A new three-year project makes 500 mid-Victorian wood engraved illustrations available as a searchable digital web database. The database will include books published in 1862, featuring significant authors like Trollope, and provide insights into 19th-century cultural history and artistic styles.
A study by Duke University researchers found that a fungus's ability to breach the immune system is linked to an enzyme called flavohemoglobin. The team discovered that this enzyme plays a crucial role in defending against nitric oxide produced by the immune system, and that disabling it can significantly reduce fungal virulence.
A study of 5,197 participants found that those with diets high in vitamin C had a 30% lower stroke risk compared to those with low vitamin C intake. Smokers with high vitamin C intake were also significantly less likely to experience a stroke, with a reduced risk of over 70%.
A team of Tufts researchers analyzed 10 trumpets, including five cryogenically treated ones, and found no improvement in sound quality. The study suggests that differences from player to player and instrument overshadow any changes caused by freezing the trumpet.
Researchers identified TL1A, a cytokine that regulates immune response, as a potential target for treating IBD. The protein's expression correlated with inflammation severity in Crohn's disease, but not ulcerative colitis.
Researchers found that women with coronary artery disease and an implantable cardioverter-defibrillator have a lower rate of sustained ventricular tachycardia or fibrillation compared to men. Additionally, automated external defibrillators (AEDs) in health clubs reversed sudden cardiac death in six out of eight victims, supporting the ...
A study predicts that monarch butterfly winter refuges in central Mexico will continue to decline due to increased storms and wet conditions. Human activities such as deforestation and logging further exacerbate the problem, threatening the survival of these iconic butterflies.
Researchers found high interleukin-1 levels in SIDS brains, which could disrupt vital brain functions and lead to sudden infant death. The study's findings may help explain the complex cause of Sudden Infant Death Syndrome (SIDS).
Research reveals that sleep deprivation impairs certain brain areas, including the cerebral cortex, but also activates others, such as the cerebellum. This study sheds light on the complex role of sleep in cellular function and suggests new possibilities for treating sleep disorders.
A recent study published in the Proceedings of the National Academy of Sciences documents harm caused by habitat fragmentation to a tree species native to Tanzania. The research found that birds that disperse seeds for the tree are rare or absent in fragmented areas, leading to poor seed regeneration and threatening the tree's survival.
A study by Duke University Medical Center cardiologists found that patients with atrial fibrillation and congestive heart failure have similar mortality rates when treated with drugs controlling the heart's rhythm compared to those controlling the heart's rate. The study, which analyzed data from over 1,000 patients, also found no diff...
A recent study on sensory interaction found that the brain amplifies information from sight and smell when they fit together well, leading to a stronger perception of odors. Additionally, research on blind individuals revealed that their sense of touch is not inferior to sighted people's, contrary to popular belief.
Researchers found that blocking blood flow to the brain, like mini-strokes, can impair mental function by reducing nerve cell fibers that use acetylcholine. This study provides insight into the effects of cerebral blood flow disruption on cognitive decline in dementia, highlighting the importance of maintaining healthy blood vessels.
Researchers find dopamine-rich brain regions associated with reward and motivation are active in individuals experiencing intense romantic love. They also discover a link between trust and oxytocin hormone release.
Researchers found that children carrying the APOE2 gene variant were more likely to have worse cognitive and motor skills outcomes after heart surgery. The study, published in the American Heart Association's Scientific Sessions, also discovered no association between APOE4 and neurodevelopmental problems in infants.
Scientists have discovered that touch input plays a crucial role in guiding the normal maturation of the pain sensitivity system during development, contradicting the long-held assumption that it is an innate process. This finding has important implications for understanding chronic pain and may lead to new therapeutic methods.
A recent study suggests that daily vitamin supplements can reduce the risk of advanced age-related eye disease (AMD) by 25% and vision loss by 19%. Researchers estimate that 1.3 million adults may develop advanced AMD without treatment, highlighting the importance of regular retina exams.
Researchers discovered that low levels of lead exposure can significantly impact the proliferation and development of neural stem cells. Dr. Jay Schneider's team found that lead inhibited the differentiation of stem cells into neurons or oligodendrocytes, but increased their ability to become astrocytes.
Researchers found that individuals vaccinated against smallpox maintained anti-smallpox antibodies for at least 60 years after vaccination. Memory B cells initially declined but then plateaued approximately ten times lower than their peak and remained stable for over 50 years.
Research on fear extinction suggests that cognitive enhancers like D-cycloserine can accelerate the learning process of fear extinction, leading to more rapid and lasting reductions in phobias. Virtual reality therapy combined with DCS resulted in significant improvements in patients' anxiety levels.
Researchers found that odor working memory is impaired by aging, while semantic memory remains relatively intact. The study suggests that different brain regions handle working and semantic memory, which may explain why odors are more vulnerable to age-related decline.
Researchers tested mononuclear bone marrow cell transplant injections in patients with severe ischemic heart failure and found improved blood flow, reduced chest pain, and increased exercise capacity. Treated patients showed significant reductions in reversible defects and improvements in oxygen consumption and metabolic equivalents.
A new study found valsartan therapy to be as effective as ACE inhibitors in reducing cardiovascular risk after a heart attack. Combining the two medications showed no additional benefit, but was associated with more adverse events.
Researchers have made advances in understanding false memories by identifying brain areas activated in true versus false memories. The right fusiform area was found to be more active in encoding objects that were later labeled as the same as those seen earlier, but less active when they were only similar or actually the same.
A recent Stanford Medicine study shows that an automatic CPR device, AutoPulse, can restore blood flow and pressure more effectively than manual compressions. The device restored blood flow and returned hearts to normal condition in 73% of treated animals.
A magnificent Maya altar stone carved in 796 AD has been recovered from a looters' hideout, providing crucial clues about the wealthiest Maya kingdoms. The altar's recovery illustrates the importance of working with indigenous peoples to restore ancient ruins.
Researchers found BMAA in increasingly higher concentrations in the food chain of Chamorro people on Guam, potentially linking their diet to neurodegenerative diseases like ALS-PDC. Biomagnification of BMAA was also detected in Canadian patients with similar conditions.
A study by Northwestern University researchers found that nearly a third of jailed teenagers have co-occurring substance abuse disorders and ADHD or behavioral disorders. The authors suggest that mental health professionals must collaborate with the juvenile justice system to improve screening, diversion, and access to treatment.
Researchers have found that a new vaccine can diminish symptoms of Alzheimer's disease by increasing clearance of amyloid beta protein from the brain. The study used monkeys and showed that vaccinating them with synthetic amyloid beta peptide enhanced clearance, leading to reduced plaques and improved cognitive function.
Researchers are developing a new drug to treat myasthenia gravis by targeting the nerve-muscle communication point and reducing complement activation. The study aims to provide a more effective treatment with fewer side effects than existing therapies, which have limited success due to their adverse effects.
Researchers found that young children growing up in musical households exhibit an enhanced brain response to music, similar to those two years older. One year of formal music training has no effect on this response.
Groundbreaking research has developed implantable microelectrode arrays that can record neural sensory responses from paralyzed individuals, allowing for accurate prediction of leg positions. A sterile surgical procedure implants the devices, which track the position of the leg using a digital camera and mathematical analysis.
Researchers have successfully treated heart attack patients with stem cells harvested from their own bone marrow, resulting in improved cardiac function and increased blood flow to the damaged area. This breakthrough therapy could potentially lead to a new treatment for heart attacks.
The Rochester center will focus on three uncommon neurological disorders: periodic paralysis, episodic ataxia, and nondystrophic myotonias. These disorders are caused by abnormal cell channels or gates that regulate crucial chemicals in our cells, leading to symptoms such as paralysis, muscle stiffness, and coordination loss.
Researchers found that tire chips can absorb nitrate, a main chemical in fertilizers, reducing pollution in groundwater. Turfgrass quality was not affected by the rubber layer, suggesting it can be used as a sustainable solution for golf courses.
A new genetic variant has been identified in individuals with obsessive-compulsive disorder (OCD), showing a strong link to the development of the condition in multiple generations. The I425V mutation affects serotonin transporter function and is rare, found in only 7 out of 833 individuals studied.
A new study found that systolic heart failure patients who received a one-hour education session with a nurse educator had a 35% lower risk of re-hospitalization or death within 180 days of discharge. The patients scored better on measures of following self-care regimens, such as salt and fluid intake restrictions.
Researchers found that green tea catechin EGCG effectively prevents HIV from binding to human T cells, a breakthrough in the fight against HIV. Further research is needed to explore the potential clinical application of EGCG as an anti-HIV drug.
A study of 177 patients found higher blood levels of sitosterol were associated with an increased risk of coronary events. Patients with high LDL cholesterol and elevated sitosterol levels were at nearly double the risk of a major coronary event.
A Phase I study for non-small cell lung cancer used stereotactic radioablation, increasing radiation doses without prohibitive toxicity. 87% of patients showed positive tumor response, with no local recurrence at the highest dose levels.
The panel concludes that researchers should establish a 'bank' with the fewest number of cell lines that reflect the most Americans, prioritizing white Americans but including HLA types common in other ancestral groups. This would enable faster clinical research and ensure fair access to therapies.
Researchers at Fox Chase Cancer Center discovered a novel DNA-repair gene mutation that causes resistance to cancer drugs, particularly in colorectal cancer. The defective MED1 enzyme interferes with chemotherapy's effectiveness, making cancers resistant to widely used treatments.
The SCOPE study found a significant 42% relative risk reduction in fatal/non-fatal strokes in the Atacand group compared to the control group. The study showed that Atacand offers important clinical benefits by reducing the risk of stroke in elderly patients with isolated systolic hypertension.
Researchers found that human bone marrow-derived multipotent stem cells can differentiate into both vessels and heart muscle, regenerating essential tissues of the heart. The study shows promise for treating acute and chronic heart failure and other blood vessel diseases.
Researchers found that platelets in heart disease patients clot more easily despite taking aspirin, increasing the risk of heart attack. Further studies will investigate additional anti-clotting agents and genetic factors affecting platelet function.
The study found that oxidation damages certain kinds of messenger RNA, leading to abnormal protein processing and neuronal death. Researchers discovered specific types of mRNA susceptible to oxidative damage, which may contribute to the onset and progression of Alzheimer's disease.
The Transdisciplinary Prevention Research Center will focus on developing methods of intervention during key developmental transitional periods. A multidisciplinary team of researchers will test new ideas, theories and methods aimed at developing novel drug abuse prevention programs.
A new study by researchers at The Wistar Institute shows that gene activation is a highly dynamic process requiring specific molecular modifications, including the addition and removal of ubiquitin. This process involves a sequence of events and not just the accumulation of molecular groups.
A recent study found that one in eight North Carolina schoolchildren have three or more heart risks, including low HDL levels and obesity. The researchers attribute this to the prevalence of overweight children among girls, which increases the risk of developing type 2 diabetes and heart disease.
A meta-analysis found that caregivers experience higher levels of stress hormones and lower antibody responses, leading to increased risk for various health problems. The study highlights the need for interventions to support caregiver health, which can benefit both caregivers and their care recipients.
Women with heart attacks tend to have milder blockages in their arteries but are less likely to receive aggressive drug therapy or undergo procedures like angioplasty. This disparity may be due to the disease itself, rather than bias against women's treatment.
Researchers at Emory University Health Sciences Center found that diabetics with non-emergency PCI procedures have similar angina-specific quality of life to non-diabetics. However, those who experienced a NQWMI had greater physical limitation, indicating worsening symptoms prior to the acute event.
Researchers found decreases in genes producing growth hormone and prolactin, key to development and immune system function, in aged mice compared to young mice. This suggests specific genetic changes in the cerebellum area of the brain may contribute to loss of motor control and balance with age.
Researchers have discovered three genetic variants linked to psoriasis, a complex trait influenced by multiple genes and environmental factors. The study may lead to improved treatments by understanding the molecular mechanisms of the disease.
Researchers found that exposure to fine particles of less than 10 micrometers increased the risk of heart attacks in smokers, even at levels lower than current national standards. Air pollution levels in Dijon remained under four on the ATMO index 86 percent of the time.
A new study published in the CREST trial found that cilostazol significantly reduces stent restenosis by 39.5% compared to standard therapy alone. The drug showed promise in patients with diabetes and small blood vessels, a subgroup previously difficult to treat.
A recent study by the American Heart Association found that heart failure patients often leave the hospital without receiving life-prolonging therapies or complete discharge instructions. The study, which analyzed data from over 33,000 patients, highlights the need for hospitals to improve their adherence to established guidelines.
The Get With The Guidelines Coronary Artery Disease (GWTG-CADSM) program improved treatment quality for heart attack patients by increasing the use of aspirin and beta-blockers. Gender gaps in treatment were also reduced, with more women receiving life-saving therapies.
Studies found that individuals with cardiovascular risk factors identified in middle age had significantly higher Medicare costs after age 65 and during their last year of life. Those with more risk factors spent more on treating cardiovascular disease and experienced greater healthcare expenditures overall.
A trial of the clot-busting drug tenecteplase suggests it may improve outcomes in some cases of cardiac arrest. A pharmacist-managed service also showed promising results by reducing recidivism among CVD patients, with women achieving lower target cholesterol levels.