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Science News for April 24, 2005


Monoclonal antibody cures West Nile virus-infected mice

Scientists have discovered a humanized monoclonal antibody that can boost survival rates of infected mice to 90% or higher. The antibody, produced by Macrogenics Inc., has potential utility against other infectious diseases and could help develop new treatments for related viruses like dengue fever.

SourceWashU Medicine·JournalNature Medicine·DateApr 24, 2005

Alzheimer's cognitive decline slowed

A new gene therapy approach has shown promising results in slowing the progression of Alzheimer's disease by reducing cognitive decline. The therapy, which involves delivering nerve growth factor to the brain, demonstrated significant improvements in patients' mental status and brain activity.

SourceUniversity of California - San Diego·JournalNature Medicine·DateApr 24, 2005
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Promising new West Nile therapy cures disease in mice

Researchers have developed an infection-fighting antibody that successfully cures disease in mice infected with West Nile virus, even when the virus had entered their brains. The monoclonal antibody was several hundred times more potent than natural antibodies and completely protected mice against death.

SourceNIH/National Institute of Allergy and Infectious Diseases·JournalNature Medicine·DateApr 24, 2005