Researchers at TGen and Washington University School of Medicine have discovered a new approach to treating endometrial cancer using a commercially available inhibitor drug. The study found that the drug can stop tumor growth and kill cancer cells, even in cases where the tumors contain a commonly occurring mutant gene.
The thawing of permafrost is expected to release a significant amount of carbon dioxide, potentially doubling current atmospheric levels. This could lead to a substantial increase in greenhouse gas emissions and further accelerate global warming.
A new randomised study has found that biolimus-eluting stents are as effective as sirolimus-eluting stents in treating patients with chronic stable coronary artery disease or acute coronary syndromes. The study also showed similar effectiveness of each stent in reducing in-stent percentage diameter stenosis.
The September 2008 issue of BioScience features research on the molecular biology toolbox, permafrost carbon vulnerability to climate change, urbanization impacts on aquatic ecosystems, warfare ecology, sociality in bats, lab-computation collaboration, deforestation and vectorborne disease, and more.
Studies show mixed results on blood glucose control and micro-vascular disease prevention, while oral drugs like metformin offer some benefits. Tight insulin control has limited proven success in reducing complications, emphasizing the need for longer-term studies.
A neuroimaging study found that chronic insomnia is associated with compromised cognitive processes, but these deficits can be reversed through non-pharmacological treatment. Sleep therapy was shown to improve verbal fluency tasks and restore altered brain function in people with insomnia.
Researchers found that depression subtypes differ in cardiotoxicity and response to antidepressive treatment, with somatic and incident depressions associated with poor prognosis. This knowledge could lead to new treatment strategies to prevent future cardiac events.
Research has identified several genes associated with autism spectrum disorders (ASD), including neuroligins and SHANK3. These genetic findings provide new understanding of the underlying causes of ASD, which affect approximately 60 in 10,000 children worldwide.
A new study published in Clinical Gastroenterology and Hepatology found that transient elastography, a non-invasive technique, can accurately diagnose late-stage liver disease. The study showed high correlation between LSM and pericellular fibrosis, allowing for better prediction of cirrhosis
The Bach study reveals MR-proANP is equally useful as BNP and NT-proBNP for diagnosing acute congestive heart failure. Adding PCT marker supports differential diagnosis of pneumonia vs. heart failure in patients with shortness of breath.
Two percutaneous approaches show promise: edge-to-edge technique reduces regurgitation in 80-90% of cases, while mitral annuloplasty achieves similar results in 90% of patients. However, further trials are needed to assess efficacy and safety compared to surgical repair
School-based programs have been shown to be effective in reducing prevalence of childhood overweight and obesity through interventions such as physical activity education and nutritional education. The URMEL-ICE program demonstrates a significant reduction in body fat mass among children after one year of participation.
Researchers at Uppsala University have discovered a new signal path for a growth factor that is crucial for the survival and growth of cancer cells. This finding has significant implications for the treatment of advanced cancers, such as breast and prostate cancer.
Researchers at the University of California and the University of Newcastle are sharing their work on telomerase, a protein that allows cancer cells to grow. The lecture aims to improve treatment outcomes for breast cancer through early detection and prevention.
A CMAJ study found significantly higher rates of anaphylaxis in young women after HPV vaccination, with a rate of 2.6 per 100,000 doses administered. However, the overall rates were low and no serious lasting effects were observed.
A study in Rwanda found that nearly half of orphaned youth aged 12-24 who head households meet criteria for depression. The combined effects of the genocide and HIV epidemic have left many orphans vulnerable to poverty, social marginalization, and poor health.
Researchers confirm that surface temperatures in the Northern Hemisphere were warmer over the last 10 years than any time during the last 1300 years. The study uses a variety of proxy data, including tree rings, marine and lake sediment cores, ice cores, and coral cores, to derive a long-term temperature record.
Researchers at Wake Forest University School of Medicine have found a second independent site within the HNF1B gene that may contribute to the risk of developing prostate cancer. The new discovery strengthens the link between genetic variants and prostate cancer risk, improving the ability to predict prostate cancer risk.
The FDA has mandated boxed warnings for COX-2 selective inhibitors and traditional NSAIDs due to their cardiovascular risks. Novel anti-VEGF therapies, such as ranibizumab and bevacizumab, may also pose cardiovascular safety concerns despite proven benefits in treating wet AMD
Prof Andre Geim and Dr Kostya Novoselov, who discovered graphene in 2004, have won the prestigious Europhysics Prize. Their work reveals graphene's remarkable electronic properties, with applications such as transistors and sensors.
Active video games can help prevent childhood obesity by increasing energy expenditure and heart rate. According to a new study, children aged 6-12 burned significantly more calories while playing active games compared to seated games.
Researchers at Boston University School of Medicine have observed a non-invasive MR imaging healing mechanism for asymptomatic carotid plaque rupture. The study, published in Circulation, shows that not all plaque ruptures are symptomatic and highlights the importance of monitoring vulnerable plaques.
New research suggests that Tutankhamen fathered twins, based on analysis of the mummified remains found in his tomb. The study, led by Professor Robert Connolly, confirms that the two foetuses are likely to be twins and were born to the teenage Pharaoh.
Robotic navigation systems, such as Sensei and Niobe, enhance catheter-based procedures by minimizing fluoroscopy times and radiation exposure. These systems have shown promising results in isolating pulmonary vein antra and ablation of atrial arrhythmias.
A study found that low-birth-weight children are more likely to experience externalizing and internalizing psychiatric problems, as well as attention problems in urban communities. Early interventions may improve attention skills and lead to better outcomes later.
A study by Fox Chase Cancer Center found 27% of college students exhibit symptoms of tanning dependence, similar to substance addictions. Thinness and cigarette smoking are linked to higher rates of tanning dependence, suggesting potential avenues for prevention.
A team of academics argues that academic health centers (AHCs) can lead the development of best practices for establishing a data sharing culture. AHCs are urged to adopt seven recommendations, including recognizing data sharing contributions and educating staff on responsible data sharing.
Antipsychotics have shown efficacy in treating psychotic disorders and other conditions in children and adolescents, but concerns about metabolic side effects and long-term safety remain. Studies have found increased risk of weight gain, dyslipidemia, and hyperglycaemia with certain antipsychotics.
A substudy of the IBIS II trial found no significant differences in cognitive assessments between postmenopausal women receiving anastrozole and placebo, but noted more endocrine symptoms such as hot flushes in the anastrozole group.
Researchers found that serotonin transporter binding potential values were higher in fall and winter, suggesting a link between lower serotonin levels and seasonal mood changes. The study suggests that variations in brain serotonin levels may explain why people feel happier on sunny days and more sluggish during the dark winter season.
The transapical aortic valve implantation (TA-AVI) technique offers a direct and antegrade approach to the aortic valve, minimizing manipulation in the aortic arch and reducing stroke risk. This method is performed as an off-pump procedure, utilizing high-quality imaging and fluoroscopic visualization.
The carotid artery's intima-media thickness (IMT) is a valuable research tool that can predict cardiovascular events. Measuring IMT using non-invasive ultrasound allows for monitoring over time and assessing the impact of risk factor interventions.
Recent trials show intermittent HIV treatment increases risk of infections and death. A large-scale survey links 'burnout' to suicidal thoughts in med students, but finds it reversible. Whistleblower-initiated legal action against Medicare fraud has increased significantly since the 1990s.
A study found that older adults who slept more during rehabilitation had less functional recovery and took longer to recover. The study suggests that interventions to improve sleep patterns may promote functional recovery in older adults.
Research at the University of Chicago shows that playing sports or watching them improves language skills for discussing their sport. The brain's motor areas are activated when listening to conversations about a sport, even if there's no intention to act.
The CoreValve ReValving System has shown high procedural success and excellent long-term outcomes in elderly patients with severe aortic stenosis. Procedural success rates reached 91%, with significant improvements in symptoms, quality of life, and mortality rates.
A study published in Archives of General Psychiatry found that family-focused therapy, combined with medication, significantly reduces depressive symptoms in adolescents with bipolar disorder. The treatment was shown to lead to faster recovery from depressive episodes and improved quality of life.
Researchers are exploring new biomarkers to detect myocardial infarction, which could lead to faster diagnosis and improved treatment outcomes. Currently, cardiac troponin is the gold standard for diagnosing myocardial necrosis, but its limitations include delayed detection and low sensitivity to ischemia.
A study found that African-Americans have a lower prevalence of periodic limb movements during sleep, which is linked to a higher rate of insomnia complaints. The overall prevalence of PLMS is 7.6 percent, with a lower prevalence in African-Americans and a higher prevalence in Caucasians.
A majority of US East coast hospitals distribute formula sample packs, contrary to major medical organization recommendations. The practice is changing significantly, with a rise in hospitals eliminating the packs and a decrease in distribution rates over the past few decades.
Research highlights the importance of diet, statins, and genetic factors in cholesterol regulation and cardiovascular health. Studies have shown that low HDL-C levels are strongly associated with an increased risk of CAD, and genetic mutations can affect HDL-C production.
The LEADERS study demonstrated that Biosensors DES is non-inferior to Cypher DES in terms of clinical events, stent thrombosis rates and angiographic follow-up data. The trial included a broad range of patients with symptomatic coronary disease, reflecting routine clinical practice.
A study published in Sleep found that heavy snoring is an independent risk factor for early carotid atherosclerosis. The prevalence of carotid atherosclerosis increases significantly with the severity of snoring, affecting up to 64% of heavy snorers.
A study found that older adults with insomnia are less sensitive to changes in skin temperature, making it harder for them to detect when their body is too hot or cold. Warming the skin can facilitate sleep onset despite this decreased sensitivity.
A comprehensive study of hip and knee replacement surgeries in England found that one in seventy-five patients require revision after three years. The research suggests that different patterns may emerge over a longer follow-up period, emphasizing the need for further research to evaluate surgical procedures and types of implants.
The World Cancer Declaration aims to tackle the growing cancer crisis in developing countries with 11 cancer-busting targets for 2020. The plan focuses on significant drops in tobacco consumption, obesity and alcohol intake, as well as universal vaccination programs and proper pain medication.
New research reveals that wolves prioritize seafood, specifically salmon, over deer when available. The study shows that wolves reduce deer hunting activity and focus on fishing during autumn when salmon is abundant.
A recent study found that children born to older fathers are at higher risk of developing bipolar disorder. The study, which analyzed data from over 13,000 patients with bipolar disorder, suggests that advancing paternal age may be associated with an increased risk of complex neurodevelopmental disorders.
A Harvard Medical School study found that direct-to-consumer advertising has a modest effect on prescription rates for some drugs, but none at all for others. The researchers compared sales of three specific drugs in English-speaking Canada and Quebec, where residents were less exposed to ads, and found no significant difference in pre...
A new study by UCLA sociologists found that even a single job displacement has a lasting impact on workers' inclination to volunteer and participate in various social and community groups. Workers who experienced involuntary displacement were 35% less likely to be involved in their communities than those who never experienced a job loss.