A newly discovered protein, PICT-1, has been found to regulate PTEN stability by regulating phosphorylation. This discovery represents a huge breakthrough in understanding the tumorigenic pathways of breast and prostate cancers.
The NIH has funded two new bioinformatics resources at UT Southwestern to improve drug discovery and vaccine development. The BioHealthBase will focus on understanding how microbes establish infections, while the ImmPort system will integrate data from different biomedical research areas to identify disease-causing genes and proteins.
Researchers at Cedars-Sinai Medical Center have discovered a mechanism by which brain tumors can evade the immune system, leading to impaired cellular immunity in patients with glioma. By blocking COX-2 expression, the study found that tumor-killing T cell responses can be restored, offering new potential treatments for brain tumors.
Researchers used high-energy X-ray fluorescence to analyze single living and dead bacterial cells, revealing differences in morphology, elemental composition, and sensitivity to heavy-metal contaminants. The study pioneers a technique for investigating microbiological systems in natural subsurface environments.
Researchers at Johns Hopkins University have found a possible link between the strange electrical waves in their hearts and the cause of accelerated heartbeats. They discovered that when implanted cardioverter defibrillators triggered a series of unusual electrical pulses, they sometimes triggered the formation of these same spiral waves.
A new analysis by California Department of Health Services reveals breast cancer is the nation's fastest-growing rate, even as Asian Americans experience a lower death rate from cancer. This disparity highlights the need to address Westernization and increase cancer screening among Asian American women.
Scientists have identified two genetic mutations in the PARK8 gene that contribute to Parkinson's disease, a condition characterized by tremors and motor impairments. The discovery provides new insights into the molecular mechanisms underlying the disease and may lead to targeted interventions.
Researchers discovered a DNA repair enzyme that bypasses damaged spots in the DNA sequence to ensure cell survival. POL-Q's two-step process is the most efficient of any known DNA polymerase, making frequent errors in the process.
Researchers tested electrical stimulation's influence on stroke recovery, showing participants experienced meaningful motor recovery gains. The study aims to validate these findings and potentially reverse paralysis, restoring patients' function and normal lifestyle.
Researchers at VIB have discovered receptor proteins in yeast cells that detect and react to glucose and sucrose, which could be good targets for new medicines. This finding raises the possibility of glucose receptors existing in human beings.
Research suggests that teenage hormone therapy to reduce adult height in tall girls is linked to impaired fertility later in life. Women who received oestrogen therapy were more likely to experience difficulty becoming pregnant and had a lower per cycle rate of conception.
The new NSF report reveals that Latin American countries have made significant strides in publishing science and engineering articles. From 1988-2001, Brazil's output quadrupled and Mexico's more than tripled, while Argentina and Chile produced the most scientific articles per capita. The region's growing influence is reflected in the ...
Researchers at OHSU have determined the structural basis underlying a crucial mechanism that allows gram-positive bacteria to adapt to available energy sources. This finding could lead to the development of new antibiotics that disrupt this mechanism, making bacteria more susceptible to counter-attacks by the human body.
Researchers discovered a molecule that brings DNA polymerase alpha to replication sites, and it stabilizes the complex. This finding suggests that targeting Mcm10 may prevent cancer cells from multiplying.
Researchers at University of Manchester create graphene, the first two-dimensional fullerene, exhibiting remarkable electronic properties. The nanofabric shows potential to replace gallium arsenide in niche markets due to low energy consumption and high electron mobility.
A group of experts recommends incorporating environmental health into pediatric medical and nursing education, citing gaps in current curricula. The study aims to equip healthcare providers with tools to recognize, treat, and prevent diseases related to environmental factors.
A study found that a mitochondrial mutation may contribute to the development of metabolic syndrome, a cluster of disorders including high blood pressure and high cholesterol. Researchers discovered the link in a four-generation family affected by hypertension, hypercholesterolemia, and other conditions.
A recent study reports four cases of angiographically-confirmed stent thrombosis after elective implantation of drug-eluting stents, resulting in myocardial infarction. The authors emphasize the need for careful long-term follow-up to assess late thrombosis risk
Operations research and manufacturing techniques will improve healthcare delivery by reducing costs and enhancing quality. Techniques such as supply chain management and scheduling systems are being adopted in hospitals and blood banks to reduce delays and improve patient care.
Researchers at the University of Florida have created a living neural network using 25,000 rat brain cells, allowing it to learn and adapt like a computer. The 'brain' can now control a simulated aircraft, paving the way for potential use in flight control systems.
A single genetic mutation in mitochondrial genes has been found to be associated with multiple risk factors for heart disease and stroke, including hypertension, high cholesterol, and low magnesium levels. The researchers also discovered a link between the mutation and other conditions such as hearing loss and weakened heart muscle.
The Lancet editorial emphasizes the need for a more compassionate approach to end-of-life medical decisions, particularly in cases where parents and doctors disagree. The article advocates for arbitration as an alternative to court proceedings, citing its potential to resolve conflicts in a more constructive manner.
A study of 54 patients who underwent gastric bypass surgery found a 52% decrease in musculoskeletal complaints and a 92% reduction in fibromyalgia syndrome pain after 6-12 months. The significant weight loss resulted from stapling the stomach to create a small pouch, leading to improved function and quality of life.
A study by Johannes Schwarz and colleagues tracked molecular changes in brains of Parkinson's patients over 7.5 years using SPECT to measure dopamine transporter binding, revealing a single exponential decline rather than linear loss. This advancement enables the development of individualized treatment for advanced Parkinson's patients.
A Northwestern University team discovered that mutant Huntingtin protein aggregates bind to the proteasome machine, preventing complete degradation of proteins and leading to disease. This interference causes a cumulative negative effect, resulting in the buildup of damaged proteins.
Researchers found that stronger, more flavorful onion varieties have higher antioxidant activity and can fight colon cancer cells more effectively. Shallots were also found to be strong cancer-fighters, outperforming milder-tasting onions.
The study confirms that patients benefit from two years of treatment with Macugen for wet AMD, demonstrating a statistically significant 45% treatment benefit. Longer-term use may be beneficial for patients suffering from this chronic disease.
The ENCODE project aims to build a comprehensive 'parts list' of human DNA's sequence-based functional elements, including protein-coding genes and regulatory elements. The initiative will analyze the remaining 99% of the human genome using novel methods and technologies.
Researchers found that bilateral motor performance improvements were seen in patients with Parkinson's disease, regardless of where the stimulation was applied. The study suggests that unilateral deep brain stimulation could be a more effective and lower-risk treatment option for some patients.
Researchers have discovered a way to disable TB protein when it binds to certain molecules, making bacteria more sensitive to treatment by ethionamide. This finding suggests that combining ethionamide with benzylacetone could reduce the dosage of potent antibacterial compounds and improve TB treatment.
Researchers found that beta interferon significantly reduced brain tissue loss and slowed MS progression, with around a third of patients showing improved outcomes. The study's results suggest that beta interferon may be an effective treatment for delaying the progression of multiple sclerosis.
A new computational approach helps researchers understand the relationship between trait differences and variations in the mouse genome, moving closer to understanding human genetic differences. The method also has potential to uncover currently unknown genetic factors contributing to various diseases.
Fossil discovery reveals ancient sea spiders are related to land spiders and scorpions, with the new species Haliestes dasos dating back 35 million years. The preserved specimens provide valuable insights into their unique body form and behavior.
A team of physicists at Georgia Institute of Technology has successfully transferred quantum information from two different groups of atoms onto a single photon. The researchers report using atomic clouds of rubidium atoms as a matter qubit and converting the entanglement into a single photon.
Researchers at Virginia Tech have developed new fiber optic sensors using UV-induced intrinsic Fabry-Perot interferometers, increasing the range and enabling real-time monitoring of large areas. The technology has the potential to create a nationwide network of sensors for infrastructure monitoring with improved multiplexing capability.
A mouse study challenges the idea that a specific gene region is responsible for Down syndrome's characteristic facial features and traits. Researchers found that mice with only two copies of this region still exhibited shorter bones, contradicting previous assumptions.
Researchers analyzed 324 combinations of public and private wind speed and damage models, finding vastly different results due to varying inputs. Creating a centralized database of wind speeds and requiring insurance companies to divulge more information about damage claims could help improve the accuracy of these models.
A report by Cornell University's David Pimentel and his students highlights the need to conserve water in US agriculture. The study found that irrigation practices can require up to three times more fossil energy than rain-fed crops, highlighting the importance of sustainable water management.
A survey of 606 recurrent chronic sinusitis or bronchitis sufferers found that nearly a quarter reported missing three or more days of work due to their illness. Antibiotics were associated with faster recovery times compared to over-the-counter medicines, particularly for symptoms lasting one to two days.
The International Human Genome Sequencing Consortium has completed the human genome sequence, confirming 19,599 protein-coding genes and identifying 2,188 potential protein-coding genes. The finished sequence covers over 99% of the euchromatic portion with an error rate of 1 base per 100,000 base pairs.
Researchers use nuclear transfer to add women's own mitochondria to eggs, preventing inherited diseases caused by mitochondrial mutations. The technique involves adding the woman's own mitochondria to her eggs, reducing controversy and potential health risks compared to using donor mitochondria.
Researchers find that pumpkins are effective in removing DDT and other pollutants from contaminated soils through phytoremediation. The study suggests a potential inexpensive and environmentally friendly alternative to traditional methods of soil cleanup.
A $2.9 million NSF grant will support a Cornell-led consortium developing techniques to anonymize census data while maintaining confidentiality. The project aims to create synthetic and coarsened datasets using virtual households and geographic information systems.
The center, established at Virginia Tech, aims to study and propagate endangered mussels. Researchers produce nearly 50,000 juvenile mussels annually and work on projects like surveying bivalves for stress indicators and studying pearl production.
Researchers found that species diversity in local areas is directly proportional to species diversity in the region, highlighting the importance of regional forces in shaping biodiversity. Latitude also plays a significant role in local species richness, with diverse regions supporting more species.
The study found that individuals with a family history of alcoholism were less sensitive to ketamine and exhibited altered NMDA receptor function. This suggests a genetic predisposition to vulnerability to heavy drinking in the presence of environmental and social factors.
Studies suggest that maximum parsimony, a simpler method, is more accurate than maximum likelihood in inferring historical relationships among species. The results published in Nature challenge the state-of-the-art technique's accuracy and highlight its limitations.
A study conducted at Cornell University found that raising office temperatures from 68 to 77 degrees Fahrenheit resulted in a 44% decrease in typing errors and a 150% increase in typing output. The findings suggest that warmer temperatures can lead to increased productivity and cost savings for employers.
Researchers at Northwestern University are using regenerative medicine to help paralyzed people walk again and enable diabetic individuals to lead normal lives without daily treatments or organ donations. The team is focusing on synthetic scaffolds and their interactions with cells, a key component of regenerative medicine.
Researchers deleted 2.3 million letters of DNA code from the mouse genome, but found no detectable changes in the resulting mice. The study suggests that the mammalian genome may not be densely encoded, challenging previous assumptions about the importance of non-coding DNA.
Leading researchers, including Gerald Schatten, explore the potential of stem cells from therapeutic cloning for treating various diseases. However, concerns over safety, efficacy, and ethical implications remain a topic of debate.
Scientists at the University of Illinois found that honey contains higher levels of antioxidants than corn syrup, which can fight cancer and heart disease. Dark-colored honey, like buckwheat honey, shows promise as a replacement for synthetic preservatives.
Researchers at UCSD School of Medicine discovered the AHI1 gene mutation responsible for Joubert Syndrome, characterized by excessive brain folds. The study also identified a potential link between the disorder and common childhood brain abnormalities like autism.
Researchers discovered that patients with medically intractable epilepsy may develop new adult brain cells post-operatively. This cell generation could be the cause of recurring seizures and provide a potential target for future treatment and prevention strategies.
Indiana University is a national leader in new federal funding for health information technology, aiming to improve healthcare quality, safety, and efficiency. The state has received $6.5 million to develop and implement a statewide health information network.
Scientists have created a genetically modified parasite to study the immune system's memory, which could aid in developing vaccines for Leishmania major, AIDS, and tuberculosis. Researchers found that central memory T cells remain primed to fight new infections even after initial infection has cleared.
A UCI study found that increased CRH can inhibit normal brain-cell development, leading to poor dendrite growth. The researchers believe this may be related to autism, depression, and dementia, and may have potential preventive treatments.
Researchers found that mice with brain tumors treated with stem cells showed increased blood supply and decreased tumor growth, living on average 50 percent longer than untreated mice. The Congress of Neurological Surgeons Annual Meeting presented this promising research.
A study by Johns Hopkins Medicine found that new-generation antipsychotics olanzpine, quetiapine, and risperidone can induce insulin resistance in children, even at moderate doses, leading to increased risk of Type 2 diabetes and heart disease.
The Infectious Diseases Society of America states that endocarditis and meningitis are better treated with bactericidal drugs, while urinary tract infections can be effectively managed with bacteriostatic drugs. Corticosteroids are recommended for bacterial meningitis to prevent inflammation.