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Science News for December 12, 2003


New way to lock DNA-slicing enzyme onto chromosomes could lead to novel anti-cancer drugs

St. Jude scientists have discovered a new method to target the Topoisomerase 1 enzyme, crucial for cell division, leading to potential novel anti-cancer drugs that can work in combination with existing agents. This approach may also reduce cancer cells' ability to become resistant to treatment.

SourceSt. Jude Children's Research Hospital·JournalProceedings of the National Academy of Sciences·DateDec 12, 2003

'Snowbirds' versus real birds

A new study finds that declining winter habitats of migratory songbirds significantly affect their ability to reproduce. Researchers measured stable carbon isotopes in the birds' blood, revealing a 'food chain signature' tied to habitat quality.

SourceQueen's University·JournalProceedings of the Royal Society of London·DateDec 12, 2003

Database study yields new insights into arthritis drug

A database study suggests that starting with lower doses of leflunomide can help patients tolerate the medication better, reducing adverse side effects and improving treatment outcomes. The research found no significant increase in severe toxicity, contrary to concerns raised during initial FDA approval.

SourceWashU Medicine·JournalArthritis Care & Research·DateDec 12, 2003

Study findings question COX-2 drug cost effectiveness

Researchers at Express Scripts found that COX-2 prescribing physicians often co-prescribe gastroprotective drugs, contradicting expert estimates. This challenges the use of expert opinion in estimating practice pattern model inputs and warrants re-evaluation of COX-2 cost-effectiveness models.

SourceExpress Scripts, Inc.·JournalThe American Journal of Managed Care·DateDec 12, 2003

Kyoto and beyond

Global per capita greenhouse gas emissions need to be reduced to a small fraction of present levels within the next hundred years. A gradual transition to an emission-free economy is possible at an acceptable price, with significant reductions in emissions necessary beyond the Kyoto horizon.

SourceMax-Planck-Gesellschaft·JournalScience·DateDec 12, 2003