A study by Dr. Bart Vanhaesebroeck and his team found that inactivating p110delta in mast cells significantly reduces the allergic response seen in mice. Current therapies targeting symptoms rather than mast cell activation are insufficient, highlighting the need for targeted treatments.
A new study found that high birth weight is associated with an increased risk of childhood acute lymphoblastic leukemia (ALL) but not acute myeloid leukemia (AML). Researchers used data from health registers in four Nordic countries to conduct a case-control study involving over 2,000 children with ALL or AML and their siblings. They a...
A pilot study found that ductal lavage detected only half of the cancers in breasts with known cancer. The procedure's effectiveness is limited by poor agreement between cytologic analysis and microscopic results. Mammography and physical examination remain the most effective methods of early detection.
A lightweight, flexible E-Z Board allows intubated patients to easily communicate their needs, reducing frustration and improving caregiver-patient interaction. The board has been sold to over 200 hospitals nationwide and is targeted at rehabilitation medicine, speech pathology, and critical care areas.
A study suggests chemotherapy, not tamoxifen, is linked to increased stroke risk in women with breast cancer. Chemotherapy remains a key component of treatment despite this finding.
Researchers will model the behavior of individual atoms to gain a better understanding of stress corrosion cracking in metals. The goal is to prevent damage and create more corrosion-resistant materials, leading to safer structures and potentially even improved comfort for travelers.
A study of monkeys found that a high-soy diet did not alter menstrual cycle characteristics or ovarian hormone levels, suggesting that soy consumption may not affect fertility. The research confirms earlier findings that stress levels can impact ovarian function and fertility.
A new gene marker has been found to increase the risk of heart disease in people with type 2 diabetes. The CD36 gene variant is associated with higher levels of free fatty acids and triglycerides, leading to a 60% increased risk of heart disease.
Researchers investigate the impact of partnership status on human sex ratios at birth, shedding new light on this complex topic. The study reveals intriguing findings about the dynamics between relationships and sex ratios, with potential implications for our understanding of human behavior.
A study found that women without recent mammograms were more than twice as likely to be diagnosed with late-stage breast cancer. The research highlights the importance of regular screenings, particularly for underserved populations.
The Lag-3 gene controls regulatory T-cell function, which can prevent autoimmune diseases but also inhibit anti-cancer immune attacks. Researchers found that manipulating Lag-3 levels on T cells might prevent autoimmune diseases or amplify immune system attacks on cancer cells.
A new medication, nitric oxide-donating aspirin, has shown promise in preventing colon cancer by inhibiting the growth of colon cancer cells. The treatment is hundreds to thousands of times more potent than traditional aspirin and may reduce the risk of development by up to 95%.
A recent study by Professor Nazilla Khanlou found that multicultural teenagers in Canada have similar levels of self-esteem, regardless of their ethnic background. The research, published in Public Health Nursing, explored influences on adolescent self-esteem and identified factors such as school, lifestyle, personality, and relationsh...
A multi-center, double-blind study found that patients taking toremifene 20 mg had a lower cumulative incidence of cancer after 12 months, with a 48% reduction compared to placebo. High-grade prostatic intraepithelial neoplasia (PIN) is a precursor to prostate cancer.
A study found that late-stage breast cancer cases were often associated with an absence of screening, followed by absence of detection or a potential breakdown in follow-up care. Women from lower socioeconomic backgrounds and those without a family history of breast cancer were more likely to be in the absence-of-screening group.
University of Illinois researchers found a correlation between academic achievement and fitness scores among school-aged children. Fit children showed improved cognitive function, including better attention and working memory, compared to their sedentary counterparts.
Researchers at Université de Montréal found that diabetes patients are three times more likely to develop liver cancer and twice as likely to get pancreatic cancer. The study analyzed data from over 3,000 cancer patients and healthy individuals.
A study found that chemotherapy, but not tamoxifen, is linked to an increased risk of stroke in breast cancer patients. Women who had not completed menopause and those with a history of hypertension or diabetes were more likely to experience a stroke. The researchers conclude that women can use tamoxifen without concern for stroke risk.
A new study by Mayo Clinic suggests that the ketogenic diet can be safely initiated as an outpatient treatment for children with epilepsy, offering improved acceptability and comfort. The study found no significant differences in long-term seizure control or mental improvement between inpatient and outpatient groups.
A study by Cornell University researchers found that falling paper and leaves exhibit chaotic motion due to air flow around sharp edges. The force depends strongly on coupling between rotating and translational motions of the object, benefiting plants in seed dispersal.
The Online Journal of Nanotechnology at AZoNano.com provides free access to high-quality articles on all aspects of nanotechnology. The revenue from advertising and sponsorship will be distributed among authors, peer reviewers, and site administrators, ensuring inclusive access to knowledge.
A study of 216 acute stroke patients found that lack of improvement within 24 hours of alteplase treatment was associated with a higher risk of poor outcome and death at 3 months. Patients with elevated glucose levels, cerebral cortex involvement, and delayed treatment also had longer hospital stays.
A study found that older age and altered level of consciousness are significant risk factors for in-hospital death in patients treated with clot-dissolving therapy after ischemic stroke. The risk of death decreased with increasing experience of the treating hospital, suggesting a need to prioritize these high-risk patients.
The grant will fund new research in high-risk areas, improve infrastructure, and enhance commercialization of nanotechnology to spur business growth. The award supports Penn State's role as an engine for economic growth in the central region and Commonwealth.
The National Science Foundation (NSF) has announced seven new Institute Partnerships: Teacher Institutes for the 21st Century, investing over $31 million to improve math and science education. The programs will provide courses and experiences for teachers to deepen their content knowledge and become leaders in their fields.
Researchers found ductal lavage detected only half of cancers in breasts with known cancer, possibly due to failure to yield fluid or cells misclassified as benign. The procedure's lack of effectiveness casts doubt on its use as a screening tool for high-risk women.
A study published in Nature Medicine reveals that heparin works by blocking the activation of the complement pathway, a series of inflammatory proteins involved in pregnancy loss and placental injury. This new mechanism suggests potential targeted therapy for patients with antiphospholipid syndrome.
Researchers used a mouse model to show that TGF-b production in tumor-infiltrating T lymphocytes is crucial for colon cancer progression. Inhibition of IL-6 trans-signaling prevented tumor growth, suggesting novel therapeutic approaches for colorectal cancer.
Researchers tracked dust particles from Sahara desert to Toronto using laser ablation mass spectrometer, revealing global pollutants on local streets. The study enables identification of pollutants without prior knowledge of their origin.
The University of Houston has received a $2.8 million NIH grant to develop an interdisciplinary approach to scientific education, combining nanoscience and biology. The grant aims to create the first generation of nanobiologists, with students able to take full advantage of resources across six member institutions.
Research finds that women who head households tend to support Democratic candidates, even in close races. This shift occurs when women become economically independent from men and develop their own perspectives.
Researchers developed a genetically altered mouse model for Sjögren's syndrome, a rare autoimmune disorder affecting 0.6 percent of the population. The Id3-deficient mice exhibited reduced tear and saliva secretion, lymphocyte infiltration, and autoantibody production, mirroring human disease characteristics.
Researchers studied recreational telephone conferences for socializing among elderly individuals and found they greatly valued the social contact provided. The study identified key factors of 'flow' in conversation that indicate enjoyment during socializing.
A study by Chelsea S. Kidwell and colleagues found that MRI detected acute bleeding not seen on CT scans, improving detection rates for chronic hemorrhage and microbleeds. The results suggest that MRI may be superior to CT as the sole imaging technique for acute stroke diagnosis.
A recent study analyzed hourly wages by gender and union affiliation among Canadians. Male visible minorities in unions earned 12% less than European background males, while unions improved women's wages on average. The findings suggest that unions must develop specific goals to target wage disparities faced by ethnic minorities.
Researchers found that a combination of two novel agents - SCH66336 and IGFBP-3 - significantly reduced lung tumor size in mice implanted with human lung tumors. The treatment blocked multiple pathways important to cancer cell survival, showing tremendous potential for treating lung cancer patients.
A new study reveals that sanguinarine enhances protein production inducing cell death and restricts pro-proliferation proteins, potentially protecting against UV radiation-induced skin cancer. Topical application of sanguinarine with sunscreen may also be effective in preventing skin cancer.
Researchers at Purdue University are developing a computer environment that enables experts to talk naturally in their specific scientific language, allowing them to take full advantage of advanced visualization capabilities. This system, called discovery informatics, promises to speed up the process of discovery in many areas of resea...
Researchers recommend baseline ultrasound screenings for men and women at high risk of stroke. The study found that carotid endarterectomy can reduce stroke risk by half in people with narrowed arteries. Regular screenings may identify pre-clinical vessel disease, allowing for preventive measures to be taken.
Communications failures occur in 30% of exchanges, with 10% jeopardizing patient safety. Researchers suggest adopting aviation-style checklists to ensure accurate and explicit data exchange.
A study by Dr. Jamie Ward reveals that synaesthesia is not about detecting hidden emotions, but rather a brain-created response to stimuli. Researchers found that people with the condition associate words and names with specific colours, including pink for positive emotions and brown for negative ones.
Researchers create strategy to trick ATM gene into overlooking premature termination codons, restoring full-length protein production and alleviating symptoms. The treatment uses aminoglycosides to make PTCs invisible to the cell's machinery, showing promise for halting disease progression and cancer risk in A-T patients.
Consuming three or more servings of vegetables daily lowered NHL risk by 40% in study participants. Higher intakes of selenium and zinc also showed protective effects, while vitamins A-C-E and carotenoids had no significant link.
Researchers have successfully grown ultralong carbon nanotubes that exhibit superior electrical properties to copper, a world record for nano-materials of this length. The discovery paves the way for innovative applications in supercomputers and healthcare.
A recent study published by the American Association for Cancer Research found that men with high-grade prostate intraepithelial neoplasia (PIN) are at a higher risk of developing invasive prostate cancer. Within one year, men in the placebo group had a 31.4% risk of being diagnosed with prostate cancer.
A new study expands the dialogue on medical errors to include patients' perspectives, highlighting preventable problems like communication barriers, disrespect, and ignoring patient opinions. The research found that patients are more likely to report psychological and emotional harm than physical harm.
Rutgers University has been awarded two major NIH Roadmap grants to support the training of graduate students in proteomics and develop computational tools for understanding molecular biology. The grants aim to foster interdisciplinary research and address pressing challenges in biomedical research.
Researchers found no statistically significant increase in antimicrobial resistance among patients with CRS over time. In fact, many patients showed reversion to lesser degrees of resistance, suggesting a possible decrease in antimicrobial use and its impact on resistance patterns.
Biomedical engineers at Case Western Reserve University have developed a new, minimally invasive sensor that can accurately monitor glucose levels and other bodily fluids. The sensor, smaller than a pencil tip, uses color changes to detect glucose levels, providing diabetics with continuous monitoring capabilities.
Researchers at UNC Chapel Hill develop new technique to trap single water molecule inside protein molecule using mass spectrometry, improving inhibitor molecules for cancer treatment. The discovery may lead to more effective combination therapies with anti-cancer agents like cytarabine.
The Global HIV/AIDS Clinical Training Materials Database provides adaptable clinical training materials tailored for international settings. The database bridges the information gap in countries hardest hit by the AIDS epidemic by adapting existing resources.
Scientists at UC Santa Cruz have successfully guided light waves through liquids and gases using novel waveguides made from silicon fabrication technology. The device enables detection of molecular fluorescence and has potential applications in fields such as chemistry, biology, and quantum optics.
A study by Wake Forest University Baptist Medical Center found that the experimental drug Trichostatin A (TSA) significantly reduced atherosclerosis in mice. TSA treatment decreased aortic arch deposits and macrophage gathering, leading to increased plaque stability.
A recent study has found that combination hormone therapy doubles breast density and quadruples the risk of abnormal mammograms. The study, led by Anne McTiernan, involved 413 postmenopausal women and showed a significant increase in breast density among older participants.
Researchers found that none of the 35 children with moderate-to-severe malaria in Gabon were severely dehydrated. This challenges the long-held view that dehydration is a major contributor to fatal cases of malaria.
Allopurinol, commonly used for gout, was found to significantly reduce the risk of colorectal cancer in patients taking the medication for at least five years. The study analyzed data from 1,781 patients and showed a notable reduction in risk.
A study found that nearly a quarter of weight loss surgery patients tested positive for H pylori, and 48% experienced significant upper GI symptoms. Treatment for these patients was recommended to alleviate postoperative foregut symptoms.
Researchers found that a class of polyphenols in apples, called procyanidins, significantly reduced precancerous lesions in laboratory animals. The study suggests that consuming whole apples, including the skin, may offer anti-cancer benefits.
A single protein, ChREBP, activates genes in liver cells to convert sugar into fat, a process crucial for energy storage. Researchers found that ChREBP directly binds to DNA of fat-formation genes, increasing expression of enzymes.
A recent study published in Annals of Internal Medicine found that telephone follow-up care did not measurably improve the health of clinically low-risk heart failure patients. In fact, half of the participants were rehospitalized, regardless of whether they received nurse care management or not.