Researchers discuss developments in acute lymphoblastic leukemia (ALL) and chronic lymphocytic leukemia (CLL), highlighting the potential of targeted drug therapies and cancer stem cell targeting. New molecular technologies aim to improve treatment outcomes and reduce toxic side effects.
The George Institute is tracking global funding for R&D of neglected diseases in developing countries through a 5-year survey. The study aims to provide donors with an updated overview of investment gaps and prevent duplication of efforts.
Waters Corporation is offering complimentary drinking water analysis to US water authorities to assess regional exposure and develop solutions for pharmaceutical residues. The program aims to provide a baseline understanding of exposure levels to facilitate long-term monitoring and action plans.
A recent molecular analysis of ancestry across Latin America has revealed a marked differentiation between regions, demonstrating a 'genetic continuity' between pre-and post Columbian populations. The research shows that mostly Native and African women and European men contributed genes to the subsequent generations.
Scientists confirm 1966 prediction that most energetic particles in the universe rarely reach Earth at full strength due to cosmic microwave background radiation. The GZK cutoff is a suppression of ultrahigh-energy cosmic rays, suggesting they come from galaxies beyond 150 million light years away.
Researchers have identified a crucial role for antibodies in protecting against nontyphoidal strains of Salmonella bacteria, which causes fatal infections in African children. Meanwhile, a study on HOXB4 gene therapy found that early precursors can cause leukemia in large animals, highlighting the need for extreme caution in human trials.
Researchers found a correlation between smoking history and increased risk of aneurysm recanalization in patients treated with coil embolization. Cigarette smoking is the only factor consistently identified as a predisposition for cerebral aneurysms.
A University of Missouri researcher has developed a program that keeps girls interested in science, with a recent study showing an 81% success rate. The Magic of Chemistry program provides hands-on, inquiry-based workshops on campus, encouraging girls to ask questions and think critically about scientific applications.
A study found that bullying in nursing workplaces leads to declining patient care quality and increased health problems among nurses. Author Dianne Felblinger recommends implementing zero-tolerance standards to prevent such incidents.
A genetic clue has been uncovered for Parkinson's disease, a progressive movement disorder affecting millions worldwide. GIGYF2 mutations have been found to be directly linked to the development of Parkinson's in people with a family history of the disease.
The SIAM Journal on Imaging Sciences (SIIMS) focuses on conceptually new ideas in imaging science, combining mathematics and applications. The journal aims to shape the future of this exciting area by reporting fundamental advances.
Researchers at Iowa State University are developing an integrated system of thermochemical and catalytic technologies to efficiently produce ethanol from plant biomass. The new nanotechnology-based catalyst addresses selectivity and control issues in the old chemistry, enabling efficient production.
Researchers have discovered a fusion protein that may contribute to Cockayne syndrome, a debilitating disorder marked by premature aging and neurodegeneration. The study suggests that the CSB gene's continued expression of CSB-related proteins or protein fragments plays a crucial role in the disease's development.
A new study by University of Oregon doctoral students calls on psychologists and vocational counselors to not only treat but also act as advocates for their transgender clients. The research highlights the need for social advocacy work, improving antidiscrimination policies, and providing resources to address workplace difficulties.
The review article reveals that nanominerals exhibit a range of physical and chemical properties depending on size and shape, influencing earth systems in complex ways. This shift in understanding has significant implications for fields like environmental science and geology.
The James Webb Space Telescope sunshield, crucial to the mission's success, has completed its preliminary design review. The five-layer sunshield will deploy in space to shade the telescope optics and enable it to reach proper operating temperature.
A team of University of Michigan scientists has identified a possible link between genetic mutations and toxic substance exposure in the development of motor neuron disease. The study found that abnormal protein changes caused by organophosphate exposure may contribute to the disease, offering new leads for diagnosis and treatment.
A study by Catholic University - Campobasso confirms flavonoids' beneficial effects on human health, particularly on the heart. The research found that rats fed an anthocyanin-rich diet were more resistant to myocardial infarction.
The EORTC Intergroup trial found that chemotherapy plus surgery on liver tumors improved progression-free survival by 26% in patients with colorectal cancer. Patients who received chemotherapy before and after surgery had a higher rate of progression-free survival compared to those who underwent surgery alone.
Researchers awarded $2.4 million NEI grant to study corneal infection (keratitis) caused by disease-causing fungi on contact lenses and in the environment. The team will focus on Fusarium solani, a fungus that causes eye infections in warm, humid areas.
Researchers have identified a plant gene cluster that produces a triterpene compound, previously unknown in plants. The study reveals how plants can assemble beneficial gene clusters to produce valuable natural products.
Researchers have discovered that mantis shrimp can perceive circular polarized light, a previously unknown visual system. This ability is thought to be used for sex-specific communication and may provide a private channel of communication unavailable to predators and competitors.
Researchers at UT Southwestern Medical Center have developed a new tool to study the mysterious link between body temperature and multiple sclerosis symptoms. By tracking eye movements, they found that as body temperature rises, eye movement disorders worsen in people with MS.
Researchers found several soybean varieties that grow well in southern Indiana and are resistant to root-knot nematodes, a plant-destroying parasite. These resistant varieties can help reduce the number of nematodes in the soil, improving crop yields and reducing environmental damage.
Researchers at Stanford University School of Medicine have identified two new proteins that make up the telomerase complex, providing new targets for cancer treatments. The discovery could lead to the development of drugs that block telomerase and slow or stop cancer cell growth.
Researchers at St. Jude Children's Research Hospital are investigating two areas of molecular science that hold promise for improving the survival and quality of life of ALL patients, including adolescents and adults. Gene-expression profiling and pharmacogenetics may help identify targets for future therapy and reduce toxicity.
Researchers found a higher incidence of community-acquired pneumonia (CAP) caused by Staphylococcus aureus, including antibiotic-resistant strains like MRSA. The study revealed a lower case-fatality rate than previously estimated, at around 13%.
The research successfully created designer enzymes for a chemical reaction known as the Kemp elimination, a non-natural chemical transformation in which hydrogen is pulled off a carbon atom. The researchers also designed an active site for the aldol reaction, involving at least six chemical transformations.
A study led by Massachusetts General Hospital confirms that a combination of gene variants associated with cholesterol levels reflect patients' cholesterol levels and increase risk of heart attack, stroke, or sudden cardiac death. The study's findings provide a foundation for personalized medicine and may lead to the development of mor...
In a tug-of-war-like mechanism, opposing motor teams determine the direction of cargo transport in cells. The winning team transports cargo quickly, while losing motors are removed from the microtubule.
Despite national guidelines for asthma treatment issued in 1997, many patients still do not receive prescription inhalers for the safest and most effective long-term control of the disease. Researchers found that elderly and minority patients were less likely to be prescribed long-acting controller medications.
Researchers found an association between high folate intake and lower levels of chromosomal abnormalities in men's sperm. The study suggests that increasing folate intake through diet or supplements may reduce the risk of chromosomal abnormalities in children.
Analysis of ancient Hadropithecus stenognathus hand bones reveals a novel joint configuration on the little finger, differing from other primates. The discovery highlights the diversity of lemurs that existed over 2,000 years ago.
A new University of Washington study found that despite public health campaigns, many women continue to use substances like tobacco, marijuana, and alcohol during pregnancy, while their partners' use remains stable. Men's patterns of substance use are bleaker, with men typically not targeted by these campaigns.
MIT researchers used computer analysis and replica construction to demonstrate the feasibility of ancient Pacific trade routes using balsa rafts. The study shows that these rafts could carry up to 30 tons of cargo and had a complex steering mechanism.
The Leopold Leadership Fellowship program selects mid-career academic environmental scientists to develop scientific information into policy. The 2008 fellows were chosen for their research and leadership ability.
The University of Pittsburgh Center for Vaccine Research has received a $11.4 million grant to study tuberculosis using new imaging technologies. The goal is to develop more effective treatments that can be tailored to individual patients, potentially improving survival rates and curtailing the global TB epidemic.
Researchers are exploring stem cell transplants to provide insulin cells for a bioartificial pancreas, addressing the shortage of human pancreatic islet tissue. They also aim to target and destroy cancer stem cells to improve therapies and develop reversible immortalized cell lines.
A study published in Neurology found that Hispanics with even small amounts of plaque build-up in the carotid artery are up to four times more likely to suffer or die from a stroke or heart attack. The study also highlights the importance of measuring plaque thickness by ultrasound as a simple tool for guiding stroke prevention therapies.
UK scientists identify 25 new biodiversity threats and opportunities until 2050, prioritizing research to mitigate surprise issues like GM crops. Horizon scanning aims to inform policy decisions, cutting the need for last-minute fixes on foreseeable problems.
Stanford researchers are developing a 3D camera with 12,616 tiny lenses to produce detailed depth maps, enabling applications such as facial recognition, biological imaging, and 3D printing. The technology has the potential to improve spatial vision for robots and enable new tasks beyond human capabilities.
The UMDNJ-University Hospital has received a grant to tailor interventions and personalize the transition from hospital to outpatient clinic for patients with type 2 diabetes. The project aims to reduce hospital emergency department visits, inpatient readmissions, and improve health-related quality-of-life and metabolic control.
Researchers have developed a tool to rapidly silence specific genes in rice, enabling faster breeding and improved crop performance. This breakthrough uses artificial miRNAs to target and disable genes of interest, with potential applications in hybrid seed production and enhanced resistance to pathogens and insects.
Researchers at the Canadian Light Source synchrotron have determined the structure of the enzyme responsible for the Norwalk virus's genetic replication. This breakthrough could lead to the development of drugs that can effectively treat outbreaks of this highly contagious and untreatable bug.
A study found that hyperactive girls are more likely to experience serious adjustment problems in adulthood, including smoking, poor job performance, and abusive relationships. The research suggests that early intervention programs targeting hyperactivity in elementary school may be crucial in preventing these issues.
A new study finds that higher CO2 concentrations increase phytoplankton productivity in the Ross Sea, Antarctica, promoting larger diatom chains. Additionally, research suggests that to stabilize global temperatures, future greenhouse gas emissions must be eliminated, committing the climate system to warming on centennial timescales.
A single injection of doxycycline hyclate has shown 100% effectiveness in preventing Lyme disease and Anaplasmosis in mice, offering a promising new treatment option. Researchers are planning to test different release kinetics and delivery methods to develop a slow-release patch for broader protection.
Researchers used fMRI to study two emotion regulation techniques: cognitive reappraisal and expressive suppression. Cognitive reappraisal reduced negative emotions by reinterpretating the meaning of disgusting images, while expressive suppression increased neural activity in the amygdala and insula.
A new study found that sleep deprivation can precipitate sleepwalking in predisposed individuals and may serve as a valuable tool in diagnosing the disorder. The study showed that sleep deprivation significantly increased the proportion of sleepwalkers experiencing complex episodes, facilitating diagnosis.
A study examines childhood ADHD in underrepresented minorities, highlighting obstacles faced by families and providing recommendations for assessment and treatment. Effective treatments exist, but many minority children lack culturally sensitive assessments, potentially leading to devastating results.
Researchers at Duke University have developed a ceramic membrane that allows fuel cells to operate at low humidity and higher temperatures, potentially improving efficiency. This new membrane could address current limitations in fuel cell technology and attract investment for its commercialization.
A multi-center study found that prostate size and urinary symptoms influence patient satisfaction with cancer treatment. Men with larger prostates may experience improved urination after surgery, while African-American men tend to be less satisfied despite receiving similar care.
A University of Oregon study reveals that Korean adoptees in the US often explore their ethnic identities through either social exposure with peers or cultural heritage. The research found that those who don't explore may assimilate into white culture, while those who do may develop a symbolic attachment to their international heritage.
Researchers Phoebe Lam and James Bishop found that the Kamchatka Peninsula and Kuril Islands are the key sources of iron in the Western North Pacific, contrary to previous assumptions. This discovery has significant implications for understanding climate change and the role of iron in the ocean carbon cycle.
Fengyan Li, a Rensselaer Polytechnic Institute assistant professor, has been recognized as a 2008 Sloan Research Fellow. Her research focuses on developing computer algorithms for solving problems in sciences and engineering, with applications in various fields such as weather forecasting, pollution control, and image processing.
Research shows that men are more likely to eat meat and poultry products, including duck and veal, whereas women favor vegetables like carrots and tomatoes. Women also have a preference for dry foods and certain fruits, such as strawberries and blueberries.
The city's transformation provides insight into the shifting dynamics of belonging and identity in small- to medium-sized U.S. cities. Woodburn's farmworker housing struggle reflects a deep resistance to Mexican immigrants, yet today there are visible changes in multicultural identity.
The Naomi Berrie Diabetes Center will receive $21 million for non-reimbursed clinical care, new pilot research, and more. The center aims to develop a cure for diabetes through focused clinical and basic science research efforts.
A new study found that men with lower folate intake have higher rates of chromosomal abnormalities in their sperm, which could affect reproductive health and birth outcomes. Higher folate intake was associated with lower rates of these abnormalities.
Researchers at Harvard Medical School have identified proteins that promote tumor growth in certain types of cancer, including breast and ovarian cancer. Targeting these proteins with small molecules may lead to new therapeutic options for patients.