A recent study found that transforaminal steroid injection is a viable alternative to surgery for lumbar radicular pain due to disc herniation, with 54% of patients achieving pain relief after 1 month. The treatment was shown to be more effective than other methods, including local anesthesia and saline injections.
Researchers discovered galangin induces apoptosis in HCC cells through a mitochondrial pathway, modulating key proteins. The study suggests galangin may be a future treatment option for HCC, offering new hope for patients with this challenging cancer.
A US-Mexico border program using a 35-minute behavioral intervention significantly reduced the incidence of HIV and STIs among female sex workers. The program, called Mujer Segura or Healthy Woman, was found to be cost-effective, with an estimated expense per intervention of less than $200.
A new technique developed by NIST scientists can detect biochemical changes in a decomposing cadaver, making it easier to find hidden graves. The device uses an alumina-coated column with a motorized pipette to pull in air samples, detecting trace amounts of ninhydrin-reactive nitrogen.
A new theory developed at Purdue University suggests that stored stress built up in the Earth's crust long ago can trigger large earthquakes. Rapid erosion from the Mississippi River ended a period of forces keeping the New Madrid fault from slipping, triggering the massive earthquakes.
A new method of attack against the AIDS virus has been developed using a prevention system that stiffens cell membranes, making them impenetrable to the virus. This research, published in Chemistry & Biology, provides a novel focus on regulating cell membrane fluidity and preventing viral fusion.
Scientists at NIST evaluated three voice-translation devices designed to improve communications between the US military and non-English speakers. The devices, called TRANSTAC, use automatic speech recognition and text-to-speech technology to translate languages in real-time.
UCLA Engineering is creating state-of-the-art collaborative labs for renewable energy, sustainable infrastructure, and environmental engineering research. The $7.5M NSF grant will renovate Boelter Hall to develop technologies for pharmaceutical biosynthesis, biofuel combustion products, and biotransformation of pollutants.
A team led by Dr. Jonathan Stamler will research the development of a new class of drugs that selectively dilate blood cells under hypoxia, enhancing soldiers' performance at high altitudes. The grant aims to improve tissue oxygenation and deliver more oxygen to tissues despite low blood oxygen content.
Researchers found that albumin and serum protein parameters are less sensitive than anthropometric measurements for evaluating nutritional status in gastric cancer patients. However, a good correlation was observed between scoring nutritional assessment tools and other general nutritional measurement tools six months after surgery.
Researchers discovered that mutations in the 'Fritz' gene can cause cell movement problems and cilia malfunctions, leading to conditions such as mental retardation, obesity, and blindness. The findings shed light on mechanisms regulating cellular machinery during embryonic development and its link to human disease.
Researchers found that bacteria can selectively target and kill cancer cells in tumors of a specific medium size, leading to complete tumor disappearance. The therapy works by germinating and growing bacterial spores in the oxygen-free tumor centers, causing damage to surrounding tumor cells.
A new trend in managing benign biliary strictures is emerging with the use of a removable covered SEMS. The stent, made of nitinol wire, imparts an outward radial force on the biliary duct to establish patency and has a radio-opaque string for easy retrieval.
Michigan State University is creating a cross-discipline, mentored program to increase the number and diversity of researchers in women's health with a $2.5 million grant from the National Institutes of Health. The program will help junior investigators by matching them with mentors and protecting their time to focus on research efforts.
The Gossamer Orbit Lowering Device (GOLD) uses a thin balloon envelope to increase drag, causing space junk to burn up and reducing natural orbit decay. This method is cost-effective, weighs less than propellant, and doesn't create new debris.
A new Northwestern University study has developed a technology that can detect imminent terrorist attacks by correlating P300 brain waves with guilty knowledge in mock terrorism scenarios. The test was accurate in identifying critical concealed information, even without prior knowledge of the planned crime.
Norwegian nursing students will be given a specially developed computer game to aid in passing a critical exam. The project aims to improve learning through visual and fun methods, addressing students' struggles with mathematics and science.
Researchers identified basal cells from benign prostate tissue as a new cell-of-origin for human prostate cancer. This discovery could lead to better predictive and diagnostic tools, as well as the development of targeted treatments. The study provides a novel model system for understanding prostate cancer development and progression.
Physicists at the University of California, Berkeley discovered that when graphene is stretched, it develops bubbles of quantized electrons behaving in a bizarre way. The discovery opens doors to room-temperature straintronics and control of electronic properties through strain.
A study by University of Calgary researchers reveals a significant increase in female fish population and feminization of males in two Southern Alberta rivers. The presence of man-made and naturally occurring chemicals, such as synthetic estrogens and bisphenol A, is linked to the sex ratio imbalance.
Mayor John Fetterman will receive the ESA's Regional Policy Award for his commitment to sustainability, revitalizing the town of Braddock through environmentally-friendly building design. The award recognizes Fetterman's innovative approach to green urban renewal and its potential economic benefits.
Researchers found that people who stay busy, even with meaningless tasks, are happier than those who sit idly. The study used a survey with two options: drop off the survey at a nearby location or wait out the remaining time by walking to a farther location.
Recent meta-analysis finds planned home births double the risk of neonatal deaths and triple when infants have congenital defects. Women should receive adequate midwife care and have quick access to hospital equipment for safe delivery.
Researchers found that TB bacteria tip the balance between cell death types, affecting immune response. Drugs targeting eicosanoid production may offer new treatment options for TB.
A Rutgers study found that male modesty is viewed as a weakness, negatively impacting employability and earnings potential. In contrast, female modesty has no negative connotations.
Researchers have successfully produced sheets of hexagonal boron nitride (h-BN), a potential insulator to complement graphene's electronic properties. The material can be deposited and transferred to various substrates, opening up possibilities for its use in graphene-based electronics.
After a decade-long search, Audubon's first published bird illustration of a running grouse has been discovered. The find sheds light on Audubon's development as an artist and provides a rare view of the Heath Hen, a subspecies that became extinct in the early 19th century.
A new study reveals that coughing and other respiratory symptoms are more accurate indicators of H1N1 infection than fever, which can lead to undetected cases. According to the research, nearly half of individuals with mild H1N1 infections may not display fever, highlighting the need for a more comprehensive screening approach.
A new lab test developed by Japanese scientists can accurately predict imatinib resistance in chronic myeloid leukemia (CML) patients. The test measures protein levels and activity markers to identify resistant cells and determine the next therapeutic option, including dose escalation or combination therapy.
Researchers discovered a common pathway critical for Salmonella's ability to cause disease and resist antibiotics. Mutant strains exhibited abnormalities under stressful conditions, highlighting the importance of stress response mechanisms.
Certain tree species have developed strategies to select bacterial communities that can break down inorganic minerals into usable nutrients. This process, known as mineral weathering, is essential for tree growth in acidic forest soils.
Researchers at UCI have found a new diagnostic tool for multiple sclerosis by detecting increased levels of antibodies that inhibit energy production in neurons. This breakthrough could lead to earlier and more effective treatment for the chronic disease.
Researchers have developed a new method to create nanostructured surfaces using polystyrene spheres and zinc oxide, which can efficiently absorb sunlight and convert it into electricity. The 'sea-urchin'-shaped structures
The Climate Adaptation Knowledge Exchange (CAKE) provides foundational knowledge on adaptation, new research, and innovative work from the field. The website enables scientists and practitioners to define and build the field of adaptation.
Researchers found that white button mushrooms enhance dendritic cell maturity, improving immune response to disease-causing pathogens. The study suggests that consuming adequate nutrients can support immune system health.
Researchers reconstructed summer temperatures on the Kola Peninsula and found a rapid temperature rise since 1990, contradicting previous cooling trends. The data suggest that solar activity may have been a significant factor contributing to Arctic temperature fluctuations until 1970.
The new fluorescent biosensor could aid in the development of drugs targeting GPCRs, a crucial class of proteins present in cells. The biosensor uses fluoromodules to monitor protein activity and provides a homogeneous assay that can screen large numbers of molecules to identify new drug leads.
The University of Nevada, Reno has successfully mapped the bottom of Fallen Leaf Lake using a state-of-the-art multi-beam sonar system, revealing details of ancient trees and earthquake activity. The technology allows for high-definition mapping with several centimeter depth resolution.
A recent report from the UK Vascular Society and Royal College of Physicians reveals patients in the UK are waiting too long for vascular surgery after stroke or TIA symptoms. The main causes of delays include delayed referral, scarcity of staff or operating theatres, and patient presentation issues.
Researchers found that a gaseous molecule called nitric oxide can trigger brain cell death in neurodegenerative diseases. The study discovered a new molecular pathway that leads to cellular suicide, offering new potential for diagnosis and treatment.
A statistical analysis of chemicals found in walleye ear bones reveals that almost all Maumee-spawned walleyes were hatched there, but only two-thirds of Sandusky-spawned walleyes originated from the same river. This study helps wildlife officials determine which rivers are at risk of overfishing.
Researchers found that prostate basal cells can spawn tumors in the prostate gland, providing a new originator of prostate cancer. The study used human prostate tissue samples to develop new techniques and identified unique cell surface markers to distinguish luminal cells from basal cells.
A study led by researchers at the University of Louisville found that individuals with a male first-degree relative with breast cancer perceive themselves as being at higher risk than those with a female relative. However, many lack awareness and discussion about genetic testing.
A study by FDA researchers found a higher incidence of malignancy in children using TNF blockers like infliximab and etanercept. The reporting rate for U.S. cases of malignancy in children was 4-18 times the estimated background rate for the general pediatric population.
A recent study found a link between elevated intrinsic brain connectivity and spontaneous pain intensity in fibromyalgia patients. The research shows an interaction of multiple brain networks, providing insights into how pain arises in these individuals.
A study published in Neuron reveals that GABA, a natural molecule in the brain, is responsible for regulating synaptic connections and facilitating the formation of new memories. The research demonstrates that variations in local GABA levels near individual synapses determine synaptic strength and heterogeneity.
Researchers found that right-handers favor their dominant hand for positive ideas and non-dominant hand for negative thoughts. Conversely, left-handers use their left hand for positive expressions and right hand for negative ones. These findings suggest people link 'good' with the side of their body they can use most fluently.
A new recurrent translocation between chromosomes 8 and 22 has been found to cause a range of genetic diseases. The disorder, characterized by mild mental retardation and developmental delays, is thought to arise from palindromic sequences in the DNA that are prone to breakage and rearrangement.
A combination treatment of naltrexone and bupropion, along with diet and exercise, has been shown to reduce body weight by 5% or more in people with obesity. The study found that patients who received the treatment experienced significant weight loss, with those in the highest dosage group losing up to 6.1kg over 56 weeks.
A new study published in The Journal of Clinical Endocrinology & Metabolism found that vitamin D deficiency is associated with increased arterial stiffness in black teens. Researchers discovered that higher doses of vitamin D supplementation (2,000 IU) improved cardiovascular health and reduced central arterial stiffness.
Researchers identify a critical lincRNA-p21 that suppresses multiple genes across the genome following p53 activation, playing a key role in mediating cellular response to DNA damage. This discovery opens up new avenues for understanding gene regulation and developing anti-cancer therapies.
Researchers at Rice University have developed a theoretical method to calculate the time it takes for long-chain polymers to translocate through nanopore geometries, shedding new light on their transport. The study found that polymers pass more quickly when entering a composite pore through its wide end.
A study of over 786 cases found that thiazolidinediones, a common diabetes medication, increased the risk of fractures in postmenopausal women and men with diabetes. Higher doses of TZDs were associated with greater fracture risk.
Researchers at Michigan State University found that protein diffusion is slower than previously thought, which could lead to new therapeutic strategies for diseases such as Alzheimer's, ALS, and cystic fibrosis. The discovery provides a fundamental understanding of the pre-folded state of proteins.
The University of Guam Sea Grant Extension Program aims to revive traditional Chamorro fishing practices, which were replaced by Western technology. The project will teach the community how to build and repair indigenous canoes and fish using pre-contact equipment, promoting sustainable seafood supply and cultural preservation. Environ...
A new study from the University at Buffalo found that 66% of youth hockey injuries were caused by accidental hits to the boards or goal posts, while only 34% were caused by checking. The study, which analyzed data from over 3,000 players, suggests that coaches should teach players to keep their heads up and avoid looking down at the puck.
A study conducted by University at Buffalo researchers found that resveratrol suppressed the generation of free radicals and reduced inflammation in human blood samples. The compound also showed promise in reducing insulin resistance and related markers, potentially benefiting conditions like type 2 diabetes and heart disease.
A Harvard University study found that small changes in perceived vaccine costs can lead to significant gaps in herd immunity, with social networks playing a crucial role in the spread of disease. The researchers discovered that increasing vaccination cost prompts more free-riding and leads to larger epidemics.
Researchers discovered that patients with high levels of albuminuria have a significantly increased risk of developing acute kidney injury, highlighting the importance of monitoring kidney function. By recognizing these warning signs, individuals can take proactive steps to prevent preventable forms of acute kidney injury.
A $1.5 million NSF grant will consolidate data from 10 natural history bee collections across the US, including Cornell's 250,000-specimen collection. This effort aims to establish conservation status and predict risks to bee pollination services from climate change and habitat loss.