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Science News for April 28, 1998


New Tuberculosis Vaccine Candidate Developed: Improved Delivery Of Antigens By Current Vaccine BCG (Bacille Calmette-Guérin)

Scientists have developed a new TB vaccine candidate that uses recombinant BCG strains to secrete pore-forming listeriolysin, improving its ability to stimulate CD8 T cells. This could lead to better protection against M. tuberculosis infection and potentially halve the estimated 2050 global TB cases.

SourceMax-Planck-Gesellschaft·JournalProceedings of the National Academy of Sciences·DateApr 28, 1998

New Clue To apoE Function

Researchers have generated mice with human apoE3 or apoE4 genes, showing that apoE3 promotes nerve cell outgrowth while apoE4 does not. This study provides new insights into the biological effects of apoE variants and may offer a common mechanism for their adverse effects on neurodegenerative diseases.

Altered Neural Circuitry May Contribute To Disturbances In Cognitive Functions In Schizophrenia, Say Pitt Researchers

Researchers found that a specific component of neural circuitry in the prefrontal cortex is altered in most people with schizophrenia, leading to disturbances in complex thinking processes. The study suggests that this alteration may be a specific brain disturbance in the disease process of schizophrenia.

SourceUniversity of Pittsburgh Medical Center·JournalProceedings of the National Academy of Sciences·DateApr 28, 1998

Scientists At The Scripps Research Institute And R.W. Johnson Pharmaceuticals Develop New Antibacterial Agents

Researchers at Scripps Research Institute and R.W. Johnson Pharmaceuticals have developed a new class of antibacterial agents that inhibit two-component signal transduction systems, a key regulatory mechanism in bacterial virulence. These inhibitors show promise as a potential tool against antimicrobial-resistant pathogens.

SourceScripps Research Institute·JournalProceedings of the National Academy of Sciences·DateApr 28, 1998