Scientists at Cold Spring Harbor Laboratory identified 130 genes that affect the replication of retrovirus-like elements in yeast. These genes have clear relatives or homologs in the human genome, providing a rich source for candidate host genes to develop new anti-retroviral therapeutics.
Researchers developed a test to measure CDK activity, which accurately predicts tumor response to Tarceva. A second study found that increased CDK activity correlates with sensitivity to Taxol, providing preclinical evidence for developing a novel device to measure CDK activity in human tissue.
Researchers analyzed gene-expression libraries from daf-2 mutants to identify genes critical to aging. They found that metabolic processes were repressed in early and mid-life adults, contributing to longevity. Stress-response factors were also differentially expressed, suggesting protection against cellular stress may increase lifespan.