A mutated protein combination is responsible for excessive sugar production in the liver, leading to high blood glucose levels. Researchers have identified PGC-1alpha and FOXO1 as key proteins that form a powerful switch for gluconeogenesis, and blocking their interaction may lead to effective diabetes treatment.
A recent study by Dr Glen Newey argues that politicians' deception is often necessary for the greater good. The researcher claims that the more people demand transparency from their leaders, the more likely politicians are to resort to lies and misrepresentation.
A study found that hostility in children is a risk factor for developing metabolic syndrome, a precursor to cardiovascular disease. High scores on hostility measures were associated with increased rates of obesity and insulin resistance in later years.
Researchers used second-harmonic generation to image tumors in mice, revealing that collagen levels correlate with tumor permeability. The study suggests that a hormone called relaxin could selectively break down tumor-matrix collagen, improving drug delivery to cancer cells.
A new study confirmed Dr. Samuel Orton's hypothesis that children 'turn off' the right hemisphere of their brain as they become accomplished readers. The research also found that different phonological skills relate to activity in different parts of the brain when children read.
Researchers used 3D imaging to study ALS mutant proteins, finding they interact incorrectly and form toxic complexes that interfere with nerve cell function. The study supports two theories: oxidative damage from mutant SOD1 protein and aggregation of protein complexes.
Researchers at UW-Madison have successfully created the world's first knockout rats using a novel combination of techniques, enabling further study of breast cancer and potential treatments. The development restores the rat as a key model for biomedical research, leveraging its genetic flexibility to gain insights into various diseases.