A meta-analysis of 165 clinical trials shows women and men respond equally to drug treatments, challenging traditional recognition of heart disease in women. The study's findings have implications for policy makers and treatment protocols.
Researchers discovered that a malfunctioning gene, M6P/IGF2r, acts as a tumor suppressor in human liver tumors. The gene's loss or mutation may predispose cells to cancerous growth, leading to the formation of liver cancer. This finding could lead to the development of early diagnostic tests and new treatments for the disease.
Researchers have discovered a novel 'left-handed' spiral structure in the protein enzyme LpxA, which could lead to the development of new antibiotics that target this unique structure. The discovery offers a promising approach to combating bacterial resistance to current antibiotics.
Researchers created a mouse model by deleting the gene for dopamine transporter, leading to an overstimulation of brain signals. This study provides a new tool to understand addiction mechanisms and develop treatments for psychiatric disorders and Parkinson's disease.
Researchers at Duke University have demonstrated that two naturally occurring growth factors significantly improved the ability of severed nerve fibers to reconnect with high accuracy. The study could lead to new strategies for improving peripheral nerve repair procedures in humans.
Scientists have long known that proteins like colicin Ia can punch holes in cell membranes to kill bacteria. Researchers at Albert Einstein College of Medicine mapped the structure of colicin Ia, revealing a massive chunk of protein must cross the membrane to form an open channel.
Researchers at Johns Hopkins Medicine have identified unique molecular footprints on the biochemical trail leading the immune system to attack its own tissues in scleroderma. Exposure to toxic oxygen products causes tissue molecules to break apart, exposing hidden parts that trigger an immune response.
Scientists discover mutant mice lacking a gene fail to form distinct layers in the cerebral cortex, leading to fatal seizures and neurological disorders. The study provides new insights into neuronal migration and signaling pathways, potentially leading to breakthroughs in understanding human brain conditions.
A recent study reveals how Huperzine A, a natural substance derived from a moss used in Chinese folk medicine, inhibits the brain enzyme acetylcholinesterase (AChE) involved in Alzheimer's disease. This specific binding could lead to the development of potent and safe Alzheimer drugs.