Researchers at Hospital for Special Surgery discovered a new mechanism involved in the pathogenesis of inflammatory diseases such as rheumatoid arthritis. The study reveals that tumor necrosis factor (TNF) activates macrophages to produce interferon-beta, leading to sustained expression of genes encoding inflammatory molecules.
Researchers have discovered a way to manipulate the lengths of genetic pulses in HIV, favoring latency over replication. This finding offers promise for developing new treatments, as the 'switch' is a key factor in determining whether the virus becomes active.
Researchers at Stanford University School of Medicine developed a new medical imaging technology that can detect early stages of colon cancer without a biopsy. The technique uses a short protein attached to fluorescent beacon to identify cancerous cells, allowing doctors to pick up the earliest possible cancers.
Researchers have identified chemical compounds, oxadiazoles, that inhibit a crucial enzyme vital to the survival of Schistosoma parasites causing schistosomiasis. The compounds showed promise in killing the parasite in all stages and were active against major species.
A genetic circuit in HIV controls whether it turns on or stays dormant. Researchers have discovered how this circuit works and can be used to force the virus into dormancy. This finding has shown promise as an avenue for HIV therapy.
Researchers tested Debio-025, an antiviral drug, on mice with muscular dystrophy and found it reduced mitochondrial swelling and cell death. The study suggests a new treatment strategy for Duchenne muscular dystrophy and may have implications for other degenerative disorders.
Researchers at the University of Rochester have discovered a second depth-perception method in the brain, combining visual cues with motion and perspective to create a representation of three-dimensional space. This new mechanism may help restore binocular vision in children with misaligned eyes and improve virtual reality experiences.
Researchers found a blood vessel protein, Robo4, that reverses or prevents damage from two devastating eye diseases. The study's discovery could lead to new drugs to treat and prevent age-related macular degeneration and diabetic retinopathy.
Job's syndrome sufferers lack Th17 cells, a type of infection-fighting white blood cell, leading to recurrent and severe infections. The study reveals the importance of Th17 cells in protecting against Staphylococcus bacteria and certain fungal infections.