Researchers at Boston Children's Hospital found that minocycline reduces later-stage tissue loss by blocking mitochondrial cytochrome c release, potentially improving quality of life for those with spinal cord injuries. The study suggests a novel post-trauma strategy using a safe, FDA-approved drug.
A study highlights the need for further thinking on research conducted in developing countries, where a majority of studies were not reviewed by local institutional boards. The survey found that 44% of respondents believed their studies were not reviewed, with concerns about cultural appropriateness and language consent forms.
A study by James Carrington and Steve Jacobsen reveals distinct classes of small RNAs in plants with specialized functions. These include genome maintenance, regulation of specific genes, and defense mechanisms, shedding light on the evolution of RNA-mediated gene silencing.
A new study by St. Jude/Mayo Clinic researchers found a direct link between the CBP gene and lymphoma development in mice, with the loss of CBP promoting T-cell lymphoma and cooperating with reduced p27Kip1 protein levels. The study suggests that CBP plays a role in cancer development despite normal p53 activity.
Researchers found that hormone replacement therapy (HRT) can lead to poorer hearing performance in women, especially in noisy environments. The study involved 32 women who had received HRT and compared their hearing with 32 women who had not.
A 26-week study found that topiramate significantly reduced monthly migraine frequency (-2.1 and -2.4 mg/d) and days with migraines compared to placebo. The medication also decreased rescue medication use, providing improved treatment outcomes for patients.
A study found that piercing ear cartilage increased the risk of infection compared to lobe piercing. The authors identified 7 confirmed Pseudomonas aeruginosa infections and 18 suspected cases, with most treated ineffectively with antibiotics.
The pilot plant uses electrolysis to produce high-purity hydrogen, with a purity exceeding 99.999 percent. The system also compresses natural gas for use as a motor fuel, reducing petroleum use and providing air emissions benefits.
Researchers at Hamilton College have found that atmospheric water clusters could play a key role in accelerating the Greenhouse effect. The team's calculations suggest that larger water clusters should be detectable in the lower troposphere.
The Eastern Tropical Pacific Seascape initiative protects 211 million hectares of marine habitat, including nesting grounds for the critically endangered leatherback turtle. The project addresses mounting evidence that the ocean is under duress, with 90% of large predatory fish populations and 75% of commercial fish populations at risk.
The giant catfish, a migratory species in Southeast Asia, is facing extinction due to the destruction of its habitats. Conservation efforts are underway to protect this vital species and the ecosystem it supports.
Critical care doctors have released the first-ever guidelines for sepsis, recommending more aggressive recognition and diagnosis, timely antibiotic therapy, and maintenance of adequate blood pressure. The guidelines aim to standardize clinical management of severe sepsis and reduce mortality rate by 25 percent.
Virginia Tech biologist Virginia Tyson earns top scientist award for his work in computational cell biology and mathematical models of molecular mechanisms controlling cellular growth and division. His research aims to understand and treat medical problems caused by molecular dys-regulation, such as cancer and nerve-cell regeneration.
The study found significant increases in methane emissions from thawing permafrost in Abisko, Sweden, potentially accelerating climate warming. Methane emissions have risen by up to 60% since 1970, with the ecosystem's sensitivity to temperature changes being rapid and dynamic.
Researchers propose a mechanism that helps uncommon species coexist with identical competitors, aligning with discoveries of cryptic fig wasp species. The evolutionary local mate competition theory is tested, revealing a demographic advantage to uncommon species.
The study found that patients who used home blood pressure monitoring were more likely to stop taking antihypertensive drugs and had lower costs, but also had less BP control. Self-measurement helped identify white-coat hypertension, supporting a step-wise strategy for evaluating blood pressure.
A study published in the American Journal of Obstetrics and Gynecology found that nearly all women take prescription medications (92%) and self-medicate with over-the-counter medications (96.5%). Researchers also discovered potential drug interactions, including those between antidepressants and herbal supplements like St. John's wort.
Researchers develop system to study small RNAs using siRNA inhibitors, providing unprecedented insight into RNA interference and microRNA functions. The technique enables rapid discovery of hundreds of microRNAs' regulatory roles, with significant implications for genetic studies.
Researchers Rampal Etienne and Han Olff propose a novel framework linking local community diversity to ancestral immigration patterns. Their approach sheds light on the relationship between biodiversity and genetic diversity in ecosystems.
A study published in Anesthesia & Analgesia found that patients who used E-TRANS Fentanyl HCI PCTS experienced better pain control and fewer withdrawals compared to those who received a placebo. The novel transdermal system, approximately the size of a credit card, allows patients to control their pain management without needles or pumps.
Early administration of reteplase plus abciximab did not reduce infarct size compared to abciximab alone in patients with acute MI referred for PCI. The study also found comparable clinical outcomes between the two treatment groups, but more major bleeding events occurred in the combination therapy group.
Researchers at the University of Minnesota are testing a new treatment for bulimia nervosa, VNS Therapy, which targets the vagus nerve to reduce urges to binge eat and vomit. The study builds on previous research that found voluntary binge eating stimulates the vagus nerve, leading to involuntary behaviors.
Researchers Haygood, Ives, and Andow analyzed the probability of transgene escape within a given period, finding that it can happen much sooner than anticipated. Even with small leakage parameters, the risk of escape increases within ten generations.
A recent study found that cigarette smoking in top-grossing films has increased to 1950s levels, with an average of 10.7 smoking incidents per hour of screen time. The rise in screen smoking is concerning for youth smoking habits, as previous studies have shown a link between movie smoking and youth tobacco use.
Researchers used molecular modeling to study the detoxifying proteins of black swallowtail butterflies and corn earworms. The earworm's protein is more flexible, allowing it to bind to and detoxify six different plant defense chemicals and three common insecticides, making it a master of adapting to new pesticides and host plants.