanism behind this association.
A Pitt professor has been awarded a prestigious Sloan Research Fellowship to study brain communication and its impact on mental disorders like schizophrenia. The two-year, $45,000 fellowship will fund his research into how brain areas interact during normal behaviors and how this interaction breaks down in schizophrenia.
A study found that increased activity in the prefrontal cortex predicts higher dopamine levels in the midbrain in individuals with the val COMT gene type, while decreased activity is seen in those with the met type. This suggests a 'tuning' model where dopamine regulates signal-to-noise ratios in brain cells.
Researchers found that nearly all psychiatrists consider metabolic side effects serious or very serious, but baseline data and regular checks are often neglected. The study highlights the need for clinicians to change their practice to reflect this concern and provide better care for patients with schizophrenia.
A new study found that an atypical antipsychotic drug can prevent brain loss in patients with schizophrenia when started early. The study, led by Dr. Jeffrey Lieberman, measured brain volume and cognitive changes in 263 first-episode schizophrenia patients and 58 non-schizophrenic volunteers over a two-year period.
A Rutgers scientist will use a new grant to investigate schizophrenia genes, with the goal of finding better treatments and reduced morbidity. The researcher aims to analyze genetic data using a new statistical analysis method and investigate a recently described class of genes involved in the central nervous system.
A recent brain imaging study found that individuals at high risk for schizophrenia show altered neural activity in the prefrontal cortex, suggesting biological changes prior to disease onset. The study used fMRI scans to identify potential biomarkers of vulnerability, which could aid in early intervention and treatment.
A comprehensive treatment approach for all schizophrenia symptoms is possible, enabling patients to recover and lead fuller lives. Atypical antipsychotics have shown promise in improving cognition and addressing depressive symptoms, but individual side effects and preferences must be considered.
A U of T researcher has discovered a connection between gene mutations and schizophrenia, suggesting the brain overcompensates for these mutations by becoming supersensitive to dopamine. This new understanding could lead to new research directions into schizophrenia.
Research found significant insulin resistance and impaired glucose effectiveness in non-obese patients treated with clozapine, olanzapine, or risperidone. This may increase the risk for diabetes mellitus in vulnerable individuals.
The NIH is providing $32.8 million to enhance its Biomedical Informatics Research Network (BIRN), a consortium of universities and research groups focused on utilizing information technology innovations to advance biomedical science. BIRN aims to create an environment encouraging collaborative research, facilitating sharing, analysis, ...
Researchers found that schizophrenic patients lacked gamma band response, indicating defective communication between neurons, while healthy brains showed synchronized activity at 40 hertz. The study suggests that drugs promoting a normal gamma response may help alleviate schizophrenia symptoms.
PKC enzyme's excessive activity is associated with symptoms of bipolar disorder and schizophrenia. Increasing PKC activity in the prefrontal cortex impairs cognitive function, while inhibition may offer therapeutic benefits.
Researchers found that a defect in RGS4 gene may cause schizophrenia-like symptoms, such as difficulty filtering out unimportant sensory information. The study uses mouse brain nerve cell circuitry to better understand the cause of schizophrenia.
Researchers used DTI scans to analyze the movement of water molecules in brain fibers, finding abnormalities in neural pathways related to verbal memory and executive functioning. The study suggests that schizophrenia may result from differences in neural connections rather than single component faults.
Physicians and individuals with stable schizophrenia report similar top treatment goals: improving mental health and overall happiness. People with schizophrenia prioritize life goals, such as returning to favorite hobbies and reducing feelings of isolation.
A new study reveals that 8 out of 10 patients with serious mental illnesses are satisfied with their Seroquel treatment, experiencing improved positive and negative symptoms. This is attributed to its effectiveness and favorable side effect profile, leading to better compliance and outcomes.
The UCI Brain Imaging Center will utilize advanced fMRI, PET, and DTI imaging techniques to study abnormal brain networks in schizophrenia. The goal is to identify the underlying biology of the disease and develop more effective treatments.
Research suggests a double dissociation in deficit and nondeficit schizophrenia, with summer births associated with deficit syndrome. The association was found across six countries in the northern hemisphere, supporting seasonal variations in etiology.
Children of parents with schizophrenia are vulnerable to developing interpersonal difficulties later in life. The study highlights the need for support to help these individuals cope with the illness.
A recent study found that people with schizophrenia in China are 24 times more likely to die by suicide than those without the condition. The research suggests a possible link between the prevalence of schizophrenia and suicide in women, who make up a larger proportion of those affected.
A mouse study has identified a potential genetic link between NPAS3 and NPAS1 genes and psychosis. The mutated mice displayed deficits consistent with schizophrenia, including impaired social interaction and startle response. Further research is needed to confirm the connection.
A new study identifies a genetic link between schizophrenia and the GRM3 gene, which regulates glutamate in brain synapses. People with the 'A' variant have lower levels of glutamate and poorer cognitive function compared to those with the 'G' variant.
A new study found that prenatal exposure to influenza may increase the risk of schizophrenia in offspring years later, with a threefold increased risk when exposure occurred during the first half of pregnancy. The study analyzed archived sera from pregnant women and their children born between 1959-1966.
Researchers Wade Berrettini and Irwin Lucki received Distinguished Investigator Awards to study gene identification and behavioral effects of neurotrophins. Monica Gonzalez won a Young Investigator Award to investigate the effect of long-term light deprivation on depression.
The studies confirm SEROQUEL's effectiveness across a range of schizophrenia symptoms, including positive and negative symptoms, and cognitive functioning. Cognitive improvements were seen in patients treated with SEROQUEL.
In a European multicentre trial, 119 schizophrenia patients showed significant improvements in positive and negative symptoms after transitioning to risperidone long-acting injection. The study found that over one-third of patients experienced an improvement of more than 20% in the PANSS total score.
Researchers found that delta-9-THC, the main active ingredient in cannabis, induced schizophrenia-like symptoms in some subjects. These symptoms included paranoia, thought disorder, and problems with memory and attention.
Cognitive impairments are a significant contributor to the disability associated with schizophrenia. Recent research indicates that medications currently available do little to remedy this aspect of the illness. New trials, part of the TURNS initiative, aim to develop new treatments for cognitive deficits in schizophrenia.
Researchers at the University of Pennsylvania School of Medicine found that dysbindin protein expression is reduced in over 80% of patients with schizophrenia, correlating with increased glutamate packets. This discovery provides a critical lead for understanding schizophrenia's cellular mechanisms.
Researchers at Yale University developed an imaging test that identifies patients with schizophrenia with 97 percent accuracy. The test targets abnormalities in the auditory cortex and has potential as a powerful clinical tool for assessing schizophrenia.
Researchers found that a gene variation associated with schizophrenia may have an evolutionary advantage, promoting human survival. The HOPA12pb polymorphism is more common in men and may be involved in resistance to infection and infant survival.
Researchers found that patients taking newer antipsychotics had less than one-third the incidence of violent behavior compared to those on older conventional medications. The study, which followed 229 patients with schizophrenia for two years, suggests that these medications may be more effective in reducing violence.
A new study found that only 41% of schizophrenia patients take their antipsychotic medication on a regular basis. Non-adherence is linked to higher medical costs and hospitalizations, with African-Americans and Latino patients more likely to be non-adherent than Caucasians. Living independently or being homeless are also associated wit...
Researchers found a moderate link between celiac disease and schizophrenia, with individuals having celiac disease three times more likely to develop the condition. A gluten-free diet may be beneficial for those genetically prone to celiac disease but undiagnosed, according to lead author Dr. William W. Eaton.
A two-year study found that quetiapine treatment resulted in statistically significant improvements in positive, negative and depressive symptoms. Patients also showed notable enhancements in quality of life, with minimal reported side effects.
Studies find that prenatal exposure to lead, alcohol, and anesthetic drugs can cause brain damage in young adults. Research suggests that these substances trigger apoptosis, a form of cell death, by interfering with neural connections.
A Swedish study found that risperidone long-acting injection reduced hospital admissions by 23% and mean hospital stay duration by 35%. This results in significant cost savings for the healthcare system, with estimates suggesting up to €6,300 per patient annually.
A new study demonstrates the benefits of Risperdal Consta in young adults with schizophrenia, improving symptoms and reducing side effects. The treatment showed significant satisfaction and improvement in health-related quality of life, making it a promising option for patients.
A new study explores the potential of erythropoietin (EPO) as a neuroprotective agent for schizophrenia. EPO was found to penetrate the blood-brain barrier and enhance cognitive functioning in patients with schizophrenia. The results suggest that EPO may be a promising compound for preventing loss of brain function in this disease.
Researchers used DTI to study adolescents with early-onset schizophrenia and found distinct differences in white brain matter of the frontal lobe. This disruption can lead to developmental abnormalities and abnormal behaviors.
A randomized, double-blinded study found no differences between olanzapine and haloperidol in reducing schizophrenia symptoms or improving quality of life. Olanzapine was associated with higher costs due to its high price tag, despite slightly better cognitive status and less restlessness.
Researchers discover that DARPP-32 interacts with multiple neurotransmitter systems to produce similar physiological symptoms in mice treated with LSD, PCP, and amphetamine. The findings provide new avenues for treating schizophrenia and suggest DARPP-32 as a critical regulator of neurotransmitters involved in mood and behavior.
A study found individuals at ultra-high risk for psychosis had difficulty identifying smells before symptom onset. This discovery could lead to a new diagnostic tool and earlier treatment options for schizophrenia and other psychoses.
A four-year study found that Risperdal significantly reduces the risk of relapse in schizophrenia patients, with a 42% lower rate compared to haloperidol. Patients taking Risperdal remained relapse-free for an average of over 15 months, whereas those on haloperidol were free for only seven months.
A new study shows significant improvements in positive and negative symptoms of schizophrenia when patients are switched to Risperdal Consta without a three-week overlap treatment period. The study found that side effects were mild to moderate, with extrapyramidal symptoms improving significantly by the first month.
A collaborative study between UGA and MCG investigated the cognitive effects of long-term use of newer schizophrenia drugs. The researchers found that while atypical antipsychotics cause fewer problems with movement disorders, their long-term impact on cognitive function is still unclear.
Studies suggest schizophrenia and bipolar disorder have reduced expression of genes responsible for myelin development in brain cells, potentially linked to environmental issues or infections. This discovery may enable early treatment before symptoms emerge in late adolescence or early adulthood.
Research suggests that schizophrenia and bipolar disorder share similar genetic causes, with key oligodendrocyte-related and myelin-related genes showing reduced expression in patients. This finding has implications for understanding the underlying mechanisms of these complex mental health conditions.
Research suggests that schizophrenia impairs habitual prospective memory, leading to high rates of non-adherence to medication. The study found that people with schizophrenia are more likely to forget to turn over a counter during an obstacle course test.
Researchers identify key genes and cellular pathways contributing to schizophrenia, providing new insights into the disorder's complex biology. The study's findings hold promise for developing novel therapeutic strategies.
Researchers have identified a genetic variant in the calcineurin pathway that may be linked to schizophrenia. The study found that mice lacking this gene exhibited severe behavioral abnormalities similar to those seen in humans with the disorder, including hyperactivity and social withdrawal.
A study using PET scans found that schizophrenics have elevated dopamine receptor levels in both basal forebrain and SN/VTA areas of the brain. Differences were observed in cortical dopamine levels, supporting the hypothesis of dysregulated neurotransmission leading to abnormal regulation of neurons.