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Science News for November 13, 2007


Cell transplants may improve severe urinary incontinence

Researchers found that skeletal myoblasts can help improve urinary incontinence in female rats with urethral sphincter deficiency when transplanted into their nerve-damaged muscles. The transplanted muscle cells increased urethral pressure, leading to significant improvement in incontinence and near-normal urethral closure pressures.

Optimal systemic and splanchnic hemodynamic state after living-donor liver transplantation

The study found that a subtle disorder in optimal systemic hyperdynamic state influences portal venous flow, which is crucial for liver regeneration after LDLT. Maintaining an ideal systemic hemodynamic state ensures sufficient splanchnic blood flow and excellent clinical outcomes in cirrhotic LDLT recipients.

SourceWorld Journal of Gastroenterology·JournalWorld Journal of Gastroenterology·DateNov 13, 2007

M. D. Anderson researchers identify tumor-suppressor gene for lung cancer

Researchers at M. D. Anderson Cancer Center have identified a tumor-suppressor gene that suppresses lung tumors in mice and could provide new approaches for lung cancer prevention, diagnosis, and treatment. The GPRC5A gene is under-expressed in human lung cancer cells and its expression was found to be lower in 61% of human non-small c...

SourceUniversity of Texas M. D. Anderson Cancer Center·JournalJNCI Journal of the National Cancer Institute·DateNov 13, 2007

Other highlights in the Nov. 13 JNCI

A new model for predicting estrogen receptor-positive breast cancer risk in postmenopausal women performs almost as well as the standard Gail model and could be used to identify high-risk women. Smoking is associated with rectal cancer, while drugs like ZD6126 may cause heart damage due to cardiovascular changes.

SourceJournal of the National Cancer Institute·JournalJNCI Journal of the National Cancer Institute·DateNov 13, 2007

STEP HIV vaccine study to be unblinded

The STEP study, sponsored by Merck & Co., Inc. and the National Institute of Allergy and Infectious Diseases, has discontinued vaccinations due to lack of efficacy. Volunteers will now be informed about receiving either the vaccine or placebo and continue to participate in ongoing risk reduction counseling and study-related tests.

HIPAA privacy rule slows scientific discovery and adds cost to research

A nationwide survey of epidemiologists found that the HIPAA privacy rule is delaying or curtailing clinical studies, making them more costly and time-consuming. The study, commissioned by the Institute of Medicine, reported that two-thirds of respondents believed HIPAA had made research 'a great deal' more difficult.

SourceUniversity of Pittsburgh Schools of the Health Sciences·JournalJournal of the American Medical Association·DateNov 13, 2007

Changing environment organizes genetic structure

A study by Deem and Jun Sun found that genetic information becomes increasingly modular when exposed to a changing environment and horizontal gene transfer. This modularity arises spontaneously due to selective pressure, resulting in complex biological structures.

SourceRice University·JournalPhysical Review Letters·DateNov 13, 2007

Leading neuroscientist seeks beauty, love and happiness

A leading neuroscientist is exploring the neural basis of creativity, beauty and love through an interdisciplinary research program funded by the Wellcome Trust. The study aims to understand how beauty and love relate and what it means to be happy, with potential implications for fields like economics and jurisprudence.