Researchers recreated natural selection in real-time, demonstrating the first quantitative evidence for natural selection on standing genetic variation. The study found that only half of gene frequencies reverted to ancestral levels, highlighting the contingent nature of evolution.
A Mayo Clinic-led international consortium discovered a genetic defect in the dynactin complex that may help explain neurodegenerative diseases like Parkinson's and amyotrophic lateral sclerosis. The mechanism implicated in Perry syndrome, a rare disorder, may also shed light on common depression and sleep disorders.
Researchers at Mayo Clinic have identified a gene variant on the X chromosome associated with an increased risk of developing late-onset Alzheimer's disease. Women who inherited two copies of the PCDH11X variant were found to be at substantially greater risk, while men with one copy also showed a significant increase in risk.
Researchers at U-M Comprehensive Cancer Center identified recurrent gene fusions that drive certain cancers to develop. New gene sequencing technology enabled quicker and easier detection of these fusions.
Ancient DNA and palaeontology researchers analyzed coprolites from giant extinct birds to build a detailed picture of an ecosystem dominated by these species. The findings suggest that some moa grazed on tiny herbs, while others are threatened or rare due to their extinction.
Researchers at UQ found that speech and language disorders can be validly and reliably assessed over the internet using a telerehabilitation application. This technology holds promise for addressing inequities in access to rehabilitation services, particularly in rural and remote areas.
A new study by UC Berkeley researchers reveals that disabling a key enzyme in fat cells allows mice to overeat without gaining weight. The enzyme, AdPLA, plays a crucial role in regulating fat metabolism and body weight, making it a promising target for obesity treatment.
Researchers at Tufts University found that long CGG repeats stall replication, leading to chromosomal fragility and breaking, and disable cellular checkpoints that repair replication malfunctions.
A study by University of Wisconsin-Madison researchers has identified a protein that regulates hormone release in the brain, with implications for women's reproductive health. The protein, Syt IV, tunes the release of hormones oxytocin and vasopressin, which control reproductive functions and fluid balance.