A new report from Dr. Anthony-Samuel LaMantia suggests a possible neuro-developmental theory of schizophrenia linked to altered brain development during the first three months of pregnancy. Abnormalities in retinoic acid signaling pathways may contribute to the development of schizophrenia.
SourceUniversity of North Carolina Health Care·JournalBiological Psychiatry·DateJul 6, 1999
New research from London's Institute of Psychiatry suggests that clozapine, an atypical drug for schizophrenia, can restore information processing abilities in patients. This restoration enables individuals to filter out background noise and focus on relevant information.
SourceInstitute of Psychiatry·JournalAmerican Journal of Psychiatry·DateJul 5, 1999
A University of Iowa study found that patients with schizophrenia who had frequent social interaction lived on average 25 percent longer than those with little or no interaction. The researchers also discovered that married patients lived somewhat longer than unmarried patients.
SourceUniversity of Iowa·JournalPsychosomatic Medicine·DateMar 22, 1999
Researchers suggest a digestive problem may lead to autism and schizophrenia symptoms, as undigested milk protein produces morphine-like compounds affecting brain function. Animal studies show 95% of autistic and schizophrenic children had high levels of the protein in their blood and urine.
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Researchers found that rats born by Caesarean section showed marked differences in brain development compared to naturally born controls. They had altered dopamine systems and responses to stress tests. The findings hint at a potential link between Caesarean births and schizophrenia risk.
SourceNew Scientist·JournalThe New Scientist·DateNov 18, 1998
A 15-year study in over 100 families and 1,000 subjects provides the first reliable evidence of genetic susceptibility to schizophrenia. The study identified a stretch of DNA on chromosome 13 associated with schizophrenia susceptibility.
SourceJohns Hopkins Medicine·JournalNature Genetics·DateSep 1, 1998
Research found an association between childhood-onset schizophrenia and large CAG/CTG repeats in male patients. The study confirms previous findings on adult-onset schizophrenia but notes a gender-specific link. Further studies are needed to confirm these results.
SourceMolecular Psychiatry·JournalMolecular Psychiatry·DateJul 30, 1998
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Researchers found that a specific component of neural circuitry in the prefrontal cortex is altered in most people with schizophrenia, leading to disturbances in complex thinking processes. The study suggests that this alteration may be a specific brain disturbance in the disease process of schizophrenia.
SourceUniversity of Pittsburgh Medical Center·JournalProceedings of the National Academy of Sciences·DateApr 28, 1998
A study found that people potentially at high risk for schizophrenia exhibit executive functioning problems before psychosis onset, which could serve as an early warning sign. This discovery may allow mental health professionals to test for and intervene in executive functioning issues.
SourceOhio University·JournalSchizophrenia Research·DateFeb 23, 1998
Researchers at UC Irvine have identified a gene associated with an increased risk of schizophrenia and manic-depressive illness. The gene encodes a potassium ion channel protein that controls electrical activity in nerves, and its altered function may contribute to brain behavior changes.
SourceMolecular Psychiatry·JournalMolecular Psychiatry·DateOct 30, 1997
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A longitudinal brain imaging study found progressive abnormal brain development in schizophrenia, particularly enlarged ventricles and reduced total cerebral volume. This may provide insights into the risk factors and neurodevelopmental abnormalities involved in the disorder.
SourceNIH/National Institute of Mental Health·JournalArchives of General Psychiatry·DateOct 16, 1997
Scientists at Yale University School of Medicine have discovered a link between the drug phencyclidine (PCP) and cognitive deficits in schizophrenia. The study found that PCP induces similar cognitive dysfunction as that found in patients diagnosed with schizophrenia, but also suggests potential for reversal using clozapine.
SourceYale University School of Medicine·JournalScience·DateAug 15, 1997