The structure of MEF2 protein reveals key to its function in regulating genes across various cell types, including muscle, brain, and immune cells. By altering the protein's binding groove, researchers may uncover new targets for therapeutic strategies.
A study by Michael DeBaun and colleagues found that children with neuropathic pain require significantly higher doses of morphine and benzodiazepine than those without. Using methadone as an alternative, the team discovered a more effective treatment approach for pain relief in these patients.
The article discusses the relationship between natural and synthetic substances in relation to human health. Key findings include the difficulty of synthesizing complex natural compounds and the potential for modification by synthetic chemists to enhance medicinal properties.
The Management of Knowledge-Intensive Dynamic Systems (MKIDS) program supports research on how information technologies can streamline processes for organizations responding to rapidly changing situations. Researchers are developing tools to design optimal organizational structures, predict failure points, and monitor organizational pe...
Researchers have identified a key function of merlin in maintaining adherens junctions, which are essential for suppressing cancer development and progression. The study reveals that loss of merlin results in destabilization of these junctions, leading to unchecked cell proliferation and tumor formation.
Researchers have developed a new method using titanium oxide nanocrystals to deliver genes into cells, potentially overcoming current limitations of gene therapy. The nanocomposites can separate when exposed to light or x-rays, allowing for targeted gene delivery.