Researchers found that grade 2 and 3 tumors are more common in HER2+ and triple negative cancers, which have a higher risk of growth and relapse. Cancer came back frequently in these subtypes, with a death rate higher in triple negative breast cancer.
A Mayo Clinic program has reduced delays between abnormal mammograms and diagnosis, improving outcomes for women with cancer. The clinic's multidisciplinary breast clinic helped overcome barriers such as lack of transportation and childcare, providing timely care to underserved women.
Researchers from Carnegie Mellon and Pitt describe a mechanism called dynamic connectivity, where neuronal circuits are rewired in response to specific patterns of stimuli. This process allows for more keenly sensed stimuli, such as recognizing scents, by filtering out noise and enhancing contrast.
A new genetic variation has been identified that affects a child's risk of developing Kawasaki disease, an illness characterized by acute inflammation of the arteries. The variation influences immune activation and response to standard treatment, with implications for alternative therapies.
Two studies from Mayo Clinic found that ER/PR negative breast cancers have the worst overall outcomes when spreading to the brain, resulting in shorter median survival times. Women with triple negative tumors and HER2+ tumors without estrogen or progesterone receptors have poor outcomes due to aggressive brain metastasis.
Researchers have discovered two new targets for drugs aimed at controlling lupus by regulating the balance between inflammatory and antiviral effects of interferons. By blocking specific kinases in the calcium-signaling pathway, they were able to suppress STAT1 activation and preserve antiviral effects.
A survey of 367 women with advanced breast cancer underscores the significance of emotional and educational needs, with psychosocial support identified as a high priority. The study also reveals dissatisfaction with treatment experiences and highlights the importance of internet access as an information resource for patients.
A combination of lapatinib and capecitabine significantly shrinks brain metastases in patients with aggressive HER2-positive breast cancer, with 10 patients experiencing a 50% reduction. The study's findings offer new hope for treatment options for women with advanced breast cancer who develop brain metastases.
Scientists discover two new mammal species, a tiny possum and giant rat, in the remote Foja Mountains. The region is also home to numerous rare and little-known bird species, including the 'lost' Bird of Paradise.