Kohn's bioresorbable polymer was successfully licensed and incorporated into REVA Medical's stent devices. The collaboration resulted in rapid development and early pre-clinical study success.
The University of Manchester has developed a new technique that allows scientists to study protein molecules in complete detail, doubling the number of visible atoms compared to current methods. This breakthrough enables the creation of more effective medicines by targeting specific proteins.
Recent studies suggest that two chemical signals, Hedgehog and Wnt, play a key role in the development of certain cancers. These signals are also active in normal stem cells that repair damaged tissue, raising the possibility that some cancers may start from these cells with accumulated mutations.
The study reveals that light-to-moderate grazing has no ill effects on the ecosystem, and can even increase vegetative ground cover and plant diversity. In contrast, ungrazed lands show more cheatgrass and reduced plant variety, highlighting the benefits of managed livestock grazing.
Scientists on a research cruise off the Alaskan coast have identified previously undiscovered deep-sea habitats and sparked debate about the causes of a devastating 1946 tsunami. The expedition used cutting-edge technology to map the seafloor, collect sediment samples, and probe the region with an ROV.
Researchers successfully produce spider silk fibers in insect cell cultures using genetic engineering, opening the way for commercial development. The fibers possess chemical resistance characteristics similar to those produced by spiders.
Researchers at Mount Sinai School of Medicine discovered a new mechanism that contributes to the development of some breast and ovarian cancers, involving the Wnt pathway. Compounds blocking this receptor can make cancer cells more sensitive to agents that induce cell death.
Researchers at UCI created oligodendrocyte cells from human embryonic stem cells that can function in a living system, forming myelin patches and restoring sensory and motor function. The study shows great promise for treating spinal cord injuries and diseases.
A new study reveals that obesity is tied to an increased risk for numerous health conditions, including life-threatening diseases like heart failure and serious illnesses like high blood pressure. The research also found a correlation between excess weight and various health complaints that reduce quality of life.
A systematic review by the Task Force on Community Preventive Services found that teaching children how to protect themselves from the sun can reduce risk of skin cancers. Younger children are more receptive to self-protective behaviors and benefit from sun-protection programs integrated into existing learning situations.
A study analyzing claims data from 11 managed care health plans found that the risk of rhabdomyolysis is relatively low with three frequently prescribed statins. The study suggests that patients taking statins and fibrates combined, such as those with diabetes mellitus, should be monitored for symptoms suggestive of rhabdomyolysis.
The Washington University CubeSat, Bandit, is a small satellite that can dock with a medicine ball-sized mothership, making it ideal for inspection tasks. Developed by students and faculty, the satellite has the potential to disrupt spacecraft design with its innovative technology.
Researchers studying Acetobacter bacteria have discovered enzymes that resist acid, shedding light on potential treatments for diseases caused by misfolded proteins. The findings could lead to more stable proteins and environmentally friendly industrial processes.
A study found that the renin-angiotensin system may be associated with physical function in older adults, and that ACE gene variants can affect exercise response. Additionally, researchers discovered a potential link between this system and cognitive impairment, suggesting new avenues for intervention.
Researchers at NYU discovered a gene mutation, Lmo, that increases sensitivity to cocaine in fruit flies. The mutation affects the fly's internal clock, modulating sensitivity to cocaine within its cells.
Researchers have re-determined the content of argon in air, finding it to be approximately 0.9332%, very close to historical measurements made 100 years ago. This new value is significant for precision mass measurements, which require accurate corrections for air density.
Researchers trained European starlings to choose between rich food sources and decoys, finding that 'irrational' preferences resulted from energetic state rather than cognitive mechanisms. The study warns against introducing confounding effects in nonbiological framework testing ideas.
Researchers found that activating FXR can prevent gallstone formation by restoring balance of bile acids and phospholipids. The study suggests a potential new direction for diagnosis and prevention of cholesterol gallstone disease, with implications for patients who have had their gallbladders removed.
Long-term obesity is associated with a significant loss of brain tissue, particularly in the temporal lobe, increasing dementia risk. The study found that women with higher BMI experienced greater atrophy and increased dementia risk over time.
Researchers identified Lmo mutants in Drosophila that showed increased response to cocaine, indicating a potential link between the fly's internal clock and drug sensitivity. The study found that Lmo-related proteins are present in key areas of mammalian brains, suggesting implications for understanding human addiction.
Researchers analyzed pharmacy and clinical databases to identify high-risk opioid prescribing patterns. Patients without cancer were more likely to receive higher doses due to factors like older age, HIV/AIDS, and co-prescription of benzodiazepines.
A study by Dr. Shrawan Kumar helps clarify the definition of whiplash by measuring neck muscle responses to low-velocity impacts. Turning the head reduces the risk of soft tissue injury, according to the research.
A nationwide hospital study found that urban teaching hospitals incurred nearly 70% of total charges for motorcycle-related cases in 2001. The majority of injured riders had longer stays and higher charges due to head injuries, with men accounting for 89% of motorcycle-related hospital discharges.
Research by Kathleen Gerson and Jerry Jacobs found that combined work hours of families, not individual work experience, reveal the time squeeze. Parents in two-income households cut back on joint working time to cope with pressures, but fathers actually work more hours when children are home.
A study published in The Journal of Neuroscience found that chronic back pain is associated with a significant decrease in gray matter volume in the brain, particularly in regions involved in processing information and memory. This suggests that proper treatment may reverse some of the brain changes caused by chronic pain.
Researchers used computer simulations to visualize the formation of amyloid fibrils, similar to those found in Alzheimer's and Parkinson's patients. The study suggests that understanding how these fibrils form could lead to discoveries of how to slow or halt their growth.
The Global Pertussis Initiative recommends introducing universal adolescent vaccination programs and vaccinating certain target groups to enhance immunity. Adolescents are at risk of contracting whooping cough if they don't receive booster shots, making them a key population for vaccination.
A positive family history of stroke increases young women's risk of both blocked and ruptured vessel strokes. High blood pressure and smoking are also strong predictors of rupture-risk, while diabetes and lack of exercise contribute to blockage-risk.
Researchers identified two new loci influencing female mate choice, favoring same-species mating over closely related ones. Genetic analysis shows female mating discrimination is inherited as a dominant trait, with genes linked to olfaction and X chromosomes.
A study examined the association between cerivastatin sodium and rhabdomyolysis to illustrate the US postmarketing safety-surveillance system's limitations. The authors suggest an outside group should review label changes, new studies, or suspension of sales to balance patient and industry interests.
A study published in Archives of Internal Medicine found a significant association between antidepressant use and risk of abnormal bleeding. The risk increased with the degree of serotonin reuptake inhibition, particularly for drugs with high levels of inhibition, which were associated with a 2.6-fold increased risk of bleeding events.
The US postmarketing surveillance system requires major restructuring to effectively monitor drug safety. An independent agency would oversee the process, ensuring complete independence from pharmaceutical industry influence.
A comprehensive study of 13,017 French adults found no significant reduction in cancer incidence with antioxidant supplements, but men showed a 31% lower risk of developing cancer than women. The researchers suggest that supplementation may be effective in men due to their lower baseline levels of certain antioxidants.
Researchers found that theobromine is nearly a third more effective than codeine in stopping persistent coughs. The new treatment works by suppressing vagus nerve activity, with no adverse effects on cardiovascular or central nervous systems.
Computer scientists capture data on pen stroke patterns and aesthetic signatures from artworks, revealing consistencies and inconsistencies within single pieces or among works by the same artist. The technique confirms what art experts have concluded about the authorship of certain paintings.
A recent pilot study found that only a minority of subjects received a diagnostic work-up according to published algorithms, and that larger nodule sizes were associated with lower use of biopsy for follow-up. Only 7% of subjects diagnosed with lung cancer within a year of the first positive screen.
A new study by Newcastle University reveals that many foreign-owned plants in the North East England fell short of their promised job creation targets. The research team found that firms which received special financial assistance were more likely to achieve their employment goals, but those involved with Invest UK were less likely to ...
Researchers followed 87 women diagnosed with BRCA mutations who underwent BCT and found no increase in cancer recurrence risk. However, more than half suffered a cancer-related event within ten years, including 37.6% with new cancers in the untreated breast.
A new fMRI study found that autobiographical memories engage different parts of the brain, even when recalling the same content. The study used 'diary' method to collect memories, revealing the frontal lobes involved in self-awareness and visual memory are more strongly activated for episodic memories.
Researchers have developed a self-cleaning coating that can be permanently integrated into fabrics, reducing the need for dry cleaning. The coating uses silver nanoparticles to repel dirt and water, making it easier to clean clothes with less water and frequency.
Researchers at UCLA have found that children with Congenital Central Hypoventilation Syndrome (CCHS) and Sudden Infant Death Syndrome (SIDS) share similar brain responses to breathlessness. The study suggests that the irregular brain mechanisms provoking CCHS may also underlie SIDS.
Researchers at UC Berkeley have created a device that allows brain cells to respond to light, enabling the potential treatment of retinitis pigmentosa and age-related macular degeneration. The breakthrough involves genetically engineering nerve cells to be sensitive to light using ion channels made light-sensitive.
Researchers at Wyeth determined the three-dimensional structure of PKCΘ, a key signaling molecule in T lymphocytes. This discovery has potential to identify selective inhibitors for autoimmune diseases by disabling T cell activation.
The Texas Bison Herd is struggling due to inbreeding depression, a condition caused by lack of genetic variation. The herd's average age has increased, and birth rates are low, posing a threat to its survival.
Researchers detected distinct brain activation patterns in individuals carrying the APOE-å4 risk factor and found potential evidence of early Alzheimer's changes. The study suggests that these individuals may be compensating for damage by switching to alternate brain networks, providing insights into disease predisposition.
A recent study found that medication errors are often caused by late administration, workplace distractions, and inadequate staffing. The researchers also highlight the benefits of using bar code medication administration systems and paperless charting systems to reduce errors.
Researchers discovered a new mechanism by which Helicobacter pylori bacteria can stick to stomach cells, allowing them to survive a strong immune response. By recombining DNA from two related genes, the bacteria can create a functional BabA gene, enabling it to bind tightly to Lewis B receptors.
A massive infestation of invasive sea squirt Didemnum has been found on Georges Bank, covering 50% or more of the seabed. The species is threatening commercial fish species and altering seabed communities.
Studies found that sit-down rounds significantly improved patient outcomes, including healthy levels of albumin and hemoglobin, lower hospitalization rates, and reduced mortality. Patients treated at clinics with regular sit-down rounds had better care team communication and were more likely to be white, married, or high school graduates.
Intellectual property experts argue that the NIH proposed policy does not alter existing copyright law, but rather builds on current practice to facilitate public access to research. This change is seen as advancing the NIH's aim to use today's information technologies to fulfill its public mission.
Researchers found that fasting reduces phospholipid levels in the heart by up to 40% after 12 hours, allowing mitochondria to become more energy-efficient. After feeding resumes, phospholipid levels return to normal, but triglyceride levels remain elevated, hinting at a memory of deprivation.
Researchers at UCSB discovered a key mechanism by which E. coli bacteria adhere to the urinary tract. The finding sheds light on the mechanisms driving urinary tract infections, allowing for potential new treatments and survival strategies under stressful conditions.
The NIH has awarded a grant of $540,000 to train 1,200 middle school teachers in the use of MedMyst, a web-based science curriculum that uses interactive computer adventures to teach kids about infectious diseases and microbes. The training will allow teachers to enrich the science curriculum for 150,000 students over two years.
A Swedish study has found a statistically significant correlation between the degree of Chernobyl fallout and an observed rise in cancer cases. The study monitored over 1,143,000 individuals for cancer development after being exposed to low levels of radioactive cesium-137.
Researchers found that alcohol impairs brain areas controlling motor functions, leading to increased speeding and crashing. Brain regions involved in decision-making and working memory were not affected until drivers reached a blood alcohol level of 0.08.
Researchers discovered that overexpression of Down Syndrome Critical Region 1 (DSCR-1) reduces tumor growth and blocks blood vessel formation. This breakthrough could lead to novel strategies for inhibiting endothelial cell dysfunction and abnormal blood vessel formation.
A new study found that taking vitamin E daily can reduce the risk of heart attack by 43% and dying of heart disease by 55% in diabetic patients with haptoglobin 2-2. The results suggest a significant public health benefit for this group, who are at high risk of cardiovascular disease due to their genetic profile.
Researchers used atomic force microscopes to study the effects of biomolecules on crystal dynamics and shape. They found that specific interactions between growth modifiers and step edges controlled the formation of complex crystal shapes, challenging long-held theories.
Researchers used gene expression profiling to develop a prognostic profile for ovarian cancer, identifying 115 genes that provide important information about prognosis. This technology holds promise for understanding the root causes of ovarian cancer and designing targeted therapies.
Research in female mice reveals estrogen's protective effects against atherosclerosis, highlighting potential risks of COX-2 inhibitors for premenopausal women. The study identifies prostacyclin as a key mediator of estrogen's benefits.