Scientists discovered that mice lacking the DNA repair enzyme NEIL1 develop severe obesity and metabolic syndrome, with enlarged livers and insulin resistance. The study suggests an important role for NEIL1 in preventing metabolic disorders.
A study by UCSD/Boston University found a small but significant increased chance of delivering an infant with severe respiratory failure (PPHN) if pregnant women take SSRIs like Prozac, Paxil, or Zoloft in the second half of pregnancy. The risk is relatively low, affecting about 6-12 mothers per thousand.
A new study suggests that persistent fatigue is a better indicator of postpartum depression than stress or family history. Women who experienced prolonged fatigue were more likely to develop symptoms of postpartum depression, highlighting the importance of early screening and intervention.
A new study found that using a combination of sedative and paralytic drugs improves the success rate of airway intubation by 3.7 times, making it the most effective method for patients in critical condition. The research used data from 49 patients transported by air ambulance over a year.
Geologists David Rowley and Brian Currie found that the Tibetan Plateau has stood at its current high elevation for at least 35 million years. The plateau widened progressively northward as the Earth's crust thickened, contradicting a popular theory that it rose due to geologic forces.
Researchers at Rensselaer Polytechnic Institute developed new nanocomposites that provide excellent damping capabilities, even at high temperatures. These materials show great potential for applications in aircraft, spacecraft, and sensors, particularly in reducing vibration and improving sound quality.
Researchers successfully synthesized a novel vancomycin analogue with enhanced binding ability, showing promise in treating vancomycin-resistant infections. The new compound could potentially lead to the development of more effective antibiotics against these resistant strains.
Researchers capture the structure of a virus poised to inject its genetic material into a host cell for the first time, providing unprecedented detail. The images show a long coil of DNA dangling inside the viral shell, waiting to be ejected via a protein channel just inside the shell exterior.
Researchers discovered that vitamin D significantly limits the ability of prostate cancer cells to invade healthy cells by reducing two key enzymes. Vitamin D also increases counterpart enzymes that inhibit these proteases, leading to reduced cancer progression.
Kengo Hirachi has been awarded the 2006 Bergman Prize for his deep work on the singularities of the Bergman and Szego kernels and their relationship to CR geometry. His research employs a range of tools in geometry and analysis, including complex variables and microlocal analysis.
Researchers at Florida Tech are developing ICT-based care systems to promote social connections and aging-in-place for caregivers. The project uses PocketPCs and Web interfaces to bridge time and space barriers.
Recent protected habitats are recovering after six years of closure, showing signs of stability. Complex bottom habitat is crucial for small fish populations, and gear like rock hopper reduces habitat complexity.
A study by Joslin's Asian-American Diabetes Initiative found that Chinese-speaking immigrants with type 2 diabetes had less knowledge of disease management and poor blood glucose control compared to English-speaking immigrants. Bilingual education improved their understanding and led to better blood glucose control in laboratory tests.
A study of nearly 49,000 postmenopausal women found a modest reduction in breast cancer incidence among those with high fat intake, but this benefit was not seen in those who reduced their fat intake. Women should focus on reducing saturated and trans fats, increasing vegetable consumption, and maintaining regular exercise for overall ...
UNSW researchers have created a new type of self-cleaning coating using titanium dioxide nanoparticles. The coating uses visible light to kill Escherchia coli and break down organic compounds, reducing the need for chemical agents. Lab trials show promising results, paving the way for further testing and potential industrial applications.
A study found that a case-based online continuing medical education (CME) program effective in improving physicians' domestic violence management skills. The program showed clear improvement in eight of the 10 measures of physician partner violence preparedness twelve months after completion.
Global warming is likely to change river flows in ways that may result in both increased flood risk and water shortages. The predictions assume atmospheric carbon dioxide concentration doubles from preindustrial levels, leading to higher winter-time river flows and lower spring and summer flows.
A multidisciplinary team at UCI will investigate the connection between genetic variations in mitochondria and metabolic syndrome symptoms. The research may lead to new diagnostic tools and treatments for conditions like diabetes and cardiovascular disease.
Berkeley researchers have created a highly selective cell adhesion system using single-stranded synthetic DNA, enabling precise patterns of multiple cell types. The technique enables the attachment of different cell types to specific locations on a surface based on nucleotide sequences.
Researchers at UC Berkeley have successfully forced a benign virus to evolve into a more effective delivery vehicle for genes in gene therapy. By accelerating the process of viral evolution, they were able to bypass the immune system's defenses and increase the virus's ability to deliver genes to target cells.
Case scientists demonstrate that motor neurons' behavioral roles change depending on body positioning, with implications for developing robots and prosthetic devices. Their research provides the first demonstration of Bernstein's hypothesis in a behaving animal.
A recent study published in JAMA Network found that a low-fat diet did not significantly decrease the risk of cardiovascular disease or stroke. However, trends toward greater reductions in CHD risk were observed in those with lower intakes of saturated fat or trans fat, or higher intakes of vegetables and fruits.
A study by McMaster University found that extremely low birth-weight infants are achieving similar levels of education, employment, and independence as normal birth-weight infants by young adulthood. The study's results show no statistically significant differences in these areas between the two groups.
Researchers tracked over 8 years and found no reduction in colorectal cancer cases with low-fat diet intervention. The study suggests that mid-to-late life dietary changes may not significantly impact colorectal cancer risk.
Researchers found that introduced foxes reduced guano deposits, affecting plants and animals at the bottom of the food web. The study showed significant differences in plant communities between fox-infested and fox-free islands.
A study found that only 11% of eligible foreign-born women in Miami received postpartum vaccinations, highlighting the need for increased vaccination efforts to prevent congenital rubella syndrome. The Centers for Disease Control and Prevention recommend vaccination for all women of childbearing age without evidence of rubella immunity.
A recent study found that reducing total dietary fat had no impact on the risk of breast cancer, colon cancer, heart disease, or stroke. Researchers believe that focusing on the types of fats consumed, rather than just reducing total fat, is crucial for disease prevention.
Mayo Clinic researchers propose a new understanding of how sepsis arises, suggesting that normal body substances may cause some cases of the deadly condition. They identify a critical receptor that triggers the sepsis cycle, which could lead to new treatments.
Researchers identified an abnormal variant of β-MSH in five out of 538 obese children, which was more common in overweight or obese family members than in normal-weight relatives. The mutation altered the hormone's structure and ability to stimulate brain receptors, leading to increased obesity risk.
The tobacco industry developed a product strategy to conceal the toxicity of cigarettes by exploiting loopholes in testing protocols. The internal documents reveal that BAT and ITL designed products to fool consumers and regulators into thinking they were safer than they actually were.
A significant majority of ELBW young adults have overcome earlier difficulties to become functional members of society. The study found no statistically significant differences in education achieved or employment status between ELBW and NBW participants at young adulthood.
A recent study found that older women are more susceptible to hip fractures, with over half experiencing significant decline in functioning. Unfortunately, many women in this age group do not undergo bone density screenings, which can help prevent fractures through osteoporosis therapy.
A team of scientists from Conservation International and the Indonesian Institute of Science discovered dozens of new species, including a rare bird of paradise, a new honeyeater, frogs, butterflies, and a tree kangaroo. The expedition revealed an untouched tropical forest ecosystem, providing insights into biodiversity conservation.
Scientists develop a new sonar method to detect squid egg clusters, allowing for efficient mapping and estimation of squid populations. This technique has immediate potential to provide resource managers with sound scientific information to sustain the fishery and protect the species' genetic diversity.
Researchers found a novel gene critical for regulating Hh signaling in mammals, revealing the first clear difference in conserved signaling pathway function between species. The discovery suggests that multi-component pathways evolve by inserting new proteins into existing pathways.
Researchers predict widespread invasion of UK estuaries by the invasive Chinese mitten crab, which could devastate native species and ecosystems. A nationwide monitoring system is recommended to control the population before it's too late.
Researchers at Florida State University have discovered a molecular mechanism that inhibits HCV replication in vitro after host cells become crowded. The study's new test can quickly monitor HCV replication and has the potential to lead to better, targeted treatments for this complex virus.
Three Pitt professors will receive CAREER awards to improve information security, solve subatomic mysteries, and develop new treatments for liver disease. Joshi's framework aims to protect complex systems like the Department of Defense's global information grid.
Ronald Breslow, a trailblazing researcher and prolific author, has been awarded the Othmer Gold Medal for his pioneering work in biomimetic systems and nonbenzenoid aromatic chemistry. His contributions have led to potential breakthroughs in cancer treatment through gene transcription modulation.
A new malaria forecasting tool developed by scientists at the University of Liverpool can predict epidemics of malaria up to five months in advance, using climate variability. The model will assist doctors and health care providers in preventing and controlling the disease.
A low-fat diet was associated with a 15% reduction in estradiol levels and a 30% risk reduction for a certain subtype of breast cancer. The study also found no significant impact on heart disease, but trends toward reduction were seen among women who made the greatest reduction in saturated fat and trans fat consumption.
Researchers at Duke University Medical Center discovered a subtle 'backrub' motion in proteins, which could have important implications for understanding protein evolution and design. The study found that this motion is common in proteins frozen in crystals and may be even more prevalent in liquid environments.
A new study by Florida State University researchers suggests that depression is a lifelong parent trap. The study found that no type of parent reports less depression than non-parents, and certain types of parenting have higher levels of depression. Parents living with minor children tend to have the least symptoms of depression.
A large study published in JAMA Network found that a low-fat diet had no significant impact on the incidence of invasive breast cancer in postmenopausal women. The Women's Health Initiative Dietary Modification Trial involved 48,835 women and followed their dietary habits over an 8.1-year period.
A study by Dr. Jill Halterman found that children with severe asthma symptoms often exhibit behavioral problems, such as anxiety and difficulty focusing, which can impact their learning. The research suggests that addressing both asthma and behavior issues simultaneously is crucial for effective treatment.
A new study calls for equal access to Hepatitis C treatment for young injection drug users, citing low reinfection and completion rates among this group. The research suggests that denying treatment due to substance use can be counterproductive, as it often fails to address underlying health issues.
A Mediterranean-style diet rich in olive oil, whole grains, fruits, vegetables, and nuts may reduce the risk of cardiovascular disease in patients with metabolic syndrome. The diet's effects are attributed to its action on inflammation and dysfunction of blood vessel cells.
A survey of over 52,000 New Jersey nurses will examine factors influencing job satisfaction and burnout, while a multi-state collaboration aims to identify issues affecting the nursing workforce and improve patient outcomes.
The study found that top 5 percent hospitals have significantly lower mortality and complication rates compared to the rest. These hospitals can avoid 21,896 complications and save 152,966 lives if they match the quality of care of top-performing hospitals.
The State Children's Health Insurance Program (SCHIP) has improved asthma care for low-income children in New York, resulting in fewer attacks and emergency room visits. SCHIP has increased access to necessary medications, preventative care, and affordable healthcare services.
A large-scale study confirms that Alzheimer's disease has a significant genetic component, accounting for 79% of risk factors. The study analyzed data from over 11,800 twin pairs and found that identical twins showed only a 45% concordance rate for the disease.
A large twin study found that genetic factors are highly influential in Alzheimer's disease development, with identical twins showing similar age at onset. The study suggests genes play a key role in disease timing, with concordance rates higher in women due to their greater longevity.
Researchers have identified a key gene associated with rare but important pregnancy disorders, including molar pregnancies, spontaneous abortions, and stillbirths. The discovery has significant implications for developing new treatments and therapies for these conditions.
A recent investigation by the US Consumer Product Safety Commission found that home paper shredder injuries disproportionately affect young children, with 71% of cases involving kids under 12 years old. The study highlights the dangers of easy access to shredders and lack of safety features, such as on/off switches and release mechanisms.
Recent advances in middle-ear function evaluation provide rapid data on health, while prevention programs can reduce noise-induced hearing loss. New research also addresses the impact of aging on hearing, tinnitus management through progressive intervention approaches, and hair cell regeneration for restoring hearing.
A study of middle-age and older adults found that about a third had cholesterol disorders requiring drug treatment, but only 54% received it. Cholesterol control was lowest in those at highest risk of heart vessel disease, highlighting the need for improved treatment and control.
Researchers at Rensselaer Polytechnic Institute have successfully synthesized hundreds of milligrams of heparin using engineered enzymes and co-factor recycling. This breakthrough could enable the widespread use of synthetic heparin in human medical treatments, reducing reliance on animal-derived products.
Researchers found that Antarctic krill can perform multiple daily vertical migrations, with some descending rapidly like parachutes. This behavior is estimated to sequester 0.02 metric gigatons of carbon per year, equivalent to annual emissions from 35 million cars.
A recent study from Tufts University found that higher whole-grain intake is associated with lower fasting blood sugar levels and a reduced risk of metabolic syndrome in elderly individuals. Consuming three or more servings of whole grains per day may help mitigate insulin resistance and impaired glucose tolerance.
Researchers used a short-lived fish species to test the effects of resveratrol on aging-related physiological decay. The compound was found to increase longevity and delay the onset of memory and muscular performance decays.