Scientists have identified new breast tumor subtypes associated with poor clinical outcomes, which can be recognized and matched with therapies. The discovery uses genomic approaches and microarray analysis to classify tumors into distinct subtypes based on patterns of gene interaction.
Researchers at Boston Children's Hospital have found that a compound blocking AMPA glutamate receptors can dampen excitotoxic brain injury in premature infants. The study suggests topiramate may be useful in preventing cerebral palsy and epilepsy in newborns.
A pilot project found that providing access to healthy food choices significantly improved weight loss and self-esteem among low-income African-American women. The Rolling Store approach offers a realistic and inexpensive solution to overcome economic and geographic barriers to healthy diets.
A recent study found that college students referred for alcohol interventions, often due to disciplinary actions or medical concerns, exhibit higher rates of binge drinking and problematic use. Brief motivational intervention (BMI) and alcohol education (AE) sessions were effective in reducing alcohol use among these students.
Researchers at USC and UT Austin have developed a device based on quantum dots that can detect infrared radiation in a crucial wavelength range. This technology has the potential to improve night vision goggles, medical sensors and environmental monitors.
Research suggests moderate drinking may lower heart disease risk in older adults but increase breast cancer risk, particularly among women with family history or hormone replacement therapy. Moderate consumption also appears to reduce the risk of diabetes and metabolic syndrome.
A study of over 200 patients with hernia found that post-surgical pain was inversely related to age, with younger patients experiencing less pain. Laparoscopic repair was also associated with lower first-day pain scores and faster return to normal activities compared to open surgery.
Researchers identify TAL1/SCL as a key player in T cell acute lymphoblastic leukemia (T-ALL), a cancer that affects 10%-15% of pediatric and 25% of adult patients. Disrupting TAL1/SCL's interaction with E47/HEB may offer new therapeutic avenues for these patients, who respond poorly to current chemotherapies.
Researchers found that adding texture to implant surfaces increased compatibility with fibroblasts, reducing the risk of dead tissue build-up and infections. The study suggests that textured surfaces could lead to fewer implant replacements and improved patient outcomes.
African American participants who received pressure-lowering eye drops had a lower risk of developing glaucoma compared to those who didn't receive treatment. Regular eye exams are crucial for determining glaucoma risk, particularly in African Americans over 40.
Research at Fred Hutchinson Cancer Center reveals that African-American women are more likely to develop aggressive and rapidly growing breast cancers. Tumors from black women tend to exhibit abnormal cell-cycle regulatory proteins, which can lead to poorer outcomes if diagnosed at later stages.
A recent study by Ohio State University reveals the link between body dissatisfaction and eating disorders in women. Constant body monitoring and certain personality traits are found to be significant predictors of disordered eating behaviors among women with body dissatisfaction.
The study found that daily pressure-lowering eye drops reduced the development of primary open-angle glaucoma in African Americans by almost 50%. This suggests that comprehensive dilated eye examinations should be recommended at least once every two years for African Americans over age 40.
Researchers discovered that the Hoxb1 gene is necessary for forming a circuit between the brain and facial muscles, controlling movements such as blinking and facial expressions. The study's findings have implications for understanding and potentially treating Mobius syndrome and other nerve-related disorders.
A long-term study published in JADA demonstrates that rinsing twice daily with Listerine Antiseptic mouthrinse is as effective at reducing plaque and gingivitis as flossing once daily. The study found that Listerine Antiseptic reduced plaque by 20% and gingivitis by 11%, while flossing led to 3.4% and 4.3% reductions respectively.
A team of scientists found that the estuaries were resilient and recovered quickly from the storms, with most shellfish and finfish populations returning to normal. However, blue crabs took longer to recover due to overfishing and floodwaters disrupting their migration patterns.
A study published in Archives of Ophthalmology found that long-term use of statins and nonstatin cholesterol-lowering medications was associated with a reduced risk of open-angle glaucoma. The study included 667 men with new diagnoses of glaucoma between 1997 and 2001.
Researchers found that delta-9-THC, the main active ingredient in cannabis, induced schizophrenia-like symptoms in some subjects. These symptoms included paranoia, thought disorder, and problems with memory and attention.
A study of 300 people found that those with more abdominal fat were four times more likely to develop hypertension. Meanwhile, a six-year study of middle-aged men found no correlation between regular aerobic exercise and reduced artery thickening.
A recent study found that fruit consumption was inversely associated with risk of neovascular ARM, a more severe type of vision loss. Participants who ate three or more servings per day had a 36% lower risk compared to those eating less than 1.5 servings.
A new study shows that VELCADE (bortezomib) can significantly extend survival and induce important responses in relapsed and refractory multiple myeloma patients. The median overall survival was 17.2 months, with a 14.1-month duration of response and 15.3-month time to disease progression.
A team of scientists led by a URI oceanographer will extract long sediment cores from Lake Bosumtwi to study West African monsoon dynamics and tropical climate linkages. The research aims to improve understanding of Earth's climate system.
A study found that targeting the Pak1-DLC1 interaction can prevent breast cancer growth. The researchers discovered that when DLC1 is modified, it interferes with cell death signals, allowing cancer cells to survive and multiply.
Researchers recreated mammalian cell self-organization patterns in a test tube using mathematical formulas dictating cell interactions. This may help improve tissue regeneration methods and understand mechanisms behind birth defects and heart disease.
Researchers developed a 'Wireless Health Outcomes Monitoring System' (WHOMS) that enables doctors to send short questionnaires to patients via mobile phone, reducing the need for printed questionnaires. The system aims to improve doctor-patient communication and prioritize patients in serious need.
Dr. Li-Huei Tsai's groundbreaking study reveals p25 protein's role in Alzheimer's disease, a key feature of which is the presence of beta amyloid plaques and neurofibrillary tangles. The research also suggests an intervention after stroke could lower or prevent additional risk of Alzheimer's
Researchers from the University of Maine have found evidence suggesting that changes in Peruvian fisheries occurred centuries before modern fishing practices. The study used archaeological data from ancient fish processing sites and correlated these shifts with El Nino climate patterns.
The Mayo Clinic discovery sheds light on the cellular mechanisms behind Non-Alcoholic Fatty Liver Disease (NAFLD), a growing global problem related to affluence and diet. Early signs include accumulation of fat in the liver, inflammation, and scarring, which can lead to impaired function.
A new map reveals that the USA's impervious surface area equals Ohio's, with significant environmental implications. Increased ISA affects ecosystems, alters stream channels, and degrades wetlands, impacting biodiversity and climate change mitigation.
A study found that liver damage risk varies by gender and drinking pattern. Women are more susceptible, especially when not eating with alcohol, whereas men's risk depends on frequency and amount of drinking.
A study of 167 men with chronic prostatitis found that the condition incurs substantial direct and indirect costs, with procedures, tests, and healthcare visits accounting for a significant portion. The average annual cost per person was $4,397, with work loss valued at an additional $551.
A multi-state E coli outbreak has been linked to fast-food beef tacos, with inspectors finding a flaw in only one restaurant's meat handling. Potential solutions include a new tracking system and increased monitoring of patients for symptoms such as bloody diarrhea.
Elderly individuals with chronic illnesses like depression, bipolar disorder, and severe pain are at increased risk of suicide. Researchers found that treatment for multiple illnesses also strongly correlates with an increased risk of suicide in this population.
A study found that men with high trait anger and low anger control are more likely to exhibit aggressive behavior when intoxicated. Researchers examined 164 healthy male social drinkers and found that those with high trait anger levels were associated with increased aggression, but only among those who reported low anger control.
Researchers discovered specific retinal cells are predisposed to becoming tumours due to genetic mutation removing protective barriers. The study found three types of cells resistant to cell death and continued dividing despite the defective gene.
A new technique for preserving fertility in young women with cancer has been successfully used on eight female patients. The method involves removing immature eggs from the ovaries, maturing them through in-vitro maturation (IVM), and freezing them for later use.
The Case School of Medicine will oversee the Mt. Sinai Center for Medical Simulation, reducing medical errors that result in 100,000 deaths annually. The center will offer training for students and healthcare professionals using innovative simulation technologies.
Researchers found that over half of COX-2 patients take aspirin, leading to a loss of GI protective effects and increased risk of bleeding. Patients should consider alternative NSAIDs or proton pump inhibitors for added protection.
A new study published in Archives of Ophthalmology suggests that daily eye drops can significantly reduce the development of primary open-angle glaucoma in African Americans by nearly 50%. The study recommends periodic eye exams starting at age 40 for high-risk individuals.
Scientists found that a protein inside the rabies virus can enhance the immune response against foreign proteins, enabling the creation of vaccines against other infectious agents. The technique could lead to the development of longer-lasting vaccines against diseases like anthrax.
The TIGR president discussed the significance of finding anthrax toxin genes in a naturally occurring microbe other than Bacillus anthracis. The study found these genes in a virulent strain of Bacillus cereus, suggesting natural horizontal gene transfer may have occurred.
Flameout in nonprofit sectors can occur when personal control structures fail to work well, leading to destructive behavior such as embezzlement or sexual misconduct. Self-regulation and board action are crucial to prevent such destruction and maintain trust in the sector.
A study by Massachusetts General Hospital found that parental reports of ADHD symptoms are as accurate as those from teachers. This breakthrough could help design better clinical trials for pediatric ADHD medications. The research supports the use of parental reports in assessing child behavior and response to treatment.