A study published in Nature Biotechnology found that feeding knockout mice with powdered purple tomatoes increased their lifespan by an average of 40 days. The high anthocyanin content of the tomatoes demonstrated significant antioxidant activity, potentially leading to new ways to prevent diseases like cancer and cardiovascular disease.
Mayo Clinic researchers have discovered a way to control oncolytic viruses using microRNAs, which can restrict them to specific tissues and make them safer for use in cancer therapy. This discovery could lead to new methods of making safer vaccines.
A University of Iowa study identifies a faulty signaling pathway that causes exercise-induced fatigue in mouse models of muscular dystrophy. The research suggests that targeting this pathway may lead to therapies for this type of fatigue. Viagra was shown to overcome the signaling defect and relieve the fatigue.
The discovery of burned flint at Gesher Benot Ya'aqov site pushes back the accepted date for man's fire-making ability by half a million years, indicating that early humans controlled fire from 790,000 years ago. This skill enabled ancient humans to leave their surroundings and populate new environments.
A review found that off-label use of anticancer drugs ranged from 6.7% to 33.2% between 1990 and 2002, primarily used in palliative care. The study highlights the need for accurate data on off-label use to inform decision-making by health professionals.
Phase III trials demonstrate iclaprim's effectiveness in treating complicated skin and skin structure infections caused by Gram-positive bacteria, including MRSA. The antibiotic showed a high clinical cure rate similar to linezolid and was well-tolerated with a favorable safety profile.
A CDC-funded study found that vaccinating new mothers and family members against influenza before a newborn leaves the hospital significantly boosts immunization rates. The 'cocooning effect' also protects unprotected children from the flu, which can be life-threatening to infants.
Researchers found a 71% higher risk of death for patients who deferred treatment compared to those who started HAART earlier. The study's findings suggest that initiating therapy at an earlier stage of HIV disease may improve patient outcomes.
Researchers have successfully expressed genes from snapdragon into tomatoes, resulting in higher levels of anthocyanins. The purple tomatoes showed promise in extending the lifespan of cancer-susceptible mice, suggesting potential health benefits for consumers.
A Phase III study found that the high-dose influenza vaccine increased immune responses to all three influenza strains compared to the standard vaccine in adults 65 years old and older. The new vaccine also showed increased immune response in those with no measurable protective antibodies before vaccination.
A study found that a higher dose of flu vaccine boosts the immune response in people aged 65 and older, increasing antibody levels by 30-80% compared to the standard dose. This could lead to better protection against the flu for those most at risk.
The guidelines aim to ensure physicians worldwide are aware of available treatments for patients with psoriatic arthritis. Newer medications inhibiting tumor necrosis factor (TNF) are recommended for consideration.