A recent study found that regional health care markets play a crucial role in implementing the national patient safety initiative. Despite initial high response rates, hospitals' progress in meeting Leapfrog standards was minor due to budget and strategic planning challenges.
The Hopi community of Orayvi split in 1906 due to the corruption of their ceremonial system, which failed to integrate outside pressure. The community divided by household rather than clan lineage, resulting in the establishment of new villages within a short radius.
The study reveals hundreds of biological differences between male and female gene expression in the cerebral cortex, indicating a long-evolved signature of sex differences. These findings have implications for medical dosages and treatments of diseases or damage to the brain.
O'Keefe's discovery of place cells revolutionized the field of cognitive neuroscience, enabling animals to navigate complex environments. His research has also shed light on Alzheimer's disease, revealing a deterioration in spatial information content in aged mice.
A new study on Uganda's commodity coffee market found that when global coffee prices rise, farmers do not see the same increase in their earnings. The influx of seasonal buyers, known as 'ddebe boys,' means price increases are not fully passed on to growers.
Research finds that people sometimes prioritize the greater good over their own interests, and poorly designed institutions can undermine this behavior. Examples include a study on day care center fines and blood donation rates., Experts argue that recognizing human altruism is crucial for designing effective policies and institutions.
A new mathematical model could lead to personalized vaccines for CML patients, strengthening the immune system during its weakest point. The study uses data from four years of imatinib therapy and recommends 'cancer vaccines' to combat drug resistance.
Microbiologists track B. burgdorferi movement and interaction with vascular walls in mice to understand dissemination mechanisms, shedding light on disease processes. Real-time imaging provides critical insight into the complex process of spirochete spread.
Research published in BMC Public Health found that schools with positive social environments and high-quality teacher relationships can significantly reduce student smoking. The study of over 5,000 Scottish students revealed that pupils from these schools were less likely to smoke.
A team of Australian researchers has received funding to develop new treatments for epilepsy, with a focus on compounds that block brain cell communication. The project aims to create effective therapies for the one-third of epilepsy patients who do not respond to current treatments.
A Finnish study of identical twins found that physical inactivity and acquired obesity impair the expression of genes involved in energy production, contributing to insulin resistance. The study suggests that lifestyle factors play a significant role in developing diabetes and heart disease.
Researchers from the University of New Hampshire and Indiana University have made a groundbreaking discovery about the patterns of mutation in yeast. They found that yeast mutates by changing one base pair for another, which is different from other model organisms like nematode Caenorhabditis elegans.
A University of Michigan study reveals how the CHFR gene affects breast cell division, leading to genomic instability and cancer. The loss of CHFR disrupts chromosome segregation, creating conditions for cancer cells to grow and thrive.
The $2.5 million initiative will develop an intelligent transportation system framework using RFID technology to analyze data on traffic use and capacity. The goal is to create a cost-effective solution to manage traffic and reduce emissions.
The Genetic Information Nondiscrimination Act (GINA) has been signed into law, providing protections for patients and research participants from genetic discrimination in health insurance and employment. However, gaps in oversight of genetic tests and the need for regulatory guidance remain to be addressed.
A study found that Ontario physicians are forced to become medical brokers in prioritizing hip and knee replacement patients due to lack of a uniform referral process. System constraints such as waiting lists and limited home care prevent many eligible candidates from receiving surgery, leaving them with conservative approaches.
A team of Swedish researchers characterized novel systems properties of insulin signaling in human fat cells through mathematical modeling. The study provided further insight into energy level maintenance via the hormone insulin, which is critical for preventing Type 2 diabetes. Insulin function impairment is a cardinal cause of the di...
The Damon Runyon Cancer Research Foundation has awarded fellowships to 14 promising young scientists conducting innovative cancer research projects. The three-year award provides independent funding to support their work in basic and translational cancer research.
New Australian research found ocean warming rates are 50% faster than previously reported, providing greater credibility to climate models. The study also improves estimates of sea-level rise and its contributions from glaciers, ice caps, and thermal expansion in the deep ocean.
A new grant will fund research to identify, forecast, and detect areas of clear-air turbulence, reducing anxiety for travelers. The study will also aid astronomers in using adaptive optics to reduce telescope image degradation caused by atmospheric optical turbulence.
Researchers developed a system that enables users to access location-specific, real-time information from other mobile phone users across the world. The virtual sticky note application combines capabilities of distributed networks, social networks, and geographic positioning technologies.
Boron-nitrogen compounds have been structurally characterized and found to possess electron-delocalized structures consistent with aromaticity. This discovery has significant implications for biomedical research and materials science.
A recent study by Dr. Rima Rozen at the Research Institute of the McGill University Health Centre shows how minor genetic differences between individuals alter the effect of a common medication, Methotrexate. The research found that mice with an altered MTHFR gene had significantly less hemoglobin and red blood cells after treatment.
A $2.5 million NIH grant will fund a study of four communities, including Boston's Chinatown and Somerville, to examine the health effects of pollution exposure in neighborhoods adjacent to major highways. The study aims to better define the most serious impacts of highway pollution on local residents.
The Plant Metabolic Network (PMN) is a web-based resource dedicated to understanding plant metabolism, providing researchers with essential information to engineer crops for food, biofuels, and medicines. The database currently contains over 500 biochemical pathways from 290 plant species.
GLAST successfully launched on June 11 and is now safely in orbit approximately 350 miles above the Earth's surface. Engineers are conducting daily checks to ensure all systems function correctly before turning on its instruments.
Researcher Don Luckey suggests that low-dose radiation could be beneficial for human health, citing studies that show improved growth rates, reduced cancer mortality and increased lifespan. He argues that humans have evolved to live with ionizing radiation and that greater exposure would improve our health.
A study by Bart Minten found that global supermarket chains charge significantly higher prices for food in poor countries, making affordable options inaccessible to the majority. In Madagascar, shoppers preferred locally sourced foods at lower margins over imported goods from multinational chains.
Researchers at Yale University have discovered that the Legionella pneumophila bacterium uses Ank proteins to evade the immune system, allowing it to survive and cause disease. By understanding this mechanism, scientists hope to develop a vaccine targeting specific elements of the protein.
The University of Manchester will lead a joint planning phase for the Biobanking and Biomolecular Resources Research Infrastructure, linking European biobanks and managing millions of biological samples. The project aims to counter fragmentation in Europe and facilitate access to valuable resources for biomedical research.
The Office of Naval Research (ONR) is offering up to $1 million in research seed funding for innovative science and technology ideas through its CNR Challenge program. The challenge encourages participants to submit white papers on specific themes and topics, with a focus on supporting the Navy's modern warfighter.
Scientists have discovered that genetic variation in Major Histocompatibility Complex (MHC) genes plays a vital role in the immune system of tailed amphibians. This finding highlights the importance of understanding species-specific adaptations for conservation strategies, particularly for globally declining amphibian populations.
Researchers have discovered a genetic variation in the plasminogen gene that affects susceptibility to invasive Aspergillus fumigatus infections. Genetic testing may help identify high-risk individuals and inform pre- and post-transplant care.
Researchers at MIT's Picower Institute for Learning and Memory have shown that star-shaped brain cells called astrocytes make noninvasive brain scans possible by regulating local blood flow. Astrocytes respond exquisitely to sensory drive, influencing neuronal responses and complex computations.
Researchers analyzed DNA haplotype data from Iceland's genealogical database to identify the origin of hereditary cystatin C amyloid angiopathy (HCCAA). The study found that carriers lived a normal life span for 200 years before experiencing shortened lifespans, highlighting the impact of dietary changes on the disease.
The Indiana University School of Medicine will be home to the nation's sole National Gene Vector Biorepository and Coordinating Center for gene therapy research. The center will help researchers share information and substances to promote discoveries and patient safety.
Researchers analyzed Greenland ice cores to understand sudden climate changes at the end of the last ice age. The results show that climatic shifts occurred rapidly over just a few years, with dramatic changes in temperature and atmospheric circulation.
Scientists have discovered a new tool for reconstructing planetary origins using iron isotopes in lava samples from the Kilauea Iki crater. The findings contradict previous views on isotopic variations and provide evidence for a giant collision between Earth and another large object to form the moon.
Researchers at Indiana University and Harvard University have discovered a protein called EpsE that acts like a clutch to temporarily stop the rotation of a bacterium's flagellum. The discovery sheds light on how bacteria balance movement and biofilm formation, which can be crucial in combating bacterial infections.
Expressing fuel efficiency in gallons per mile rather than miles per gallon can help consumers choose more fuel-efficient cars. This format reveals the actual gas savings from improvements in fuel efficiency, making it easier for families to identify the most efficient option within their chosen car class.
A RAND Corporation study explores six urban regions' collaborations to increase access to arts learning for children. The initiatives demonstrate the potential of pooling resources and coordinating activities to make arts education a priority.
Researchers have developed a method to classify liver toxins using gene-expression profiling of blood samples, improving the precision of compound classification. The study highlights the importance of 'phenotypic anchoring' in linking gene expression data analysis to traditional measures of toxicology.
A major international clinical trial has found that a simpler approach to treating atrial fibrillation in patients with congestive heart failure can significantly reduce hospitalization rates and eliminate the need for repeated cardioversions. The study, published in the New England Journal of Medicine, enrolled 1,376 patients at 123 h...
Patients with early stage PAH treated with bosentan show reduced clinical decline, improved exercise capacity, and lower risk of worsening events compared to placebo. Bosentan treatment is associated with improvements in pulmonary vascular resistance and prevention of clinical deterioration.
Researchers analyze sodium content of grains from the Semarkona meteorite, finding higher-than-expected levels that contradict previous models. The discovery suggests dust clouds were denser than thought, leading to a new understanding of the solar system's formation.
A new computational tool provides accurate insights into DNA and protein sequence evolution by avoiding systematic errors. The results suggest that sequence turnover is much more common than assumed, with a higher frequency of insertions and lower frequency of deletions.
The prevalence of allergies has increased, with patients facing inadequate specialist care and resources. Community pharmacists are suggested as a solution to bridge the treatment gap, according to a recent editorial in The Lancet.
A supercomputer was used to explore the biochemical landscape and find memory switches. Researchers found nearly 4,500 reaction topologies that demonstrate switching behavior, revealing a comprehensive map of biochemical switches.
Researchers from NIAMS identified a promising new target for autoimmune disease treatment, a cell-surface receptor called DR3. Blocking this receptor could slow or stop damaging inflammation characteristic of autoimmune diseases without leaving the body vulnerable to serious infections.
Researchers have developed a mathematical model that predicts optimal timing for a cancer vaccine in CML patients based on their immune response, which may lead to a cure. The model suggests boosting the immune system at a specific time when it starts weakening can provide a strong stimulation to combat leukemia cells.
A new theory on nitrogen fixation in ecosystems may help scientists better predict the effects of climate change. The researchers found that temperature constraints and phosphorus acquisition abilities play a crucial role in shaping the distribution of nitrogen-fixing plants across global ecosystems.
A trial found that aciclovir did not reduce the risk of HIV-1 infection in HSV-2 positive women and MSM. However, it did reduce incidence of genital ulcers by 47% and HSV-2 ulcers by 63%. The authors suggest novel strategies are needed to interrupt interactions between HSV-2 and HIV-1.
Laquinimod, an oral treatment, shows promise in reducing multiple sclerosis disease activity and is well-tolerated. The study found a significant reduction in MRI disease activity with laquinimod 0.6mg daily, while laquinimod 0.3mg daily showed no significant effects.
A study by Drs. Seungho Ryu and Yoosoo Chang found that healthy individuals who gain weight, even up to a normal BMI, are at increased risk for developing chronic kidney disease. The U-shaped association between weight change and CKD development suggests that both significant weight loss and gain pose risks.
The research focuses on designing miniature components called compressors and evaporators, critical for refrigeration systems. The team developed an analytical model and validated it with experimental data, showing that it is feasible to design a prototype system small enough to fit in a laptop.
A recent study published by Dr. Nicolas Christou of the McGill University Health Centre (MUHC) suggests that bariatric surgery reduces the risk of developing cancer by up to 80% in morbidly obese patients. The research, which compared over 1,000 patients who underwent bariatric surgery with those who did not, found significant decrease...
Researchers have discovered a complex process in the brain that regulates synaptic connections during learning and memory, involving a specific presynaptic protein regulated by postsynaptic calcium. This understanding may lead to interventions for human brain disorders and age-related memory loss.
Researchers are studying the architecture and behavior of ovaries to find new treatments for fertility disease and age-related infertility. A new imaging device, resembling a tiny drum, is being developed to measure ovary rigidity and understand symptoms of polycystic ovary syndrome.
A study of a Greenland ice core has shown that two temperature spikes prior to the last ice age were tied to fundamental shifts in atmospheric circulation. The research found abrupt warming events that occurred suddenly, challenging modern societies' ability to adapt, and provided insights into the sequence of climate change
A recent study published in PLOS Genetics reveals hundreds of biological differences between male and female brains, with some differences persisting for millions of years. The findings suggest that these sex differences may have functional implications for brain function and disease treatment.