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Science News for May 16, 2004


New screening method turns up potential compound for treating anthrax

The team discovered a compound called DS-998 that shows promising activity against anthrax lethal factor in cell cultures, blocking the molecule's harmful cutting action. Mass spectrometry is used to screen a library of compounds, enabling rapid screening and reducing costs associated with drug development.

SourceUniversity of Chicago·JournalNature Biotechnology·DateMay 16, 2004

New compound may act to keep thyroid activity in check

Researchers discovered a new compound, T1 amine, that rapidly induces hypothermia, slows heart rate, and drops blood pressure in mice. This effect may provide a valuable tool to manage patients with acute hypermetabolic states, including hyperthyroidism.

SourceOregon Health & Science University·JournalNature Medicine·DateMay 16, 2004
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University of Pittsburgh approach has lung recipients taking far fewer drugs

The University of Pittsburgh's novel clinical protocol has shown promising results in reducing immunosuppressive medication use for lung transplant patients. With over a year of follow-up, the approach has led to improved one-year survival rates and fewer complications associated with traditional treatments.

SourceUniversity of Pittsburgh Medical Center·DateMay 16, 2004

Gene discovered for Cornelia de Lange syndrome, a disabling genetic disease

Researchers identified the NIPBL gene on chromosome 5 as the cause of Cornelia de Lange syndrome, a condition characterized by mental retardation, impaired growth, and heart defects. The discovery may lead to genetic tests for confirmation and comfort for families affected by the disease.

SourceChildren's Hospital of Philadelphia·JournalNature Genetics·DateMay 16, 2004

Research targets biologic profile of obesity

A study found that morbidly obese patients experience increased minimal distending pressure and exaggerated gastric accommodation during meals, leading to overeating and weight loss challenges. Researchers suggest addressing biological barriers differently through surgery or alternative methods.

SourceAmerican Gastroenterological Association·DateMay 16, 2004
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