Preliminary results from the study show that E7389 induces partial responses in patients with refractory breast cancer. The predominant serious side effect was neutropenia, but mild to moderate side effects were also reported.
Astronomers have created detailed maps of invisible dark matter in two young galaxy clusters, lending credence to the theory that galaxies form at dense regions of cosmic webs. The study used the Hubble Space Telescope's Advanced Camera for Surveys to overcome atmospheric turbulence and measure subtle gravitational lensing effects.
A new microscope combining confocal and atomic force microscopy enables three-dimensional imaging of samples at the atomic level. Researchers can study material structure and link small changes on the cell membrane with structures inside a cell.
Scientists have found that Golgi outposts, previously thought to play only a central role, are actually distributed throughout the length of growing dendrites. This discovery sheds light on how neurons sort proteins and regulate their growth, with implications for understanding brain development and neurodegenerative diseases.
A study by Oregon State University researchers found that switching between tasks, like driving and cell phone use, leads to delays in response time and accuracy. The study suggests that simplifying tasks can help efficiency, but technology is complicating everything, including driving.
Researchers at the Medical College of Wisconsin have developed a new vaccine technology that confers broad-spectrum, short-term immunity against unknown biothreat agents. This breakthrough could revolutionize defense against germ warfare and treatment of infectious diseases in populations.
The North Magnetic Pole's movement may be part of a normal oscillation and will eventually migrate back toward Canada. Scientists tracked the pole's movement using sediment records from Arctic lakes, providing a reliable timeline and revealing a 'jerk' in the magnetic field every 500 years.
Researchers have found that women are increasingly represented among pediatric medical subspecialties, with more than 70% of practitioners in certain areas such as adolescent medicine and neurodevelopment being women. The trend is seen in 17 out of the 16 specialties studied.
A European study found pramipexole significantly reduces RLS severity and improves quality of life, with notable improvements in Vitality and Bodily Pain scores. The treatment showed efficacy using two measurement criteria: IRLS and CGI-I scale.
Using a new geochemical tool, researchers documented how fast glaciers eroded the Coast Mountains of British Columbia, finding rates six times faster than rivers and landslides. Glaciers scraped at least 2 kilometers of rock from mountains around 1.8 million years ago, shaping the landscape.
Dr. Olson and Dr. Abraham Rudolph receive the Pollin Prize for their work on congenital heart disease and gene control. Their research has advanced understanding and treatment of this common birth defect.
Researcher Steven W. Van Sciver is investigating the properties of liquid helium to develop a cryogenic technique for separating particles at the submicron level. This could lead to more efficient medication delivery, particularly for respiratory medications that require precise particle sizing.
A clinical trial found that patients with RLS who continued treatment with pramipexole experienced a significantly longer time before symptoms worsened compared to those on placebo. Pramipexole also improved quality of life scores, demonstrating its potential as a long-term treatment option for RLS.
A study found that patients who trust their doctors more have improved health outcomes, with less trust associated with delayed care and unmet healthcare needs. However, some groups, such as African Americans, Hispanics, the poor, and uninsured individuals, showed no correlation between trust and these issues.
Researchers from Mayo Clinic found no association between patent foramen ovale (PFO) and increased risk of stroke. PFOs are common congenital conditions that may be 'innocent bystanders' rather than causative factors, according to the study.
The Mayo Clinic Cancer Center has reported significant advancements in quality of life assessments for cancer patients. The researchers tackled philosophical and statistical issues to develop practical methods for capturing QOL data. They emphasized the importance of including patient perspectives to provide personalized care.
Researchers at UC Davis are studying the Madden-Julian Oscillation to improve weather and climate forecasting. The phenomenon has subtle effects on US weather patterns, including links between intense rainfall and droughts.
A new study conducted at Ohio State University found that combining the immune substances IL-12 and interferon is safe for patients with advanced cancer. The treatment combination was shown to stop disease progression in five patients for at least six months, with no serious side effects reported.