Diabetic patients undergoing periodontal therapy show improved metabolic control, with a 20% reduction in HbA1c levels. The study suggests that periodontal treatment may help diabetic patients move from the 'at-risk' category to a healthy range.
Researchers propose a new model of p53 regulation that suggests a novel anticancer strategy using Mdm2 and Mdm4. The study reveals that Mdm4 renders p53 inactive, while Mdm2 mainly controls the stability of p53's structure.
The American Chemical Society has announced the winners of its nationwide student chemistry competition. The top prizes were awarded to Marissa Hohman, Jeanette Lawrence, and Andrew Gomez for their outstanding posters in grades K-2, 3-4, and 9-12, respectively.
A study of postmenopausal women found that those taking conjugated equine estrogens (CEE) had a lower rate of invasive breast cancer, total breast cancer, and localized disease compared to placebo group. CEE also showed a decrease in the risk of ductal carcinomas, but not lobular disease.
Yale researchers found that environmental toxins like TBT can alter the balance of chloride ions in outer hair cells, causing profound changes in sound amplification in the inner ear. This study confirms that whales and other marine mammals exposed to TBT have altered hearing and may contribute to beaching incidents.
Researchers have discovered a bacterial adhesive that is 70 newtons per square millimeter strong, comparable to the downward force exerted by three cars. This finding suggests that the substance may be the strongest glue in nature, surpassing common commercial glues.
CDF collaboration presents first precise measurement of matter-antimatter transition rate, oscillating at 3 trillion times per second, using Tevatron Run II data. Scientists hope to understand the early universe and role of exotic bottom quarks in its development.
A case report identified a serious oral post-surgical complication in a patient receiving IV bisphosphonates for breast carcinoma-related osteopenia. The patient developed osteonecrosis following periodontal surgical therapy, emphasizing the importance of dental evaluations before initiating IV bisphosphonate therapy.
AIDS researchers propose a global research agenda to study the impact of large-scale social changes, such as climate change, wars, and economic disruptions, on HIV transmission. The agenda aims to facilitate cross-disciplinary studies and address emerging issues in HIV/AIDS social research.
A joint study largely confirms earlier predictions that global warming will lead to mass species extinctions, particularly in biodiversity hotspots. The research assesses the potential effects of climate change on terrestrial biodiversity on a global scale, revealing catastrophic species loss across the planet.
New research uncovers factors triggering sex reversal in black sea bass, a key challenge for aquaculture. By studying hormones and enzymes, scientists aim to control sex change and improve breeding outcomes.
The J. David Gladstone Institutes will develop and implement a three-year, stem cell-specific curriculum for 10 postdoctoral fellows using the first third of $2.4 million grant. The program aims to educate scholars from various scientific backgrounds in stem cell biology and disease.
The malaria parasite affects antigen-presenting dendritic cells in mice, reducing their ability to activate helper T cells and produce cytokines. This impairment leads to the failure of B-cell activation and antibody production, compromising the immune system's response to infection.
The study refutes existing assumptions about inherent meaning in visuals, showing that creative directors and consumers share a similar understanding of white space. The researchers connect this to the minimalist movement and corporate art, highlighting the importance of socially agreed rules of language.
Researchers found that promotion-focused individuals prioritize their ability to follow through with healthy behaviors, while prevention-focused individuals prioritize the effectiveness of the behavior itself. This study has important implications for distributing information about healthy practices.
A new study finds that estrogen-only therapy does not increase the risk of breast cancer in postmenopausal women, contradicting previous findings. In contrast, hormone therapy combining estrogen and progestin was linked to a 26% higher risk of breast cancer.
Researchers found that chemotherapy improvements reduced recurrence risk by 21-55% in ER-negative tumors, while 9-26% in ER-positive tumors. This suggests that newer chemotherapies offer substantial benefits for patients with ER-negative disease.
A study at Mayo Clinic found that patients treated with shock wave therapy for kidney stones were at higher risk of developing diabetes and hypertension, with risks nearly four times and one-and-a-half times respectively. The researchers believe the association may be due to damage inflicted on the pancreas or scarring in the kidneys.
A Hopkins-led clinical study found that men's brains show a significantly higher dopamine release in response to amphetamines compared to women. This discovery may lead to more effective treatments for amphetamine abuse and brain diseases.
Researchers find that growth factor SCF promotes tumor angiogenesis by interacting with normal neurons, leading to worsened prognosis in patients. Decreased SCF expression improves survival in mouse glioma models, highlighting the importance of considering normal cells in cancer treatment.
Research challenges previous assessments suggesting large increases in soil carbon with rising CO2 levels. Plants can pump nitrogen into soils, but this process cannot keep up with increasing CO2 unless essential nutrients are added as fertilizers.
The study suggests that the binding of CRP to leptin may be responsible for the reduced effectiveness of leptin in obese individuals. Researchers found that CRP can inhibit leptin's signaling, leading to increased food intake and weight gain.
Researchers used fMRI to show that a brain region called the intraparietal sulcus is activated when both four-year-olds and adults perceive numerical quantities. The study suggests that basic math skills are laid down early in development and continue to process mathematical information into adulthood.
Researchers found that computer animations can heighten a person's confidence but not necessarily accuracy when it comes to making fair decisions. The study suggests that animations can introduce additional bias, leading to harsher penalties.
Researchers found that genetic makeup can predict fat distribution patterns and obesity risk, identifying key genes involved in controlling development. The study suggests that different forms of obesity may be a developmental problem starting early in life.
A recent study published in the Public Library of Science Biology found that brain region IPS is activated when both four-year-olds and adults perceive numerical quantities. The researchers used fMRI to image blood flow in brain regions reflecting activity, revealing a similar neural basis for basic math skills in children and adults.
The VELScope device emits blue light, causing cells to absorb energy and re-emit fluorescence, helping dentists detect abnormal tissue. The device correctly identified all normal biopsies and 98% of cancers, offering a promising solution for early oral cancer detection.
Research reveals substandard living conditions among North Carolina farmworker families, with many experiencing overcrowding, inadequate sanitation, and exposure to toxic substances. The study highlights the need for policy changes and education to mitigate these detrimental effects on family health.
A recent disease outbreak in China, caused by Streptococcus suis, has resulted in 38 deaths and highlights the importance of occupational exposure to pigs. Researchers found that the pathogen was linked to outbreaks in local pig populations, but a new strain may be responsible for the severity of symptoms.
Despite growing evidence, many European countries only vaccinate high-risk groups against infant pneumococcal disease (IPD), while the US adopted universal vaccination in 2000. Universal vaccination of infants and young children reduces risk and provides indirect herd protection for unvaccinated community members.
A study analyzing data from the Women's Health Initiative found that postmenopausal hormone therapy may increase the risk of developing venous thromboembolism, particularly in women with higher physical activity levels and lower HDL cholesterol. The risk was significantly increased for deep vein thrombosis, but not for pulmonary embolism.
Researchers have made a breakthrough in understanding the role of AMPA receptors in strokes, with potential to prevent brain damage and improve learning and memory. By modifying one part of the genetic blueprint of these receptors, they aim to protect neurons from lethal calcium flows, which can cause irreversible brain damage.
A study by Penn State researchers found that stricter law enforcement policies have led to an increase in girls' arrests for assault, not a rise in violence. Despite this, other national sources of information on youth violence show little overall change in girls' levels of aggression over the past two decades.
Researchers at MIT and Brigham have developed a way to design nanoparticles that can selectively deliver chemotherapy to cancer cells while leaving healthy cells intact. The particles, which are about 150 nanometers in size, use targeting molecules called aptamers to home in on cancer cells.
Researchers at Children's Hospital in Pennsylvania have successfully performed liver transplants on patients with maple syrup urine disease (MSUD), a rare genetic disorder that causes amino acid accumulation. The study shows improved metabolic stability and reduced risk of brain swelling, stroke, and learning disabilities.
Researchers found a significant association between Epstein-Barr virus infection and multiple sclerosis (MS), with elevated antibody levels before symptom onset. The study suggests Epstein-Barr virus may predispose individuals to autoimmunity, paving the way for new treatments and prevention strategies.
A recent study published in Cancer found that parent-child HRQL assessments are significantly similar, with correlations most consistent in families with cancer. However, parents tend to overestimate their child's physical function and experience greater challenges.
Researchers found that IL-25 promotes type 2 responses driving asthma, but also limits destructive inflammation associated with inflammatory bowel disease. The study suggests IL-25 may offer a treatment avenue for chronic inflammatory diseases.
Researchers identified four genetic subtypes of multiple myeloma, each with distinct gene signatures that predict patient outcomes. The findings provide a clear path for targeted therapies and could lead to improved treatments for this incurable blood cancer.
The landmark book celebrates the centennial of Alzheimer's discovery, narrating its evolution from a major cause of late-life dementia. The publication brings to life classic studies defining the disease research, featuring contributions from prominent researchers.
A group intervention program has been shown to improve the psychological and emotional well-being of young siblings with chronic illness or developmental disabilities. The program increased their knowledge of their sibling's condition, feelings of connectedness, and competence.
Researchers investigate tropical forest structure, uncovering intricate relationships between tree diversity, spatial distribution, and environmental factors. The study reveals that tropical forests exhibit complex characteristics that resist simplistic explanations, highlighting the need for nuanced understanding of these ecosystems.
The UQ Centre for Integrated Preclinical Drug Development is developing new tools to streamline the preclinical trials process. This will improve productivity across the pharmaceuticals industry and address a blockage in the drug production pipeline.
Research papers in Geophysical Research Letters and Paleoceanography reveal the connection between terrestrial gamma-ray flashes and intracloud lightning, as well as the potential of dinoflagellate microfossils to document past climate changes. The findings suggest that these marine organisms can provide valuable information on ocean c...
Treatment with ACE inhibitors significantly reduces risk of death from any cause, cardiovascular death, myocardial infarction and stroke. ACE inhibitors also appear to reduce risk of additional outcomes such as diabetes, congestive heart failure hospitalization and cardiac arrest.
A study of 37,692 DCIS and 4,490 LCIS patients found LCIS patients were at greater risk for invasive lobular carcinoma ILC and ipsilateral invasive breast cancer. The research suggests LCIS may be a precursor lesion to ILC and warrants localized treatment.
A recent study published in Neurology found that individuals who have had near-death experiences tend to experience REM state intrusion, which can disrupt normal sleep-wake patterns. This phenomenon was observed in 60% of people with near-death experiences, compared to 24% of those without.
Researchers found that older men who drank moderately or heavily and had comorbidities worsened by alcohol use had a 20% higher mortality rate than other drinkers. The study also revealed that lower drinking thresholds should be recommended for older adults with specific conditions.
Dr. Varshavsky's pioneering studies revealed ubiquitin's diverse roles in cell cycle, DNA repair, and responses to stress, advancing the field of molecular genetics. The March of Dimes Prize acknowledges his significant contributions to understanding birth defects, neurodegenerative syndromes, cancer, and immune disorders.
Researchers found that a single bacterial cell can withstand stress equivalent to five tons per square inch due to its adhesive properties. Hypothetically, the glue could be mass-produced for use in surgical adhesives, presenting a promising biodegradable alternative.
Researchers found that children with at least one parent who snores frequently are more likely to develop allergies and snore themselves. The study suggests early detection is crucial to prevent morbidity due to untreated obstructive sleep-disordered breathing in young children.
A study of 23,191 black women found a significant association between hormone use and breast cancer risk, with the longest cumulative exposure increasing the risk. The strongest association was seen in leaner women, who may be more susceptible to the effects of estrogen due to fat tissue producing this hormone.
A special issue of PLoS Medicine explores how corporate sponsorships are creating new diseases, medicalizing everyday life, and promoting unnecessary treatments. The articles highlight examples of disease mongering, including the marketing of Viagra for 'normal' men and the over-diagnosis of bipolar disorder in children.
Researchers are conducting a year-long study on pastoral care for older Australians, gathering insights from elderly individuals, relatives, and caregivers. The project seeks to understand the value and practice of pastoral care in Australia's rapidly aging population, with a focus on its spiritual significance.
The study reveals high molecular heterogeneity in multiple myeloma, with new recurrent amplifications and deletions pointing to yet-to-be-discovered oncogenes and tumor suppressor genes. These findings define new disease subgroups with distinct clinical outcomes and potential therapeutic implications.
A large family study has pinpointed genetic linkage in drug addiction, identifying genes that influence opioid dependence and its symptom cluster traits. The study provides a foundation for further research on the genetic factors contributing to substance dependence risk.
Drs. Heck and Dindo are restoring Robinson Island's seagrass beds by planting birdstakes for seabirds to use as resting areas, fertilizing the shoal grass beneath them. The project aims to bring the habitats back to their peak condition through a combination of educational signage, replanting sea oats, and fertilizer.
A study of 2,946 patients with age-related macular degeneration (AMD) found that those with more severe AMD had poorer cognitive function and lower brain reserve. This association remained even after controlling for other factors, suggesting a link between vision and cognitive impairment.
Researchers at the University of Cincinnati have discovered a hormone receptor involved in breast cancer growth, finding that it can be slowed by a synthetic neuropeptide Y hormone. The study suggests that targeting this receptor may lead to more effective drug therapy for breast cancer patients.
A new study published in the American College of Chest Physicians journal found that infant snoring is strongly linked to parental snoring. Children born to atopic parents are nearly three times more likely to develop habitual snoring, highlighting the importance of early detection and treatment.