The Membrane Protein Structural Dynamics Consortium aims to unite structure and function through dynamic studies of membrane proteins, enabling better drug development for diseases like heart disease and diabetes.
A Kansas State University research team is investigating the mutated ADAM12 gene's role in breast cancer, with findings suggesting its high expression in cancer stem cells. This discovery could lead to more targeted therapies, as conventional treatments often fail on these aggressive cells.
Researchers at McGill University have discovered that the facultative enzyme Mnk plays a key role in developing prostate cancer. By blocking Mnk's activity, mice became resistant to prostate cancer growth, offering hope for targeted treatments.
Scientists create a new system that utilizes porous nanomaterials driven by a magnetic core to release drugs inside living cancer cells, improving targeted drug delivery and imaging in cancer treatment. The system has the potential to deliver anti-cancer drugs only to cancer cells while leaving healthy cells unharmed.
Scientists have found 'grid cells' for the first time outside of the entorhinal cortex in the rat brain, expanding our knowledge of how the brain generates internal maps. These grid cells work together with other neural cells to create a series of maps that help with navigation and recognition of specific landmarks.
Vertebroplasty is effective in providing greater pain relief than conservative treatment, resulting in a significant reduction in Visual Analog Scale (VAS) scores. Patients experienced immediate and sustained pain relief lasting up to one year, making it a safe option for those with acute fractures.
Researchers found that individuals with greater neural sensitivity to social rejection exhibit increased inflammatory activity, which can increase the risk of disorders such as asthma, rheumatoid arthritis, and depression. Chronic inflammation can also lead to cardiovascular disease and certain types of cancer.
Dr. David Awschalom has been awarded the 2010 Materials Research Society Turnbull Award for his groundbreaking research in semiconductor spintronics, including fundamental discoveries of spin transport and coherence in the solid state.
Researchers identified two apparent faults cutting young deposits near Olympia, Washington, suggesting recent fault activity and potential earthquake hazards. The study utilizes marine seismic reflection data to explore shallow structures associated with inferred faults in the Tacoma and Olympia areas.
Researchers have discovered that ROCK2 protein is involved in regulating the production of IL-17 and IL-21, which are linked to autoimmunity. Administration of a ROCK inhibitor has shown promise in reducing disease symptoms and ameliorating conditions in mice models.
Researchers find salps capture food particles as small as bacteria and phytoplankton, making them hardier and more plentiful than thought. This allows them to play a crucial role in carbon cycling by consuming the entire 'microbial loop' and sinking large amounts of carbon to the ocean bottom.
A researcher is studying a gene that may contribute to aggressive breast cancer. If successful, the study could lead to new treatments for the disease.
Researchers have created comprehensive genetic interaction maps for mammalian cells, revealing which genes work together and their roles in disease. The study, published in Genome Research, offers valuable information for research and potential therapeutic targets.
A recent Stanford University School of Medicine study found that physicians are losing ground in prescribing recommended medications for treating congestive heart failure. The use of ACE-inhibitors and beta blockers has declined since the early 2000s, with only about one-third of patients receiving these life-saving treatments.
Researchers found salps can capture particles as small as 0.5 microns using a process called direct interception, making them more efficient filter feeders. This ability helps explain their survival in the open ocean and enhances their role in carbon cycling.
A new study reveals that Latino children with asthma often inaccurately perceive their lung function, resulting in increased emergency room visits and hospitalizations. The study's findings suggest that cultural differences, socioeconomic factors, and limited access to healthcare may contribute to these disparities.
Scientists at Ohio State University have successfully tested a new type of computer memory that uses the spin of electrons to store data. This innovative technology, known as spintronics, has the potential to increase data storage capacity, reduce power consumption, and enable more portable electronics.
Researchers develop a new method to target cancer tumors using heat and magnets, reducing side effects and damage to healthy tissue. The innovative technique uses biomarkers attached to individual tumors and excites nano-particles with an external magnetic field, killing the tumor cells.
A new tetravalent vaccine developed by NIAID is being tested in a Phase I human clinical trial to prevent dengue fever. The vaccine, which protects against all four dengue viruses, aims to provide efficient and cost-effective prevention against the mosquito-borne disease.
Researchers have reconstructed the Earth's climate belts between 460 and 445 million years ago, finding patterns that suggest ancient carbon dioxide levels were more modest than thought. The study reveals a 'modern-looking' pattern in ancient oceans, emphasizing the stability of the atmosphere and climate through deep time.
Despite the benefits of cell phones, such as improved daily life and access to market prices, their impact on economic development is limited. Researchers found that while there is positive micro-economic impact, macro-economic improvements are still lacking in African countries.
The American Ceramic Society has announced two new Distinguished Life Members, L. David Pye and Louis J. Trostel Jr., who have made significant contributions to the field of ceramic and glass materials. The organization also elevated 19 new members to Fellow status, recognizing their expertise in academia, research labs, industry, and ...
A study published in Archives of Neurology found that nearly 75% of stroke patients remained on their prescribed medications after hospital discharge. Factors associated with persistent medication use included cardiovascular disease, insurance coverage, and understanding the purpose of the medications.
The development enhances fluoromodule technology by making probes glow five- to seven-times brighter than EGFP, allowing researchers to monitor biological activities in real-time. Dendron-based dyedrons amplify the signal emitted by fluoromodules, providing a single compact protein tag with signal enhancement.
Research by UCLA and Harvard University found that white children and those from below the poverty level have higher rates of frequent ear infections. The study's findings highlight racial and socioeconomic disparities in access to healthcare for these vulnerable populations.
Researchers found that five nights of restricted sleep produced intense recovery sleep following each wake cycle, with both longer and deeper sleep. Chronic sleep restriction evokes the same brain response as acute total sleep deprivation.
A leading international expert in vitamin D, Anthony Norman, recommends increasing daily intake to 2,000-4,000 IU for most adults to maximize health benefits. This could effectively eradicate rickets in infants and reduce the frequency of diseases such as cancer, cardiovascular disease, and autoimmune type-1 diabetes.
A study published in Archives of Internal Medicine found that larger waist circumferences are associated with a greater risk of dying from any cause. The research, which included over 48,000 men and women, found that very large waists were linked to approximately twice the risk of death, even among those at normal weight.
A study of 216 patients with open-angle glaucoma found that older patients and those with abnormal anticardiolin antibodies experienced faster visual field decline. Reducing intraocular pressure modestly slowed this decline, particularly in younger patients.
High plasma beta-amyloid levels are associated with faster cognitive decline, even in those without dementia. Cognitive decline was more pronounced in memory domains than other areas.
The University of Maryland's new bio-filtration system improves phosphorus and nitrogen removal from urban runoff, reducing pollution in the Chesapeake Bay. The system combines bioretention projects with advanced technologies to conserve rainwater and reduce environmental impact.
The study found that energy states follow contours of constant electric potential, creating energy gaps within isolated patches on the surface. These gaps are due to a subtle interaction with the substrate, which consists of multilayer graphene grown on a silicon carbide wafer.
A new study published in Alcoholism: Clinical and Experimental Research found that increasing alcohol taxes can significantly reduce death rates from diseases caused by chronic heavy drinking. The study analyzed data from 1969 to 2004 and estimated that adjusting for inflation, would save around 1,500 Floridian lives per year.
A report found that certain vena cava filters, used to prevent blood clots from reaching the lungs, can fracture and cause life-threatening complications. The filters were found to have a high rate of fracture, with some fragments traveling to the heart and causing symptoms such as rapid heartbeat or fluid buildup.
Researchers developed a specialized CPOE system to alert doctors to potentially hazardous medications for older hospital inpatients. The system resulted in a significant decrease of 20% in orders for flagged medications, highlighting its potential to reduce adverse drug events and improve care for vulnerable elderly patients.
Researchers found that bacteria cells start dividing normally but unexpectedly 'pop' when the colony reaches a certain density. This phenomenon is linked to the amplification of plasmids in response to cell density, highlighting the importance of considering hidden interactions in engineered gene circuits.
Oil rig workers increasingly rely on telemedicine to receive medical attention due to limited access to healthcare. The use of technology enables real-time communication between nurses and emergency physicians, reducing response times and improving patient care.
BGU Professor Ron N. Apte received the 2010 Samuel and Paula Elkeles Prize for Outstanding Scientist in the Field of Medicine. His research focuses on inflammation in malignant processes, with a major emphasis on IL-1-mediated inflammation in tumor invasiveness and metastasis.
A new study found that rising temperatures in Asia will slow rice production, with daily minimum temperature increases cutting yield growth rate by 10-20 percent in several locations. This could lead to food insecurity and poverty for the over three billion people who rely on rice as their staple food.
Magnetic nanoparticles are injected into tumors to generate heat for cancer treatment. Magnetic relaxometry measures the relaxation of magnetic moments to determine particle quantity, allowing for selective tumor treatment.
A new study reveals that men who experience stiff competition for female attention live shorter lives, with mortality rates increasing by 1.6% among those with higher sex ratios. The researchers suspect that this phenomenon is caused by a combination of social and biological factors, including stress and embodiment of the social world.
Recent research found that forest fires stimulate the conversion of ammonia to nitrates, a crucial step in the nitrogen cycle. This process is triggered by charcoal deposition and can continue well after the fire has passed, benefiting coniferous forests in the inland Northwestern US.
Children of incarcerated parents face increased risks of behavioral problems, substance abuse, and lower academic performance. A strong attachment with alternative caregivers can mitigate these effects, according to research by Julie Poehlmann at the University of Wisconsin-Madison.
Researchers at Duke University have developed a method for injecting substances into single cells using sharp fluid jets, which may revolutionize stem cell research and cellular-level studies. The technique allows for the introduction of live cells to nontoxic substances without significantly damaging them.
Research from Northwestern University found that healthy eggs require high levels of zinc to mature and be fertilized. The study may lead to advances in fertility treatment by enabling doctors to assess the best eggs for successful embryo formation.
USC neuroscientists use new method to trace brain circuits, revealing a distributed network that overcomes local damage and has alternate pathways. The study suggests the brain may be more like the Internet than previously thought.
Researchers at Massachusetts General Hospital found that brain-wave patterns predict the ease of disruption by noise, with participants maintaining consistent spindle rates during sleep. The study aims to develop solutions to help patients stay asleep in noisy environments, such as hospitals.
Scientists find that water fleas facilitate bacterial dispersal, allowing microbes to reach inaccessible habitats. The 'conveyor-belt' hypothesis is confirmed through lab and field experiments.
Researchers identified a signature of three biomarkers in cerebrospinal fluid that can correctly classify patients with Alzheimer's disease. The study suggests that these biomarkers can detect the pathogenic process of Alzheimer's disease at an early stage, potentially leading to earlier diagnosis and treatment.
The Farming Systems Greenhouse Gas Emissions Calculator helps farmers maximize their potential economic returns in greenhouse gas markets. By changing farming practices, users can reduce greenhouse gas losses and gain an economic advantage.
Engineers and physicians at the University of Washington have developed a scaffold that supports the growth and integration of stem cell-derived cardiac muscle cells. The scaffold accelerates oxygen and nutrient supply to transplanted tissue, promoting heart repair and vascular tissue engineering.
Research led by UNC studies found that corporal punishment is prevalent globally, with 79% of preschool children in the US and varying rates in other countries. Harsh physical discipline was epidemic in all communities, and mothers with fewer education years were more likely to use physical punishment.
A new test for oral cancer, developed by researchers at the University of Sheffield, uses a brush to collect cells from a patient's mouth and analyzes them in under 20 minutes. This technology has the potential to significantly increase early detection rates and improve patient outcomes.
Researchers at Columbia University have found that ROCK2 may be a good therapeutic target for treating autoimmune disorders, while targeting CD13+ CSCs in liver cancer could provide a new treatment approach. Additionally, scientists at Stanford University developed ways to enhance RNAi efficacy and persistence while decreasing toxicity.
A new study re-examines the mosasaur fossil, considered the world's finest, revealing that these marine reptiles were better swimmers than previously thought. The team demonstrates that advanced shark-like swimming began in mosasaurs millions of years earlier than previously believed.
The American Dietetic Association emphasizes that schools and communities share the responsibility of providing students with access to high-quality, affordable nutritious foods and beverages. Strong wellness policies promote environments that enhance nutrition integrity and help students develop lifelong healthy behaviors.
A Penn State study found that home health aides who received training had lower injury rates and higher job satisfaction. Training also reduced turnover intentions, benefiting both employees and organizations. Employees' perceptions of their training and workplace played a crucial role in their risk of injury.
A recent study published in Psychological Science found that people find humor in moral violations when they seem harmless or non-threatening. The researchers tested this theory by presenting volunteers with different scenarios and rewarding them with candy bars. They discovered that the situations involving a moral violation were more...
A study found that improved Medicare Part D coverage led to an increase in antibiotic use among older adults, especially for broader-spectrum antibiotics. This suggests that reimbursement may play a role in addressing inappropriate antibiotic prescribing and use.
A new antiviral drug has shown significant promise in treating hepatitis C, particularly in patients with genotype 1, the most difficult to treat. Adding the drug nearly doubled the treatment's effectiveness when given for 48 weeks.