Researchers found that knocking out laccase-2 enzyme prevents tanning in red flour beetle, revealing protein responsible for hardened exoskeleton. The discovery opens possibilities for developing new insecticides and bio-rational methods to control pest populations.
Research has found a positive association between body mass index, fat-free mass, and waist circumference with an increased risk of myeloid leukemia. Additionally, modifications of the vimentin gene can be detected in fecal DNA of people with colon cancer, potentially serving as a biomarker for the disease.
A practical screening tool was developed to diagnose severe acute malnutrition in children under five in sub-Saharan Africa. The tool uses a combination of clinical signs and laboratory results to identify at-risk children, enabling timely intervention and improving survival rates.
A study by Dr. Mihai Covasa and colleagues found that a high-fat diet can reduce the body's sensitivity to cholecystokinin, a hormone that helps regulate appetite, in rats. This reduced sensitivity leads to increased overconsumption of highly palatable foods high in dietary fat.
A study evaluated the Quebec Neuroblastoma Screening Project and found that not implementing screening programs saved $574.1 million in unnecessary health costs. The study also found that widespread use of neuroblastoma screening across North America would have caused adverse health effects.
A JAMA study investigates how social and political factors influence refugee mental health, highlighting the need for culturally sensitive interventions. The research suggests that addressing these underlying factors can improve mental well-being among refugees.
A study by UT Southwestern researchers found significant differences in C-reactive protein levels among men and women, as well as between black and white patients. Women typically had higher CRP levels than men, while blacks had higher levels than whites, with a notable disparity in cardiovascular disease rates.
Researchers Jane Schneider and Peter Schneider uncover a diverse Sicily, where the mafia and antimafia have distinct values and practices. The study reveals Sicilians' ability to organize democratically for community goals, challenging established views on their culture.
A study found that prenatal exposure to famine in China's Wuhu region increased the risk of schizophrenia in later life. Birth rates dropped significantly during the famine years, and the risk of developing schizophrenia increased among those born during this time.
Lowering PSA cutoff from 4.0 ng/mL to 2.5 ng/mL would call for more biopsies, with 10.7% of US men aged 50-59 and 17% of those aged 60-69 affected.
A randomized controlled trial found that cognitive therapy significantly reduced repeat suicide attempts in adults who recently attempted suicide, with a 50% decrease compared to usual care. The therapy also improved depression and hopelessness levels.
Craniofacial plastic surgery helps children with facial deformities gain social acceptance and improve their learning capabilities. The procedure can positively change how others interact with them, leading to better relationships and overall well-being.
The largest study of unrelated bone marrow transplantation for leukemia has demonstrated similar survival rates for T-cell depletion and immunosuppressive drug therapy approaches. The study, published in The Lancet, also found no appreciable differences in cost or quality of life between the two methods.
A recent study highlights the dangers of Solar Proton Events (SPEs) and Coronal Mass Ejections (CMEs) on a manned Mars mission. The researcher recommends improving space weather monitoring and developing lightweight mechanisms to detect dangerous space weather, as well as creating more robust models for propagation over larger distances.
The Penn State Regional Center will conduct research on climate change's effects on regional terrestrial ecosystems, including the Northeast region with high population density and urbanization. The center aims to develop models predicting climate change impacts and analyze carbon exchange between ecosystems and the atmosphere.
A UCSF study found that limited English proficiency is an independent risk factor for difficulty in understanding medical situations. Respondents who were LEP reported more comprehension problems despite having access to physicians speaking their native language.
The UN model predicts 60.8% of people will live in towns and cities by 2030, but a new model suggests this number is lower at 49.2%. Most population growth between 2025-2030 will come from 10 large developing countries.
The study analyzed the relationship between past violent behavior and future homicide rates among male offenders in the US. The findings suggest that a history of violent behavior is associated with an increased risk of future homicides.
Researchers found that preschoolers with high levels of autonomy support from their parents tend to have better social adjustment and academic achievement in later years. This association was observed even after controlling for other factors, suggesting a positive link between parental autonomy support and child development.
Researchers suggest primordial doublet code evolved into triplet system, explaining 20 amino acids and error tolerance. The theory also points to a hot primordial soup as the origin of life.
A new review of the American College of Cardiology and American Heart Association guidelines aims to streamline diagnosis and treatment of acute coronary events. The goal is to provide faster treatment that may even prevent a heart attack or damage to the heart before it happens, benefiting millions of patients each year.
Researchers analyzed home videotapes of 56 children to find that infants with autism who experience regression show more frequent word use and babble than normal infants at 12 months. Early onset ASD infants display the least frequency of language development.
The human cerebellum and cortex age at vastly different rates, with the cortex showing pronounced and consistent changes, while the cerebellum experiences smaller and less coordinated changes. This study, published in PLoS Biology, reveals that the functions of brain regions influence how they age.
A new study suggests that the Olmec civilization imported pottery from other cultures, contradicting previous claims that it was the sole source. The findings use petrography to identify minerals in pottery fragments and reveal reciprocal trade between highland and lowland centers.
Researchers understand the mechanism of smooth muscle cell growth, which allows for contraction and expansion of blood vessels. The discovery opens up new avenues for treating vascular disorders by targeting the Foxo4 protein.
Research suggests that severely mentally ill individuals are disproportionately victimized by crime, with a prevalence rate six to 23 times greater than the general population. The study's findings highlight the need for improved mental health treatment and support services to reduce revictimization.
According to a survey of 228 Pennsylvania high schools, bottled water and fruit juice are widely available in vending machines, while the top-selling a la carte items include hamburgers, pizza, and sandwiches. The survey also found that nearly 60% of schools sell carbonated beverages through vending machines.
Researchers found that levels of enterococci bacteria were higher at beaches during full and new moon phases, increasing the risk of illness. The study suggests using tidal patterns as a tool for assessing water quality and identifying potential sources of pollution.
A new study suggests that surgical myectomy can significantly improve symptoms in patients with severe obstructive hypertrophic cardiomyopathy (HCM), resulting in comparable life expectancies to those who never had the condition. By correcting blood flow obstructions, surgery offers a better quality of life for these younger patients.
The study found age-related changes in gene expression in the human brain's cortex, but not in non-brain tissues. The results support a theory that DNA damage and protein degradation contribute to aging, with more metabolically active tissues showing greater gene activity reduction.
Researchers at the University of Pennsylvania School of Medicine have found that inhibitors of cellular enzyme cathepsin L prevent the SARS virus from entering target cells. This breakthrough discovery could lead to the development of new therapeutics against the SARS virus.
Researchers have found that amphetamine-related drugs, such as MDMA, can effectively alleviate symptoms of Parkinson's disease in a mouse model. By eliminating dopamine recycling and production, these drugs bypass the usual limitations of L-DOPA treatment, offering new hope for patients with the debilitating condition.
Scientists at Ohio State University created a mouse model of lung cancer that loses the FHIT gene's protein early in development, leading to larger and more numerous tumors. The study suggests that even low levels of the protein might prevent lung cancer.
Researchers at Rice University developed a new nanoprobe that uses quantum dots to visualize proteolytic activity in vivo, solving the problem of distinguishing between disease signals and background noise. The probes are activated by enzymes associated with specific diseases, allowing for early detection and monitoring.
A new study found that females prefer males with higher ocelli density but also those with shorter tails, suggesting they value the visual perception of a dense cluster. This preference is driven by both ocelli density and male displaying activity, providing peahens with information about male health.
A new study has established a significant correlation between waist circumference and components of the metabolic syndrome, including elevated blood pressure, insulin resistance, and high-density lipoprotein cholesterol levels, in children. The research found that abdominal obesity, as measured by waist circumference, is an independent...
The sensor uses ambient radiation to detect objects based on how brightly they reflect natural radiation. Once developed, it could be used for luggage scanning and aircraft runway detection during bad weather.
Researchers found that omega-6 fatty acids can stimulate cell growth in prostate cancer cells by activating the production of cPLA2 and COX2 enzymes. A diet high in omega-6 fatty acids may contribute to increased risk of prostate cancer, while a new class of drugs targeting cPLA2 could offer a safer alternative to existing treatments.
A study by Linda Teplin et al found that over one quarter of individuals with severe mental illness were victims of violent crime in the past year, nearly 17% for completed violence. The authors recommend systematic screening and monitoring, skill-based prevention programs, and policy-level changes to address this public health problem.
A new study reveals that insulin therapy preserves endothelial function in critically ill patients, improving oxygen supply to cells. This finding opens doors for novel treatments and progress in intensive care medicine.
The study found that hemodialysis was more beneficial for patients with cardiovascular disease, while peritoneal dialysis was better suited for healthier patients. The findings suggest that choosing the right dialysis treatment can impact mortality rates.
A recent study found that adolescent girls who experienced violence are more likely to perpetrate violent acts, with the highest risk at age 14. The research also suggests that improving community safety can help reduce violent behavior among these girls.
Researchers have identified 141 distinct proteins in the healthy human cornea, including classical blood proteins and anti-angiogenic factors. This comprehensive protein study may lead to future therapeutics for various corneal disorders, improving clinical classifications and potentially generating artificial corneas for transplantation.
A new analysis of existing studies reveals that individuals with overweight or obesity are at a higher risk of experiencing GERD symptoms, erosive esophagitis, and esophageal cancer. In contrast, researchers found no significant difference in mortality rates between patients undergoing peritoneal dialysis or hemodialysis for end-stage ...
Researchers investigate Akt1's impact on cardiac function, finding it can enhance cardiac function after heart failure but also contribute to maladaptive effects. A new gene therapy approach successfully treats severe combined immunodeficiency (SCID) in mice, offering promising implications for its treatment.
Researchers found a significant risk factor for early respiratory failure following stem cell transplantation: patients with low lung function test scores prior to treatment. The study analyzed 2,852 patients who received allogeneic transplants between 1990 and 2001.
Researchers have discovered that monarch butterflies use specialized UV photoreceptors in their eyes to guide their long-distance migration. The butterflies' biological clock also plays a crucial role, with input from both the light-detecting navigation sensors and brain clock combining to provide direction.
Researchers at UTMB discovered that oxidative stress from pollen is as important as antigen exposure in triggering severe respiratory inflammation. Antioxidant substances may help forestall allergy or asthma attacks, and longer-lived antioxidants could be effective in treatment and prevention.
Researchers found that older patients with newly diagnosed diabetes are considered a high-risk group for developing pancreatic cancer. The study, conducted by the Mayo Clinic College of Medicine, included 2,122 patients aged 50 and older who were diagnosed with diabetes between 1950 and 1995.
Using RoboLase, Australian scientists successfully performed sub-cellular surgery on a laser microscope system in California, demonstrating the potential for remote medical procedures. The technology enabled researchers to collaborate without traveling to a single laboratory site, paving the way for increased global scientific collabor...
The TIMSS 1999 Video Study found that while countries exhibit unique teaching patterns, there is also significant global convergence in classroom methods. This suggests that teachers from different countries can recognize familiar practices and be surprised by their differences.
The JAK/STAT signaling pathway is a crucial regulator of cell growth and survival in various organisms. Research at the Cold Spring Harbor Laboratory has shed light on the molecular mechanisms underlying this pathway.
Researchers halt Phase IIB/IIIA clinical trial of heparinase I due to higher incidences of negative side effects, including bleeding and infections. The study's lead author emphasizes the need for further research to develop an effective alternative to protamine.
A study by Mayo Clinic found that 72% of discharged patients couldn't list their medications or 58% couldn't recall their diagnosis. Dr. Friedman recommends improving communication through language, practicality, and time to avoid noncompliance.
Researchers discovered a new protein, CBP21, that speeds up chitin degradation by breaking down its structure. This discovery has potential applications in combating fungi and producing biofuels.
According to a survey of 180 Ph.D. recipients in Earth and space sciences, the vast majority (87%) found work in their field, earning commensurate or slightly higher salaries than in 2001 and 2002. Most graduates were employed in academia, with positive attitudes towards their employment situation and challenging yet relevant work.
Researchers discovered that monkeys perceive vibration frequency by analyzing neuronal firing patterns, particularly in the first 250 milliseconds. The findings suggest a complex process where attention to the initial response dominates perception, with subsequent firings becoming less significant.
Residential injuries are a major cause of death in US children and teens, with the majority being preventable. A study found that fatal residential injuries decreased by 22% between 1985-1997, but disparities persist due to socioeconomic factors.
Key findings highlight the importance of including women in clinical trials due to differences in response to drug therapy, such as higher levels of adverse reactions and varying mortality rates. This lack of data affects treatment strategies, with many drugs prescribed to women adapted from studies conducted mainly in men.
Dr. Gragoudas is being recognized for his groundbreaking work on protein beam irradiation and photodynamic therapy for intraocular melanoma and neovascular age-related macular degeneration. He has made significant contributions to the clinical practice of ophthalmology, particularly in the study of retinal vascular diseases.